- |||||||||| clozapine / Generic mfg.
Preclinical, Journal: Glutamate neurotransmission from leptin receptor cells is required for typical puberty and reproductive function in female mice. (Pubmed Central) - Jul 15, 2024
We collected blood sequentially before and for 1 hr after intravenous clozapine-N-oxide injection...Control LeprloxTB mice with PMv LepRb rescue showed vaginal opening, follicle maturation, and became pregnant, while LeprloxTB;Vglut2flox mice showed no pubertal development. Our results indicate that glutamatergic neurotransmission from leptin sensitive neurons regulates the reproductive axis, and that leptin action on pubertal development via PMv neurons requires Vglut2.
- |||||||||| sertraline / Generic mfg.
Journal: Sertraline-Induced Galactorrhoea: A Case Report. (Pubmed Central) - Jul 15, 2024
https://irct.behdasht.gov.ir/, identifier IRCT20140126016374N2. The advent of new selective serotonin reuptake inhibitor (SSRI)
- |||||||||| memantine / Generic mfg.
Journal: Memantine Inhibits Calcium-Permeable AMPA Receptors. (Pubmed Central) - Jul 15, 2024
Furthermore, we demonstrate that memantine reverses a gain of function AMPAR mutation found in a patient with a neurodevelopmental disorder and inhibits CP-AMPARs in nerve injury. Our findings alter the paradigm for the memantine mechanism of action and provide a blueprint for therapeutic approaches targeting CP-AMPARs.
- |||||||||| ondansetron ultra-low dose (AD04) / Adial
AD04 Global HIV migration () - Jul 15, 2024 - Abstract #AIDS2024AIDS_4680;
Our stories set the stage for a set of keynote speakers who highlighted the political, policy and programmatic challenges that continue to face people living with HIV if they wish to migrate or simply travel to other countries.The hugely influential Global Database on HIV-specific Travel and Residence Restrictions (hivtravel.org) will soon have a new look and home with the HIV Justice Network. Your stories will help shape this revamp.Now is the chance for you to share your story.The booth is hosted by the HIV Justice Network, Queensland Positive People, National Association of People Living with HIV Australia and Global Database on HIV-specific Travel and Residence Restrictions.
- |||||||||| ketorolac / Generic mfg., nefopam / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date, Head-to-Head: Comparison of Patient-controlled Analgesia Regimenfor Postoperative Pain in Patients Undergoing Total Knee Arthroplasty (clinicaltrials.gov) - Jul 14, 2024
P=N/A, N=98, Completed,
Your stories will help shape this revamp.Now is the chance for you to share your story.The booth is hosted by the HIV Justice Network, Queensland Positive People, National Association of People Living with HIV Australia and Global Database on HIV-specific Travel and Residence Restrictions. Recruiting --> Completed | Trial completion date: Feb 2024 --> Jul 2024 | Trial primary completion date: Dec 2023 --> Jul 2024
- |||||||||| amitriptyline / Generic mfg., fingolimod / Generic mfg.
Journal: Platelet Function is Independent of Sphingolipid Manipulation. (Pubmed Central) - Jul 14, 2024
The findings suggest that hemolymph levels of AMI may be a useful indicator of feeding and reproductive disruptions in wild population of freshwater gastropods, and confirm the applicability of the FPM to molluscs for comparative pharmaceutical hazard identification. Sphingolipid modulating agents, such as FTY720, SLM6031434, S1P, amitriptyline, ceramide, and d-sphingosine do not appear to independently impact platelet aggregation in murine models.
- |||||||||| Verzenio (abemaciclib) / Eli Lilly
Journal: Synergistic Enhancement of Antitumor Effects by Combining Abemaciclib with Desipramine. (Pubmed Central) - Jul 13, 2024
The combination treatment significantly reduced tumor size compared with control or single treatment without causing apparent toxicity to normal tissues. Although additional in vivo studies are necessary, this study suggests that the combination therapy of abemaciclib and desipramine may represent a novel therapeutic approach for treating solid tumors.
- |||||||||| Review, Journal: The Effect of Neuropsychiatric Drugs on the Oxidation-Reduction Balance in Therapy. (Pubmed Central) - Jul 13, 2024
They are starting with those proving their protective effect and ending with those confirming disturbances in the oxidation-reduction balance. The presented publication reviews the state of knowledge on the role of oxidative stress in the most frequently used therapies for neuropsychiatric diseases using first- and second-generation antipsychotic drugs, i.e., haloperidol, clozapine, risperidone, olanzapine, quetiapine, or aripiprazole, mood stabilizers: lithium, carbamazepine, valproic acid, oxcarbazepine, and antidepressants: citalopram, sertraline, and venlafaxine, along with a brief pharmacological characteristic, preclinical and clinical studies effects.
- |||||||||| Trulicity (dulaglutide) / Eli Lilly
Review, Journal: All GLP-1 Agonists Should, Theoretically, Cure Alzheimer's Dementia but Dulaglutide Might Be More Effective Than the Others. (Pubmed Central) - Jul 13, 2024
Although there is only one study of cognition that used dulaglutide, it was randomized, placebo controlled, and very large; it involved 8828 participants and showed significant benefit to cognition. A clinical trial to test the hypothesis that dulaglutide may cure AD should have, as its primary outcome, a 30% greater cure rate of AD by dulaglutide than that achieved by an equipoise arm of, e.g., lithium plus memantine.
- |||||||||| Avastin (bevacizumab) / Roche
PRO 02 - Brain Metastases Radiotherapy while Mitigating Radionecrosis and Neurotoxicity (Room 146) - Jul 13, 2024 - Abstract #ASTRO2024ASTRO_8;
2)Neurocognitive preservation: What does it actually mean to patients (tips on counseling, any supportive resources), differences with SRS vs. whole brain, memantine (role, considerations when prescribing, taper), hippocampal avoidance (how to and planning), role for additional substructure sparing. 3) Radionecrosis: Prevention strategies for intact brain mets (dose/fraction, technique/platform considerations, composite dosing or serial treatment days), diagnosis tools (PET, rCBV), and management (Avastin, LITT, excision, etc).
- |||||||||| clozapine / Generic mfg.
Journal: Clozapine-Related Cecal Volvulus. (Pubmed Central) - Jul 12, 2024
3) Radionecrosis: Prevention strategies for intact brain mets (dose/fraction, technique/platform considerations, composite dosing or serial treatment days), diagnosis tools (PET, rCBV), and management (Avastin, LITT, excision, etc). No abstract available
- |||||||||| olanzapine / Generic mfg., clozapine / Generic mfg.
Journal: Psychotropic drugs, eating behaviour and weight gain. (Pubmed Central) - Jul 12, 2024
Altered eating behaviour can serve as an earlier measure of the risk of weight gain and can be examined easily in clinical practice. Detecting these changes can enable earlier action in terms of switching treatments and starting pharmacological and nonpharmacological preventive strategies.
- |||||||||| Review, Journal: The Black Book of Psychotropic Dosing and Monitoring. (Pubmed Central) - Jul 12, 2024
While acetylcholinesterase inhibitors and memantine have been available for decades, these drugs modestly improve cognition in Alzheimer's disease patients and do not alter the progressive course of the illness...While it remains to be seen how useful these new agents will be in clinical practice, they do represent an approach to treating neuropsychiatric disorders that are a notable departure from the pharmacotherapy of the past half century. It seems likely that some patients who have not been able to respond to or tolerate traditional pharmacotherapy will find hope in these new medications.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Review, Journal: Managing giant omphalocele: A systematic review of surgical techniques and outcomes. (Pubmed Central) - Jul 12, 2024
It seems likely that some patients who have not been able to respond to or tolerate traditional pharmacotherapy will find hope in these new medications. Definitions of giant omphalocele in the literature were heterogeneous with a variety of management approaches described.
- |||||||||| sertraline / Generic mfg., paroxetine / Generic mfg.
Review, Journal: Antidepressant Medication Use During Lactation: A Review for Providers. (Pubmed Central) - Jul 11, 2024
Optimizing treatment of maternal depression is a complicated undertaking, which should be made in conjunction with the provider through shared decision making with the patient. Specific properties of any proposed medication, such as the relative infant dose and side effect profile, should always be taken into account during the decision-making process.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap, Aimovig (erenumab-aooe) / Amgen, Novartis
Journal, Real-world evidence, Real-world: Additional effect of erenumab for patients with chronic migraine treated with onabotulinumtoxin A-real-world data from a preliminary cohort study. (Pubmed Central) - Jul 11, 2024
It is hypothesized that the observed additive effects are due to the independent modes of action of erenumab and onabotulinumtoxin A. This study suggests that the combination of erenumab with onaBoNT-A may offer an improved approach for the treatment of chronic migraine in selected patients. However, the results highlight the need for prospective, controlled studies to validate these findings and determine the optimal combination of treatments tailored to the individual patient.
- |||||||||| chlorpromazine / Generic mfg.
Retrospective data, Journal: Chlorpromazine overdose: a case series. (Pubmed Central) - Jul 11, 2024
The major limitations of the study were a retrospective design and no analytical confirmation of ingestion. We found that the most common effect of chlorpromazine overdose was central nervous system depression and that endotracheal intubation was associated with larger reported doses ingested, particularly in single chlorpromazine ingestions.
- |||||||||| Tivicay (dolutegravir) / ViiV Healthcare
Journal: Management of the Drug-Drug Interactions Between Valproic Acid and Dolutegravir-A Case Study. (Pubmed Central) - Jul 11, 2024
We are confident that our findings can contribute to a better understanding of the clinical problems that infectious disease physicians encounter in their daily management of people with HIV and how therapeutic drug monitoring may add value in this context. This case also highlights the importance of multidisciplinary services for the optimal management of polypharmacy in people with HIV.
- |||||||||| Fintepla (low-dose fenfluramine) / UCB
Retrospective data, Review, Journal: Efficacy of Pharmacotherapies for Bulimia Nervosa: A Systematic Review and Meta-Analysis. (Pubmed Central) - Jul 11, 2024
This meta-analysis indicates that most pharmacotherapies decreased the frequency of binge-eating and vomiting episodes, body weight, and depressive symptoms in BN patients, but the efficacy was not significant. In each drug the efficacy is different, treating different aspects, different symptoms to improve the clinical performance of bulimia nervosa.Appeared originally in BMC Pharmacol Toxicol 2023; 24:72.
- |||||||||| escitalopram / Generic mfg.
Enrollment closed: The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms (clinicaltrials.gov) - Jul 11, 2024
P4, N=46, Active, not recruiting,
These findings underscore the role of altered gene expression in understanding the pathogenesis of SCZ and provide a reliable SCZ model for future therapeutic interventions and biomarker discovery. Recruiting --> Active, not recruiting
- |||||||||| Aduhelm (aducanumab) / Neurimmune, Eisai
Journal: Acquired Risk Factors that Influence Risk for Dementia and Possibly Alzheimer Disease. (Pubmed Central) - Jul 10, 2024
Though initiating treatment after being diagnosed with AD is important, significance should be placed on recognizing known acquired risk factors in order to potentially decrease the likelihood of developing dementia and perhaps specifically AD. This article summarizes the acquired factors that influence risk for dementia.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal: New-Onset Seizures in an Adolescent Following Use of LSD while on Low-Dose Lithium Therapy: A Case Study. (Pubmed Central) - Jul 10, 2024
Although the definitive causal link cannot be established, this case report suggests an increased seizure risk with combination of LSD and lithium, even at subtherapeutic serum lithium levels. This case emphasizes the need for further research, careful clinical practice, and patient education regarding the potential dangers of using psychedelic substances with psychopharmacological treatment.
- |||||||||| methamphetamine / Generic mfg.
Journal: Trajectories of craving in the course of pharmacotherapy trials for methamphetamine use disorder. (Pubmed Central) - Jul 10, 2024
Two medications, modafinil daily and ondansetron at a dose of 1 mg two times daily, appear to be associated with greater reduction in craving in the course of treatment compared with placebo. A decrease in methamphetamine craving shows promise as an early indicator of recovery from methamphetamine use disorder.
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