Serotonin 

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  • ||||||||||  citalopram / Generic mfg., escitalopram / Generic mfg.
    Review, Journal:  Citalopram & escitalopram: Mechanisms of cardiotoxicity, toxicology predisposition and risks of use in geriatric & hemodialysis populations. (Pubmed Central) -  Oct 1, 2024   
    Our review extends to the geriatric population's use of citalopram and escitalopram, emphasizing the significance of assessing a patient's medical history and cumulative drug use to evaluate their susceptibility to cardiac adverse events. Finally, we scrutinize the compound relationship between QTc-prolongation, proton pump inhibitors (PPIs) and serum-to-dialysate potassium gradients in influencing the proarrhythmic potential of citalopram/escitalopram in hemodialysis patients.
  • ||||||||||  Journal:  Evaluation of Antipsychotic-Induced Neuroleptic Malignant Syndrome Using a Self-Organizing Map. (Pubmed Central) -  Oct 1, 2024   
    First, 31 antipsychotics branched off into groups with loss of consciousness, with one group (10 TAPs) consisting entirely of TAPs, and the other consisting of antipsychotics that were further separated into two groups with coma induced by TAPs and AAPs. Conclusion The results of this study provide a reference for healthcare providers when predicting the NMS characteristics induced by each drug in patients, thereby facilitating the effective treatment of schizophrenia.
  • ||||||||||  aripiprazole / Generic mfg., clozapine / Generic mfg.
    Journal:  Aripiprazole Augmentation as a Treatment for Clozapine-Induced Weight Gain. (Pubmed Central) -  Oct 1, 2024   
    Conclusion The results of this study provide a reference for healthcare providers when predicting the NMS characteristics induced by each drug in patients, thereby facilitating the effective treatment of schizophrenia. No abstract available
  • ||||||||||  Diacomit (stiripentol) / Biocodex, Meiji Seika
    Journal:  Camel FGF21 Protein Enhances FGF21 Signaling and its Targeted Compounds Screening. (Pubmed Central) -  Oct 1, 2024   
    Future drug development should include pharmacogenetics and focus on drugs for specific aspects of psychosis. This study has provided new ideas for developing therapeutic strategies based on FGF21 protein modification and exploring novel disease treatment strategies based on the compounds-protein combination.
  • ||||||||||  sertraline / Generic mfg.
    Review, Journal:  Understanding and Addressing Male Postpartum Depression: Incidence, Causes, Diagnosis, and Management Strategies. (Pubmed Central) -  Oct 1, 2024   
    The proposed treatment methods of postpartum depression, such as sertraline or cognitive-behavioral therapy, enable patients to recover and provide appropriate support...Further research should focus on identifying risk factors in men from different social classes, considering environmental, personal, and ethnic characteristics, and on the effectiveness of postpartum depression treatment in men. This article aims to review the incidence, causes, diagnosis, and management of male postpartum depression.
  • ||||||||||  clozapine / Generic mfg.
    Journal:  Exploration of Clozapine-Induced Cardiomyopathy and Its Mechanism. (Pubmed Central) -  Oct 1, 2024   
    Transcriptomic analysis showed that Egr1, Egr2, ler2, Jun, Mapk9, Nr1d2, Atf3, Bhlhe40, Crem, Cry1, Cry2, Dbp were hub genes for clozapine injury to the myocardium, and that these genes may play an important role in the myocardial ACM-like changes caused by clozapine. Combined with the results of pathological examination and transcriptomic analysis, it can be concluded that the long-term action of clozapine on cardiomyocytes leads to cellular autophagy and subsequent structural remodeling of the heart, and in the remodeling affects fatty acid metabolism, which eventually leads to ACM-like changes.
  • ||||||||||  agomelatine / Generic mfg.
    Preclinical, Journal:  Agomelatine-loaded nanostructured lipid carriers alleviate neuropathic pain in rats by Nrf2/HO-1 signalling pathway. (Pubmed Central) -  Sep 30, 2024   
    ATRA substantially downregulated Nrf2 expression and exacerbated thermal hyperalgesia, whereas Nrf2 and HO-1 expressions were significantly upregulated after AGM-NLCs administration. Overall, the results demonstrated that AGM-NLCs offer promising antinociceptive and anti-inflammatory properties in alleviating neuropathic pain symptoms, which can be attributed to improved drug delivery and therapeutic outcomes compared with AGM alone.
  • ||||||||||  Review, Journal, Metastases:  Navigating the 'Pits and Perils' of Analgesic Therapy in Advanced Liver Disease and Cirrhosis. (Pubmed Central) -  Sep 30, 2024   
    Topical analgesics, including NSAIDs, lidocaine, and rubefacients, are deemed safe for use in cirrhosis, offering localized relief with minimal systemic effects...This review provides healthcare professionals with valuable insights into the complex landscape of analgesic therapy in cirrhosis. Meticulous consideration of drug metabolism, hepatic safety, and individual patient factors is paramount in optimizing pain management strategies for this challenging patient population.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Review, Journal:  Management Strategies for Patients with Non-Infectious Cystitis: A Review of the Literature. (Pubmed Central) -  Sep 30, 2024   
    Several novel treatments have shown promise as management options including combination antihistamine therapy, phosphodiesterase 5 inhibitors, alpha lipoic acid supplements, and onabotulinumtoxin A. Recent studies have also found pentosan polysulfate sodium to have adverse ophthalmologic effects...Multimodal regimens are often the most effective. Treatment should be started with conservative options and escalated as necessary to oral treatments, intravesical options, or procedural management.
  • ||||||||||  risperidone / Generic mfg.
    Journal:  Risperidone-Induced Urinary Incontinence in Schizoaffective Disorder: A Case Report. (Pubmed Central) -  Sep 30, 2024   
    Behavioral modifications such as bladder training, biofeedback, and lifestyle modifications can also be effective in reducing the frequency of incontinence episodes. This case report emphasizes the importance of prompt identification and intervention to minimize the debilitating effects of urinary incontinence on patients with psychiatric conditions.
  • ||||||||||  venlafaxine / Generic mfg.
    Journal:  Exploring Cotard's Delusion Within the Context of Major Depressive Disorder With Psychotic Features: A Case Report. (Pubmed Central) -  Sep 30, 2024   
    This outcome, highlighting the potential inefficacy of antipsychotics and the success of venlafaxine, underscores the need for better understanding and additional pharmacological research into Cotard's delusion, particularly within the context of MDD with psychotic features. The exact mechanism through which venlafaxine achieved a positive response remains unknown, necessitating further comprehensive studies.
  • ||||||||||  risperidone / Generic mfg., olanzapine / Generic mfg., quetiapine / Generic mfg.
    Journal:  Evaluation of the Impact of the Addition of Atypical Antipsychotics to Continuous Infusion Propofol Therapy. (Pubmed Central) -  Sep 30, 2024   
    Patients who received an adjunctive antipsychotic saw resulting propofol rate reductions of 8.6% at 24 hours, 19.4% at 48 hours, and 54.2% at 72 hours. However, research on this topic should not end here, as further investigation with higher-level study design is needed to determine the true impact of these agents for this indication.
  • ||||||||||  frovatriptan / Generic mfg.
    Journal:  Equivariant Neural Networks Utilizing Molecular Clusters for Accurate Molecular Crystal Lattice Energy Predictions. (Pubmed Central) -  Sep 30, 2024   
    The trained model exhibits remarkable accuracy in predicting lattice energies, aligning closely with those computed by plane-wave based DFT methods, thus representing significant cost reductions. Furthermore, the Allegro network was seamlessly integrated with the USPEX framework, accelerating the discovery of low-energy crystal structures during crystal structure prediction.
  • ||||||||||  Journal:  Drug overdose deaths during prison riots and mental states of prisoners: a case study. (Pubmed Central) -  Sep 30, 2024   
    Immunochemical screening and gas chromatography-mass spectrometry were employed to detect a spectrum of drugs, including MDMA, methadone, morphine, cannabis derivatives, benzodiazepines, and others...Tramadol and mirtazapine were implicated in one case, while methadone was a common factor in the deaths of two inmates, one of whom also ingested diazepam...The prison environment also amplifies pre-existing psychiatric disorders, and incidents like riots can trigger a cascade of uncontrollable psychological reactions. The three potential scenarios are drug dependence, accidental overdose in recreational drug use, and suicide attempts through substance ingestion.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Journal:  Agitated Depression Associated With Flurazepam Discontinuation. (Pubmed Central) -  Sep 30, 2024   
    She finally had a complete resolution of these symptoms with a combination of alprazolam, zopiclone, and olanzapine. This case provides insight into this unique variant of depression and the role of GABA agonists in its pathology and management.
  • ||||||||||  ZEMBRACE SymTouch (sumatriptan succinate) / Tonix
    Journal:  Select autosomal dominant DFNA11 deafness mutations activate Myo7A in epithelial cells. (Pubmed Central) -  Sep 30, 2024   
    Our findings reveal that Myo7A is regulated by specific IQ motifs within its lever arm, and that this regulation can function at least partially independent of its tail sequence. Importantly, we demonstrate that many of the DFNA11 deafness mutations reported in patients activate Myo7A targeting, providing a potential explanation for the autosomal dominant genetics of this form of deafness.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  IpsiHand Brain-Computer Interface Therapy Induces Broad Upper Extremity Motor Rehabilitation in Chronic Stroke. (Pubmed Central) -  Sep 30, 2024   
    P=N/A
    BCI therapy resulted in significant motor function improvement across the proximal and distal upper extremities of patients, which significantly correlated with theta-gamma CFC increases in the motor regions. This may represent rhythm-specific cortical oscillatory mechanism for BCI-driven rehabilitation in chronic stroke patients.
  • ||||||||||  Emirace (nemonapride) / Astellas
    Preclinical, Journal:  Effects of dopamine receptor antagonists and radiation on mouse neural stem/progenitor cells. (Pubmed Central) -  Sep 29, 2024   
    We conclude that a therapeutic window for dopamine receptor antagonists in combination with radiation potentially exists, making it a novel combination therapy against glioblastoma. Normal tissue toxicity following this treatment scheme likely differs depending on age and sex and should be taken into consideration when designing clinical trials.
  • ||||||||||  blonanserin / Generic mfg.
    Journal:  Preparation and release pattern study of long-term controlled release Blonanserin microspheres. (Pubmed Central) -  Sep 29, 2024   
    When the ratio of 15?kDa and 75?kDa was 1:9 (F3), the Bn-MS had a low burst release rate, moderate release rate, no release hysteresis period, a long release period of up to 35?days, and a stable release pattern close to the zero level. The results of the release mechanism study indicated that the hybrid PLGA improved the release behavior of the microspheres by adjusting the dissolution degradation rate of Bn-MS, which in turn affected the release mechanism of the microspheres.
  • ||||||||||  paroxetine / Generic mfg.
    Preclinical, Journal:  Aphrodisiac activities of aqueous extract of Anthonotha macrophylla (P. Beauv) leaves in paroxetine-induced sexual dysfunction male Wistar rats. (Pubmed Central) -  Sep 29, 2024   
    In contrast, AEAML significantly (p < 0.05) lowered/reduced the paroxetine-induced related increases in the ML, IL, EL, PEI, and prolonged/ increased (p < 0.05) the paroxetine-induced related decreases in the MF, IF and EF. The AEAML also reversed (p < 0.05) the paroxetine-induced related decreases in the weight of the caudal epididymis, seminal vesicle, ventral prostate, testis, levels of DHT, testosterone, LH, FSH, dopamine, ACH, NO, cGMP and the paroxetine-induced related increases in the levels of serotonin, GABA, PDE 5 and ACHE AEAML contains aphrodisiac bioactive agents and can be explored as lead drug for MSD in Wistar rats.
  • ||||||||||  clomipramine / Generic mfg.
    Journal, Adverse events:  A higher desmethylclomipramine to clomipramine ratio predicts more effectiveness and fewer adverse effects in major depressive disorder. (Pubmed Central) -  Sep 29, 2024   
    The AEAML also reversed (p < 0.05) the paroxetine-induced related decreases in the weight of the caudal epididymis, seminal vesicle, ventral prostate, testis, levels of DHT, testosterone, LH, FSH, dopamine, ACH, NO, cGMP and the paroxetine-induced related increases in the levels of serotonin, GABA, PDE 5 and ACHE AEAML contains aphrodisiac bioactive agents and can be explored as lead drug for MSD in Wistar rats. No abstract available
  • ||||||||||  mirtazapine / Generic mfg.
    Journal:  Mirtazapine blood levels and antidepressant response. (Pubmed Central) -  Sep 29, 2024   
    The study suggests that serum concentration of mirtazapine is not strongly associated with the antidepressant efficacy of mirtazapine. This is probably attributed to its pharmacodynamic profile, even though higher blood levels seem to be marginally more effective.
  • ||||||||||  duloxetine / Generic mfg.
    Journal, HEOR:  Cost-utility analysis of duloxetine in osteoarthritis: from Chinese healthcare perspective. (Pubmed Central) -  Sep 29, 2024   
    These results were consistent with the sensitivity analyses; 53.64% and 53.93% of the patients were willing to use duloxetine comparing with etoricoxib, for which the thresholds were 1.0 and 3.0 per capita gross domestic product (GDP), respectively. Duloxetine is a valuable option for patients with OA; however, uncertainties exist in the model, and these suggestions can be adopted with caution.