- |||||||||| olanzapine / Generic mfg.
Journal: The effect of differences in trial design on estimates of efficacy of olanzapine in randomized studies. (Pubmed Central) - May 5, 2024
Trials with OLZ used as investigational drug differ from those of trials with OLZ as comparator for baseline PANSS scores and study duration; these differences may produce differences in estimates of efficacy. As a consequence, the severity of illness at enrollment and trial duration should be carefully considered to ensure the reliability of indirect comparisons among antipsychotics.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Journal: Use of botox for sialorrhea and dysphagia in the neonatal population. (Pubmed Central) - May 5, 2024
BoNT injection is a safe, non-invasive alterative for management of sialorrhea in neonates. Further extensive study needs to be performed to identify the optimal dose per gland in this population.
- |||||||||| ondansetron / Generic mfg.
Review, Journal: Treatment of nausea in hospitalized patients with acute illness. (Pubmed Central) - May 5, 2024
Intravenous fluid and treatment directed against underlying pathology is recommended as a first-line treatment against nausea in these patients. If an antiemetic is clinically warranted, ondansetron has the most favourable ratio between side effects and price, as argued in this review.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Paraganglioma or Benign Ectopic Thyroid Tissue? (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_2938;
Even a very thorough workup can mistake the identity of a mysterious mass; only the tissue itself can make the diagnosis.References: 1. Cooper, David S., and Paul W. Ladenson.
- |||||||||| SSRI Induced Graves' Disease Reactivation (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_2874;
The patient had been on Escitalopram for depression for years, which was changed to Sertraline and then Paroxetine three months prior to presentation...Her Burch-Wartofsky score was 10, suggesting against thyroid storm.The methimazole dose was increased to 20 mg TID for 3 days with a subsequent taper to 10 mg...There has been only one case of clinically significant hyperthyroidism induced by fluoxetine...It is not uncommon for patients to be treated for thyroid dysfunction and mood disorders at the same time. Monitoring the side effects of mood-regulating medications on thyroid function should be routine practice.
- |||||||||| Lantus (insulin glargine) / Sanofi
An unusual movement disorder, case of diabetic striatopathy! (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_2604;
This case describes rare case of simultaneous NKH-CB with history of CVA and antipsychotic medication use in a patient with poorly controlled DM which resolved with treatment of hyperglycemia. Thus offers valuable insights into the diagnostic challenges associated with this condition as well as potential links to other neurological complications.
- |||||||||| Lantus (insulin glargine) / Sanofi, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
A Case Report of Polypharmacy With Combined Adverse Effects of SGLT-2 Related Euglycemic DKA and Lithium Induced Nephrogenic DI (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_2570;
In the USA, 67 percent of hospitalizations are linked to four medications or classes: warfarin, insulins, oral antiplatelet agents, and oral hypoglycemic agents...Patient has been taking Lantus, Glipizide (sulfonylurea), and Empagliflozin, Bupropion and Aripiprazole at home...This case report will enforce the importance of ensuring appropriate drug prescribing involves factors such as avoiding inappropriate medications, monitoring for side effects and drug levels, preventing drug interactions, and incorporating patient values through active involvement. This case is an unique opportunity to learn ADEs, contributing to diagnostic challenges which can increase mortality across various age groups without proper vigilance.
- |||||||||| clozapine / Generic mfg.
Disruption of Transient Receptor Potential Channel 5 Causes Obesity and Maladaptive Behavior (251 - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_2061;
Importantly, chemogenetic inactivation using designer receptor exclusively activated by designer drugs (DREADD) of hM4Di-expressing Pomc neurons with clozapine N-oxide (CNO; i.p., 1 mg/kg) effectively blocked BTD-induced anorexia and c-Fos expression in Pomc neurons...Our findings suggest that melanocortin receptor agonists might be effective in treating severe obesity in individuals carrying TRPC5 variants. We suggest that TRPC5 should be included in diagnostic gene panels for severe childhood-onset obesity.
- |||||||||| fluoxetine / Generic mfg.
Serotonin Receptor Antagonist Alleviates Vascular Defects Produced by Selective Serotonin Reuptake Inhibitor Treatment During Gestation (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1738;
Preliminary work in our laboratory revealed placental apoptosis in pregnant dams treated with fluoxetine (FLX) and dams genetically deficient for the serotonin transporter gene.We hypothesize that SSRIs decrease placental blood flow, causing apoptosis and organ death via signaling through the serotonin 2A/2C receptors.Pregnant female C57BL6 mice were randomized to be treated daily, via I.P. injection, from E10-17.5 with saline (CON; n=6), 2 mg/kg FLX (n=5), or 2 mg/kg ketanserin plus 2 mg/kg FLX (n=5)...These data suggest that treatment with ketanserin could be utilized to alleviate the reproductive side effects of antidepressant usage for pregnant mothers while allowing the mother to remain on antidepressants. Future research should further investigate the effects of SSRI and ketanserin on blood flow to the fetus through the umbilical cord.
- |||||||||| Partial Xp Duplication and Xq Deletion in a Patient with Premature Ovarian Failure: A Rare Case Report (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1702;
It is important to note her concurrent use of risperidone, sertraline, and lorazepam at that time.In the first evaluation at the Endocrinology department, the patient reported amenorrhea and denied galactorrhea...Genetic counseling is recommended for these patients, particularly for those considering parenthood. It is also advisable to assess the chromosomal alteration in parents to determine if the change is inherited and to evaluate the risk to other family members.
- |||||||||| Pheochromocytoma in the ICU- Hiding in Plain Sight (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1653;
Confounders like vasopressors (increases catecholamines), intrinsic stress of critical illness (increases catecholamines), and quetiapine use (can increase normetanephrine levels) make it difficult to analyze labs. In these cases, a thorough history and imaging are key to establishing a diagnosis and initiating life-saving treatment.
- |||||||||| risperidone / Generic mfg.
Sweet Moves: Hyperglycemia-related Chorea Ballismus (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1452;
Although stroke was also considered as a possible cause of her movement disorder, the resolution of chorea with glycemic control and risperidone made hyperglycemia related chorea-ballismus more likely...The clear mechanism of the movement disorder associated with uncontrolled diabetes has not been clearly elucidated. Nonetheless, this uncommon complication of hyperglycemia is important to recognize in order to provide appropriate and timely treatment.
- |||||||||| clozapine / Generic mfg.
A DREADD-base Chemogenetic Approach to Quiz the Impact of the Delta Cell Input on Islet Hormone Secretion (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1415;
The utilization of DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) that are gated by clozapine-N-oxide (CNO) enables the selective stimulation of genetically specified cell types in vivo...These results encouraged us to explore the potential application of DREADD tools in isolated human islets. We will discuss our current approaches whilst using viral vectors to drive the expression of DREADDs in human ?-cells and its impact in the overall islet secretory output.
- |||||||||| cabergoline / Generic mfg.
Cabergoline Induced Psychosis in a Patient with no Previous History of Psychiatric Disorder (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_1309;
Patients who are on cabergoline should be closely monitored for any psychotic symptoms. Further studies are warranted to identify patients at risk of developing psychosis while on cabergoline to tailor an individualized approach to therapy and monitoring.
- |||||||||| clozapine / Generic mfg.
Disruption of Transient Receptor Potential Channel 5 Causes Obesity and Maladaptive Behavior (156ABC - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_890;
Importantly, chemogenetic inactivation using designer receptor exclusively activated by designer drugs (DREADD) of hM4Di-expressing Pomc neurons with clozapine N-oxide (CNO; i.p., 1 mg/kg) effectively blocked BTD-induced anorexia and c-Fos expression in Pomc neurons...Our findings suggest that melanocortin receptor agonists might be effective in treating severe obesity in individuals carrying TRPC5 variants. We suggest that TRPC5 should be included in diagnostic gene panels for severe childhood-onset obesity.
- |||||||||| New onset Graves (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_760;
Causes of autoimmune conversion are not well understood. Viral infection or radiation exposure in genetic susceptible patients have been assumed as triggers (1).
- |||||||||| cabergoline / Generic mfg.
Cabergoline-induced psychiatric symptoms in a patient with a pituitary macroadenoma (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_285;
Other treatment options also include aripiprazole and quetiapine. However, when patients have treatment resistant macroprolactinomas and are unable to tolerate cabergoline, one would have to consider surgical treatment options for the treatment of hyperprolactinemia from pituitary macroadenomas.
- |||||||||| quetiapine / Generic mfg., dexmedetomidine / Generic mfg.
Acute Psychosis and the Diagnosis of Cushing (ENDOExpo PosterArea - BCEC) - May 5, 2024 - Abstract #ENDO2024ENDO_282;
He was initially sedated with dexmedetomidine and started on quetiapine. In this patient, the diagnosis of Cushing
- |||||||||| Stendra (avanafil) / IEH Biopharma, Menarini, Endo
Journal: Simultaneous measurement of duloxetine hydrochloride and avanafil at dual-wavelength using novel ecologically friendly TLC-densitometric method: application to synthetic mixture and spiked human plasma with evaluation of greenness and blueness. (Pubmed Central) - May 4, 2024
Moreover, the proposed technique was evaluated in terms of greenness using four contemporary ecological metrics: The Analytical Greenness software (AGREE), the Green Analytical Procedure Index (GAPI), Eco-Scale, and the National Environmental Method Index (NEMI). Additionally, the Blue Applicability Grade Index (BAGI), a newly developed tool for evaluating the practicality (blueness) of procedures, was taken into consideration when evaluating the sustainability levels of the established approach.
- |||||||||| risperidone / Generic mfg., olanzapine / Generic mfg.
Journal: Antipsychotic drug-induced behavioral abnormalities in common carp: The potential involvement of the gut microbiota-brain axis. (Pubmed Central) - May 4, 2024
To our knowledge, the present study is the first to investigate the effects of antipsychotics on various complex behaviors (swimming performance and social behavior) in common carp, highlighting the potential health risks associated with antipsychotic drug-induced neurotoxicity in fish. Although these results do not fully elucidate the mechanisms underlying the effects of antipsychotic drugs on fish behavior, they serve as a valuable initial investigation and form the basis for future research.
- |||||||||| dexamethasone / Generic mfg., amitriptyline / Generic mfg., sumatriptan succinate / Generic mfg.
Pressing Emergency At The Concussion Center (Hynes CC-306) - May 4, 2024 - Abstract #ACSM2024ACSM_3589;
We believe this is the first report of PRES associated with concussion.TREATMENT AND OUTCOME1.PRES is usually self-limited. With supportive treatment, patient's vision improved during 4 day hospitalization and he felt 85% better by neurology follow 3 weeks post discharge.
- |||||||||| Dizziness In The College Soccer Player (Hynes CC-309) - May 4, 2024 - Abstract #ACSM2024ACSM_3574;
In the ER, treated with Ativan 1mg IV, Zofran 4mg IV, 1L bolus of LR.2. Neurology consulted and clinical presentation most consistent with a peripheral vestibular neuritis of L CN VIII.
- |||||||||| Anxiety With Panic Attacks - Lacrosse (Hynes CC-306) - May 4, 2024 - Abstract #ACSM2024ACSM_3541;
Right axis deviation.CXR: Trace left pleural effusion.Echo: Abnormal septal wall motion d/t RV pressure overload. RV enlarged w/reduced systolic function.
- |||||||||| amitriptyline / Generic mfg.
Chronic Ankle Pain - Cross-country Athlete (Hynes CC-309) - May 4, 2024 - Abstract #ACSM2024ACSM_3529;
FINAL WORKING DIAGNOSIS: Complex regional pain syndromeTREATMENT AND OUTCOMES:Ordered a pre-/post-therapy video gait analysis showing improved running mechanics and hip stability. Completed formalized physical therapy for CRPS desensitization locally with 80% improvement of symptoms after 3 months.
- |||||||||| sertraline / Generic mfg., ziprasidone / Generic mfg.
Bilateral Calf Pain In A High School Athlete (Hynes CC-309) - May 4, 2024 - Abstract #ACSM2024ACSM_3481;
Bilateral US Arterial and Venous Duplex: unremarkable arterial US and no signs of DVT. Autoimmune panel: negative.
- |||||||||| Fever In Collegiate Athlete With Recent Travel (230; Hynes CC-Hall A) - May 4, 2024 - Abstract #ACSM2024ACSM_2629;
Mild bilateral inguinal lymphadenopathy.Pelvic US: Left ovarian simple cyst. Small amount of free fluid in cul-de-sac.CTH w/, w/o: No evidence for acute intracranial pathology.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Retrospective data, Journal: Sequential administration of peripheral nerve blocks and (Pubmed Central) - May 3, 2024
In this retrospective chart review, there was no significant difference in adverse events or therapy discontinuation between patients receiving sequential peripheral nerve block(s) and onabotulinumtoxinA injections versus those receiving either peripheral nerve block(s) or onabotulinumtoxinA injections alone. As a result, we concluded that the combination procedure is likely safe and well tolerated in routine clinical practice.
- |||||||||| Journal: A case of Pitt-Hopkins syndrome: psychopharmacological approach for anxiety, insomnia, and agitation. (Pubmed Central) - May 3, 2024
After admission to our hospital, aripiprazole and hydroxyzine were prescribed for anxiety and ASD-related irritability...Hydroxyzine was stopped, and quetiapine was given to eliminate sleep disturbance...For the anxiety symptoms, escitalopram was prescribed...Patients with genetic syndromes may have various psychiatric complaints. Psychopharmacological interventions should be administered carefully for the side effects.
- |||||||||| erythromycin / Generic mfg., clozapine / Generic mfg.
Journal: Use of Erythromycin in Clozapine Induced Constipation: A Case Report. (Pubmed Central) - May 3, 2024
In contrast, BoNT/A did not appear to alter facial pain sensitivity induced by inflammation, suggesting that mechanisms other than baseline CGRP could be implicated in the elevated thresholds in the CFA model. No abstract available
- |||||||||| Emgality (galcanezumab-gnlm) / Eli Lilly, Daiichi Sankyo, Organon
Pharmacological treatment of cluster headache (Room Copenhagen) - May 3, 2024 - Abstract #EAN2024EAN_490;
Noninvasive neurostimulation techniques and deep brain stimulation offer potential avenues for medically refractory cases. This presentation will comprehensively review cluster headache treatment options, ensuring an evidence- based and up- to- date approach to patient care.
- |||||||||| clozapine / Generic mfg.
Review, Journal: Identification and treatment of individuals with childhood-onset and early-onset schizophrenia. (Pubmed Central) - May 2, 2024
Since early age of illness onset is a consistent risk factor for treatment-resistant schizophrenia (TRS), clinicians need to be competent in diagnosing TRS and using clozapine...Targeting functional outcomes and quality of life in addition to symptom remission can improve overall patient well-being. Comprehensive evaluations, age-specific assessments, and targeted interventions are needed to address the unique challenges of EOS and COS.
- |||||||||| fluoxetine / Generic mfg.
Preclinical, Journal: Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice. (Pubmed Central) - May 2, 2024
Group I: control (negative control) exposed to open-space forced swim test (OSFST) without any treatment, Groups II, III and IV received graded doses of Cinnamon 12.5, 25, and 50 mg/kg, group 5 (positive control) received fluoxetine 20 mg/kg orally...In conclusion, cinnamon has shown antidepressant-like effect in open-space forced swim-induced depression in mice. Keywords: Cinnamon, Depression, Cognitive impairment, Immobility time, Behavioural despair.
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