Serotonin 

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  • ||||||||||  clozapine / Generic mfg.
    Journal:  Improved insomnia is one pathway underlying the anti-suicidal properties of clozapine. (Pubmed Central) -  Jun 7, 2024   
    Findings warrant replication in a larger sample with standard instruments in the assessment of insomnia and suicide, but suggest beneficial effects on sleep as a mediator of the anti-suicidal properties of clozapine. Future mechanistic studies are also needed.
  • ||||||||||  sertraline / Generic mfg., milrinone / Generic mfg.
    Journal:  Fetal ductal constriction caused by SSRI: A case report. (Pubmed Central) -  Jun 7, 2024   
    A 31-week fetus was diagnosed with premature ductal constriction due to maternal treatment with sertraline...The baby was born in a severely depressed condition, with supra-systemic pulmonary hypertension, requiring intubation, mechanical ventilation, and milrinone infusion...The baby was discharged home at 38?weeks postmenstrual age, in good general condition, without any signs of pulmonary hypertension, requiring no respiratory support. The echo examinations on the first and third months after birth were normal.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Blood Sausage to BOTOX: The Story of the Miracle Toxin. (Pubmed Central) -  Jun 7, 2024   
    How best to incorporate antipsychotics into the treatment of BPSD in clinical settings lies in the hands of us Japanese clinicians. No abstract available
  • ||||||||||  olanzapine / Generic mfg.
    Journal:  Pragmatic clinical trials to advance research in children and adolescents with eating disorders. (Pubmed Central) -  Jun 6, 2024   
    These results indicate that SIRT1-Nrf2 signaling loop activation is indispensable for the protective effect of F2 against myocardial I/R injury, and may provide new insights for the treatment of ischemic heart disease. Pragmatic clinical trials provide alternatives to RCT design that can help bolster research in EDs that aims to explore real-world effects of interventions.
  • ||||||||||  escitalopram / Generic mfg.
    Journal:  Individual differences in the boldness of female zebrafish are associated with alterations in serotonin function. (Pubmed Central) -  Jun 6, 2024   
    We found that escitalopram had opposing effects on thigmotaxis in bold and shy female animals: the drug caused bold fish to spend more time near the center of the tank and shy fish spent more time near the periphery. Taken together, our findings indicate that variation in serotonergic function has sex-specific contributions to individual differences in risk taking behavior.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Three-point Method Nerve Block for Relieving Pain of Microbotox Injection in Middle and Upper Face. (Pubmed Central) -  Jun 6, 2024   
    Following microdrop Botox injection of the middle and upper face, 100 patients underwent a self-controlled study to analyze whether a three-point nerve block surpasses topical anesthesia for reducing injection pain...The three-point method exerted prominent analgesic effects during middle and upper facial treatments, with benefits including a precise block region, high satisfaction, and simple operation technique. Therefore, clinicians can easily master and apply this method.
  • ||||||||||  citalopram / Generic mfg., sertraline / Generic mfg., paroxetine / Generic mfg.
    Journal:  Sertraline, citalopram and paroxetine in lactation: passage into breastmilk and infant exposure. (Pubmed Central) -  Jun 6, 2024   
    Given the well-known benefits of breastfeeding, our findings support breastfeeding of infants by mothers who are taking sertraline, citalopram or paroxetine is safe. Sertraline and paroxetine are the preferred antidepressants during breastfeeding, reaching mostly undetectable infant drug levels.
  • ||||||||||  citalopram / Generic mfg., sertraline / Generic mfg.
    Journal:  Anticipatory anxiety of seizures: What is the best treatment? (Pubmed Central) -  Jun 6, 2024   
    We aimed to provide practical guidelines and tools for the screening and treatment of anxiety disorders in PWE. Regarding psychotropic medication, Sertraline or Citalopram might be good options for first-line treatment of AAS, since they are efficient against anxiety and well-tolerated in epilepsy.
  • ||||||||||  Nuplazid (pimavanserin) / Acadia Pharma
    Journal:  Parkinson's Disease Psychosis and the Marketing of Pimavanserin. (Pubmed Central) -  Jun 6, 2024   
    Reframing PDP as a unique condition is a typical example of condition branding. The establishment of PDP expanded the use of pimavanserin and is likely to have resulted in many avoidable deaths.
  • ||||||||||  olanzapine / Generic mfg.
    Journal:  LC-MS/MS quantification of olanzapine in hair after alkaline digestion. (Pubmed Central) -  Jun 6, 2024   
    The variation of OLZ concentrations in 12 hair segments (2 from Case 1 and 10 from Case 2) from two drug-positive patients, ranging from 0.131 to 0.460?ng/mg, is presented in this study. Although several studies have been conducted to determine OLZ in hair samples using segmental analysis via hair solubilization, this study is the first to determine OLZ in hair samples after "digestion" with comparative parameters prior to chromatographic analysis.
  • ||||||||||  Alervil (pheniramine maleate) / Incepta Pharma
    Clinical, Review, Journal:  Interventions for postburn pruritus. (Pubmed Central) -  Jun 5, 2024   
    Most studies were small and at a high risk of bias related to blinding and incomplete outcome data. Where there is moderate-certainty evidence, practitioners should consider the applicability of the evidence for their patients.
  • ||||||||||  chlorpromazine / Generic mfg.
    Journal, Patient reported outcomes:  Sex differences in patient-reported outcome measure of psychotic symptoms in schizophrenia. (Pubmed Central) -  Jun 5, 2024   
    Assessing and being aware of the self-perceived symptoms of patients with schizophrenia should be considered in the clinic, especially in men, as there appears to be a lack of agreement on certain items. This would allow treatments to be more focused on patients' need by sex, and would make them feel part of the therapeutic process, improving their therapeutic adherence, evolution and quality of life.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Anesthesia Spearheading Perioperative Safety Efforts in a Patient with Inclusion Body Myositis: A Case Report. (Pubmed Central) -  Jun 5, 2024   
    Due to the progression of his disease, he eventually developed dysphagia, hence he was scheduled for esophagoscopy, cricopharyngeal Botox injection, and percutaneous endoscopic gastrostomy...The hospital course was uncomplicated and the patient was discharged well after one day. This report emphasizes how improvements in resources, technology, and healthcare delivery, especially in anesthesia, help prevent perioperative adverse events.
  • ||||||||||  aripiprazole / Generic mfg.
    Journal:  "It's been a long time since I drank like that": A case report of binge drinking associated with aripiprazole. (Pubmed Central) -  Jun 5, 2024   
    Individuals who engage in binge drinking demonstrate consistent impulse control deficits that are unrelated to the rewarding effects of alcohol. Aripiprazole may be related to this patient's return to binge drinking from an ICP standpoint rather than driven by alcohol cravings as other psychosocial factors remained stable throughout this time.
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
    Journal:  A 12-month longitudinal naturalistic follow-up of cariprazine in schizophrenia. (Pubmed Central) -  Jun 5, 2024   
    Extrapyramidal symptoms occurred in a minority of patients and in mild or mild/moderate forms: no patient showed moderate forms of psychic/motor akathisia or dystonia, three subjects showed moderate parkinsonism. This study confirms a good efficacy profile of cariprazine in both positive and negative symptoms in patients with Schizophrenia, combined with a good tolerability profile in extrapyramidal symptoms.
  • ||||||||||  risperidone / Generic mfg., quetiapine / Generic mfg.
    Journal:  Idiopathic young-onset Fahr's disease with schizophrenia-like presentation: a case report. (Pubmed Central) -  Jun 5, 2024   
    This case underscores the importance of conducting comprehensive imaging studies at the time of initial psychiatric diagnosis, regardless of the apparent typicality of the presentation. Additionally, it emphasizes the need for patience and adherence to the "Start Low and Go Slow" approach in medication management to minimize the risk of exacerbating psychiatric symptoms and aggression.
  • ||||||||||  olanzapine / Generic mfg., trazodone ER / Generic mfg., erythromycin / Generic mfg.
    Biomarker, Journal:  Acute exposure and biomarkers assessment in rainbow trout exposed to selected pharmaceuticals. (Pubmed Central) -  Jun 4, 2024   
    Pharmaceuticals with lower molecular weight, physiological pKa, moderate hydrophobicity, low biotransformation and DNA strand breaks were generally more toxic to fish. However, this should be considered as guidelines in studies dealing with the toxicity of pharmaceuticals in non-target organisms.
  • ||||||||||  fluoxetine / Generic mfg.
    Preclinical, Journal:  Fluoxetine Can Cause Epileptogenesis and Aberrant Neurogenesis in Male Wild Type Mice. (Pubmed Central) -  Jun 4, 2024   
    In conclusion, fluoxetine could induce considerable adverse effects in wild type mice, including seizure-like activity. Fluoxetine-induced neurogenesis increases could be related to this activity, therefore proneurogenic effects of fluoxetine and other antidepressants, especially in the absence of any behavioral therapeutic effects, should be interpreted with caution.