Serotonin 

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  • ||||||||||  fluoxetine / Generic mfg.
    Tetradystonics patients may be misdiagnosed? (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1876;    
    In our case, the patient presents not just one, but four changes (tremor, ataxia, generalized dystonia and task-specific dystonia). The presence of sardonic laughter is also relevant, a classic finding in Wilson's disease, but which is far from being pathognomonic.
  • ||||||||||  risperidone / Generic mfg., clozapine / Generic mfg.
    Parkinsonism in combined Fragile X and XYY Syndromes: A Case Report (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1743;    
    After switching to clozapine, he still presented with a slightly asymmetric (left > right) akinetic-rigid syndrome, hypomimia, postural tremor and dysarthrophonia... Parkinsonism (both Parkinson
  • ||||||||||  Treatment Patterns in Essential Tremor: Real-World Evidence from Germany (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1697;    
    Our findings revealed a substantial proportion of patients either discontinuing treatment during follow-up or never treated. Despite several treatment options, most patients received traditional beta-blockers, which highlights the need for new pharmacological agents specifically targeted for ET.
  • ||||||||||  risperidone / Generic mfg., haloperidol / Generic mfg., quetiapine / Generic mfg.
    Gaps in Diagnosing and Treating Tic Disorders in Latin America: A Survey of Healthcare Workers (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1673;    
    However, there are several limitations, such as a lack of well-defined referral pathways and a shortage of specialists with expertise in tic disorders. Furthermore, patients have limited access to non-pharmacological therapies and information about tics.
  • ||||||||||  clonazepam / Generic mfg., nortriptyline / Generic mfg.
    Benzodiazepines in the Management of Restless Legs Syndrome: A Systematic Review and Meta-Analysis (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1650;    
    Due to treating crossover studies as parallel-groups, our findings were affected by unit-of-analysis issues, possibly resulting in wider confidence intervals. Furthermore, the number of analyzed patients was small and no studies compared BZD to first-line treatments for RLS, reinforcing the need for new, larger RCTs with BZD, assessing beneficial and side effects.
  • ||||||||||  teriflunomide / Generic mfg., amisulpride / Generic mfg.
    Unusual Causes of Reversible Myoclonus: A Video Based Case Series (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1643;    
    She was under therapy with amisulpride 400 mg/day for three years for a psychiatric diagnosis of depression with somatisation...Case 2: A 42-year-old lady on treatment for MS with teriflunomide 14 mg per day, presented with upper limb tremulousness for one month... Accurate identification of the etiology of a myoclonic syndrome is essential, which can expedite recovery and appropriate patient outcomes
  • ||||||||||  quetiapine / Generic mfg., amantadine / Generic mfg.
    Diabetic striatopathy with stroke  (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1529;    
    Diabetic striatopathy is a rare neurological condition affecting diabetics that is commonly misdiagnosed as hemorrhagic stroke. However, it is important for physicians to be aware of this condition because if properly treated, it has a good prognosis and can lead to improved life quality for patients.
  • ||||||||||  Austedo (deutetrabenazine) / Teva
    Chorea Acanthocytosis Misdiagnosed as Functional Movement Disorder (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1521;    
    The diagnostic challenges encountered were due to motor manifestations overshadowed by psychological symptoms. Our case highlights the importance of genetic testing for young patients with chorea and chronic psychiatric symptoms.
  • ||||||||||  haloperidol / Generic mfg.
    Cryptococcal meningitis as a rare cause of acute generalized chorea: a report of an interesting case (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1515;    
    Although cryptococcal meningitis is a rare cause of generalized chorea, it should be highly suspected in a patient with acute generalized chorea with a clinical setting compatible with meningitis. Early detection and management of this condition could lead to a better neurological outcome.
  • ||||||||||  Choreoballism due to Bisphosphonate-Induced Antiphospholipid Syndrome: A Case Report (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1511;    
    There is only one other report of a movement disorder following bisphosphonate administration which was ultimately attributed to hypocalcemia [4]. Increasing awareness can inform providers to recognize these rare reactions.
  • ||||||||||  Treatment of status dystonicus in children using pallidal deep brain stimulation (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1301;    
    GPi-DBS is effective in relieving of pharmacoresistant SD of various etiologies and reduces dystonia severity in the short term. In the long term, outcome varies individually and is characterized by a high incidence of complications and possible SD recurrence.
  • ||||||||||  Austedo (deutetrabenazine) / Teva
    Treatment of Severe Tardive Syndrome with Pallidotomy: A Case Report (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1281;    
    This case provides evidence for the safety and utility of MRI-guided LITT pallidotomy in treatment of refractory tardive syndrome. This procedure should be considered for those patients with a contradiction for implantation of DBS hardware.
  • ||||||||||  buspirone/zolmitriptan (JM-010) / Bukwang Pharma
    Buspirone/zolmitriptan combination exerts synergistic reduction in dyskinesia without worsening Parkinson disease motor symptomatology (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1054;    
    P2
    In this short, proof-of-concept pilot study, addition of buspirone/zolmitriptan to the patients PD medication regimen significantly reduced LID severity without worsening Parkinsonian motor function. The buspirone/zolmitriptan oral formulation (JM-010) has been modified in ongoing multi-center clinical trials investigating PD patients with LID (in the EU: NCT03956979; in the US: NCT04377945).
  • ||||||||||  ampreloxetine (TD-9855) / Theravance Biopharma
    Long-term Safety of Ampreloxetine in Patients with Symptomatic Neurogenic Orthostatic Hypotension (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_844;    
    P3
    The safety findings in this long-term study were consistent with the existing safety profile for ampreloxetine, with minimal incidences of related TEAEs and serious TEAEs. The low dropout rate and continuation of treatment for up to two years in this open-label extension study further supports the long-term safety and tolerability of ampreloxetine.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Revitalizing Lives: The Dystonia Care Rehabilitation Program (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_741;    
    This multimodal program, integrating botox and neuro rehab, effectively addresses functional limitations and non-motor changes, empowering individuals to regain control and improve overall function and well-being... The Cervical Dystonia Care Program yields significant improvements in quality of life, daily activity engagement, self-efficacy in managing the condition, and reduced dependence on over-the-counter medication for the group of eight individuals.
  • ||||||||||  olanzapine / Generic mfg.
    Oro-facial Dyskinesia and akathisia following Treatment by Olanzapine (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_662;    
    Some studies revealed risperidone correlated with dose, while quetiapine did not dose-dependent for TD occurrence. He was treated for his Neurobeh
  • ||||||||||  Ingrezza (valbenazine) / Neurocrine, Austedo (deutetrabenazine) / Teva
    Comorbid Tardive Dyskinesia (TD) and Restless Leg Syndrome (RLS) (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_661;    
    Reduced dopaminergic signaling is implicated in RLS. TD is thought to arise from dopamine hypersensitivity in the nigrostriatal pathway due to long-term neuroleptic use.
  • ||||||||||  fluvoxamine / Generic mfg.
    Acute dystonic dyskinesias in a patient used fluvoxamine. Case report (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_656;    
    The patient underwent a course of intravenous amantadine sulfate 400 mg for 8 days followed by tablets (100 mg). It is recommended to prescribe SSRIs with caution.
  • ||||||||||  risperidone / Generic mfg.
    Tardive Dystonia Following Risperidone Treatment : A Case Report and Therapeutic Approach (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_655;    
    This case highlights the importance of recognizing SGAs like risperidone, as a systemic contributor of the development of focal dystonia, particularly tardive dystonia, due to its impact on the dopamine system. Early detection and appropriate management, including the use of botulinum toxin therapy and antipsychotic modifications, can lead to significant improvement in patient outcomes.
  • ||||||||||  aripiprazole / Generic mfg.
    Bistriatal hypermetabolism on 18-FDG PET-CT in tardive dyskinesia (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_654;    
    We here report the first case in our knowledge of TD associated with intense striatal hypermetabolism in PET-CT. PET-CT imaging of our patient
  • ||||||||||  haloperidol / Generic mfg.
    GPR30 agonists attenuate haloperidol-induced neurotoxicity in SH-SY5Y cells and adult zebrafish. (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_646;    
    These results underscore the potential of natural compounds in mitigating haloperidol-induced VCMs in rats, suggesting a protective role against this side effect. Findings suggest that raloxifene and fulvestrant can activate the Bcl2/Nrf2/HO-1/CREB signaling pathways showing a neuroprotective effect against haloperidol-mediated toxicity.
  • ||||||||||  haloperidol / Generic mfg.
    Drug-Induced Parkinsonism and Tardive Dyskinesia in Rats Chronically Treated with Haloperidol (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_644;    
    Findings suggest that raloxifene and fulvestrant can activate the Bcl2/Nrf2/HO-1/CREB signaling pathways showing a neuroprotective effect against haloperidol-mediated toxicity. Haloperidol-induced movement disorders involve both indirect and direct pathways.
  • ||||||||||  Comorbidity of schizophrenia and Parkinson's disease: a clinical case report (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_615;    
    Because of the overlap in clinical manifestations between Parkinson's disease and schizophrenia, differential diagnosis of these diseases is often extremely difficult. Modern literature suggests that these disorders are etiologically and pathogenetically united, as this clinical example illustrates.
  • ||||||||||  paroxetine / Generic mfg., ziprasidone / Generic mfg.
    Pharmacokinetic Intersections in Geriatric Neuropharmacology: A Parkinson's Disease Case Study with Concomitant Refractory Major Depressive Disorder (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_608;    
    It emphasizes the critical need for physicians to possess acute awareness of complex pharmacokinetic interactions, championing the ethos of interdisciplinary collaboration to preempt adverse drug interactions. This discourse significantly enriches the conversation on refining neuropharmacological approaches, with a paramount focus on patient safety and optimizing treatment outcomes in the delicate nature of geriatric patient care.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Multiple System Atrophy in a Patient with Normal Pressure Hydrocephalus (Poster Hall (Exhibit Hall A)) -  Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_271;    
    We report a case of a patient initially diagnosed with NPH with partial response to CSF drainage and shunt who subsequently presented to our clinic for further evaluation and was diagnosed with MSA. We considered the possibility that there was a misdiagnosis of NPH given the lack of clear clinical benefit following VPS implantation with recurrent adjustments, however her disproportionate ventriculomegaly strongly suggestive of NPH and neuropsychological testing showing subcortical cognitive dysfunction would not be expected in MSA, but it doesn't rule it out.
  • ||||||||||  sertraline / Generic mfg.
    Journal:  Differential effects of antidepressant sertraline in glochidia-fish interactions involving drug transfer from parasite to host. (Pubmed Central) -  Aug 8, 2024   
    Importantly, this study provides the first evidence of sertraline transfer from exposed glochidia to nonexposed host fish, as indicated by elevated levels of sertraline (12.8 ng g-1) in the brain tissue of nonexposed hosts. These findings highlight the subtle yet significant effects of pharmaceutical pollutants on freshwater ecosystems but also underscore the importance of understanding the unexpected dynamics of such contamination to predict and address future ecological changes.
  • ||||||||||  Reyvow (lasmiditan) / Eli Lilly, Daiichi Sankyo, Organon
    Preclinical, Journal:  Lasmiditan ameliorates serotonergic itch in mice: Possible involvement of 5-HT1F receptors. (Pubmed Central) -  Aug 8, 2024   
    These findings highlight the subtle yet significant effects of pharmaceutical pollutants on freshwater ecosystems but also underscore the importance of understanding the unexpected dynamics of such contamination to predict and address future ecological changes. Further, the levels of TLR-4, IL-31, CGRP & TRPV4 were substantially reduced upon the administration of Lasmiditan (1
  • ||||||||||  memantine / Generic mfg.
    Preclinical, Journal, Metabolomic study:  Protective signature of xanthohumol on cognitive function of APP/PS1 mice: a urine metabolomics approach by age. (Pubmed Central) -  Aug 8, 2024   
    Memantine (Mem) was selected as positive control...In conclusion, dietary treatment with Xn altered the urinary metabolite profile at different stages of administration in APP/PS1 mice. The identified potential endogenous metabolic biomarkers and signal pathways open new avenues to investigate the pathogenesis and treatment of AD.