- |||||||||| Dysport (abobotulinumtoxinA) / Ipsen
Enrollment change, Trial completion date, Trial primary completion date: DIRECTION: A Study to Compare the Safety and Efficacy of Dysport (clinicaltrials.gov) - Jul 28, 2024
P4, N=450, Recruiting,
However, the spontaneous reporting system has several limitations, requiring further research for validation. N=298 --> 450 | Trial completion date: Jun 2025 --> Mar 2026 | Trial primary completion date: Jun 2025 --> Mar 2026
- |||||||||| ulotaront (SEP-363856) / Otsuka, PsychoGenics
Review, Journal: Ligands of the trace amine-associated receptors (TAARs): A new class of anxiolytics. (Pubmed Central) - Jul 28, 2024
N=298 --> 450 | Trial completion date: Jun 2025 --> Mar 2026 | Trial primary completion date: Jun 2025 --> Mar 2026 The anxiolytic potential of ulotaront, a full agonist at the human TAAR1, is currently being investigated in patients with generalized anxiety disorder...No abstract available
- |||||||||| lysergic acid diethylamide (MM-120) / Mindmed, University Hospital Basel
Review, Journal: Visual hallucinations originating in the retinofugal pathway under clinical and psychedelic conditions. (Pubmed Central) - Jul 28, 2024
Psychedelics like LSD (Lysergic acid diethylamide) and psilocybin are known to modulate perceptual modalities due to the activation of mostly serotonin receptors in specific cortical (e.g., visual cortex) and subcortical (e.g., thalamus) regions of the brain...This paper presents an understanding of how the retinofugal pathway communicates and modulates visual information in psychedelic and clinical conditions. Therefore, we elucidate a new theory of psychedelic modulation in the retinofugal pathway.
- |||||||||| Qelbree (viloxazine) / Supernus Pharma, Knight Therap
Retrospective data, Review, Journal: Efficacy and safety of monoamine reuptake inhibitors in attention deficit hyperactivity disorder: A Bayesian network meta-analysis. (Pubmed Central) - Jul 28, 2024
Other drugs (centanafadine, duloxetine, edivoxetine, reboxetine, tipepidine, vortioxetine) were no better than placebo in reducing symptom severity of ADHD...Among all, duloxetine (OR:15; 95%CrI:1.8130) showed significantly more treatment-emergent adverse events than methylphenidate. In conclusion, venlafaxine, viloxazine, and bupropion are the most efficacious MRIs for ADHD symptom reduction as compared to placebo with high certainty of evidence.
- |||||||||| Perseris (risperidone sustained-release 1-month depot) / Indivior, Reckitt Benckiser, HLS Therap
Preclinical, Journal: Towards in vitro - In vivo correlation models for in situ forming drug implants. (Pubmed Central) - Jul 28, 2024
In conclusion, venlafaxine, viloxazine, and bupropion are the most efficacious MRIs for ADHD symptom reduction as compared to placebo with high certainty of evidence. The predictability of the model passed external validation using the reference listed drug (RLD), Perseris
- |||||||||| fluoxetine / Generic mfg.
Journal: SERT and OCT mediate 5-HT1B receptor regulation of immobility behavior and uptake of 5-HT and HIS. (Pubmed Central) - Jul 28, 2024
Intraperitoneal injections of SERT inhibitor fluoxetine (FLX) and/or OCTs inhibitor decynium (D22) were used prior to local perfusion of 5-HT1B agonist CP93129 into the ventral hippocampus to measure immobility times in the FST and TST, to measure 5-HT uptake efficiencies and HIS uptake efficiencies derived from linear regressions using the transient no-net-flux quantitative microdialysis in C57BL/6 mice...Both SERT and OCT are the target effectors mediating 5-HT1B regulation of immobility time and 5-HT uptake, OCT mediates 5-HT1B regulation of HIS uptake. Their underlying signal transductions need to be further explored.
- |||||||||| ondansetron / Generic mfg.
Journal: Serotonin-Mediated Anti-Allodynic Effect of Yokukansan on Diabetes-Induced Neuropathic Pain. (Pubmed Central) - Jul 27, 2024
Intrathecal administration of 5-HT receptor antagonists (WAY-100635, ketanserin, and ondansetron) inhibited the protective effects of YKS. YKS exhibited an anti-allodynic effect, suggesting that YKS may activate 5-HT receptors in the spinal cord, thereby alleviating diabetic neuropathic pain.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Journal: Acute and Preventive Treatment of COVID-19-Related Headache: A Series of 100 Patients. (Pubmed Central) - Jul 27, 2024
The drugs with the highest proportion of a 2 h pain-freedom response were dexketoprofen (58.8%), triptans (57.7%), and ibuprofen (54.3%)...The drugs with the highest 50% responder rate were amitriptyline (45.5%), mirtazapine (50%), and anesthetic blockades (38.9%)...The most frequently used drug was amitriptyline, which obtained the best results. In some treatment-resistant patients, anesthetic blockades and onabotulinumtoxinA were also beneficial.
- |||||||||| clozapine / Generic mfg.
Review, Journal: The Use of Ascorbic Acid in Adjunctive Treatment for Schizophrenia-Current State of Knowledge. (Pubmed Central) - Jul 27, 2024
We analyze existing clinical studies and the mechanisms of action of vitamin C, suggesting its promising role as an adjunctive therapy in the treatment of schizophrenia. These insights, though not yet widely disseminated, may be significant for the further development of therapeutic strategies for this mental illness.
- |||||||||| olanzapine / Generic mfg.
Journal: Olanzapine Modulate Lipid Metabolism and Adipose Tissue Accumulation via Hepatic Muscarinic M3 Receptor-Mediated Alk-Related Signaling. (Pubmed Central) - Jul 27, 2024
However, cotreatment with Cevimeline significantly reversed the lipid metabolic disturbance and adipose tissue accumulation, as well as the upregulation of the hepatic Alk signaling caused by Olanzapine. This study demonstrates evidence that Olanzapine may cause metabolic disturbance by modulating hepatic Alk signaling via M3R, which provides novel insight for modulating the hepatic Alk signaling and potential interventions for targeting metabolic disorders.
- |||||||||| fluoxetine / Generic mfg.
Review, Journal: New Advances in Attention-Deficit/Hyperactivity Disorder-like Dogs. (Pubmed Central) - Jul 27, 2024
In spite of the fact that there is no veterinary consensus about the diagnosis of ADHD-like, some validated questionnaires could be helpful, but these cannot be used as a unique diagnostic tool. The use of drugs, such as fluoxetine, in addition to an adequate environmental enrichment, relaxation protocols, and behavior modification can achieve an adequate quality of life for both the dog and caregivers.
- |||||||||| clozapine / Generic mfg.
Journal: Descending facilitation from rostral ventromedial medulla mu opioid receptor-expressing neurons is necessary for maintenance of sensory and affective dimensions of chronic neuropathic pain. (Pubmed Central) - Jul 27, 2024
A single systemic administration of hM4D(Gi) agonist clozapine-N-oxide (CNO) reversibly inhibited hind paw tactile allodynia and produced conditioned place preference only in MORCre mice with PSNL...Thus, in male mice, activity of spinally projecting RVM-MOR cells is required (1) for expression and manifestation of both sensory and affective dimensions of established neuropathic pain and (2) to promote descending facilitation that overcomes apparently intact descending inhibition to maintain chronic pain. Enhanced descending facilitation likely regulates the output signal from the spinal cord to the brain to shape the pain experience and may provide a mechanism for nonopioid management of pain.
- |||||||||| Rexulti (brexpiprazole) / Lundbeck, Otsuka
Journal: Brexpiprazole for Agitation Associated With Dementia Due to Alzheimer's Disease. (Pubmed Central) - Jul 27, 2024
The approval of brexpiprazole signals favorably for upcoming agents for this indication, including escitalopram and dextromethorphan-bupropion. Both escitalopram and dextromethorphan-bupropion are currently undergoing clinical trials.
- |||||||||| paroxetine / Generic mfg.
Reimbursement, US reimbursement, Journal, Medicare: National patterns of paroxetine use among US Medicare patients from 2015-2020. (Pubmed Central) - Jul 26, 2024
Despite the American Geriatrics Society's prohibition against paroxetine use in older adults and many effective treatment alternatives, paroxetine was still commonly used in the US in this population, especially in Kentucky and North Dakota and by neuropsychiatry and geriatric medicine. These findings provide information on the specialty types and states where education and policy reform would likely have the greatest impact on improving adherence to the paroxetine prescription recommendations.
- |||||||||| diazepam / Generic mfg., paroxetine / Generic mfg.
Journal: Exploring the sedative properties of natural molecules from hop cones (Humulus lupulus) as promising natural anxiolytics through GABA receptors and the human serotonin transporter. (Pubmed Central) - Jul 26, 2024
Compounds 3,5-dihydroxy-4,6,6-tris(3-methylbut-2-en-1-yl)-2-(3-methylbutanoyl)cyclohexa-2,4-dien-1-one (5) and (S,E)-8-(3,7-dimethylocta-2,6-dien-1-yl)-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one (15) showed stable binding and favorable energy parameters, indicating their potential for targeting GABA receptors and the SERT. This study provides a basis for future clinical research on these promising compounds.
- |||||||||| ondansetron / Generic mfg.
Clinical, Journal: Comparing healthcare systems between the Netherlands and Australia in management for children with acute gastroenteritis. (Pubmed Central) - Jul 26, 2024
The lower annual incidence and per-case costs for childhood gastroenteritis in Australia cannot solely be explained by the differences in healthcare system functions. Nevertheless, Australia's robust public health system, characterized by legislation for vaccinations and quarantine, and the Netherland's well-established clinical care system, featuring fully funded continuity of care and lower ondansetron dosages, offer opportunities for enhancing healthcare in both countries.
- |||||||||| thioridazine / Generic mfg.
Journal, Cancer stem: Stimuli-Responsive Hydrogels Potentiating Photothermal Therapy against Cancer Stem Cell-Induced Breast Cancer Metastasis. (Pubmed Central) - Jul 26, 2024
Here, a thermoresponsive hydrogel is developed by coencapsulating aggregation-induced emission (AIE)-active photothermal agent and thioridazine (THZ), demonstrating a controllable delivery system triggered by the AIE agent to augment THZ-mediated CSC ablation...Consequently, effective CSC inhibition and significant suppression of tumor recurrence and metastasis are demonstrated in mice with breast cancer. We believe that this intelligent hydrogel-based delivery system represents a promising treatment strategy for metastatic breast cancer with clinical potential.
- |||||||||| Akineton (biperiden) / Endo, AbbVie
Journal: Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans. (Pubmed Central) - Jul 26, 2024
In contrast, delay discounting was reduced under haloperidol, but not affected by biperiden. Together, our data suggest that dopamine, acting at D2 receptors, modulates both effort and delay discounting, while acetylcholine, acting at M1 receptors, appears to exert a more specific influence on effort discounting only.
- |||||||||| Enbrel (etanercept) / Pfizer, Amgen
Preclinical, Journal: Etanercept ameliorates chronic mild stress-induced depressive-like behavior in rats: crosstalk between MAPK and STAT3 pathways and norepinephrine and serotonin transporters. (Pubmed Central) - Jul 26, 2024
Together, our data suggest that dopamine, acting at D2 receptors, modulates both effort and delay discounting, while acetylcholine, acting at M1 receptors, appears to exert a more specific influence on effort discounting only. From the beginning of the third week, rats were treated either with saline daily or with etanercept twice a week (0.3
- |||||||||| Qelbree (viloxazine) / Supernus Pharma, Knight Therap
Review, Journal: Current nonstimulant medications for adults with attention-deficit/hyperactivity disorder. (Pubmed Central) - Jul 26, 2024
While according to clinical guidelines, atomoxetine may serve as the only second-line option in adults with ADHD, several other nonstimulant compounds may be effectively used in order to personalize treatment based on comorbid conditions and ADHD features. Nevertheless, further research is needed to identify and test more personalized treatment strategies for adults with ADHD.
- |||||||||| lithium carbonate ER / Generic mfg.
Biomarker, Review, Journal: Pharmacotherapeutic value of inflammatory and neurotrophic biomarkers in bipolar disorder: A systematic review. (Pubmed Central) - Jul 26, 2024
Nevertheless, further research is needed to identify and test more personalized treatment strategies for adults with ADHD. Inflammation in BD requires further investigation to understand the underlying immunologic mechanism, to identify predictors of treatment response, and to make informed decisions about the use and development of more effective pharmacological interventions for BD.
- |||||||||| quetiapine / Generic mfg.
Journal: Vitreous humor in the forensic toxicology of quetiapine and its metabolites. (Pubmed Central) - Jul 26, 2024
The results of the study indicate the usefulness of vitreous humor in toxicological analysis for the determination of these substances, especially when the traditional biological materials are not available. The levels of quetiapine and its metabolites in vitreous humor as well as the vitreous humor to blood concentration ratios can provide important information for a more thorough toxicological investigation of forensic cases.
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