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- ketamine / Generic mfg.
Effects of the Early Treatment With the Positive Allosteric Modulator of the mGLU2 Receptor JNJ-46356479 on the BCL-2 Levels in a Postnatal Ketamine Mouse Model (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_532;
Protein expression was measured in CA1, CA2, CA3 and DG separately. Significant differences between the treatment groups were observed on CA1, CA3 and DG.
- aripiprazole / Generic mfg., amisulpride / Generic mfg.
Differential Effects of D2/D3 Antagonism and D2/D3 Partial Agonism on Negative Symptoms and Reward Processing in Healthy Humans: A Placebo-Controlled, Double-Blind Crossover Study (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_531;
50 completed the study (25 AMI, 25 ARI). Mean age was 26.6
- clozapine / Generic mfg.
The Effects of Clozapine on Behavioural and Psychological Symptoms of Dementia: A Retrospective Chart Review (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_530;
The highest stable mean CLZ dose attained was 206.9 mg. There was a significant decrease in the number of psychotropic PRN medications administered for BPSD at the 2-4 (M:5 [IQR:10.5]; p=0.035), 4-6 (M:0 [IQR:9]; p=0.017), and 8-10 (M:0 [IQR:12.5]; p=0.027) week time points post CLZ initiation, as compared to pre CLZ initiation (M:11 [IQR:10]).
- imipramine / Generic mfg., clozapine / Generic mfg.
Clozapine-Induced Retrograde Ejaculation Treated With Imipramine: A Case Report and Literature Review (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_529;
Conference abstracts and research titles without any abstracts or full articles were excluded. Many of the included studies were case reports, with relatively few reports on clozapine.
- Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck
Comparative Effectiveness of Long-Acting Injectable Paliperidone With Other Long-Acting Injectable and Oral Antipsychotic Drugs in Schizophrenia (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_528;
With a reference of the LAI paliperidone, oral antipsychotics were associated with a higher risk of treatment discontinuation (1.68, 1.61-1.74). The LAI aripiprazole had no significant difference in the risk of treatment discontinuation compared with the LAI paliperidone (0.99, 0.92-1.08).
- olanzapine / Generic mfg., lurasidone / Generic mfg., ziprasidone / Generic mfg.
Dysglycemia Associated With Antipsychotic Use: A Systematic Review and Meta-Analysis (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_527;
The LAI aripiprazole had no significant difference in the risk of treatment discontinuation compared with the LAI paliperidone (0.99, 0.92-1.08). Specifically, so-called
- Lodopin (zotepine) / Astellas, Clopixol (zuclopenthixol) / Lundbeck
Living Systematic Review and Meta-Analysis of Pharmacokinetic Drug-Gene Interactions in Schizophrenia Pharmacotherapy: The Importance of CYP450 Genetic Polymorphism (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_525;
This living systematic review and meta-analysis will aim to encompass all clinically relevant antipsychotic drugs that are metabolized by at least one liver enzyme that is coded by the polymorphic gene. This way, the comprehensive database of pharmacokinetic drug-gene interactions relevant for the schizophrenia therapy will be created.
- The Influence of Sex and Menopause on Antipsychotic Serum Concentrations (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_524;
Pairwise post hoc comparisons revealed that that serum concentrations of clozapine were highest in women <45 compared to men, and compared to women ? 45.
- haloperidol / Generic mfg., amphetamine / Generic mfg., clozapine / Generic mfg.
Beyond Dopamine D2 Receptor Antagonism for the Treatment of Positive Symptomatology of Schizophrenia (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_523;
Only scPCP-treated rats showed further sensitisation from week 2 to week 3 (p<0.05). Both haloperidol (0.05 mg/kg) and clozapine (5 mg/kg) prevented amphetamine-induced hyperlocomotion in the scVeh group.
- clozapine / Generic mfg.
Psychiatrist Concerns Regarding Potencial Side Effects of Clozapine: An Argentinean Study (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_522;
According to the data stemming from the drug company, our sample represents 35% of clozapine prescribers in Argentina. Conforming to the 2024 Congress of the Schizophrenia International Research Society Liker scale rating, the level of concern was rated as follow; Neutropenia as moderately concerned (26%, n = 79), hypersalivation as moderately concerned (28%, n=85), gastrointestinal hypomotility/ileus as somewhat concerned (33%, n=99), myocarditis as moderately concerned (30%, n=85), pulmonary embolism as somewhat concerned (31%, n=95), seizures as moderately concerned (30%, n=91), metabolic syndrome as moderately concerned (34%, n=104).
- dizocilpine (MK801) / Merck (MSD)
Predictive Validity of Behavioral Assays Relevant to Schizophrenia in Zebrafish (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_521;
MK-801 also reduced the time in the interaction zone (experiment 1) and increased the distance traveled (experiment 1) and the immobility time 2024 Congress of the Schizophrenia International Research Society (experiment 2). In the open tank test, MK-801 decreased distance traveled, absolute turn angle, and clockwise rotations, while increased immobility time; these results were observed in both experiments.
- Abilify Asimtufii (aripiprazole two-month) / Lundbeck, Otsuka
Aripiprazole 2-Month Ready-To-Use: A Novel Long-Acting Injectable Antipsychotic Formulation for Administration Once Every 2 Months (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_520;
Background: Schizophrenia and bipolar I disorder (BP-I) are chronic mental health conditions that require maintenance pharmacological treatment to ensure symptom control. Ari 2MRTU has been shown to be generally well tolerated; investigators
- ulotaront (SEP-363856) / Sumitomo Pharma, Otsuka, PsychoGenics
A Living Synthesis and Triangulation of the Evidence From Clinical Trials and Preclinical Animal Experiments Investigating Trace Amine-Associated Receptor 1 (TAAR1) Agonists for Psychosis (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_519;
Conversely, TAAR1 agonists appeared to reduce model-induced hyperlocomotion in animal models of psychosis with a large effect size based on data from over 100 experiments but with notable heterogeneity (potential sources of heterogeneity under examination). The analyses and the triangulation meeting are ongoing, and the final results of the initial review iteration will be presented at the congress.
- clozapine / Generic mfg.
Alteration of Gray Matter Microstructures in Patients With Treatment Resistant Schizophrenia After Commencing Clozapine Treatment (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_514;
Patients with NTRS showed no significant alterations among features from ROIs. When comparing the significant texture features of TRS and NTRS patients from each time point, only uniformity from the frontal cortex after treatment (t = -2.18, p = 0.036) but none showed a difference between groups.
- clozapine / Generic mfg.
Glutamate and GABA Levels in the Anterior Cingulate Cortex in Treatment Resistant First Episode Psychosis Patients (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_506;
The two groups did not significantly differ on gender, IQ, use of medication, and substance use. The TR patients had longer duration of antipsychotic use and higher symptom severity scores.
- chlorpromazine / Generic mfg.
Changes in Resting Cerebral Blood Flow in People With Chronic Schizophrenia: Striatal Hyperperfusion Accompanying Widespread Cortical Hypoperfusion (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_500;
Exploratory linear regression analyses in the PSz revealed that rCBF in these two striatal regions was not significantly associated with overall symptom severity (total score on the Brief Psychiatric Rating Scale) nor an estimate of current antipsychotic medication dose (chlorpromazine equivalent dose). Our findings fall in line with a recent meta-analysis of rCBF studies of PSz reporting that the strongest effects were decreased rCBF in frontal and other cortical areas, and increased rCBF in the putamen relative to controls (du Sert et al.
- aripiprazole / Generic mfg., amisulpride / Generic mfg.
The Longitudinal Effect of Antipsychotic Drugs on Striatal Dopamine Synthesis Capacity in Drug-Naive First-Episode Psychosis (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_499;
Mean PANSS total score of FEP patients at baseline, 6-week and 1-year follow-up were 67.8, 47.8, and 40.0, respectively. All patients showed treatment response after 2024 Congress of the Schizophrenia International Research Society 6-week treatment of amisulpride, while 2 patients had worsening of psychotic symptom and 1 patient had switched to another antipsychotic drug due to adverse effect, afterwards.
- olanzapine / Generic mfg., clozapine / Generic mfg.
Predicting Treatment Response Using MRI Measures of Dopamine and Glutamate (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_489;
Preliminary results show no significant differences between individuals on olanzapine (M = 13.22, SD = 1.78) and individuals on clozapine (M = 15.01, SD = 2.14) in neuromelanin signal in the SN (t(4.87) = 1.21, p = 0.28), nor between olanzapine (M = 0.68, SD = 0.07) and clozapine groups (M = 0.67, SD = 0.01) in glutamate concentration in the dACC (t(3.21) = 0.30, p = 0.79). Logistic regression showed moderate power at predicting treatment group membership (AUC = 0.75).
- The Real-World Utilisation of Mood Stabilisers as an Augmentation Strategy in Psychosis: A Mirror Image Design (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_483;
Logistic regression showed moderate power at predicting treatment group membership (AUC = 0.75). Background: Across the globe, 5-24% of people on an antipsychotic will be prescribed an anticonvulsant / mood stabiliser, and this may be increasing (1
- clozapine / Generic mfg.
Association of Schizophrenia Polygenic Risk Scores With Treatment-Resistance (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_468;
Patients win the top 10% of SCZ-PRS were at 4.76 folds the likelihood of being treatment resistant compared to the other patients (p=0.006), after adjusting for covariates. Our findings support the potential use of genetic risk scores for schizophrenia in predicting treatment outcomes.
- The Anxiolytic Effect of Atypical Antipsychotics in Patients With Schizophrenia: A Systematic Review and Meta-Analysis (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_461;
Excluding one study of quetiapine in first-episode patients (SMD=-3.05, n=73), AAPs showed a small anxiolytic effect versus haloperidol without heterogeneity (SMD=-0.23, 95%CI [-0.35,-0.12], p=01; I2=%0). Risperidone
- clozapine / Generic mfg.
The Longitudinal Structure of Negative Symptoms in Treatment Resistant Schizophrenia (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_423;
These communities remained highly stable and independent over time. The communities remained stabled when considering psychosis, depression, and sedation severity, and these causes of secondary negative symptoms were clustered into the MAP community.
- clozapine / Generic mfg.
Complex Seizure Disorder Symptoms Manifesting in Treatment-Resistant Schizophrenia Spectrum Disorders in Young Adults With Prior Cannabis Use: A Clinical Overview (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_419;
The analysis and treatment outcomes of eight cases will be synthesized herein. All cases demonstrated exposure to marijuana and nearly all had exposure to psychostimulants.
- Abilify Asimtufii (aripiprazole two-month) / Lundbeck, Otsuka
Development of a Population Pharmacokinetic Model to Describe the Pharmacokinetics of Aripiprazole 2-Month Ready-To-Use, a Novel Long-Acting Injectable Formulation of Aripiprazole for Administration Once Every 2 Months (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_413;
Absorption of the Ari 2MRTU formulation was modeled by a parallel zero-order and lagged first-order process that accounted for an identified double peak in plasma concentrations of aripiprazole post-administration of Ari 2MRTU. All disposition parameters were shared between the formulations except Vc/F (oral and AOM formulations, 93.4 L; Ari 2MRTU formulation, 2035 L); the different Vc/F value for the Ari 2MRTU formulation was attributed to the terminal half-life being absorption driven.
- chlorpromazine / Generic mfg.
Linking Cerebellum and Cerebellar Processes to Psychosis Phenotypes (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_412;
Within the psychosis group, no significant direct effect (cerebellar volume ? psychomotor disturbance) was observed in this mediation model (
- aripiprazole / Generic mfg.
Investigating Associations Between Antipsychotic Dosage, Movement Disorders, Body Mass Index, and Waist Circumference in Patients After a First Episode of Psychosis (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_408;
There was also a significant association between decreased parkinsonism and OLZE reduction/discontinuation across 12 months (B=-2.720, p=0.007). No significant associations between other domains of movement disorders and OLZE were found.
- evenamide (NW-3509) / Newron
Treatment With Evenamide for 1 Year in TRS Patients Not Benefitting to Current Antipsychotics is Associated With Sustained, Clinically Important Benefit: Results From a Prospective, Pilot, 1 Year, Randomized, Open-Label Trial (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_407;
Furthermore, the attrition rate was extremely low (~25% at 1-year) in contrast to published TRS studies (Homman et al., 2021). After 1 year of treatment, the overall improvement in symptoms from baseline was -20% (PANSS total), with a clinically important benefit in the positive subscale (-26%).
- clozapine / Generic mfg.
Immunophenotyping Schizophrenia Subtypes Stratified by Antipsychotic Response (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_387;
Mucosal-associated invariant T (MAIT) cells (p = 3.20 x 10-5), plasmablasts (p = 3.60 x 10-4), IgG+ B cells (p = 7.38 x 10-3), IgD- CD27+ Memory B cells (p = 0.042), CD8+ T cells (p = 2.60 x 10-3), exhausted CD8+ T cells (CD57+ CD8+) (p = 9.35 x 10-3), (CD69- KLRG1+ CD8+) (p = 1.20 x 10-3) and CD8+ memory T cells (CD45RA- CD27+ CD8+) (p = 0.0286), were among the top cell populations to be downregulated in schizophrenia, with lower proportions seen with increasing treatment resistance. Conversely, CD4+ memory T cells (CD69- KLRG1- CD4+) (p = 0.0331) and na
- clozapine / Generic mfg.
Event-Related Spectral Perturbation and Spectral Analysis of Treatment Resistant and Ultra-Treatment Resistant Schizophrenia (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_373;
Disparity in gamma band activity between eyes-open and eyes-closed states was only significant in TRS patients. In the visual Stroop experiment, UTRS patients exhibited diminished gamma power at frontal-central and occipital electrode sites from stimulus onset to 800ms post-stimulus.
- chlorpromazine / Generic mfg.
Metabolic Parameters as a Predictor for Relapse in Patients with Schizophrenia Tapering Antipsychotics (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_371;
Of the 88 patients who entered the program, blood samples and relapse status after one year were available for 78 individuals (43 females). Their mean age was 37 (range 20
- risperidone / Generic mfg.
Therapeutic Importance of Complement Pathway Proteins in Early Intervention in Psychosis: A Proteomic Based Validation Study in Clinical High Risk and First Episode Psychosis Patients (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_370;
We have now replicated in three independent cohorts of psychosis patients by showing the relationship of complement proteins especially C4a with psychotic symptoms and functioning. These findings suggest that complement protein levels could be a strong markers for predicting the course of the disease in high-risk state.
- clozapine / Generic mfg.
Unveiling the NRN1 Gene Epigenetic-Expression Brain Correlates in Schizophrenia (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_301;
The PLS-DA analyses revealed that NRN1 methylation, whether in the prefrontal or hippocampal regions, did not distinguish between HS and SZ-Free. Nevertheless, the hippocampal NRN1 methylation effectively stratified between HS and SZ-Clz and correlated with hippocampal NRN1 mRNA levels.
- aripiprazole / Generic mfg.
SchizOMICS: A Ciber Multidisplinary Design to Optimize Schizophrenia Treatment Based on Multi-Omics Data and Systems Biology Analysis (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_296;
This project will be formed by five work packages (WP): WP1: To set up a randomized open-label clinical trial to compare effectiveness and security of aripiprazole and paliperidone... Understanding patient
- Clopixol (zuclopenthixol) / Lundbeck
Case Report of Treatment of Neuroleptic Malignant Syndrome in Child and Adolescent (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_295;
Pineal cystoma and pituitary microadenoma were detected incidentally on MRI conducted after hospitalization, and consultation with the department of pediatrics recommended close observation. Because 7 mg of risperidone monotherapy, initiated after hospitalization, caused akathisia, it was reduced to 6 mg.
- Long-Term Impact of Antipsychotic Treatment on Renal Function in Individuals With a First Episode of Psychosis: A 3-Years Prospective Study (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_267;
ANCOVA analysis covarying for potential confounders (i.e.: age, sex, BMI, tobacco use, and basal GFR) showed a significant differences between psychosis and control groups in GFR change; although both groups increased their GFR overtime, the increase was significantly smaller among psychosis patients (estimated marginal means: 2.7 vs 6.4 ml/min/1.73 m2, p=0.021). ANCOVA analyses comparing the effect of 6 different antipsychotic treatments (i.e.
- Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck
Comparative Efficacy of Oral Vs. LAI Formulations of Eight Second-Generation Antipsychotics in Acute Schizophrenia Treatment: A Network Meta-Analysis and Systematic Review (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_260;
All drugs were significantly more efficacious than placebo with the sequence olanzapine LAI -0.66 [-1.00; -0.33], risperidone LAI -0.59[-0.73;-0.46], olanzapine oral -0.55[-0.62;-0.48], aripiprazole LAI -0.54[-0.71; -0.37], risperidone oral -0.48[-0.55;-0.41], paliperidone oral -0.47[-0.58;-0.37], paliperidone LAI -0.45[-0.57;-0.33], aripiprazole oral -0.40[-0.50; -0.31]. Further sensitivity analysis concerning 2024 Congress of the Schizophrenia International Research Society overall symptoms yielded consistent findings.
- clozapine / Generic mfg.
Investigating the Effects of Adjunctive Transcranial Direct Current Stimulation on Treatment Adherence in Schizophrenia: Study Progress (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_253;
The mean age is 43.5 (SD = 14.6). The male to female ratio is 15:2.
- Risperdal Consta (risperidone depot formulation) / J&J
Switching Patients With Schizophrenia to TV-46000, a Long-Acting Subcutaneous Antipsychotic (LASCA), From Risperidone Microspheres (R064766): An Exploration of Population Pharmacokinetic (PopPK) (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_251;
The male to female ratio is 15:2. The objective of this analysis was to use PopPK modeling to characterize dosing conversions and switching strategies from R064766 (an intramuscular [im] LAI formulation of risperidone microspheres administered once every 2 weeks [q2w]; Risperdal Consta
- olanzapine / Generic mfg.
Syndrome Metabolic Induced by Antipsychotics and Hematological Abnormalities (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_248;
The objective of this analysis was to use PopPK modeling to characterize dosing conversions and switching strategies from R064766 (an intramuscular [im] LAI formulation of risperidone microspheres administered once every 2 weeks [q2w]; Risperdal Consta We feed a rabbits with
- chlorpromazine / Generic mfg., clozapine / Generic mfg.
Argentine Consensus-Statement on Management Treatment-Resistant Schizophrenia: Up-To-Date (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_247;
TRS was defined as, no response to at least two antipsychotics, one of second-generation antipsychotics (SGA), either at doses equivalent to 600 mg chlorpromazine or full doses of second-generation antipsychotics, for at least six weeks each.SGA with a long-acting formulation must be considered when nonadherence occurs. Pseudo-resistance, comorbidities such as substance abuse, and no-adherence to pharmacological treatment should be assessed before considering TRS.
- clozapine / Generic mfg.
Prevention, Detection, and Management of Clozapine-Induced Myocarditis (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_245;
Prescribers should also consider the pharmacokinetic effects of concomitant medication including valproate, olanzapine, and altered clozapine 2024 Congress of the Schizophrenia International Research Society metabolism related to changes in CYP1A2 enzyme activity due to inflammation. Additionally, stringent CIM screening and management ensure timely detection of CIM thus increasing patient safety and the chance for a restitutio ad integrum.
- ketamine / Generic mfg., clozapine / Generic mfg.
Effect of Glutamate Modulator JNJ-46356479 and Clozapine on Glutamate and GABA Brain-Levels in a Postnatal Ketamine Mouse Model of Schizophrenia (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_244;
The analysis revealed significant differences in the number of GLU vesicles among the HPC subregions across treatment groups (CA1 (F (11,30) = 5,39, p < 0.001), CA2 (F (11,30) = 2,23, p = 0.049 and CA3 (F (11,30) = 5,39, p < 0.001)). Post-hoc test indicated a significant increase in the number of GLU vesicles between the KET group and vehicle (VEH) group, particularly in the CA3 region (p = 0.012).
- fluvoxamine / Generic mfg., clozapine / Generic mfg.
Hyperclozapinemia: Clinical Implications and the Risk of Misinterpreting Psychotic Symptoms (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_243;
Maximum clozapine blood levels of the cases ranged between 2000-3621 ng/ml. management eventually was based on detecting hyperclozapinemia, reducing clozapine dose, adjusting by further blood tests, and stopping fluvoxamine.
- dizocilpine (MK801) / Merck (MSD)
Sensory Processing Deficits of MK-801 Responds to Risperidone Across ASSR-EEG, PPI and 5-CSRTT (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_242;
Risperidone was able to partially reverse the MK-801 ASSR deficit (p<0.001) and reversed the increased high-gamma dose dependently (p<0.001). PPI: MK-801 reduced % PPI in a dose dependent manner (p<0.001).
- Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck
Comparative Effectiveness of Antipsychotics for Relapse Prevention Among 131,476 Real-World Patients With a Schizophrenia-Spectrum Disorder (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_238;
During the follow-up (max 15 years, mean 10.4, SD 5.7), 48.5% (N=63730) experienced relapse at least once. All specific antipsychotics were associated with decreased relapse risk compared with non-use of antipsychotics.
- clozapine / Generic mfg.
Clozapine and Long-Term Mortality Risk in Patients With Schizophrenia in Hong Kong: Evidence From the Clinical Data Analysis and Reporting System (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_237;
Propensity score matching successfully 2024 Congress of the Schizophrenia International Research Society matched 6,304 controls. Among the matched groups, imbalanced covariates included age (SMD: 0.29), schizophrenia duration (SMD: 0.21), and count of previous antipsychotics (SMD: 1.40).
- olanzapine / Generic mfg.
Effect of Acute Olanzapine Treatment on Transcriptomics in the Hypothalamus (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_235;
In contrast, it downregulates hypothalamic pathways involved in protein folding. The latter is linked to endoplasmic reticulum (ER) stress, which occurs when there is a build-up of unfolded or misfolded proteins in tissues.
- clozapine / Generic mfg.
Clozapine as a Therapeutic choice: Longitudinal Analysis of Positive and Negative Symptom Scale Scores in a Naturalistic Setting (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_233;
The improvement was generally sustained during subsequent treatment. All subdomains of the PANSS significantly improved during the course of the first year of treatment.
- clozapine / Generic mfg.
Determinants of Clozapine and Norclozapine Plasma Levels in a Chilean Sample: New Insights From a Multivariate Analysis (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_232;
We included 566 clozapine/norclozapine plasma levels from 333 clozapine users. Median age of patients was 40.9 years (IQR 29
- ulotaront (SEP-363856) / Sumitomo Pharma, Otsuka, PsychoGenics
State-Dependent Modulation of Striatal and Hippocampal Glutamate Function by TAAR1 Agonist Ulotaront (Cavaniglia Pavilion) - Mar 16, 2024 - Abstract #SIRS2024SIRS_208;
Interestingly, ulotaront potentiated electrically-evoked excitatory synaptic transmission in both brain regions, with the striatal effect being specific to a subpopulation of D2 MSNs. Similar striatal effects were also observed with the TAAR1 agonist, RO5166017.