Serotonin 

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  • ||||||||||  citalopram / Generic mfg., fentanyl citrate / Generic mfg., venlafaxine / Generic mfg.
    Journal:  Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths. (Pubmed Central) -  Apr 26, 2024   
    This complex phenomenon can have a significant impact on the analysis, interpretation of genotypes, and accurate conclusions in forensic toxicology. Nevertheless, more research with more cases in the future is needed to confirm these results.
  • ||||||||||  haloperidol / Generic mfg.
    Review, Journal:  Pharmacological Treatment for Terminal Agitation, Delirium and Anxiety in Frail Older Patients. (Pubmed Central) -  Apr 26, 2024   
    This mixed methods review demonstrates the lack of good quality evidence that is needed to help clinicians with pharmacological treatment decisions when confronted with psychological symptoms in the last days of life in frail older patients. Population aging will only emphasize the need for further research in this specific population.
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, emraclidine (CVL-231) / Cerevel Therap
    Journal:  Understanding the therapeutic action of antipsychotics: from molecular to cellular targets with focus on the islands of Calleja. (Pubmed Central) -  Apr 26, 2024   
    We will emphasize the potential role of dopamine D3 and M4 muscarinic acetylcholine receptor expressed at highest level by the islands of Calleja, as well as their involvement in schizophrenia-associated neurocircuitries. Finally, we will discuss the implications of new data showing ongoing adult neurogenesis of the islands of Calleja, as a very promising antipsychotic target linking long-life neurodevelopment and dopaminergic dysfunction in the striatum.
  • ||||||||||  Review, Journal:  Anti-Calcitonin Gene-Related Peptide Monoclonal Antibodies in Migraine: Focus on Drug Interactions. (Pubmed Central) -  Apr 26, 2024   
    However, monoclonal antibodies may worsen diseases with already weakened CGRP neurotransmission, Raynaud phenomenon and constipation. Monoclonal antibodies used for prevention of migraine do not engage in significant pharmacokinetic interactions with other drugs; however, they do engage in pharmacodynamic interactions with other anti-migraine drugs, additively augmenting their prophylactic action, but also increasing frequency and severity of adverse reactions, which are a consequence of the CGRP neurotransmission interruption.
  • ||||||||||  aripiprazole / Generic mfg., risperidone / Generic mfg., haloperidol / Generic mfg.
    Review, Journal:  The use of antipsychotics in obsessive compulsive disorder. (Pubmed Central) -  Apr 26, 2024   
    Antipsychotic augmentation may be also related to side-effects, particularly in the long term (e.g., alteration in metabolic profile, sedation, extrapyramidal symptoms). The present mini-review sought to provide the most updated evidence on augmentative antipsychotic use in treatment-resistant patients with OCD, providing a road map for clinicians in daily practice and shedding light on avenues for further research.
  • ||||||||||  memantine / Generic mfg.
    Journal:  Time-Dependent Long-Term Effect of Memantine Following Repetitive Mild Traumatic Brain Injury. (Pubmed Central) -  Apr 26, 2024   
    Although memantine is already being prescribed chronically to address persistent symptoms associated with rmTBI, this study represents the first evidence of which we are aware to suggest a small, but durable effect of memantine treatment in mild, concussive injuries. This effect suggests that memantine, while potentially beneficial, is insufficient to treat all aspects of rmTBI alone, and should be combined with other therapeutic agents in a multi-therapy approach, with attention given to the timing of treatment.
  • ||||||||||  ondansetron / Generic mfg., doxylamine/pyridoxine / Generic mfg., metoclopramide / Generic mfg.
    Clinical guideline, Journal:  The Management of Nausea and Vomiting in Pregnancy and Hyperemesis Gravidarum (Green-top Guideline No. 69). (Pubmed Central) -  Apr 26, 2024   
    This effect suggests that memantine, while potentially beneficial, is insufficient to treat all aspects of rmTBI alone, and should be combined with other therapeutic agents in a multi-therapy approach, with attention given to the timing of treatment. [Grade A] There are safety and efficacy data for first line antiemetics such as anti (H1) histamines, phenothiazines and doxylamine/pyridoxine (Xonvea
  • ||||||||||  fluoxetine / Generic mfg., dextromethorphan / Generic mfg.
    Trial completion date, Trial primary completion date:  Study of Dextromethorphan in OCD and Related Disorders (clinicaltrials.gov) -  Apr 26, 2024   
    P2,  N=60, Recruiting, 
    [Grade A] There are safety and efficacy data for first line antiemetics such as anti (H1) histamines, phenothiazines and doxylamine/pyridoxine (Xonvea Trial completion date: Aug 2025 --> Dec 2025 | Trial primary completion date: Aug 2024 --> Apr 2025
  • ||||||||||  clozapine / Generic mfg.
    Enrollment change:  Cannabidiol (CBD) for Clozapine Refractory Schizophrenia (CanCloz) (EUDRACT) -  Apr 26, 2024   
    P2,  N=88, Recruiting, 
    Trial completion date: Aug 2025 --> Dec 2025 | Trial primary completion date: Aug 2024 --> Apr 2025 N=40 --> 88
  • ||||||||||  Dysport (abobotulinumtoxinA) / Ipsen, Xeomin (incobotulinumtoxinA) / Merz Pharma, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    New trial:  Strategy to Adapt Botulinum Toxin Doses in Dystonia (clinicaltrials.gov) -  Apr 25, 2024   
    P=N/A,  N=100, Not yet recruiting, 
  • ||||||||||  clozapine / Generic mfg.
    Journal:  Editorial: Psychosis in low- and middle-income countries (LMIC). (Pubmed Central) -  Apr 25, 2024   
    Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects. No abstract available
  • ||||||||||  sertraline / Generic mfg., fluoxetine / Generic mfg.
    New trial:  FB+: The Friendship Bench Plus Trial (clinicaltrials.gov) -  Apr 25, 2024   
    P=N/A,  N=296, Not yet recruiting, 
  • ||||||||||  ondansetron intravenous / Generic mfg., cisplatin / Generic mfg.
    Trial completion date, Trial primary completion date:  Chemo-embolization for Head and Neck Cancer (clinicaltrials.gov) -  Apr 25, 2024   
    P2,  N=48, Not yet recruiting, 
    Not yet recruiting --> Recruiting | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Jun 2024 --> Jun 2025 Trial completion date: Jan 2026 --> Jan 2029 | Trial primary completion date: Jan 2025 --> Jan 2028
  • ||||||||||  bortezomib / Generic mfg., duloxetine / Generic mfg.
    A randomized phase III clinical trial of acupuncture for chemotherapy-induced peripheral neuropathy treatment (ACT). (Hall A; Poster Bd #: 277b) -  Apr 24, 2024 - Abstract #ASCO2024ASCO_2898;    
    P3
    Currently, duloxetine is the only ASCO-recommended painful CIPN treatment after chemotherapy completion...Major eligibility criteria include 1) adults who have no evidence of disease or stable diseases, 2) who have completed neurotoxic chemotherapy such as platinum agents, taxanes, vinca alkaloids, and bortezomib at least three months before enrollment, and 3) who have a clinical diagnosis of CIPN with moderate to severe pain, defined as a score of at least four on the Brief Pain Inventory (BPI) average pain item...We anticipate initiating participant enrollment at DFCI in February 2024. Accrual completion is expected by December 2024.
  • ||||||||||  Prevalence of cannabis related potential medication interactions (PMI) among patients with cancer during treatment. (Hall A; Poster Bd #: 202) -  Apr 24, 2024 - Abstract #ASCO2024ASCO_2823;    
    The most common cannabis-related PMIs were with acetaminophen (9.5%), dexamethasone (8%), and ondansetron (6.3%). This is one of the first studies to assess cannabis-related drug interactions in patients receiving cancer treatment, and results indicates a significant proportion of cannabis users are at risk for moderate to major PMIs including with chemotherapy.
  • ||||||||||  Akynzeo oral (netupitant/palonesteron FDC) / Helsinn, Roche, Otsuka, Akynzeo IV (fosnetupitant/palonosetron) / Helsinn
    An Indian real-world experience of intravenous fosnetupitant-palonosetron (IV NEPA) in preventing delayed and extended delayed CINV. (Hall A; Poster Bd #: 199) -  Apr 24, 2024 - Abstract #ASCO2024ASCO_2820;    
    Cisplatin-Paclitaxel (19.10%) and Carboplatin-Paclitaxel (35.39%) were the most common HEC and MEC regimens respectively... IV NEPA demonstrated high efficacy and good tolerability in a real world Indian setting, exhibiting response rates of >92% in both delayed and extended delayed phases in patients receiving HEC/MEC regimens.
  • ||||||||||  sertraline / Generic mfg.
    Journal:  Insight into chemically reactive metabolites of aliphatic amine pollutants: A de novo prediction strategy and case study of sertraline. (Pubmed Central) -  Apr 24, 2024   
    Molecular orbital analysis supports the reactivity preference for toxicological-relevant C-N desaturation over N-hydroxylation of sertraline, possibly extended to several other aliphatic amines based on the Bell-Evans-Polanyi principle. It was further validated toward some other wide-concerned aliphatic amine pollutants involving atrazine, ?-caprolactam, 6PPD via in silico and in vitro assays, thereby constituting a complete path for de novo prediction from case study to general applications.
  • ||||||||||  hydroxyzine hydrochloride / Generic mfg., risperidone / Generic mfg.
    Journal:  Priapism Associated With the Addition of Hydroxyzine to Risperidone: A Case Report. (Pubmed Central) -  Apr 24, 2024   
    It was further validated toward some other wide-concerned aliphatic amine pollutants involving atrazine, ?-caprolactam, 6PPD via in silico and in vitro assays, thereby constituting a complete path for de novo prediction from case study to general applications. This case report demonstrates the risk of addition of hydroxyzine to antipsychotics which can result in an increased risk of priapism or prolonged episodes.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Polystyrene microplastics alter the trophic transfer and biotoxicity of fluoxetine in an aquatic food chain. (Pubmed Central) -  Apr 24, 2024   
    In addition, the specific neurotransmission biotoxicity in fish induced by fluoxetine was mitigated by MPs, whilst the oxidative damage, apoptosis, and immune responses in zebrafish were reversely enhanced by MPs due to the stimulating effect. These findings highlight the alleviating effects of MPs on the trophic transfer and specific biotoxicity of fluoxetine in the food chain, providing new insights into the carrier effects of MPs in aquatic environments in the context of increasing global MP pollution.
  • ||||||||||  methylphenidate tablet / Generic mfg., fluoxetine / Generic mfg.
    Preclinical, Journal:  Methylphenidate with or without fluoxetine triggers reinstatement of cocaine seeking behavior in rats. (Pubmed Central) -  Apr 24, 2024   
    The low dose of MP (2?mg/kg) with or without FLX did not reinstate cocaine seeking behavior. Our results suggest that acute exposure to a high dose of MP, with or without FLX, may increase the risk for relapse in individuals who used cocaine during the juvenile period.