Serotonin 

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  • ||||||||||  Caplyta (lumateperone) - Intra / Cellular Therapies
    PK/PD data, Journal:  Pharmacodynamic properties of lumateperone and its efficacy in acute bipolar depression: a mechanistic hypothesis based on data. (Pubmed Central) -  Apr 16, 2024   
    The original model suggests that a constellation of effects on different receptors is necessary, but refinements, including the present study, suggest that the inhibition of the serotonin reuptake at the first level, the 5HT-2A blockade at the second level, and the norepinephrine alpha-1 receptors blockade at a third level in combination with D1 blockade contribute to the antidepressant effect in acute bipolar depression. The D2 blockade acts as a protective mechanism and reduces the risk of switching to mania/hypomania.
  • ||||||||||  ondansetron / Generic mfg.
    Trial completion:  EFFECT OF SACRAL ERECTOR SPINA PLAN BLOCK ON TOTAL HIP ARTHROPLASTY (clinicaltrials.gov) -  Apr 16, 2024   
    P=N/A,  N=50, Completed, 
    As the result, decrease of plasma serotonin concentrations may be related to the efficacy of DLX in relieving pain and depression in COP patients. Recruiting --> Completed
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Retrospective data, Journal:  Effect of antipsychotics and mood stabilisers on metabolism in (Pubmed Central) -  Apr 15, 2024   
    Recruiting --> Completed After eliminating possible sensitivity, risperidone ranked 1st in elevating fasting serum glucose (SUCRA
  • ||||||||||  clozapine / Generic mfg.
    Review, Journal:  Clozapine Prescripers-Dogmatic or Pragmatic? (Pubmed Central) -  Apr 15, 2024   
    Clozapine, amongst antipsychotics, has a unique composite mode of action that might translate into an expanded therapeutic potential on clinical grounds. Sorely, clozapine remains underutilized.
  • ||||||||||  aripiprazole / Generic mfg., haloperidol / Generic mfg., ziprasidone / Generic mfg.
    Journal:  New role of platelets in schizophrenia: predicting drug response. (Pubmed Central) -  Apr 15, 2024   
    Given PLTc's easy measurement and clinical relevance, it warrants increased attention from psychiatrists. ChiCTR-TRC-10000934.
  • ||||||||||  erastin - Whitehead Institute for Biomedical Research, Dana / Farber Cancer Institute, Columbia University, Prolexys, Caplyta (lumateperone) - Intra / Cellular Therapies
    FDA event, Journal:  Identifying eleven new ferroptosis inhibitors as neuroprotective agents from FDA-approved drugs. (Pubmed Central) -  Apr 15, 2024   
    1176 drugs have been screened against erastin-induced ferroptosis in HT22 cells, resulting in 89 ferroptosis inhibitors...The most active ferroptosis inhibitor is lumateperone tosylate at nanomolar level...Notably, the active properties of some drugs were firstly revealed here. These ferroptosis inhibitors increase the chemical diversity of ferroptosis inhibitors, and offer new therapeutic possibilities for the treatments of related neurological diseases.
  • ||||||||||  Lodonal (naltrexone low dose oral) / Immune Therap, Statera BioPharma
    Journal:  Low-Dose Naltrexone Improves post-COVID-19 condition Symptoms. (Pubmed Central) -  Apr 15, 2024   
    Post-COVID-19 condition symptoms may improve in patients taking medications adapted from myalgic encephalomyelitis and chronic fatigue syndrome. Randomized controlled trials should evaluate these medications and translational studies should further evaluate their mechanisms of action.
  • ||||||||||  sertraline / Generic mfg., quetiapine / Generic mfg.
    Personalized Psychiatry Insights: Imaging-Derived Predictors of Treatment Outcomes () -  Apr 14, 2024 - Abstract #SOBP2024SOBP_1109;    
    During our discussions, we will present our findings on brain signatures within the context of pharmacological interventions (i.e., lithium/quetiapine, sertraline) and non-pharmacological interventions (i.e., cognitive behavioral therapy, rTMS). Importantly, we will delve into whether personalized approaches enhance clinical outcomes, offering new insights into the role of neuroimaging in psychiatry research.
  • ||||||||||  ketamine / Generic mfg., fluoxetine / Generic mfg.
    Behavioral and Neurochemical Effects of Increased MAOA Activity in the Prefrontal Cortex in Mice () -  Apr 14, 2024 - Abstract #SOBP2024SOBP_1016;    
    Importantly, we will delve into whether personalized approaches enhance clinical outcomes, offering new insights into the role of neuroimaging in psychiatry research. Our model provides the opportunities to cross-compare the effects of elevated MAOA in different cell types and brain regions (mPFC, hippocampus) on behavioural, biochemical, and neurochemical outcomes, and to directly test the hypothesis that elevated MAOA serves as a causal factor for treatment response.
  • ||||||||||  lysergic acid diethylamide (MM-120) / Mindmed, University Hospital Basel
    LSD-Assisted Therapy in Patients with Anxiety: A Prospective 12-Month Follow-Up (Griffin Hall) -  Apr 14, 2024 - Abstract #SOBP2024SOBP_811;    
    Similar effects were observed for comorbid depression with change from baseline BDI scores of -8.1 (-13.2, -3.1), d=0.71, p<0.01, and -8.9 (-12.9, -4.9), d=1.21, p<0.01, for the LSD-first and placebo-first groups, respectively. Personality trait neuroticism decreased (p<0.0001) and trait extraversion increased (p<0.01) compared with study inclusion.
  • ||||||||||  escitalopram / Generic mfg.
    CLAUDIN-5 and Blood-Brain Barrier Integrity in Prefrontal Cortex in Suicide (Griffin Hall) -  Apr 14, 2024 - Abstract #SOBP2024SOBP_747;    
    High CLAUDIN-5 and ALBUMIN levels could serve as biomarkers for suicide risk. Future in vitro assessments should evaluate novel therapeutics promoting CLAUDIN-5 expression for suicide prevention.
  • ||||||||||  aripiprazole / Generic mfg., risperidone / Generic mfg.
    Cerebellar-Cortical Connectivity and Prediction of Antipsychotic Treatment Response in First-Episode Psychosis (Griffin Hall) -  Apr 14, 2024 - Abstract #SOBP2024SOBP_676;    
    In both samples, patients received baseline resting-state fMRI scans and 12-week randomized antipsychotic monotherapy with either risperidone or aripiprazole. Findings highlight the role of cerebellar cingulo-opercular, default mode, and secondary visual systems in predicting antipsychotic treatment and imply the potential of cerebellar connectivity as a prognostic biomarker in early-stage psychotic disorders.
  • ||||||||||  olanzapine / Generic mfg.
    Metabolic Phenotyping of an Olanzapine Compounded Diet-Induced Obesity Model (Griffin Hall) -  Apr 14, 2024 - Abstract #SOBP2024SOBP_545;    
    Using multiple concentrations of olanzapine embedded into high-fat diet (HFD), our preliminary data show that olanzapine-HFD, as compared to HFD alone, demonstrate (a) accelerated obesity and metabolic dysfunction, (b) increased food intake is associated with increased dose of olanzapine, and (c) modified energy expenditure. Conclusions Discoveries made from further deep metabolic profiling of olanzapine-HFD fed mice may provide novel insights into previously unappreciated mechanisms tying antipsychotic use to obesity and metabolic dysfunction.
  • ||||||||||  sertraline / Generic mfg., bupropion / Generic mfg.
    Depression Scale Component Scores Differentiate Antidepressant Drug Responses (Griffin Hall) -  Apr 14, 2024 - Abstract #SOBP2024SOBP_509;    
    Symptom components of the HDRS identified distinct drug effects in this clinical trial follow-up phase. Symptom factors provide a superior method for distinguishing specific biological effects of antidepressant treatments.
  • ||||||||||  clozapine / Generic mfg.
    Prefrontal Cortex Astroglia Modulate Anhedonia-Like Behavior (Griffin Hall) -  Apr 14, 2024 - Abstract #SOBP2024SOBP_419;    
    Our results demonstrate that cortical GFAP-astroglia loss is sufficient to induce anhedonia, that chronic stress-induced anhedonia-like deficits can be reversed by increased GFAP-astroglia activity and that astroglial and neuronal activity are effect by chronic stress. Altogether, our work suggests a critical role of astroglia in the expression and the treatment of key symptoms of MDD.
  • ||||||||||  clozapine / Generic mfg.
    Identifying Predictors of Clozapine-Induced Weight Gain Through a Naturalistic Retrospective Chart Review (Griffin Hall) -  Apr 14, 2024 - Abstract #SOBP2024SOBP_76;    
    This analysis revealed that pre-CLZ weight gain and BMI are risk factors for significant weight gain after CLZ initiation. Understanding predictors of weight gain could allow for early identification of the minimum metabolic threshold and clinical profile that would benefit from adjunctive metabolic interventions to prevent significant weight gain with CLZ.
  • ||||||||||  agomelatine / Generic mfg.
    Open Trial Agomelatine Treatment in Elderly MDD Patients With SSRI-Induced Hyponatremia (Griffin Hall) -  Apr 14, 2024 - Abstract #SOBP2024SOBP_50;    
    Our open trial study suggests that agomelatine may be a safe and effective treatment option for elderly patients suffering from major depressive disorder and SSRI-induced hyponatremia. Further research involving larger patient samples is required to validate our findings.
  • ||||||||||  paroxetine / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
    Retrospective data, Journal:  Evaluating the Use of Selective Serotonin Reuptake Inhibitors (SSRIs) and Male Infertility: A Critical Retrospective Study. (Pubmed Central) -  Apr 13, 2024   
    Regarding the sperm analysis and the use of SSRIs, the impact of SSRIs use showed no significant differences in sperm liquefaction (p = 0.1), motility (p = 0.17), viscosity (p = 0.16), or count (p = 0.069) with escitalopram, fluoxetine, or paroxetine use; Our study showed no significant difference in the sperm analysis between the SSRI and non-SSRI cohorts. However, the relationship between SSRI use and sperm count warrants further investigation and consideration in clinical practice.
  • ||||||||||  olanzapine / Generic mfg.
    Journal:  Association of Antipsychotic Polypharmacy and Two-Year All-Cause Mortality: A Population-Based Cohort Study of 33,221 Italian Continuous Users. (Pubmed Central) -  Apr 13, 2024   
    Adjustments were made for the presence of metabolic disturbances, total antipsychotic dosage amount (olanzapine equivalent doses), age, and sex...Patients treated with antipsychotic polytherapy showed an adjusted mortality risk increased by 17% (95% CI: 2%, 33%) compared to monotherapy. The study highlights the potential risks associated with antipsychotic polypharmacy, emphasizing the importance of optimizing drug prescriptions to improve patient safety and reduce mortality rates in individuals receiving antipsychotic therapy.