Serotonin 

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  • ||||||||||  Chirocaine (levobupivacaine) / Purdue, AbbVie
    Review, Journal:  Gene polymorphism impact on opioid analgesic usage. (Pubmed Central) -  Sep 20, 2024   
    From those articles, we reviewed the impact of gene polymorphism on pain management and drug pharmacokinetics. Based on this systematic review, we concluded that gene polymorphism of gene affects analgesic, specifically opioid mechanisms.
  • ||||||||||  memantine / Generic mfg., amantadine / Generic mfg.
    Journal:  Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity. (Pubmed Central) -  Sep 20, 2024   
    On the other hand, in SH-SY5Y differentiated cells, conjugate 18c functionalized with (R)-1-aminoindane counteracted the toxicity elicited by paraquat (p < 0.0001), while Glypromate was found to exacerbate the neurotoxicity. Altogether, this work adds new insights into Glypromate research by demonstrating that chemical conjugation and annular constriction are effective strategies to tune neuroprotective responses against different neurotoxic stimuli, paving the way for the development of new neurotherapeutics.
  • ||||||||||  ondansetron / Generic mfg.
    Journal:  Reply to the letter by Satici MH. (Pubmed Central) -  Sep 20, 2024   
    No data was found to support the use of antidepressants in juvenile BD. No abstract available
  • ||||||||||  aripiprazole / Generic mfg., topiramate / Generic mfg.
    Review, Journal:  An update on the pharmacological management of Tourette syndrome and emerging treatment paradigms. (Pubmed Central) -  Sep 20, 2024   
    The same holds true for vesicular monoamine transporter-2 inhibitors, as they are deemed to be safe and effective in real-world use and open-label trials despite not meeting primary endpoints in placebo-controlled trials. Cannabinoids may be considered in adults if the approaches above do not control tics.
  • ||||||||||  ondansetron / Generic mfg.
    Journal:  Letter to the article by Shirozu K, et al. (Pubmed Central) -  Sep 20, 2024   
    Cannabinoids may be considered in adults if the approaches above do not control tics. No abstract available
  • ||||||||||  paroxetine / Generic mfg.
    Journal:  Paroxetine Effect on Nerve Growth Factor, Human Neurotrophin-4, Brain-Derived Neurotrophic Factor Levels in Post-stroke Depression. (Pubmed Central) -  Sep 20, 2024   
    HAMD and NIHSS at T0 were compared; T1 and T2 were lower than T0, T2 was lower than T1, and observation group was lower (P?<?0.05); HAMD and NIHSS were compared among groups, time, and interaction (P?<?0.05). For post-stroke depression, paroxetine treatment can effectively improve NGF, NT-4, BDNF, 5-HT, Hcy, and NE levels and effectively reduce the degree of neurological damage and depression, which has high clinical application value.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Enrollment closed, Trial completion date, Trial primary completion date:  Zinc Supplementation Prior to Botox Injections for Spasmodic Dysphonia (clinicaltrials.gov) -  Sep 20, 2024   
    P1/2,  N=36, Active, not recruiting, 
    Recruiting --> Completed Enrolling by invitation --> Active, not recruiting | Trial completion date: May 2024 --> Dec 2024 | Trial primary completion date: May 2024 --> Dec 2024
  • ||||||||||  ketamine / Generic mfg.
    Trial completion date, Trial primary completion date:  KetHead: Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches (clinicaltrials.gov) -  Sep 20, 2024   
    P3,  N=56, Recruiting, 
    Enrolling by invitation --> Active, not recruiting | Trial completion date: May 2024 --> Dec 2024 | Trial primary completion date: May 2024 --> Dec 2024 Trial completion date: Feb 2024 --> Feb 2026 | Trial primary completion date: Oct 2023 --> Oct 2025
  • ||||||||||  Adbry (tralokinumab-ldrm) / LEO Pharma, AstraZeneca, Blenrep (belantamab mafodotin-blmf) / GSK
    Journal, Adverse events, Real-world evidence, Real-world:  Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study. (Pubmed Central) -  Sep 20, 2024   
    Identifying the specific risks and timing of drug-induced keratitis can support the development of preventive measures. Identifying the specific drugs related to medication-related keratitis is of significant importance for drug vigilance in the occurrence of drug-related keratitis.
  • ||||||||||  5-methoxy-dimethyltryptamine dry-powder intranasal (BPL-003) / Beckley Psytech
    Enrollment closed:  An Open-Label, Single Dose Study in Patients with Alcohol Use Disorder (clinicaltrials.gov) -  Sep 20, 2024   
    P2,  N=13, Active, not recruiting, 
    Identifying the specific drugs related to medication-related keratitis is of significant importance for drug vigilance in the occurrence of drug-related keratitis. Recruiting --> Active, not recruiting
  • ||||||||||  Victoza (liraglutide) / Novo Nordisk, Aphthasol (amlexanox) / Abeona Therap, Esteve, Lipaglyn (saroglitazar) / Zydus Lifesci
    Review, Journal:  Protein Kinases in Obesity, and the Kinase-Targeted Therapy. (Pubmed Central) -  Sep 20, 2024   
    Co-treatment of antiobesity and antidiabetic herbal compound, berberine with antipsychotic drug olanzapine decreases the accumulation of triglyceride. While low-dose rapamycin, metformin, amlexanox, thiazolidinediones, and saroglitazar protect against insulin resistance, glucagon-like peptide-1 analog liraglutide inhibits palmitate-induced inflammation by suppressing mTOR complex 1 (mTORC1) activity and protects against lipotoxicity.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Pharmacological Mechanism of Herbal Interventions for Bipolar Disorder. (Pubmed Central) -  Sep 20, 2024   
    Though different treatments are available, like lithium, risperidone, valproic acid, etc., which are widely used, they come with certain limitations, including narrow therapeutic index, hypothyroidism, weight gain, extrapyramidal symptoms, etc. The interest in herbal- based treatments for bipolar disorder arises from the desire for alternative, potentially more natural, and holistic approaches with fewer side effects. The current review focuses on the potential effects of herbal drugs and their derivatives to alleviate the symptoms of bipolar disorder.
  • ||||||||||  Aduhelm (aducanumab) / Neurimmune, Eisai, Leqembi (lecanemab-irmb) / Biogen, Eisai, Kisunla (donanemab-azbt) / Eli Lilly
    Journal:  Recent Advances in the Treatment and Management of Alzheimer's Disease: A Precision Medicine Perspective. (Pubmed Central) -  Sep 20, 2024   
    Another medication that can temporarily alleviate dementia symptoms is memantine, which blocks the N-methyl-D-aspartate (NMDA) receptor...For some Alzheimer's pa-tients, the FDA-approved monoclonal antibody, aducanumab, is an option; for others, phase 3 clinical studies are underway for drugs, like lecanemab and donanemab, which have demonstrat-ed potential in eliminating amyloid protein. However, additional study is required to identify and address these limitations in order to reduce the likelihood of side effects and maximize the thera-peutic efficacy.
  • ||||||||||  Ibrance (palbociclib) / Pfizer, Xenical (orlistat) / Roche, GSK
    Journal, Adverse events:  Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system. (Pubmed Central) -  Sep 20, 2024   
    The drug with the highest ranking was lenalidomide (7,730 cases, 4.55%), with the most prevalent drug class being antineoplastic and immunomodulating agents...However, four drugs (orlistat, nintedanib, palbociclib, and dimethyl fumarate) presented an unexpected risk of constipation. Ranked by signal values, sevelamer carbonate emerged as the drug with the strongest risk signal [reporting odds ratio (95% CI): 115.51 (110.14, 121.15); PRR (?2): 83.78 (191,709.73); EBGM (EB05): 82.63 (79.4); IC (IC025): 6.37 (4.70)]...The median TTO for orlistat was 3
  • ||||||||||  chlorpromazine / Generic mfg.
    Trial suspension:  Efficacy of chlorpromazine as a adjunctive therapy for esketamine on major depression: a randomized controlled trial (EUDRACT) -  Sep 20, 2024   
    P=N/A,  N=338, Suspended, 
    Ranked by signal values, sevelamer carbonate emerged as the drug with the strongest risk signal [reporting odds ratio (95% CI): 115.51 (110.14, 121.15); PRR (?2): 83.78 (191,709.73); EBGM (EB05): 82.63 (79.4); IC (IC025): 6.37 (4.70)]...The median TTO for orlistat was 3 Not yet recruiting --> Suspended
  • ||||||||||  amitriptyline / Generic mfg., nortriptyline / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Application of a molecular networking approach using LC-HRMS combined with the MetWork webserver for clinical and forensic toxicology. (Pubmed Central) -  Sep 20, 2024   
    Using MetWork, metabolites and parent drugs such as amitriptyline, its metabolite nortriptyline and amitriptyline glucuronide phase 2 metabolites were anticipated and proposed as putative annotations. The workflow increases confidence in toxicological screening by highlighting putative structures in biological matrices in combination with CFM-ID (Competitive Fragmentation Modeling for Metabolite Identification) and MetWork to extend the annotation of potential drugs even without a reference standard.