Serotonin 

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  • ||||||||||  risperidone / Generic mfg., paroxetine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Clinical effects of CYP2D6 phenoconversion in patients with psychosis. (Pubmed Central) -  Sep 23, 2024   
    Phenoconversion led to a large increase in poor metabolizers (PMs; 17-82, 16% of sample), due to concomitant use of the serotonin reuptake inhibitors fluoxetine and paroxetine...Risperidone, however, was most affected by the CYP2D6 genotype...CYP2D6 may play a limited role in side effects, symptoms and well-being measures. However, due to the high frequency of occurrence, phenoconversion should be considered in future clinical trials.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal, Video:  Area of Focus in 3D Volumetry and Botulinum Toxin A Injection for Giant Diaphragmatic Hernia with Loss of Domain: A Case Report with Video Illustration. (Pubmed Central) -  Sep 23, 2024   
    We assessed the risk of loss of domain using a 3D volumetry based on the Sabbagh score and decided to use Botox injection before laparoscopic reduction of the hernia due to the high risk of complications related to the loss of domain...The patient presented an excellent functional result with a normal physical activity. This report is among the first to highlight the utility of 3D reconstruction in assessing the risk associated with loss of domain and in preparing the abdominal wall with botulinum toxin A for diaphragmatic hernia repair.
  • ||||||||||  hypidone hydrochloride (HHT101) / Zhejiang Huahai Pharma
    Preclinical, Journal:  The role of 5-HTergic neuron activation in the rapid antidepressant-like effects of hypidone hydrochloride (YL-0919) in mice. (Pubmed Central) -  Sep 23, 2024   
    These changes were drastically different from those of the selective serotonin reuptake inhibitor (SSRI) fluoxetine, which suggested that the antidepressant-like effects of the two compounds were mechanistically different. Together, these results reveal a novel role of 5-HTergic neurons in the DRN in mediating the fast-acting antidepressant-like effects of YL-0919, revealing that these neurons are potential novel targets for the development of fast-acting antidepressants for the clinical management of MDD.
  • ||||||||||  Journal:  Evaluation of outcomes of clinical phenotyping-based treatment for bladder pain syndrome/interstitial cystitis. (Pubmed Central) -  Sep 23, 2024   
    Patients with Hunner's lesions (HL) (CP4) underwent hydro distension and ablation of the lesion, followed by intravesical instillation of heparin and hydrocortisone...Overall, 16% (4/25) patients had unsatisfactory, 56% (14/25) attained good, and 28% (7/25) had an excellent response at the completion of the study. Using clinical phenotyping-based features indicative of etiology could potentially improve treatment outcomes by targeting the specific pathological processes contributing to the patients' symptoms.
  • ||||||||||  risperidone / Generic mfg., lorazepam / Generic mfg., bromocriptine / Generic mfg.
    Journal:  Dual Toxidrome of Anti-cholinergic Storm and Neuroleptic Malignant Syndrome: A Therapeutic Challenge Overcome by Intrathecal Neostigmine. (Pubmed Central) -  Sep 23, 2024   
    We present the case of a 23-year-old young male with polysubstance dependence, admitted following combined trihexyphenidyl and risperidone toxicity...Treatment of NMS included lorazepam and bromocriptine...The patient subsequently recovered and was discharged. This case highlights the complexity of managing dual toxidromes and the need for alternative therapeutic strategies in resource-limited settings.
  • ||||||||||  Journal:  Emerging therapies for opioid-induced constipation: what can we expect? (Pubmed Central) -  Sep 23, 2024   
    Other treatment options, including intestinal secretagogues like lubiprostone and linaclotide, selective 5-HT receptor agonists such as prucalopride, and emerging adjunctive therapies like transcutaneous electrical nerve stimulation (TENS) and electroacupuncture were mentioned...Emerging therapies and adjunctive treatments offer promising results but require further validation through rigorous studies. Future research should focus on long-term outcomes, cost-effectiveness, and comparative effectiveness to better address the complex needs of patients with OIC and refine treatment protocols.
  • ||||||||||  olanzapine / Generic mfg.
    Journal:  A spectrum of altered non-rapid eye movement sleep in schizophrenia. (Pubmed Central) -  Sep 22, 2024   
    Some sleep metrics including fast spindle density showed exaggerated age-related effects in SCZ, and patients exhibited older predicted biological ages based on the sleep EEG; further, among patients, certain medications exacerbated these effects, in particular olanzapine. Collectively, our results point to a spectrum of N2 sleep deficits among SCZ patients that can be measured objectively and at scale, with relevance to both the etiological heterogeneity of SCZ as well as potential iatrogenic effects of antipsychotic medication.
  • ||||||||||  Review, Journal, Epigenetic controller:  Role of histone deacetylases and their inhibitors in neurological diseases. (Pubmed Central) -  Sep 21, 2024   
    Additionally, the current pharmacological situation, problems, and developmental prospects of HDAC inhibitors are described. A better understanding of the pathogenic mechanisms of HDACs in the nervous system may reveal new targets for therapeutic interventions in diseases and help to relieve healthcare pressure through preventive measures.
  • ||||||||||  lysergic acid diethylamide (MM-120) / Mindmed, University Hospital Basel
    Clinical, Journal:  Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response. (Pubmed Central) -  Sep 21, 2024   
    This study compared the subjective effects of lysergic acid diethylamide (LSD) and psilocybin between patients undergoing PAT and healthy volunteers...Patients may experience more challenging psychedelic effects and reduced ego dissolution. Hourly assessment of drug effects may predict clinical outcomes better than retrospectively assessed mystical experiences, and the impact of relaxation during PAT should be investigated further.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  VGLUT2 may improve cognitive function in depressed rats by protecting prefrontal cortex neurons. (Pubmed Central) -  Sep 21, 2024   
    After 28?days of CUMS combined with isolation rearing, rats exhibited impairments in mood, cognition, learning, and social abilities, with neuronal damage and decreased VGLUT2 protein levels in the prefrontal cortex. Following fluoxetine intervention, VGLUT2 protein expression increased, neuronal repair in the prefrontal cortex occurred, depressive-like behavior improved, and cognitive learning and social abilities were restored.
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
    Review, Journal:  Cariprazine in Psychiatry: A Comprehensive Review of Efficacy, Safety, and Therapeutic Potential. (Pubmed Central) -  Sep 21, 2024   
    Continued research and clinical exploration may discover additional insights, broadening its use in diverse patient populations. This article aims to review the role of cariprazine, a dopamine D2/D3 and serotonin 5-HT1A receptor partial agonist, in the management of psychotic illnesses, including schizophrenia, bipolar disorder, addiction therapy, and pediatric treatment.
  • ||||||||||  rivaroxaban / Generic mfg., risperidone / Generic mfg.
    Journal:  Disproportionality Analysis and Characterisation of Medication Errors in EudraVigilance: Exploring Findings on Sexes and Age Groups. (Pubmed Central) -  Sep 21, 2024   
    Signals of disproportionate reporting, not described in the literature, were found for vaccines, oxycodone, rivaroxaban and risperidone, and may prompt further examination by stakeholders. Top-reported MEs ("Inappropriate schedule of product administration", "Incorrect dose administered" and "Wrong technique in product usage process") emerged as a general priority focus to perform a further root-cause analysis involving healthcare providers, manufacturers and regulatory bodies, to improve the understanding and prevention of MEs.
  • ||||||||||  olanzapine / Generic mfg.
    Preclinical, Journal:  PROTECTIVE EFFECTS OF MENTHOL AGAINST OLANZAPINE-INDUCED METABOLIC ALTERATIONS IN FEMALE MICE. (Pubmed Central) -  Sep 21, 2024   
    EEG changes associated with SSRIs, SNRIs and vortioxetine are also highly replicated findings across mixed studies and populations. and implications- Our results suggest possible therapeutic implications of menthol in the management of antipsychotic-induced weight gain and other metabolic alterations.
  • ||||||||||  mirtazapine / Generic mfg.
    Preclinical, Journal:  Microdialysis-integrated HPLC system with dual-electrode detection using track-etched membrane electrodes for in vivo monitoring of dopamine dynamics. (Pubmed Central) -  Sep 21, 2024   
    Furthermore, subsequent measurements following the intraperitoneal injection of mirtazapine showed no increase in dopamine levels in the right dorsal striatum...The consistency between dopamine collection efficiency from standard solutions and dialysate indicated the absence of interfering electroactive substances overlapping with the dopamine peak in the chromatogram. This integrated analysis system successfully tracked temporal fluctuations in dopamine concentration within the mouse brain.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Enrollment change, Trial withdrawal:  Efficacy of Zinc Supplementation on Botox Treated Forehead Rhytids (clinicaltrials.gov) -  Sep 20, 2024   
    P=N/A,  N=0, Withdrawn, 
    The high price of PP1M might be an obstacle to its widespread use. N=40 --> 0 | Not yet recruiting --> Withdrawn
  • ||||||||||  chlorpromazine / Generic mfg.
    Trial completion date:  Chlorpromazine and Standard of Care in Glioblastoma (clinicaltrials.gov) -  Sep 20, 2024   
    P1,  N=10, Active, not recruiting, 
    N=40 --> 0 | Not yet recruiting --> Withdrawn Trial completion date: Jul 2024 --> Apr 2025
  • ||||||||||  Nuplazid (pimavanserin) / Acadia Pharma
    New P2 trial:  Psilocybin Mechanism of Action (MOA) (clinicaltrials.gov) -  Sep 20, 2024   
    P2,  N=60, Not yet recruiting, 
  • ||||||||||  clozapine / Generic mfg.
    Journal, Adverse events:  Clozapine, relapse, and adverse events: a 10-year electronic cohort study in Canada. (Pubmed Central) -  Sep 20, 2024   
    Clozapine was associated with lower relapse overall, but this was accompanied by higher adverse events for adults. For children/youth, clozapine was associated with lower relapse all throughout and had no difference in adverse events compared with other antipsychotics.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Unilateral Stereotactic Radiofrequency Lesioning as a Surgical Treatment Option for Meige Syndrome. (Pubmed Central) -  Sep 20, 2024   
    First-line treatment typically involves Botox injections...Bilateral facial symptoms improved in four patients (67%). Conclusion Unilateral RF lesioning for Meige syndrome demonstrated the potential to improve bilateral symptoms and may be considered a viable treatment option for patients with refractory cases.