- |||||||||| Eight-teen years of triptan use in Korea: A nationwide population-based study () - Jun 18, 2024 - Abstract #AHS2024AHS_253;
Despite the exponential growth in the volume of triptan prescriptions, the proportion of migraine patients receiving triptans remains low, and there is significant variability in prescribing practices across medical specialties. Efforts to reduce the gap in treatment approaches among doctors through more education are needed.
- |||||||||| Characterization of patients seeking migraine care via telemedicine in the United States () - Jun 18, 2024 - Abstract #AHS2024AHS_246;
This study offers a thorough characterization of more than 50,000 patients utilizing telemedicine for migraine treatment. Despite prior medication attempts, patients at their first consultation reported substantial burden due to migraine, highlighting the need for more accessible and specialized care for patients with migraine in the US.
- |||||||||| Xeomin (incobotulinumtoxinA) / Merz Pharma, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Rare case of complete facial diplegia after botulinum toxin injections for chronic migraine () - Jun 18, 2024 - Abstract #AHS2024AHS_222;
To our knowledge, this is the first reported case of complete facial diplegia occurring as an indiosyncratic reaction to botulinum toxin therapy for chronic migraine. Importantly, this occurred with use of incobotulinumtoxinA, which is an off-label but often used substitute for chronic migraine and has a lower molecular weight (150 kiloDalton) compared with onabotulinumtoxinA (900 kiloDalton).
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Hemangioma of the temporal bone triggering secondary occipital neuralgia () - Jun 18, 2024 - Abstract #AHS2024AHS_208;
We hypothesize that the expansion of the petrous bone triggered pain in the region of the lesser occipital nerve. This could be directly from the occipital nerve itself or from branches of the posterior auricular nerve which communicates with the lesser occipital nerve.
- |||||||||| levetiracetam / Generic mfg.
Burning mouth syndrome exquisite response to levetiracetam therapy () - Jun 18, 2024 - Abstract #AHS2024AHS_199;
In this patient, we establish that his migraines began concurrently with initiation of gender-affirming hormone therapy with intramuscular testosterone. At this point, she was on oxcarbazepine 150
- |||||||||| Zavzpret (zavegepant nasal spray) / Pfizer
A case of adult-onset cyclical vomiting syndrome responsive to a gepant () - Jun 18, 2024 - Abstract #AHS2024AHS_186;
While CVS has historically been thought to be a childhood periodic syndrome, it is important to keep this syndrome on the differential even for adults who present with recurrent episodes of emesis with a negative gastrointestinal workup. The case also suggests the potential role of gepants in acute therapy of CVS attacks.
- |||||||||| sumatriptan succinate / Generic mfg.
Miniscope-based in vivo blood vessel imaging enables a novel assay for testing migraine therapeutic candidates () - Jun 18, 2024 - Abstract #AHS2024AHS_179;
Ongoing research strives to enhance our understanding of the relationship between vascular dynamics and migraine pathophysiology. Efforts include employing these methods to investigate additional potential mechanisms and therapeutic targets implicated in migraine, such as CGRP, VIP or, for instance, assessing whether migraine abortives like Sumatriptan prevents PACAP-induced vasodilation.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
BoNT/A targets sensitized TRPV1-positive DRG neurons at therapeutic concentrations () - Jun 18, 2024 - Abstract #AHS2024AHS_173;
Efforts include employing these methods to investigate additional potential mechanisms and therapeutic targets implicated in migraine, such as CGRP, VIP or, for instance, assessing whether migraine abortives like Sumatriptan prevents PACAP-induced vasodilation. Background: Botulinum neurotoxin type A (BoNT/A) is the active ingredient in onabotulinumtoxinA (onabotA; BOTOX
- |||||||||| sumatriptan succinate / Generic mfg.
Affective brain network dynamics in a CGRP mouse model of migraine () - Jun 18, 2024 - Abstract #AHS2024AHS_171;
Such findings provide evidence for central nervous system changes that may reflect a neuroprotective return to homeostasis following peripheral administration of CGRP. These data can be used to inform centrally-targeted therapeutic approaches.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Review, Journal: OnabotulinumtoxinA is now an important tool for managing pediatric neurogenic lower urinary tract dysfunction. (Pubmed Central) - Jun 18, 2024
In this review, the current evidence regarding the safety, tolerability, and efficacy of BTX-A use in pediatric NLUTD will be summarized. Additionally, we will attempt to define the current role of BTX-A in the management of patients with NLUTD, discuss limitations to the current body of literature, and suggest future avenues of study.
- |||||||||| risperidone / Generic mfg.
Review, Journal: Sleep disruptions and the pathway to psychosis: An in-depth case and literature review. (Pubmed Central) - Jun 18, 2024
Here we describe the case of a patient who first presented with insomnia, but whose condition improved with the use of risperidone and was diagnosed with first-episode psychosis...The connection between dopamine, sleep disturbances, and psychosis, specifically the role of D2 dopamine receptors, highlights a potential pathway bridging sleep irregularities with psychosis. The study underscores the need for further research to delineate the relationship between sleep disturbances and psychosis and to assess the efficacy of various therapeutic interventions targeting both conditions.
- |||||||||| fluoxetine / Generic mfg.
Biomarker, Journal, Metabolomic study: NMR-based metabolomics approach to study the effect and related molecular mechanisms of Saffron essential oil against depression. (Pubmed Central) - Jun 17, 2024
we established a chronic restraint stress (CRS) induced depression model in mice and employed fluoxetine as a reference drug...In summary, SEO effectively mitigates depressive-like behaviors in CRS mice, predominantly via modulation of glycolysis, amino acid metabolism, and energy metabolism, and potentially exerts antidepressant effects through neural regulation. Our study offers insights into small molecule metabolite alterations in CRS mice through a metabolomics lens, providing evidence for the antidepressant potential of plant essential oils and contributing to our understanding of the mechanisms of traditional Chinese medicine in treating depression.
- |||||||||| clozapine / Generic mfg.
Journal: Rare variants and clozapine: Reply. (Pubmed Central) - Jun 17, 2024
The information provided in this article may be useful to improve disease burden and support healthcare professionals, patients, and caregivers navigating the complex pathways to TRS management. No abstract available
- |||||||||| Rexulti (brexpiprazole) / Lundbeck, Otsuka
Journal, Adverse events: Successful Use of High-Dose Brexpiprazole for Psychosis in Lewy Body Dementia without Adverse Effects. (Pubmed Central) - Jun 17, 2024
We report a 71-year-old patient with a diagnosis of probable dementia with Lewy body (DLB) whose psychotic symptoms benefit from a higher dose of brexpiprazole (4 mg per day) without adverse effects. Though more studies were needed to confirm the safety and efficacy of brexpiprazole in the treatment of DLB, this case suggests that brexpiprazole is a potential treatment choice and it is safe even at the maximum daily dose (i.e., 4 mg per day).
- |||||||||| memantine / Generic mfg.
Preclinical, Journal: Role of Memantine in Limiting Cochleotoxicity in Rats. (Pubmed Central) - Jun 17, 2024
On histologic exam, the cochlear structures of group C rats and, although to a lesser extent, group D rats showed less severe cochlea damage. Memantine plays a protective role, resulting in restoring partially cochlear structures when administered either simultaneously with or after completion of amikacin i.p. treatment in rats.
- |||||||||| clozapine / Generic mfg.
Journal: Do psychotropic drugs cause seizures? (Pubmed Central) - Jun 17, 2024
Among antipsychotics, clozapine stands out for its heightened seizure risks, especially during titration and at high doses, necessitating close monitoring and individualized approaches...By recognizing the complexities of psychiatric comorbidities in epilepsy and considering the unique challenges they pose, healthcare providers can make informed decisions to enhance patient safety and treatment outcomes. This review offers practical insights to guide clinicians in navigating the intricate landscape of managing psychiatric comorbidities in patients with epilepsy.
- |||||||||| clozapine / Generic mfg.
Preclinical, Journal: Activation of pyramidal neurons in the infralimbic cortex alleviates LPS-induced depressive-like behavior in mice. (Pubmed Central) - Jun 17, 2024
These results collectively suggest that targeted activation of pyramidal neurons in the IL cortex mitigates microglial response and ameliorates depressive-like behaviors induced by systemic LPS administration. Therefore, our findings offer potential therapeutic targets for the development of interventions aimed at alleviating depressive symptoms by modulating IL cortical circuitry and microglial activity.
- |||||||||| Review, Journal: Intervening in the Premonitory Phase to Prevent Migraine: Prospects for Pharmacotherapy. (Pubmed Central) - Jun 17, 2024
Asians required lower doses of clozapine as compared with Caucasians, while clozapine pharmacokinetics in sub-Saharan Africans should be further investigated in larger trials. Early small studies using domperidone, naratriptan and dihydroergotamine have suggested that this approach could be useful; these studies were methodologically less rigorous
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Journal: Aesthetic Procedures and Psychological Wellbeing in Saudi College Students: An In-Depth Exploration. (Pubmed Central) - Jun 17, 2024
The most ranked motivators were being painless, with no side effects (8.8 out of 10), followed by being free (8.0 out of 10) and enhancing self-confidence (7.4 out of 10). No significant difference recorded at the overall psychological well-being score between who underwent cosmetic procedures and who did not.
- |||||||||| buspirone/zolmitriptan (JM-010) / Bukwang Pharma
Enrollment change, Trial completion date, Trial termination, Trial primary completion date: SHINE: Study in Parkinson's Disease Patients With Dyskinesia With Combinations of JM-010 and Its Individual Components (clinicaltrials.gov) - Jun 17, 2024
P2, N=41, Terminated,
No significant difference recorded at the overall psychological well-being score between who underwent cosmetic procedures and who did not. N=148 --> 41 | Trial completion date: Jan 2025 --> Feb 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Jan 2025 --> Feb 2024; Business reasons
- |||||||||| buspirone/zolmitriptan (JM-010) / Bukwang Pharma
Trial completion: ASTORIA: A Study in Parkinson's Disease in Patients With Moderate to Severe Dyskinesia (clinicaltrials.gov) - Jun 17, 2024
P2, N=89, Completed,
N=148 --> 41 | Trial completion date: Jan 2025 --> Feb 2024 | Active, not recruiting --> Terminated | Trial primary completion date: Jan 2025 --> Feb 2024; Business reasons Active, not recruiting --> Completed
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
Journal: Impacts of land use/land cover and climate change on landscape sensitivity in Tunca River sub-basin: Use in spatial planning and sectoral decision processes. (Pubmed Central) - Jun 16, 2024
Future scenarios from 2050 to 2070 indicate noteworthy changes in landscape sensitivity, showing an increase in sensitivity in the upper regions of the basin...Protection and improvement strategies are recommended for areas with high and moderate sensitivity, while use-oriented strategies are suggested for those with low sensitivity. This study also establishes a scientific foundation for guiding the protection and management of ecologically sensitive basin areas, offering insights into the effects of landscape change processes at the micro-basin level in connection with climate change models.
- |||||||||| Preclinical, Journal: Results from a Joined Prospective Study to Evaluate the Sensitivity of the In Vivo Dog QT Assay in Line with the ICH E14/S7B Q&A Best Practices. (Pubmed Central) - Jun 16, 2024
By-timepoint analysis showed QTc prolongation induced by moxifloxacin, dofetilide, dolasetron, ondansetron, and quinine within human relevant plasma exposures ranges...As expected, levocetirizine showed no statistically significant effect on QTc across a range of exposure, well exceeding the therapeutic Cmax...Finally, concentration-QTc modeling enabled to predict the minimal plasma concentration needed to detect a 10?milliseconds QTc prolongation, including for quinine. The comparison with clinical available data supported the relevance of dogs under these experimental conditions as a robust translational predictor of drug-induced QTc prolongation in humans as a key pillar of the integrated risk assessment.
- |||||||||| Clinical, Journal: Pharmacological treatment of cancer (Pubmed Central) - Jun 16, 2024
Respondents expressed the lack of high-quality evidence- based information from RCTs. We call for evidence from methodologically high-quality RCTs to be available to inform physicians about the benefits and harms of pharmacological treatments for common symptoms in palliative care.
- |||||||||| Journal, Metastases: Patient perceptions of advanced practice radiation therapists prescribing medication in radiation therapy. (Pubmed Central) - Jun 16, 2024
The study revealed that although patients were happy with the process of prescribing medication, they all agreed that having an advanced practice radiation therapist prescribe would improve care. Patient responses further demonstrated the need for future research in regards to side effect management as a whole by APRTs as well as how role clarification can impact patient perceptions of APRTs.
- |||||||||| PK/PD data, Review, Journal, CINV: Pharmacokinetics, pharmacodynamics, safety, and tolerability of dopamine-receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting. (Pubmed Central) - Jun 16, 2024
Eight D2,3-RAs, amisulpride, domperidone, droperidol, haloperidol, metoclopramide, metopimazine, olanzapine and prochlorperazine are reviewed focusing on pharmacokinetics, pharmacodynamics, antiemetic effect and side effects...It should be emphasized, that most of these drugs are not selective for dopamine receptors.The multi-receptor targeting agent, olanzapine, is recommended in the prophylaxis of HEC-induced CINV as part of a four-drug antiemetic regimen, including a 5-HT3-RA, dexamethasone and a NK1-RA...Domperidone and metoclopramide are prokinetics, whereas metopimazine delays gastric emptying and haloperidol does not influence gastric motility. Many D2,3-RAs increase the risk of prolonged QTc interval; other side effects include sedation and orthostatic hypotension.
- |||||||||| amitriptyline / Generic mfg., naltrexone / Generic mfg., cyclobenzaprine / Generic mfg.
Journal: TLR4 inhibitors through inhibiting (MYD88-TRIF) pathway, protect against experimentally-induced intestinal (I/R) injury. (Pubmed Central) - Jun 16, 2024
Additionally, there was a decrease in NF-?BP65 and macrophages CD68 staining compared to rats in the I/R groups. This study focuses on how TLR4 inhibitors enhance intestinal function and protect against intestinal (I/R) injury by influencing macrophages CD86 through (MYD88-TRIF) pathway, as well as their effects on oxidation and inflammation.
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