Serotonin 

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  • ||||||||||  verapamil / Generic mfg., flunarizine / Generic mfg., memantine / Generic mfg.
    Phenotypic Variability in Patients with Pathogenic Variants in ATP1A2 and ATP1A3 (Colorado Convention Center | 605) -  Mar 8, 2024 - Abstract #AAN2024AAN_2408;    
    Seizures and developmental delay are the most common findings, with developmental delay often preceding medical attention. Patients also may present with movement disorders, encephalopathy, migraine, apneic episodes, or cardiac arrest.
  • ||||||||||  donepezil / Generic mfg., levetiracetam / Generic mfg., sumatriptan succinate / Generic mfg.
    Pilot Study: Implementation of a Neurology-free Clinic in Columbus, Ohio (Colorado Convention Center | Exhibit Hall B-E) -  Mar 8, 2024 - Abstract #AAN2024AAN_2016;    
    The implementation of neurological clinical care to uninsured/underinsured patients can be achieved through collaborative work between students, residents, and ancillary services. This model of care can be replicated by other specialties and institutions to provide free care for patients in need of such services.
  • ||||||||||  Diacomit (stiripentol) / Biocodex, Meiji Seika, Fintepla (low-dose fenfluramine) / UCB, Nippon Shinyaku
    Healthcare Utilization and Persistence in Patients with Dravet Syndrome: A Retrospective Analysis Using U.S. Claims Data (Colorado Convention Center | Exhibit Hall B-E) -  Mar 8, 2024 - Abstract #AAN2024AAN_1989;    
    Meaningful reductions in healthcare utilization were seen among individuals with DS treated with fenfluramine for ?6 months. Further, fenfluramine demonstrates a strong persistency compared to valproate and levetiracetam, suggesting improved long-term outcomes.
  • ||||||||||  botulinum neurotoxin type A gel formulation (RT001) / Revance Therap, Daxxify (daxibotulinumtoxinA) / Revance Therap
    Influence of Novel Formulation in DaxibotulinumtoxinA on Efficacy for Treatment of Cervical Dystonia (Colorado Convention Center | Exhibit Hall B-E) -  Mar 8, 2024 - Abstract #AAN2024AAN_1952;    
    We have demonstrated that the interaction of RTP004 with the 150-kDa BoNT/A can enhance binding to neurons and cleavage of the intracellular substrate, SNAP-25. This data illustrates the importance of formulation on the clinical performance of a BoNT product and the impact of the novel peptide excipient in DAXI.
  • ||||||||||  imipramine / Generic mfg., venlafaxine / Generic mfg., quetiapine / Generic mfg.
    Clinical, Journal:  A genetic risk score to predict treatment nonresponse in psychotic depression. (Pubmed Central) -  Mar 7, 2024   
    Overall, an increased risk for nonresponse and nonremission was seen in patients with GRSs in the top 40%. Our results suggest that a treatment-resistant depression GRS is predictive of treatment nonresponse and nonremission in psychotic depression.
  • ||||||||||  Akineton (biperiden) / Endo, AbbVie
    Clinical, Retrospective data, Review, Journal:  Drug Efficacy in the Treatment of Antipsychotic-Induced Akathisia: A Systematic Review and Network Meta-Analysis. (Pubmed Central) -  Mar 7, 2024   
    Cyproheptadine, clonazepam, zolmitriptan, and valproate did not yield significant effects...Trazodone, mianserin, and propranolol appeared as effective alternatives with slightly less favorable efficacy and tolerance profiles. These findings should assist prescribers in selecting an appropriate medication for treating AIA.
  • ||||||||||  fluoxetine / Generic mfg.
    Trial completion date, Trial primary completion date:  The Effects of Fluoxetine and/or DHEA (clinicaltrials.gov) -  Mar 6, 2024   
    P1,  N=60, Recruiting, 
    Active, not recruiting --> Completed Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Feb 2024 --> Feb 2025
  • ||||||||||  haloperidol / Generic mfg., clozapine / Generic mfg.
    Preclinical, Journal:  Chronic social stress in early life can predispose mice to antisocial maltreating behavior. (Pubmed Central) -  Mar 6, 2024   
    Chronic social stress in childhood might predispose a mouse to antisocial behavior. Our maltreating behavior assay system, including the MS/SD/SI model, is a good animal system for research on and drug screening for brain disorders associated with antisocial or psychotic behavior.
  • ||||||||||  fluoxetine / Generic mfg.
    To investigate the effect of fluoxetine combined with radiation therapy on hepatocellular carcinoma (Section 45) -  Mar 5, 2024 - Abstract #AACR2024AACR_2505;    
    To conclude, the induction of apoptosis, DNA damage, and autophagy emerges as a crucial mechanism contributing to the heightened sensitivity of HCC cells to RT when combined with Fluoxetine. These results suggest that the combination of Fluoxetine with RT presents a promising novel approach for the treatment of HCC.
  • ||||||||||  psilocybin (COMP360) / Compass Pathways
    Trial completion date, Trial primary completion date:  PSILAUT: Psilocybin in Adults With and Without Autism Spectrum Disorder (clinicaltrials.gov) -  Mar 5, 2024   
    P=N/A,  N=70, Recruiting, 
    Trial completion date: Dec 2023 --> Dec 2024 Trial completion date: Dec 2024 --> Sep 2025 | Trial primary completion date: Dec 2024 --> Sep 2025
  • ||||||||||  ondansetron / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  Ondansetron for the Management of Atrial Fibrillation (clinicaltrials.gov) -  Mar 5, 2024   
    P4,  N=80, Recruiting, 
    These results suggest that vortioxetine may be a treatment option for older prostate cancer patients who experience cognitive decline after ADT. Trial completion date: Dec 2026 --> Dec 2027 | Initiation date: Jan 2024 --> May 2024 | Trial primary completion date: Dec 2026 --> Dec 2027
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Concentrations of Fluoxetine Enantiomers Decline During Pregnancy and Increase After Birth. (Pubmed Central) -  Mar 4, 2024   
    Adjunctive brexpiprazole is efficacious in reducing core depressive symptoms, sleep, and appetite, as well as improving functioning, in patients with MDD and anxious distress who have inadequate response to ADTs. These data do not support a recommendation for routine plasma concentration monitoring or CYP2D6 pharmacogenetic testing for pregnant people treated with FLX; however, monitoring for symptom relapse is recommended because of declining plasma drug concentrations.
  • ||||||||||  ondansetron / Generic mfg.
    Journal:  Prevention of post-spinal anaesthesia hypotension in caesarean delivery using delayed supine positioning - A randomised controlled trial. (Pubmed Central) -  Mar 4, 2024   
    Combining pharmacological methods such as norepinephrine infusion, ondansetron and non-pharmacological methods in delayed supine positioning better impacts the maternal haemodynamic profile...In addition, the Sitting group had a reduced hypotension incidence and a lower rate of ephedrine use than the other group, but bradycardia incidence was comparable between both groups. In elective caesarean delivery, combining pharmacological and non-pharmacological methods achieve better results regarding maternal hypotension, vasopressor consumption, nausea and vomiting, and foetal outcomes.
  • ||||||||||  escitalopram / Generic mfg.
    PK/PD data, Journal:  Assessment of Pharmacokinetic Effects of Herbal Medicines on Escitalopram. (Pubmed Central) -  Mar 4, 2024   
    The co-administration of escitalopram with Gami-soyosan, Banhasasim-tang, Ojeok-san, or Bojungikgi-tang did not exert significant PK effects on escitalopram. These findings provide valuable insights into the safe use of herbal medicines along with escitalopram.
  • ||||||||||  paroxetine / Generic mfg., alprazolam / Generic mfg.
    Journal:  Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder. (Pubmed Central) -  Mar 4, 2024   
    This study reports that PD, like other anxiety disorders, may affect serum nesfatin-1, leptin, orexin-A, and total ghrelin levels, and there may be a relationship between PD treatment and the levels of these neuropeptides. The variability of this relationship among the neuropeptides examined indicates that various factors other than treatment play a role in this process.
  • ||||||||||  trifluoperazine / Generic mfg., quetiapine / Generic mfg.
    Review, Journal:  Antipsychotic agents in anxiety disorders: An umbrella review. (Pubmed Central) -  Mar 4, 2024   
    Although potentially effective for anxiety disorders, FGAs and SGAs may have risks and side effects that outweigh their efficacy, although there were limited data. Further long-term and larger-scale studies of antipsychotics in anxiety disorders are needed.
  • ||||||||||  Review, Journal:  The VEGFs/VEGFRs system in Alzheimer's and Parkinson's diseases: pathophysiological roles and therapeutic implications. (Pubmed Central) -  Mar 4, 2024   
    Specific VEGFRs targeting, aimed at selective VEGFR-1 inhibition, while preserving VEGFR-2 signal transduction, appears as a promising strategy to hit the molecular mechanisms underlying AD pathology. Moreover, therapeutic VEGF-based approaches can be proposed for PD treatment, with the aim of fine-tuning its brain levels to amplify its neurotrophic/neuroprotective effects while limiting an excessive impact on vascular permeability.
  • ||||||||||  sertraline / Generic mfg.
    Retrospective data, Review, Journal:  Cognitive Outcomes After Antidepressant Pharmacotherapy for Late-Life Depression: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Mar 4, 2024   
    Thirteen of 19 studies showed an improvement on at least one cognitive test after antidepressant pharmacotherapy, with the most robust evidence for the memory and learning (nine of 16 studies) and processing speed (seven of 10 studies) domains and for sertraline (all five studies)...This effect may be mediated by an improvement in depressive symptoms. Studies comparing individuals receiving pharmacotherapy with untreated control participants are needed.