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- | sertraline / Generic mfg.
Journal: Sertraline-Induced Hypoglycemia in Drug-Induced Liver Injury. (Pubmed Central) - Sep 25, 2024
Two days later, the patient was admitted to the hospital with a severe hypoglycemia, while the liver function tests were in amelioration. Clinical and biological evaluation were in favor of sertraline-induced hypoglycemia, a side effect rarely reported in non-diabetic patients, and in the context of hepatic injury.
- || sumatriptan/naproxen / Generic mfg., naproxen / Generic mfg.
Review, Journal: Sumatriptan-naproxen sodium in migraine: A review. (Pubmed Central) - Sep 25, 2024
Multi-mechanistic therapeutic agents offer an opportunity to optimise acute medications by targeting multiple mediators involved in the pathogenesis of migraine. Sumatriptan-naproxen sodium resulted in greater initial and sustained pain freedom, compared with either sumatriptan, naproxen-sodium and/or placebo, for the treatment of single or multiple attacks of migraine across both adult and adolescent study populations.
- || Balversa (erdafitinib) / J&J
PK/PD data, Journal: New drug combination regimen based on pharmacokinetic characteristics-Erdafitinib combined with sertraline or duloxetine. (Pubmed Central) - Sep 25, 2024
This study utilized pharmacokinetic methods to propose a new formulation of erdafitinib combined with sertraline or duloxetine. The findings suggest that this combination has potential for clinical co-administration based on a database analysis, thereby providing a novel strategy for anti-tumor treatment with fibroblast growth factor receptor (FGFR) inhibitors.
- | metformin / Generic mfg.
Journal: Metformin inhibits OCT3-mediated serotonin transport in the placenta. (Pubmed Central) - Sep 25, 2024
Our findings across all experimental models show inhibition of placental OCT3 by metformin, resulting in reduced serotonin uptake by the trophoblast. This sheds light on mechanisms that may underpin metformin-mediated effects on fetal development.
- amitriptyline / Generic mfg., fluoxetine / Generic mfg., duloxetine / Generic mfg.
The Relations of Analgesic Antidepressants Use to Knee or Hip Replacement Among Osteoarthritis Patients Compared to Selective Serotonin Reuptake Inhibitors in a Large Prospective Cohort (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2770;
AAD initiation was associated with a higher risk of knee/hip replacement compared with SSRI initiation. These results may reflect confounding by indication and/or may suggest that agents that predominantly impact depression may also have beneficial symptom effects in knee OA.
- amitriptyline / Generic mfg., fluoxetine / Generic mfg., duloxetine / Generic mfg.
Relation of Different Types of Antidepressants Use to Pain Severity and Measures of Pain Sensitization in Kneeosteoarthritis (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2768;
Whether these effects are reflective of confounding by indication or effects through depression is unclear. Nonetheless, these results may suggest that managing depressive symptoms is important for pain management in OA.
- pregabalin / Generic mfg., duloxetine / Generic mfg.
All-Cause Mortality in Patients with Chronic Musculoskeletal Pain Using Pregabalin or Duloxetine: A Retrospective Cohort Study in US Veterans (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2730;
Nonetheless, these results may suggest that managing depressive symptoms is important for pain management in OA. In this retrospective cohort study of US Veterans ages 18-89 years who have chronic non-cancer musculoskeletal pain, there was no statistically significant difference in all-cause mortality between pregabalin and duloxetine.
- Tonmya (cyclobenzaprine SL) / Tonix
Randomized, Double-Blind, Placebo-Controlled Confirmatory Phase 3 Trial of Bedtime Sublingual Cyclobenzaprine (TNX-102 SL) in Fibromyalgia (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2722;
TNX improved depressive symptoms, cognitive function and female sexual function in exploratory analyses. TNX had a favorable tolerability profile.
- ondansetron / Generic mfg.
Preliminary Results of the Ondansetron Pre-medication Trial in Juvenile Idiopathic Arthritis: A Pragmatic Randomized Controlled Trial Nested in the CAPRI Registry (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_1448;
P=N/A
Based on these results, the Data and Safety Committee deemed enrolling additional patients was unlikely to change findings. It recommended stopping recruitment into the trial and completing follow-up of all subjects already enrolled.NCT04169828.
- | agomelatine / Generic mfg.
Journal: Effectiveness of Agomelatine in Generalized Anxiety Disorder Comorbid to Bipolar 1 Disorder in a Male Adolescent Patient. (Pubmed Central) - Sep 24, 2024
The treatment of generalized anxiety disorder comorbid with BD involves certain challenges, as antidepressant medications, which are standard in the treatment of anxiety disorder, have the risk of shifting to manic episodes and rapid cycling. In this case report, the response to agomelatine treatment in generalized anxiety disorder comorbid with bipolar 1 disorder was evaluated.
- || sertraline / Generic mfg.
Clinical, Journal: EEG measures of brain arousal in relation to symptom improvement in patients with major depressive disorder: Results from a randomized placebo-controlled clinical trial. (Pubmed Central) - Sep 24, 2024
When considering both treatment arms, a significant arousal group x time x treatment interaction emerged, highlighting specificity to the sertraline arm. Although findings indicate that arousal stability is likely to be a treatment-specific marker of response, further out-of-sample validation is warranted.
- | chlorpromazine / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Response to Fiorani et al., Chlorpromazine as a Viable Alternative to Midazolam for Palliative Sedation in a Liver Transplant Recipient with HCC. (Pubmed Central) - Sep 24, 2024
Although findings indicate that arousal stability is likely to be a treatment-specific marker of response, further out-of-sample validation is warranted. No abstract available
- | Firdapse (amifampridine) / BioMarin, Catalyst Pharma, Dydo Pharma, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Trial primary completion date: Effect of Amifampridine on Neuromuscular Transmission in Patients Treated With OnabotulinumtoxinA (clinicaltrials.gov) - Sep 24, 2024
P1, N=20, Recruiting, Sponsor: Wake Forest University Health Sciences
No abstract available Trial primary completion date: Sep 2024 --> Dec 2024
- Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Topography of Corrugator Supercilii Muscle Relative to the Eyebrow and Its Clinical Application for Blepharospasm (DEMAND) - Sep 24, 2024 - Abstract #AAO2024AAO_2269;
Purpose This study aimed to map the corrugator supercilii muscle (CSM) location relative to the eyebrow to guide onabotulinumtoxinA (OBT-A) injections for blepharospasm treatment...Conclusion For effective targeting of the CSM, it is recommended to administer OBT-A injections precisely at the center of the medial end of the eyebrow and just above the midpupillary line. Considering the minimal presence of the CSM beyond the midpupillary line, injecting OBT-A into the CSM in this lateral region are typically considered unnecessary.
- Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
The Management of Albinoid Nystagmus in 52 Cases (DEMAND) - Sep 24, 2024 - Abstract #AAO2024AAO_2242;
OnabotulinumtoxinA injections were applied to the horizontal recti for nine patients previously to simulate operation, retrobulbar for one case for aesthetic reasons...Strabismus problem was solved in 17 patients. Conclusion Surgical and medical treatment can be beneficial in certain cases with albinism.
- Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
201 : Lotions, Potions, OnabotulinumtoxinA and Fillers: Nonlaser Rejuvenation for the Ophthalmologist (E353A) - Sep 24, 2024 - Abstract #AAO2024AAO_465;
Cases will be reviewed to emphasize the integration of lotions, potions and injectables to optimize outcomes. Video case examples will be reviewed by the panel.
- | risperidone / Generic mfg.
Journal: Microfluidic preparation of monodisperse PLGA-PEG/PLGA microspheres with controllable morphology for drug release. (Pubmed Central) - Sep 24, 2024
This feature could potentially address the issue of delayed release commonly observed in sustained-release formulations. This study presents a straightforward yet effective approach to construct precisely engineered microspheres offering enhanced control over drug release dynamics.
- | chlorpromazine / Generic mfg.
Journal: ATG10S promotes IFNL1 expression and autophagic degradation of multiple viral proteins mediated by IFNL1. (Pubmed Central) - Sep 24, 2024
These results clarified that ATG10S promoted autophagosome formation with the assistance of IFNL1 to ensure autophagy flux and autophagic degradation of multiple viral proteins and that ATG10S could also act as a novel transcription factor to promote IFNL1 gene expression. Importantly, this study further explored the antiviral mechanism of ATG10S interaction with type III interferon and provided a theoretical basis for the development of ATG10S into a new broad-spectrum antiviral protein drug.
- || Rexulti (brexpiprazole) / Lundbeck, Otsuka
Retrospective data, Review, Journal: Efficacy and safety of brexpiprazole for the treatment of agitation in Alzheimer's disease: a meta-analysis of randomized controlled trials. (Pubmed Central) - Sep 24, 2024
Our results suggest that brexpiprazole is more efficacious than placebo in the treatment of agitation in AD patients. Further studies are still necessary to confirm long-term effects of brexpiprazole.Prospero registry: CRD42023486694.
- || lurasidone / Generic mfg.
P1 data, PK/PD data, Journal: Pharmacokinetics and safety of a new generic lurasidone: a phase I bioequivalence study in healthy Chinese subjects. (Pubmed Central) - Sep 24, 2024
Further studies are still necessary to confirm long-term effects of brexpiprazole.Prospero registry: CRD42023486694. The results displayed that lurasidone and Latuda
- | citalopram / Generic mfg.
Preclinical, Journal: Interaction effect of crocin and citalopram on memory and locomotor activity in rats: an insight into BDNF and synaptophysin levels in the hippocampus. (Pubmed Central) - Sep 24, 2024
The results of the open field test were unchanged. In conclusion, we suggested that BDNF and synaptophysin may be involved in the effects of both citalopram and crocin.
- | Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
Journal: Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT2A receptor. (Pubmed Central) - Sep 24, 2024
In addition, G protein-selective partial agonism was found for aripiprazole and cariprazine...Computational analyses of the pharmacological and structural fingerprints support a mechanistically based clustering that recapitulate the clinical classification (typical/first generation, atypical/second generation, third generation) of the antipsychotic drugs. The study provides a new framework to functionally classify antipsychotics that should represent a useful tool for the identification of better and safer neuropsychiatric drugs and allows formulating hypotheses on the links between specific signaling cascades and in the clinical outcomes of the existing drugs.
- | tropisetron / Generic mfg.
Journal: Zacopride stimulates 5-HT4 serotonin receptors in the human atrium. (Pubmed Central) - Sep 24, 2024
The study provides a new framework to functionally classify antipsychotics that should represent a useful tool for the identification of better and safer neuropsychiatric drugs and allows formulating hypotheses on the links between specific signaling cascades and in the clinical outcomes of the existing drugs. The positive inotropic effect of zacopride in HAP was attenuated by either 10
- | minocycline / Generic mfg., clozapine / Generic mfg.
Journal: Genetic contribution to microglial activation in schizophrenia. (Pubmed Central) - Sep 24, 2024
Overall, despite the increased expression of inflammatory genes, we observed no clear functional signs of hyperactivation in microglia from patients with SCZ. We conclude that microglia of the patients with SCZ have gene expression aberrations related to inflammation response and extracellular matrix without contributing to increased microglial activation.
- | Journal: Selective Myectomies Alone vs Selective Myectomies Combined with Selective Neurectomies in Patients with Post-paretic Synkinesis - Comparing Outcomes. (Pubmed Central) - Sep 24, 2024
This study suggests that selective myectomies and selective myectomies with selective neurectomies provide overlapping and differing benefits to perioral synkinesis. Selective neurectomies and platysma myectomy provided slightly improved excursion and significantly decreased botulinum injections to the platysma.
- | imipramine / Generic mfg.
Journal: Evidence for the involvement of keratinocyte-derived microvesicle particles in the photosensitivity associated with xeroderma pigmentosum type A deficiency. (Pubmed Central) - Sep 24, 2024
Finally, the aSMase inhibitor imipramine blocked UV-induced MVP release in HaCaT keratinocytes, as well as XPA knockout mice. These studies support the concept that the photosensitivity associated with XPA involves PAF- and aSMase-mediated MVP release and provides a potential pharmacologic target in treating this form of photosensitivity.
- | mirtazapine / Generic mfg.
Observational data, Journal: Psychotropic Drug Use and Associated Factors Among Acutely Admitted Older People: A Cross-Sectional Study of a Clinical Sample. (Pubmed Central) - Sep 24, 2024
These studies support the concept that the photosensitivity associated with XPA involves PAF- and aSMase-mediated MVP release and provides a potential pharmacologic target in treating this form of photosensitivity. The most common psychotropic drugs used by community-dwelling older people admitted to the acute
- | bupropion / Generic mfg., fluoxetine / Generic mfg.
Journal: High-performance liquid chromatography-tandem mass spectrometry was used to measure 20 antidepressants in human serum. (Pubmed Central) - Sep 24, 2024
It can identify 20 antidepressants in blood simultaneously. This can be used to monitor blood drug levels and medication metabolism.
- | lamotrigine liquid oral suspension / OWP Pharma, Belsomra (suvorexant) / Merck (MSD)
Journal: Bipolar Disorder in a female with CDKL5 Deficiency Disorder: A Case Report. (Pubmed Central) - Sep 24, 2024
Conclusions : While sleep and behavioral disorders fall within the expected phenotype for CDD, this is the first report of bipolar disorder. Careful attention to patterns of sleep and behavior that may indicate mood cycling in this population is required, particularly in the setting of limited communication and functional abilities.
- | aripiprazole / Generic mfg.
Journal: Interictal psychosis of epilepsy: What is the role of the neurologist? (Pubmed Central) - Sep 24, 2024
Careful attention to patterns of sleep and behavior that may indicate mood cycling in this population is required, particularly in the setting of limited communication and functional abilities. The patient was diagnosed with an interictal psychotic episode and was treated with aripiprazole which resulted in significant improvement after reaching a 20
- ||| clozapine / Generic mfg.
Journal, Adverse events: Normocytic Anemia as a Side Effect of Clozapine: A Case Report. (Pubmed Central) - Sep 24, 2024
This rare case underscores the importance of considering red blood cell parameters in patients on clozapine, offering insights that go beyond the commonly reported agranulocytosis side effect and potentially expanding awareness of adverse hematological effects associated with this antipsychotic medication. Further research is crucial to unravel the underlying mechanisms and establish definitive causality.
- Rexulti (brexpiprazole) / Lundbeck, Otsuka
Timing and Duration of Adverse Events During 24 Weeks of Brexpiprazole Treatment in Patients With Agitation Associated With Dementia due to Alzheimer's Disease: Results From a Randomized Trial and an Extension Trial () - Sep 24, 2024 - Abstract #CTAD2024CTAD_381;
- | nitroglycerin / Generic mfg., sumatriptan succinate / Generic mfg.
Journal: The neurotrophin artemin and its receptor GFR?3 mediate migraine-like pain via the ion channel TRPM8. (Pubmed Central) - Sep 24, 2024
Further, we show TRPM8 expression in the meninges and that direct supradural infusion of either a TRPM8-specific agonist or artemin itself produces mechanical allodynia, the latter dependent on TRPM8 and ameliorated by concurrent treatment with sumatriptan. These results indicate that neuroinflammatory events in the meninges can produce migraine-like pain in mice via artemin and GFR?3, likely acting upstream of TRPM8, providing a novel pathway that may contribute to migraine pathogenesis.
- || Review, Journal: Facial vein thrombophlebitis post facial skin infection: a case report and review of the literature. (Pubmed Central) - Sep 24, 2024
This case highlights the potential for facial vein thrombophlebitis as a complication of facial skin infections. Early diagnosis and prompt initiation of appropriate management are crucial to prevent potentially fatal consequences.
- || Clinical data, Journal: Incorporation of a specialist mental health clinical pharmacist within a primary care network: patient referrals, prescribing decisions, and clinical outcomes. (Pubmed Central) - Sep 24, 2024
Developing and implementing a service incorporating a specialist mental health pharmacist within a PCN mental health team is potentially valuable in improving patient care quality, reducing workload for GPs and CMHTs, and enabling faster access to secondary care initiated and recommended medications. This innovative service addressed several national targets, including prevention, early intervention, and access to quality compassionate care.
- || Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Review, Journal: Non-cosmetic use of botulinum toxin in surgical conditions. (Pubmed Central) - Sep 24, 2024
In many cases, this is despite weak evidence and without approval from the European Medicine Agency (EMA). This narrative review describes how BTX is used in the different surgical specialties and provides a brief overview of the use of BTX for non-cosmetic surgical conditions.
- olanzapine / Generic mfg.
A nationwide double-blind phase III randomized clinical trial (RCT) of olanzapine vs. prochlorperazine for the treatment of refractory nausea in patients receiving moderately or highly emetogenic chemotherapy among NCI Community Oncology Research Program (NCORP) practices. (Lower B2 Level, Yerba Buena Ballroom 8) - Sep 24, 2024 - Abstract #ASCOQLTY2024ASCOQLTY_55;
P3
OLZ demonstrates superior max nausea control with clinically and statistically significant improvements in QOL. This study fills the gap in empirical comparisons and solidifies OLZ's position as a promising intervention for refractory nausea.
- | ropivacaine / Generic mfg.
New trial: AoA-AAA: AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair (clinicaltrials.gov) - Sep 24, 2024
P=N/A, N=75, Completed, Sponsor: Micha? Stasiowski
- | Journal: Long-term stability of five atypical antipsychotics (risperidone, olanzapine, paliperidone, clozapine, quetiapine) and the antidepressant mirtazapine in human serum assessed by a validated SPE LC-MS/MS method. (Pubmed Central) - Sep 24, 2024
Furthermore, all analytes were stable for five freeze-thaw cycles. We recommend storage at -80
- | olanzapine / Generic mfg.
Observational data, Journal: Olanzapine-Induced Weight Gain and Glycolipid Metabolism Aberrations in First-Episode and Antipsychotic-Na (Pubmed Central) - Sep 24, 2024
After 4 weeks of OLA treatment, SCZ patients experienced significant weight gain, deteriorating insulin resistance, and increased LEP levels. In addition, baseline FPG emerged as a predictor of BMI changes after 4 weeks of OLA treatment.
- | Trintellix (vortioxetine) / Lundbeck, Takeda
Journal: Disease-Modifying Symptomatic Treatment (DMST): The Potential Role of Vortioxetine in the Treatment of Depression in Patients with Multiple Sclerosis. (Pubmed Central) - Sep 24, 2024
However, extrapolating from existing research in major depressive disorder, it is plausible that vortioxetine's multimodal mechanism could provide a favorable therapeutic approach. This position paper, which summarizes the output of annual clinical meeting held by the DMSTs in MS Italian Study Group, is focused on the possible role that vortioxetine could play as symptomatic treatment (ST) of depressed patients with MS, hypothesizing a direct impact on the clinical course of the disease.
- | amitriptyline / Generic mfg., duloxetine / Generic mfg.
Preclinical, Journal: Amitriptyline and duloxetine attenuate activities of superficial dorsal horn neurons in a rat reserpine-induced fibromyalgia model. (Pubmed Central) - Sep 23, 2024
These results show that SDH neurons are the site of action for AMI and DLX in a rat reserpine-induced FM model. Spinal mechanisms may underlie the therapeutic effects of these drugs in patients with FM.
- | Vyloy (zolbetuximab) / Astellas
Journal: Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets. (Pubmed Central) - Sep 23, 2024
Fosaprepitant showed suppressive effects on emesis, and use of dexamethasone or concomitant use of fosaprepitant with other antiemetics tended to alleviate gastric tissue damage. The onset of emesis in humans receiving zolbetuximab may be associated with damage in the gastric mucosa, and antiemetics may mitigate gastrointestinal adverse events.
- || Paxlovid (nirmatrelvir/ritonavir) / Pfizer, Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
Review, Journal: The Impact of Antidepressants on COVID-19 and Post-Acute COVID-19 Syndrome: A Scoping-Review Update (Pubmed Central) - Sep 23, 2024
In regions where neither vaccines nor antiviral agents currently approved for the prevention or treatment of COVID-19 are available, AD and in particular fluvoxamine would be a cost-effective alternative to protect against a severe course, even if this AD appears to have a smaller effect against COVID-19 than the currently approved antiviral agents, but with presumably better tolerability. A direct comparative clinical trial with approved antiviral agents is still pending and should be positive to further open the door for a guideline-based recommendation of fluvoxamine (or perhaps even AD) for COVID-19 or its aftermath.
- || Retrospective data, Review, Journal: Effect of long-term pharmacological treatments on Alzheimer disease: A systematic review and network meta-analysis. (Pubmed Central) - Sep 23, 2024
In this network meta-analysis of studies of patients with AD and a follow-up period of at least 1 year, EGb 120?mg demonstrated cognitive benefits, while placebo posed the least harm for AD. More RCTs are required to address the uncertainty surrounding the efficacy of medication.
- | Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Journal: Quality and reliability analysis of migraine Botox treatment information on YouTube. (Pubmed Central) - Sep 23, 2024
In our analysis of migraine Botox treatment videos on YT, we observed that the information on migraine Botox treatment had a wide spectrum, high-quality content, and that there were videos that may mislead viewers. In conclusion, we believe that the platform is not sufficient in its entirety, and that it should be supported with renewed, fact-checked, easy-to-understand language, and video-duration optimized videos.
- || aripiprazole / Generic mfg., cabergoline / Generic mfg., bromocriptine / Generic mfg.
Review, Journal: Drug induced hypoprolactinemia. (Pubmed Central) - Sep 23, 2024
These patients warrant careful evaluation for comorbidities. This review aims to increase awareness about the potentially detrimental effects of drug-induced hypoprolactinemia, which should be considered in clinical practice decisions.
- | trimetazidine / Generic mfg.
Preclinical, Journal: Targeting Toll-like Receptor 4/Nuclear Factor-?B and Nrf2/Heme Oxygenase-1 Crosstalk via Trimetazidine Alleviates Lipopolysaccharide-Induced Depressive-like Behaviors in Mice. (Pubmed Central) - Sep 23, 2024
This review aims to increase awareness about the potentially detrimental effects of drug-induced hypoprolactinemia, which should be considered in clinical practice decisions. Male Swiss albino mice were injected with LPS (500
- | clozapine / Generic mfg.
Journal: Improving the Monitoring and Management of Clozapine-Induced Gastrointestinal Hypomotility (CIGH) in Community Mental Health Services: A Quality Improvement Approach. (Pubmed Central) - Sep 23, 2024
It was evident from staff and our patient feedback that further efforts would be required to continue to raise awareness about harms of unmanaged constipation among this client group. Future approaches may include enhanced collaborative efforts with primary care, and improving the skill mix in existing clozapine clinics, which could include the utilisation of mental health pharmacists.
- | paroxetine / Generic mfg.
Journal: Influence of panic disorder and paroxetine on brain functional hubs in drug-free patients. (Pubmed Central) - Sep 23, 2024
Paroxetine ameliorated patients' symptoms while altering their brain FC. SVM and SVR models, utilizing baseline DC, effectively distinguished the patients from HCs and accurately predicted TR.