- |||||||||| risperidone / Generic mfg., rosuvastatin / Generic mfg.
Journal: Psychotic Disorder after Left Posterior Cerebral Artery Stroke-An Atypical Event. (Pubmed Central) - Mar 12, 2024
Due to the lack of guidelines on approaching PSPsy, most patients are treated with the same strategies used for non-stroke patients. A better comprehension of the anatomical basis underlining the symptomatology in these patients could deepen the understanding of psychosis and psychotic disorders.
- |||||||||| Exparel (bupivacaine liposome injectable suspension) / Pacira
Trial completion date, Trial primary completion date: SKOAP: A Sequenced Strategy for Improving Outcomes in People With Knee Osteoarthritis Pain (clinicaltrials.gov) - Mar 12, 2024
P3, N=1800, Recruiting,
These results suggest that WS could have potential as a therapeutic agent for treating PTSD by attenuating anxiogenesis, neuroimmune axis activation, and oxidative stress. Trial completion date: Aug 2024 --> Mar 2025 | Trial primary completion date: Apr 2024 --> Nov 2024
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Single-Dose versus Multi-Dose Course of Prophylactic Antibiotics for Bladder Onabotulinumtoxin-A Injection: A Prospective Randomized Controlled Trial (302A) - Mar 12, 2024 - Abstract #AUA2024AUA_3347;
For the multi-day group, twice daily dosing of trimethoprim/sulfamethoxazole, cephalexin, nitrofurantoin, or ciprofloxacin were prescribed as first, second, third-, and fourth-line therapy, respectively. For office injection of bladder BoNT-A for uncomplicated OAB, a single dose of oral prophylactic antibiotic is non-inferior to a multiple doses course for the prevention of UTI.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Emerging Technique for Posterior Endoscopic Urethroplasty with Graft (Video Abstract Theater) - Mar 12, 2024 - Abstract #AUA2024AUA_2615;
Modified endoscopic posterior urethroplasty using buccal graft is a viable minimally invasive approach to urethroplasty using devices commonly used by urologists and available in most settings. The outcomes compared to other similar techniques or the gold standard have yet to be elucidated.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Amniotic Bladder Therapy in Patients with Interstitial Cystitis/Bladder Pain Syndrome (303A) - Mar 12, 2024 - Abstract #AUA2024AUA_2031;
Our findings suggest that ABT shows promise as a treatment for refractory IC/BPS patients. However, further study is needed to establish treatment protocol, better understand the mechanism of action and determine the durability of therapeutic response of ABT in IC/BPS.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
New sub-classification and treatment algorithm for Chronic Scrotal Content Pain (CSCP) syndrome (221B) - Mar 12, 2024 - Abstract #AUA2024AUA_1178;
For microsurgical spermatic cord denervation (MSCD) failures we provided option for Salvage Ultrasound-guided Targeted Cryoablation, Botox injections and Posterior-Inferior Scrotal denervation... The subdivision of scrotal pain syndrome to 5 different types could help general urologist to concentrate assessment efforts accordinly and should simplify the stepwise treatment process.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Robot-asistted augmentation enterocystoplasty as treatment of overactive bladder (Learning Lab) - Mar 12, 2024 - Abstract #AUA2024AUA_1032;
Augmentation ileocistoplasty is an effective and safe alternative in cases of refractory overactive bladder syndrome. Robot-assisted laparoscopic approach allows for minimally invasive surgery with better visualization, increased precision, and reduced rates of bleeding, transfusion, and hospital stay.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
CASE PRESENTATION: TREATMENT AND MANAGEMENT OF INCONTINENCE IN AN INDIANA POUCH (Learning Lab) - Mar 12, 2024 - Abstract #AUA2024AUA_1031;
Clinicians may consider intra-pouch injections of OnabotulinumtoxinA to alleviate storage-related stomal incontinence prior to revision or augmentation of the continent diversions. Furthermore, needle depth up to 3 mm appears sufficient in a thin, intestinal pouch, although shorter lengths were not investigated.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Long Term Outcomes of Intradetrusor OnabotulinumtoxinA Use in Pediatric Patients with Spina Bifida (304A) - Mar 12, 2024 - Abstract #AUA2024AUA_978;
Thirty-seven percent of SB patients with long-term FU have been successfully managed with regular BTX injections. Repeat VUD after initial BTX injection may help identify patients who may benefit from repeat injections, but identifying objective criteria to predict long-term success remains challenging.
- |||||||||| MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
Preclinical, Journal: Proteasome localization and activity in pig brain and in vivo small molecule screening for activators. (Pubmed Central) - Mar 12, 2024
In piglets treated intravenously with pyrazolone derivative and chlorpromazine over 24?h, brain proteasome CTL activity was modestly increased. This study shows that the proteasome in the pig brain has relative regional uniformity, prominent nuclear and perinuclear presence with catalytic activity, a mitochondrial association with activity, 26S-single cap dominance, and indications from small molecule systemic administration of pyrazolone derivative and chlorpromazine that brain proteasome function appears safely activable.
- |||||||||| pantoprazole / Generic mfg., escitalopram / Generic mfg.
FDA event, Journal: Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7). (Pubmed Central) - Mar 12, 2024
Among the identified 11 hits, compound 6 (oxybutynin), 7 (ketotifen), 10 (pantoprazole sodium), and 11 (escitalopram) also showed anti-cancer activity with an effect on the expression of proto-oncogenes and tumor-suppressor gene at mRNA level in HCT116 cells. The compounds identified in this study can serve as potential leads for further studies.
- |||||||||| lysergic acid diethylamide (MM-120) / Mindmed, University Hospital Basel
Trial initiation date: LPC: Lysergic Acid Diethylamide (LSD) in Palliative Care (clinicaltrials.gov) - Mar 12, 2024
P2, N=60, Recruiting,
MH CPPs provide care for complex patients with schizophrenia, bipolar disorder, and MDD in VA. Initiation date: Sep 2023 --> Mar 2024
- |||||||||| Nuplazid (pimavanserin) / Acadia Pharma
Enrollment open: Pimavanserin for Sleep in Parkinson Disease (clinicaltrials.gov) - Mar 12, 2024
P1, N=10, Recruiting,
Initiation date: Sep 2023 --> Mar 2024 Not yet recruiting --> Recruiting
- |||||||||| frovatriptan / Generic mfg.
LAMMPS-ANI: Large scale molecular dynamics simulations with ANI neural network potentials | Poster Board #2124 (In-person; Poster Board #2124; Hall C (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_10000;
We highlight our work in large-scale molecular dynamics using ANI potentials, presenting benchmark results for water boxes (up to 100 million atoms) and solvated HIV virus capsids (44 million atoms). We also present results for accurately simulating complex reaction processes at unprecedented scales, such as methane combustion (300 thousand atoms) and early Earth experiments (228 thousand atoms) that led to the formation of glycine.
- |||||||||| frovatriptan / Generic mfg.
Simulating nanometer-sized supported Ag nanoparticles under catalytic reaction conditions | Poster Board #2131 (In-person; Poster Board #2131; Hall C (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_9883;
GPAW is used to initially calculate systems that are computationally affordable using DFT (smaller than Ag 300 ) and an MLIP is trained via Allegro with iterative and committee training methods to extend the system size to systems that are larger and minimize DFT evaluations...We also compare MLIP-predicted NP structures against geometries formed via the Winterbottom construction and discuss the limitations of these constructions. This work marks an important progress towards understanding nanometer-sized NPs' appearance under realistic reaction conditions using near-DFT quality computational methods and models.
- |||||||||| tianeptine / Generic mfg.
Analysis of Zaza Red for tianeptine content via HPLC and UV-Vis | Poster Board #435 (In-person; Poster Board #435; Hall C (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_5265;
The response was then compared to a calibration curve created with tianeptine standards to quantify the amount of tianeptine in the pills. The quantification of the response was done so that users of the supplements can understand the dose they are ingesting, as well as to see if the pills contain any additives not listed in the ingredients.
- |||||||||| fluoxetine / Generic mfg.
Multifaceted quantification of drug-polymer complexes on gold nanoparticles (Hybrid; Room 239 (Ernest N. Morial Convention Center)) - Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_2477;
A series of linear polyacrylamides functionalized with varying amounts of fluoxetine and 3-methyl(thiol)propylamine were synthesized via a thermally induced free radical polymerization...Synthesized polymers were linked to the surface of citrate-capped AuNPs via the thioether moiety of MTP, with successful attachment confirmed by UV-Vis spectroscopy, Dynamic Light Scattering, Zeta Potential, and ICP-OES measurements. This work demonstrates a variety of techniques that can be used to determine the loading of the polymer-drug-nanoparticle construct at a number of different end points.
- |||||||||| Invega Sustenna (paliperidone palmitate extended-release 1-month injection) / J&J, Invega Hafyera (paliperidone palmitate extended-release 6-month injection) / J&J, Invega Trinza (paliperidone palmitate extended-release 3-month injection) / J&J
Review, Journal: Evaluating the 6-month formulation of paliperidone palmitate: a twice-yearly injectable treatment for schizophrenia in adults. (Pubmed Central) - Mar 12, 2024
PP6M allows a longer dosing interval than any other LAI antipsychotics, potentially reducing nonadherence and disease relapses. In future, an increase in the prescription rates of PP6M is expected and real-world efficacy and tolerability studies will be conducted.
- |||||||||| haloperidol / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Acute encephalopathy in the ICU: a practical approach. (Pubmed Central) - Mar 12, 2024
Dexmedetomidine is effective for mechanically ventilated patients with delirium, while haloperidol has minimal effect of delirium but may have other benefits. Specific treatments for coma in nonprimary brain injury are still lacking.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Xcopri (cenobamate) / SK Bio, Angelini Group, Endo, Fintepla (low-dose fenfluramine) / UCB, Nippon Shinyaku
Review, Journal: The latest advances in the pharmacological management of focal epilepsies in children: a narrative review. (Pubmed Central) - Mar 12, 2024
Future treatments should be increasingly personalized and targeted on patient-specific pathways. Future research should focus not only on discovering new chemical compounds but also on repurposing medications used for other indications.
- |||||||||| clozapine / Generic mfg.
Retrospective data, Review, Journal: Immunoinflammatory and oxidative alterations in subjects with schizophrenia under clozapine: A meta-analysis. (Pubmed Central) - Mar 12, 2024
In conclusion, our results show that clozapine treatment causes a time-dependent mixed immune profile characterized by increased IL-6 levels and CIRS activation, which may contribute to this drug mechanism of action and adverse effects. Future studies must be designed to investigate the relationship between clozapine-induced immune alterations and symptom remission, treatment resistance, and adverse effects, given the importance of this drug for treating resistant schizophrenia.
- |||||||||| olanzapine / Generic mfg.
Review, Journal: A Possible Role of Akkermansia muciniphila in the Treatment of Olanzapine-Induced Weight Gain. (Pubmed Central) - Mar 11, 2024
Clinicians should avoid the regular use of haloperidol and risperidone, and future human studies should be conducted with atypical antipsychotics. Multiple strain probiotics and Akkermansia muciniphila alone have been administered both in mice models and in clinical populations demonstrating efficacy on antipsychotic-induced metabolic impairment and showing a contribution in reducing induced weight gain.
- |||||||||| chlorpromazine / Generic mfg.
Journal: A retrotransposon-derived DNA zip code internalizes myeloma cells through Clathrin-Rab5a-mediated endocytosis. (Pubmed Central) - Mar 11, 2024
Endocytosis inhibitors identified that Monensin and Chlorpromazine hydrochloride significantly reduced MM-ZC internalization...Overall, the current study provides valuable insights into the cellular uptake and intracellular trafficking of MM-ZC in myeloma cells. Identifying these mechanisms and molecular players involved in MM-ZC uptake contributes to a better understanding of the delivery and potential applications of cell-specific Zip-Codes in gene delivery and drug targeting in cancer research.
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