Serotonin 

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  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Self-Administered Botulinum Injection Causing Rare Masquerade of Systemic Botulism. (Pubmed Central) -  Aug 20, 2024   
    She had self-administered 100 units of onabotulinumtoxin A (BoNT-A) by injection into her face two weeks prior for cosmetic purposes. This case study highlights the rare but potential complication of systemic botulism.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Retrospective data, Journal:  Minimally Invasive Stapled Abdominal Wall Repair: A New Surgical Technique. (Pubmed Central) -  Aug 20, 2024   
    Possible enhancements include use of preoperative Botox to treat defects larger than 6 cm. Multicentric analysis is needed to validate the technique, and longer follow-up is required to assess the recurrence rate.
  • ||||||||||  Ajovy (fremanezumab-vfrm) / Teva, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Enrollment closed, Trial completion date, Trial primary completion date, Monotherapy:  COACT Study: CGRPmAbs + OnabotulinumtoxinA Assessment of Chronic Migraine Treatments Study (clinicaltrials.gov) -  Aug 20, 2024   
    P4,  N=50, Active, not recruiting, 
    Multicentric analysis is needed to validate the technique, and longer follow-up is required to assess the recurrence rate. Recruiting --> Active, not recruiting | Trial completion date: Dec 2024 --> May 2025 | Trial primary completion date: Oct 2024 --> Mar 2025
  • ||||||||||  Urolieve (lidocaine alkalized intravesicular) / Regent Pacific Group, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal, HEOR, Cost-analysis:  Cost Analysis of Oral Phenazopyridine vs Intravesical Lidocaine for Preprocedural Analgesia for Intradetrusor OnabotulinumtoxinA Injections. (Pubmed Central) -  Aug 20, 2024   
    Phenazopyridine provides cost savings compared to lidocaine for analgesia before office intradetrusor onabotulinumtoxinA injection for the treatment of idiopathic overactive bladder. If adopted by providers nationwide, phenazopyridine may reduce health care spending and minimize office visit time while maintaining patient pain control and satisfaction.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Effect of an antidepressant on aquatic ecosystems in the presence of microplastics: A mesocosm study. (Pubmed Central) -  Aug 19, 2024   
    The behavior of the decomposer A. aquaticus significantly decreased at higher fluoxetine concentrations, potentially leading to reduced decomposition rates near the sediment. Our study demonstrates that effects observed upon short-term exposure result in more pronounced ecosystem-level effects following chronic exposure.
  • ||||||||||  sertraline / Generic mfg.
    Journal:  Sertraline induced acute hepatocellular liver injury in patient with major depressive disorder: a case report. (Pubmed Central) -  Aug 19, 2024   
    The findings contribute to the existing body of evidence on the hepatotoxic risks associated with SSRIs and highlight the need for personalized treatment strategies to mitigate adverse effects and enhance patient safety. Further research is needed to explore the long-term safety and efficacy of sertraline, particularly in vulnerable populations.
  • ||||||||||  Journal:  Selective inhibitor of sodium-calcium exchanger, SEA0400, affects NMDA receptor currents and abolishes their calcium-dependent block by tricyclic antidepressants. (Pubmed Central) -  Aug 19, 2024   
    Here the effects of selective high-affinity sodium-calcium exchanger (NCX) isoform 1 inhibitor, SEA0400, on NMDA-activated whole-cell currents and their block by amitriptyline, desipramine and clomipramine recorded by patch-clamp technique in cortical neurons of primary culture were studied...In agreement, SEA0400 did not change the IC50 for clomipramine, which acts as a pure NMDAR open-channel blocker. Thus, NCX seems to represent a promising molecular target to treat neurological disorders, because of the ability to modulate NMDARs by decreasing the open probability through the enhancement of their CDD.
  • ||||||||||  trazodone ER / Generic mfg., carbamazepine / Generic mfg., amoxicillin / Generic mfg.
    Journal, Metabolomic study:  Metabolomic and sphingolipidomic profiling of human hepatoma cells exposed to widely used pharmaceuticals. (Pubmed Central) -  Aug 18, 2024   
    Under both drug treatments, a decrease in various ceramide species (related to cell signaling) was observed, along with reduced taurine levels (related to the biosynthesis of bile acid conjugates) and carnitine levels (suggesting an impact on energy production). These and other drug-specific changes indicate that cellular functions in liver cells might be altered under low doses of these CECs, potentially affecting the health of other organs.
  • ||||||||||  amitriptyline / Generic mfg.
    Journal:  Modulating a model membrane of sphingomyelin by a tricyclic antidepressant drug. (Pubmed Central) -  Aug 17, 2024   
    Tricyclic medicine such as amitriptyline (AMT) hydrochloride, initially developed to treat depression, is also used to treat neuropathic pain, anxiety disorder, and migraines...Small-angle X-ray scattering (SAXS) measurements on multilamellar vesicles (MLVs) have revealed that the AMT molecules partition into the hydrophobic core of the lipid membrane, modifying the organization of lipids in the membrane. The modified physical state of less rigid membrane and the transformed electrostatics of the membrane could influence its interaction with synaptic vesicles and neurotransmitters making higher availability of the neurotransmitters in the synaptic cleft.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Clinical, Journal:  Results of a study examining the use of onabotulinumtoxinA in pediatric patients with overactive bladder. (Pubmed Central) -  Aug 17, 2024   
    P3
    OnabotulinumtoxinA injections were well tolerated in children with OAB at all doses studied. Although the primary endpoint was not met, the significantly greater treatment response rate observed with onabotulinumtoxinA 100U versus 25U suggests additional benefit of the higher dose, without additional safety concerns.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal, Surgery:  Decompression Surgery in Elderly Patients with Hemifacial Spasm Refractory to Botulinum Toxin. (Pubmed Central) -  Aug 17, 2024   
    This study provides evidence that elderly patients can undergo botulinum toxin treatment for hemifacial spasm without compromising their likelihood of achieving spasm-freedom with future surgical decompression. Therefore, surgical decompression of the facial nerve is an effective therapy for elderly patients with hemifacial spasm refractory to botulinum toxin.
  • ||||||||||  ondansetron / Generic mfg., haloperidol / Generic mfg.
    Journal:  The Incidence of Torsades de Pointes With Perioperative Triple Antiemetic Administration. (Pubmed Central) -  Aug 16, 2024   
    No episodes of TdP were identified in patients receiving triple antiemetic therapy perioperatively, though the cause of death in 1 patient could not be determined. This suggest that low-dose triple antiemetic therapy is low risk for the development of TdP.