Serotonin 

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  • ||||||||||  tianeptine / Generic mfg., methadone / Generic mfg.
    Journal:  Tianeptine as an opiate replacement in a patient on methadone treatment: A case report. (Pubmed Central) -  Mar 31, 2024   
    The current opioid epidemic, the emerging use of tianeptine, and the lack of physician awareness have emphasized the need for further research on the role of tianeptine in medication-assisted treatment for OUD. This case report aims to demonstrate how medication-assisted therapy can be successfully utilized in a patient with opioid and severe other (tianeptine) drug use disorder.
  • ||||||||||  carbamazepine / Generic mfg., haloperidol / Generic mfg.
    Journal:  Case 327. (Pubmed Central) -  Mar 30, 2024   
    Noninvasive ventilation was initiated. Imaging performed during the second ICU hospitalization included noncontrast chest CT (Fig 2), MRI of the chest without contrast enhancement (Fig 3), and fluorine 18 fluorodeoxyglucose PET/CT (Fig 4).
  • ||||||||||  escitalopram / Generic mfg.
    Biomarker, Journal:  Utilizing Pharmacogenomics Results to Guide Antidepressant Selection: A Case Report. (Pubmed Central) -  Mar 30, 2024   
    A 79-year-old female who had been experiencing a suboptimal response to escitalopram following dose escalation over a period of three years was referred for a PGx consultation. A clinical pharmacist assessed significant drug-gene, drug-drug, and drug-drug-gene interactions, and relevant clinical information to recommend alternative antidepressant therapy, which resulted in mood improvement.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  How the Food and Drug Administration Drug Approval Process Relates to the Potential Approval of Intravenous Racemic Ketamine for Treatment-resistant Major Depression. (Pubmed Central) -  Mar 29, 2024   
    This column focuses specifically on whether generally small-scale studies done in academic centers are sufficient for drug approval, and it briefly reviews lithium and clozapine as examples of psychiatric medications that had such academic research in the literature, as well as clinical use in other countries...While safety concerns were specifically addressed in the registration trials for esketamine, comparable research remains to be done for intravenous racemic ketamine. Understanding how the FDA's drug approval process works is important for prescribers, their patients, and the public.
  • ||||||||||  Journal, Real-world evidence, Real-world:  Comparison of the Efficacy of Anti-Obesity Medications in Real-World Practice. (Pubmed Central) -  Mar 29, 2024   
    All the AOMs were effective at inducing and maintaining weight loss, in the absence of significant changes in muscle mass, over a 6 month period, and the short-term use of phentermine and the long-term use of phentermine/topiramate or liraglutide would be practical choices for the treatment of obesity. However, further, large-scale studies are necessary to confirm these findings.
  • ||||||||||  Journal:  Magnetic Particle Spray Mass Spectrometry. (Pubmed Central) -  Mar 29, 2024   
    MPS-MS opens a new line of developments in the association of sample preparation with ambient ionization. New sorbents, device configurations, and physical and chemical conditions can also be analyzed for the analysis of many other analytes in different samples.
  • ||||||||||  hydroxyzine hydrochloride / Generic mfg., diazepam / Generic mfg., quetiapine / Generic mfg.
    Journal:  Prevalence of use of on-label and off-label psychotropics in the Greek pediatric population. (Pubmed Central) -  Mar 29, 2024   
    Data from Greece show that a relevant number of patients are prescribed psychotropics, with 1 in 7 being under off-label use. Due to the limitations inherent to pharmacy claims databases, further research using clinical data for a longer follow-up period could confirm and identify trends in psychotropics use in Greece.
  • ||||||||||  quetiapine / Generic mfg.
    Journal:  Distribution of quetiapine between serum and whole blood in therapeutic drug monitoring specimens. (Pubmed Central) -  Mar 29, 2024   
    Quetiapine was consistently present at lower concentrations in whole blood than in serum. If so inclined to, a conversion factor of approximately 0.7 may be considered for extrapolation of concentrations from serum to whole blood, at least in cases with therapeutic quetiapine concentration levels.
  • ||||||||||  hydroxychloroquine / Generic mfg., colchicine / Generic mfg., amitriptyline / Generic mfg.
    OPTIMIZING REFERRAL TO RHEUMATOLOGY  (Poster View) -  Mar 29, 2024 - Abstract #EULAR2024EULAR_1530;    
    In this unselected cohort, only 2.5% of all IRDs had been missed. IRD diagnoses likely to be missed by such an approach will be CTD, nr-axSpA and PsA.
  • ||||||||||  Enrollment open:  Migraine Medication Effects on Urinary Symptoms (clinicaltrials.gov) -  Mar 29, 2024   
    P=N/A,  N=200, Enrolling by invitation, 
    IRD diagnoses likely to be missed by such an approach will be CTD, nr-axSpA and PsA. Not yet recruiting --> Enrolling by invitation
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Botulinum toxin: a new differential diagnosis for a lytic bone lesion. (Pubmed Central) -  Mar 28, 2024   
    Our search of the literature failed to identify any previous cases of this occurring. However, as the popularity of this cosmetic procedure only increases, we believe that this represents an important possible differential for isolated lytic lesion after administration of "Botox" injection.
  • ||||||||||  olanzapine / Generic mfg.
    Preclinical, Journal:  Evaluation of Suitable Polymeric Matrix/Carriers during Loading of Poorly Water Soluble Drugs onto Mesoporous Silica: Physical Stability and In Vitro Supersaturation. (Pubmed Central) -  Mar 28, 2024   
    The aim of this study was to evaluate ternary olanzapine (OLN) ASDs with Syloid 244FP and to find an appropriate polymeric carrier...Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) studies showed that the development of stronger molecular interactions can be provided as an explanation for this synergistic effect, as the formation of robust H-bonds may be considered responsible for inhibiting the precipitation of the supersaturated API. Therefore, the incorporation of coPVP into OLN ASDs with Syloid 244 FP is considered a highly promising technique for increasing the degree of OLN supersaturation in in vitro dissolution studies and improving the stability of systems.
  • ||||||||||  lurasidone / Generic mfg.
    Journal:  Microneedle-Assisted Transdermal Delivery of Lurasidone Nanoparticles. (Pubmed Central) -  Mar 28, 2024   
    The microneedles demonstrated robust preformation in a characterization test evaluating their insertion capacity, mechanical strength, and the uniformity of microneedle arrays, and were able to deliver a dose equivalent to 20 mg oral administration. Therefore, the potential of a transdermal delivery system for lurasidone using microneedles with nanoparticles was demonstrated.
  • ||||||||||  lurasidone / Generic mfg.
    Review, Journal:  The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review. (Pubmed Central) -  Mar 28, 2024   
    The efficacy of lurasidone in treating patients with first-episode psychosis who present with predominant depressive symptoms suggests that this medication may be a valuable treatment option not only for established cases of schizophrenia but also for individuals in the early stages of the illness. The good tolerability of lurasidone is an important factor that may positively influence treatment decisions.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Review, Journal:  Esophagogastric Junction Outflow Obstruction (EGJOO): A Manometric Phenomenon or Clinically Impactful Problem. (Pubmed Central) -  Mar 28, 2024   
    Uncontrolled trials show effectiveness for pneumatic dilation and peroral endoscopic myotomy to treat confirmed EGJOO; Botox and Heller myotomy may also be considered but data for confirmed EGJOO is more limited...PD and POEM are effective in confirmed EGJOO, Heller myotomy may also be considered but data for confirmed EGJOO is limited. Randomized controlled trials are needed to clarify optimal management of EGJOO.
  • ||||||||||  dexamethasone / Generic mfg., tropisetron / Generic mfg.
    Trial completion, Phase classification, Trial completion date, Trial primary completion date:  Efficacy of Three Antiemetics in Preventing Nausea and Vomiting (clinicaltrials.gov) -  Mar 27, 2024   
    P=N/A,  N=200, Completed, 
    Future studies with appropriate sample sizes calculated based on this study are needed. Recruiting --> Completed | Phase classification: P1 --> PN/A | Trial completion date: Feb 2023 --> Nov 2023 | Trial primary completion date: Feb 2023 --> Oct 2023
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Partial facial paralysis induced by sialolithiasis of the parotid gland: a case report. (Pubmed Central) -  Mar 27, 2024   
    It underscores the potential involvement of parotid sialolithiasis, particularly in patients with a history of recurrent parotitis or facial trauma. Prompt recognition of such uncommon presentations can prevent undue interventions, aid in timely appropriate management, and significantly contribute to the patient's recovery and prevention of long-term complications.
  • ||||||||||  metformin / Generic mfg.
    Journal:  Modulating the antibacterial effect of the existing antibiotics along with repurposing drug metformin. (Pubmed Central) -  Mar 27, 2024   
    Further, molecular dynamics simulation revealed that the docked complexes were relatively stable during the 100 ns simulation period. This study suggest Metformin and other experimented drugs can be used as adjuvants boost up antibiosis but further study is needed to find out the safety and efficacy of this non-antibiotic drug as potent antibiotic adjuvant.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Botox Optimization Algorithm: A New Human-Based Metaheuristic Algorithm for Solving Optimization Problems. (Pubmed Central) -  Mar 27, 2024   
    Comparative analysis against twelve well-known metaheuristic algorithms demonstrates the BOA's superior performance across various benchmark functions, with statistically significant advantages. Moreover, application to constrained optimization problems from the CEC 2011 test suite highlights the BOA's effectiveness in real-world optimization tasks.