Serotonin 

 448 Products   448 Products   1070 Diseases   113911 News 


«12...6667686970717273747576...11171118»
  • ||||||||||  Resolor (prucalopride) / J&J, Takeda
    COMPARING EFFICACY OF PRUCALOPRIDE WITH 2-L PEG VERSUS 2-L PEG FOR BOWEL PREPARATION: A RANDOMIZED CONTROLLED TRIAL (146C - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_4218;    
    Of relevance to future studies patients who had moderate to severe nausea normal rather than slow GE and experienced less fullness during lipid infusion with ondansetron were more likely to benefit from ondansetron. Prucalopride may be an effective and safe adjunct to PEG that leads to an improved quality of bowel preparation.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    SAFETY AND EFFICACY OF PERORAL ENDOSCOPIC MYOTOMY AFTER FAILED INTERVENTIONS (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_3570;    
    Prior interventions including botox injection (BI) pneumatic dilation (PD) and Heller myotomy can result in significant scarring and fibrosis of the submucosal space thereby making this procedure technically challenging...Conclusion : In our study there was no difference in POEM performance and outcomes in patients with or without prior interventions. Given its safety profile and efficacy POEM can be considered as a feasible rescue therapy.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    PREDICTORS OF CLINICAL FAILURE AFTER PERORAL ENDOSCOPIC MYOTOMY FOR ACHALASIA (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_3543;    
    Prior interventions including Botox injection pneumatic dilation and Heller myotomy were seen in 6% of the study cohort (n= 0)...ConclusionsIn our study longer disease duration and sigmoid esophagus were risk factors associated with POEM failure. Development of risk-scoring systems to identify such patients will help optimize treatment strategies to improve clinical outcomes.
  • ||||||||||  Resolor (prucalopride) / J&J, Takeda, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    10-YEAR TRENDS IN MANAGEMENT OF GASTROESOPHAGEAL REFLUX AND PEDIATRIC FEEDING DISORDERS IN INFANTS AND TODDLERS (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_3477;    
    Other treatment strategies include prokinetics [e. g. erythromycin (EES) metoclopramide or prucalopride] medications targeting gastric accommodation/appetite [e. g. cyproheptadine] or procedures impacting pyloric functioning [e. g. intrapyloric botulinum injection (IPBI)]...Patients receiving IPBI were identified based on procedure codes and onabotulinum toxin orders...Practice patterns have changed over time with more children prescribed H B over PPI later in the study as well as increased prescribing of EES prucalopride cyproheptadine and IPBI. Future research should focus on these and other novel treatments that target a variety of physiologic mechanisms beyond acid suppression.
  • ||||||||||  clozapine / Generic mfg.
    SEXUAL DYNAMIC CONTRIBUTION OF DRG MACROPHAGES AND SATELLITE GLIAL CELLS IN VISCERAL PAIN (140AB - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_2000;    
    Colitis also increased CSF1R + CD11b + monocytes infiltration of DRG in both sexes with CSF1R + GFP + macrophages accumulated around DRG neurons. AP20187 treatment of MAFIA mice with colitis mitigated the population of CD11b + monocyte infiltration in DRG of both sexes, however, only attenuated colitis-induced tumor necrosis factor alpha (TNF-?) upregulation in DRG of female but not male mice.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    ENDOSCOPIC SUTURE GASTROPLASTY FOR DELAYED GASTRIC EMPTYING AFTER ESOPHAGECTOMY (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_1741;    
    After pyloric dilation Botox injection and per oral pyloromyotomy to treat DGE the patient's symptoms persisted due to the dilated and tortuous gastric conduit. Endoscopic suture gastroplasty has been a safe repeatable intervention which has successfully reduced the symptoms of DGE.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    SAME DAY DISCHARGE, MEDICAL AND NON-MEDICAL ADMISSION AFTER PER ORAL ENDOSCOPIC PYLOROMYOTOMY (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_1515;    
    Some had also failed gastric pacemaker and pyloric Botox injections...ConclusionsAfter about 10 years of practice G-POEM is a safe endoscopic therapeutic modality. This study showed that most patients undergoing G-POEM can be discharged on the same day while only a few of the patients are admitted for medical issues related to the procedure.
  • ||||||||||  FROM MIND TO GUT: DECODING THE RELATIONSHIP BETWEEN PSYCHOTROPICS AND COLITIS (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_1140;    
    Management included discontinuing the culprit drug and substituting it with mirtazapine or bupropion treating colitis and using nonpharmacologic modalities...By damaging nerves in the myenteric plexus chlorpromazine caused necrotizing colitis requiring hemicolectomy...Stool impaction triggers cytokine which activates CMV replication inhibits cytochrome (CYT) 1A and causes clozapine toxicity...Olanzapine induces metabolic syndrome and thrombosis...Gastroenterology should be involved sooner and the causative agent should be discontinued if all other causes have been ruled out. More research is needed to clarify the time of onset severity of symptoms predisposing factors and medication rechallenge effects.
  • ||||||||||  venlafaxine / Generic mfg., mebeverine / Generic mfg., duloxetine / Generic mfg.
    THE EFFICACY OF SEROTONIN NORADRENALINE REUPTAKE INHIBITORS IN IRRITABLE BOWEL SYNDROME: A META-ANALYSIS (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_1120;    
    Subgroup analyses were conducted based on the types of medication (duloxetine venlafaxine) and treatment regimens(single or combination therapy)...05) compared to the placebo or conventional treatment group (mebeverine)...Conclusions Existing evidence suggests that SNRIs have encouraging efficacy in improving abdominal pain and comorbid anxiety and depression in IBS patients. It is necessary to conduct multicenter RCTs to further evaluate the efficacy indication optimal regimen safety and the therapeutical mechanism of SNRIs in the treatment of IBS patients.
  • ||||||||||  clozapine / Generic mfg.
    SATELLITE GLIAL CELLS DRIVE PIEZO2 UPREGULATION IN DRG NEURONS VIA A PARACRINE ACTION (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_1093;    
    Experiments from a variety of distinct approaches reveal an underlying mechanism by which SGC activation leads to Piezo upregulation in small DRG neurons presumably nociceptors and increases the mechanosensitivity of DRG neurons via a paracrine mechanism mediated by gliotransmitters. These findings pave the way for novel strategies in targeting SGCs for the treatment of diseases such as mechanical pain including visceral hypersensitivity.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Observational data, Journal:  Acceptance of Surgical and Non-surgical Cosmetic Procedures: A Cross-Sectional Study From Jazan, Saudi Arabia. (Pubmed Central) -  Mar 14, 2024   
    This specialization encompasses various interventions, both surgical, such as blepharoplasty, rhinoplasty, and breast augmentation, and non-surgical, including procedures such as chemical peeling, Botox injections, and dermal fillers...Age, sex, marital status, income level, familial influence, and prior experience all played significant roles in shaping these attitudes. The perceived lack of a need for the procedures and religious beliefs were common reasons for not accepting cosmetic procedures.
  • ||||||||||  Dopergin (lisuride) / Bayer
    Journal:  Comparative Pharmacological Effects of Lisuride and Lysergic Acid Diethylamide Revisited. (Pubmed Central) -  Mar 14, 2024   
    Overall, our findings show that lisuride is an ultrapotent 5-HT1A agonist in C57BL/6J mice, limiting its use as a 5-HT2A ligand in mouse studies examining acute drug effects. Results also indicate that the 5-HT2A partial agonist-antagonist activity of lisuride explains its lack of psychedelic effects.
  • ||||||||||  Priligy (dapoxetine) / AbbVie
    Journal:  Dapoxetine versus glans penis injection with hyaluronic acid gel in treatment of premature ejaculation. (Pubmed Central) -  Mar 14, 2024   
    However, when comparing the improvement of ILET in group A (Dapoxetine) and group B (HA injection), there were high significance differences in favor of group B in the 1st,3rd, and 6th-month follow-up. Although both treatment modalities have improved IELT and premature ejaculation, but HA injection with five punctures technique was significantly better than oral Dapoxetine with self-limited side effects.
  • ||||||||||  Review, Journal:  Emergency department management of acute agitation in the reproductive age female and pregnancy. (Pubmed Central) -  Mar 13, 2024   
    While randomized control studies cannot be ethically conducted on pregnant patients requiring sedation, animal models and epidemiologic studies have demonstrated the effects of psychotropic medication exposure in utero. As the fetal risk associated with multiple doses of psychotropic medications remains unknown, weighing the risks and benefits of each agent, while utilizing the lowest effective dose remains critical in the treatment of acute agitation within the EDs.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  A framework for inferring and analyzing pharmacotherapy treatment patterns. (Pubmed Central) -  Mar 13, 2024   
    Furthermore, our outcomes are also indications for both disease and treatment. Despite these limitations, we demonstrate the usefulness of our framework in providing operational insight into clinical practice, and our results underscore the need for increased monitoring during critical points of treatment.
  • ||||||||||  paroxetine / Generic mfg.
    Journal:  Inhibition of TNBC Cell Growth by Paroxetine: Induction of Apoptosis and Blockage of Autophagy Flux. (Pubmed Central) -  Mar 13, 2024   
    Additionally, the combination of PX and chemotherapeutic agents demonstrated moderate inhibitory effects on 4T1 tumor growth in an in vivo model. These findings indicate that PX may exert its effects on TNBC through modulation of critical molecular pathways, offering important implications for improving chemosensitivity and identifying potential therapeutic combinations for clinical use.
  • ||||||||||  trazodone ER / Generic mfg.
    Preclinical, Journal:  Sage (Salvia officinalis) alleviates trazadone induced rat cardiotoxicity mediated via modulation of autophagy and oxidative stress. (Pubmed Central) -  Mar 13, 2024   
    The antidepressant drug trazodone (TRZ) is commonly used for treating depression, anxiety, and insomnia, however, it causes cardiotoxicity, which is one of its limitations...However, administration of sage in both protective and curative groups show marked improvement of the cardiac alterations. In conclusion, sage ameliorated the alterations in the heart induced by trazadone through modulation of autophagy and oxidative stress.
  • ||||||||||  Ztalmy (ganaxolone oral) / Marinus, Belviq (lorcaserin) / Eisai
    Journal:  Using artificial intelligence to identify drugs for repurposing to treat l-DOPA-induced dyskinesia. (Pubmed Central) -  Mar 13, 2024   
    In conclusion, although our data do not support the repurposing of lorcaserin, acamprosate or ganaxolone per se for LID, we demonstrate value of an in silico approach to identify candidate molecules which, in combination with an in vivo screen, can facilitate clinical development decisions. The present study adds to a growing literature in support of this paradigm shifting approach in the repurposing pipeline.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice. (Pubmed Central) -  Mar 13, 2024   
    Similar reversal effects of fluoxetine and vortioxetine were observed, including SERT in the amygdala and NET in the mPFC, whereas different reversal effects were observed for NET in the hippocampus and vesicular monoamine transporters expression in the nucleus accumbens. Overall, these results demonstrate the validity of the LBN paradigm to induce depression-like behaviors in female mice, highlight the involvement of region-specific MATs in ES-induced depression-like behaviors, and provide insights for further investigation of neurobiological mechanisms, treatment, and prevention associated with depression in women.
  • ||||||||||  psilocybin (COMP360) / Compass Pathways
    Enrollment closed:  The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder (clinicaltrials.gov) -  Mar 13, 2024   
    P2,  N=22, Active, not recruiting, 
    Overall, these results demonstrate the validity of the LBN paradigm to induce depression-like behaviors in female mice, highlight the involvement of region-specific MATs in ES-induced depression-like behaviors, and provide insights for further investigation of neurobiological mechanisms, treatment, and prevention associated with depression in women. Recruiting --> Active, not recruiting