- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Retrospective data, Journal: Minimally Invasive Stapled Abdominal Wall Repair: A New Surgical Technique. (Pubmed Central) - Aug 20, 2024 Possible enhancements include use of preoperative Botox to treat defects larger than 6 cm. Multicentric analysis is needed to validate the technique, and longer follow-up is required to assess the recurrence rate.
- |||||||||| Ajovy (fremanezumab-vfrm) / Teva, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Enrollment closed, Trial completion date, Trial primary completion date, Monotherapy: COACT Study: CGRPmAbs + OnabotulinumtoxinA Assessment of Chronic Migraine Treatments Study (clinicaltrials.gov) - Aug 20, 2024 P4, N=50, Active, not recruiting, Multicentric analysis is needed to validate the technique, and longer follow-up is required to assess the recurrence rate. Recruiting --> Active, not recruiting | Trial completion date: Dec 2024 --> May 2025 | Trial primary completion date: Oct 2024 --> Mar 2025
- |||||||||| Chantix (varenicline) / Pfizer
Review, Journal: Analytical Methodologies to Detect N-Nitrosamine Impurities in Active Pharmaceutical Ingredients, Drug Products and Other Matrices. (Pubmed Central) - Aug 19, 2024 Consequently, this review aims to concentrate on products recently reported to contain N-nitrosamine impurities. These products include rifampicin, champix, famotidine, nizatidine, atorvastatin, bumetanide, itraconazole, diovan, enalapril, propranolol, lisinopril, duloxetine, rivaroxaban, pioglitazones, glifizones, cilostazol, and sunitinib.
- |||||||||| Fintepla (low-dose fenfluramine) / UCB
Journal: Successful use of Fenfluramine in super-refractory status epilepticus in a patient with tuberous sclerosis complex and Lennox-Gastaut syndrome. (Pubmed Central) - Aug 19, 2024 These products include rifampicin, champix, famotidine, nizatidine, atorvastatin, bumetanide, itraconazole, diovan, enalapril, propranolol, lisinopril, duloxetine, rivaroxaban, pioglitazones, glifizones, cilostazol, and sunitinib. The following 6
- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Rexulti (brexpiprazole) / Lundbeck, Otsuka
Journal, Adverse events, Real-world evidence, Real-world: Characteristics of eye disorders induced by atypical antipsychotics: a real-world study from 2016 to 2022 based on Food and Drug Administration Adverse Event Reporting System. (Pubmed Central) - Aug 19, 2024 In terms of the types of adverse events, our study found that aripiprazole was associated with 28 types of ocular adverse events, followed by quetiapine. Clozapine was only associated with two types of ocular adverse events.
- |||||||||| Journal: Selective inhibitor of sodium-calcium exchanger, SEA0400, affects NMDA receptor currents and abolishes their calcium-dependent block by tricyclic antidepressants. (Pubmed Central) - Aug 19, 2024
Here the effects of selective high-affinity sodium-calcium exchanger (NCX) isoform 1 inhibitor, SEA0400, on NMDA-activated whole-cell currents and their block by amitriptyline, desipramine and clomipramine recorded by patch-clamp technique in cortical neurons of primary culture were studied...In agreement, SEA0400 did not change the IC50 for clomipramine, which acts as a pure NMDAR open-channel blocker. Thus, NCX seems to represent a promising molecular target to treat neurological disorders, because of the ability to modulate NMDARs by decreasing the open probability through the enhancement of their CDD.
- |||||||||| trazodone ER / Generic mfg., carbamazepine / Generic mfg., amoxicillin / Generic mfg.
Journal, Metabolomic study: Metabolomic and sphingolipidomic profiling of human hepatoma cells exposed to widely used pharmaceuticals. (Pubmed Central) - Aug 18, 2024 Under both drug treatments, a decrease in various ceramide species (related to cell signaling) was observed, along with reduced taurine levels (related to the biosynthesis of bile acid conjugates) and carnitine levels (suggesting an impact on energy production). These and other drug-specific changes indicate that cellular functions in liver cells might be altered under low doses of these CECs, potentially affecting the health of other organs.
- |||||||||| Reyvow (lasmiditan) / Eli Lilly, Daiichi Sankyo, Organon, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Clinical guideline: Migraine treatment consensus document of the Spanish Society of Neurology (SEN), Spanish Society of Family and Community Medicine (SEMFYC), Society of Primary Care Medicine (SEMERGEN) and Spanish Association of Migraine and Headache (AEMICE) on migraine treatment. (Pubmed Central) - Aug 18, 2024 We also discuss preventive treatment consisting of oral preventive drugs, botulinum toxin, and treatments that block the action of calcitonin-related peptide (CGRP). Finally, we emphasize that pharmacological treatments must be complementary to carrying out general measures consisting of identifying and managing/deletion the precipitating factors of the attacks and the chronicizing factors, controlling the comorbidities of migraine and eliminating analgesic overuse.
- |||||||||| amitriptyline / Generic mfg.
Journal: Modulating a model membrane of sphingomyelin by a tricyclic antidepressant drug. (Pubmed Central) - Aug 17, 2024 Tricyclic medicine such as amitriptyline (AMT) hydrochloride, initially developed to treat depression, is also used to treat neuropathic pain, anxiety disorder, and migraines...Small-angle X-ray scattering (SAXS) measurements on multilamellar vesicles (MLVs) have revealed that the AMT molecules partition into the hydrophobic core of the lipid membrane, modifying the organization of lipids in the membrane. The modified physical state of less rigid membrane and the transformed electrostatics of the membrane could influence its interaction with synaptic vesicles and neurotransmitters making higher availability of the neurotransmitters in the synaptic cleft.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Clinical, Journal: Results of a study examining the use of onabotulinumtoxinA in pediatric patients with overactive bladder. (Pubmed Central) - Aug 17, 2024 P3 OnabotulinumtoxinA injections were well tolerated in children with OAB at all doses studied. Although the primary endpoint was not met, the significantly greater treatment response rate observed with onabotulinumtoxinA 100U versus 25U suggests additional benefit of the higher dose, without additional safety concerns.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Journal, Surgery: Decompression Surgery in Elderly Patients with Hemifacial Spasm Refractory to Botulinum Toxin. (Pubmed Central) - Aug 17, 2024 This study provides evidence that elderly patients can undergo botulinum toxin treatment for hemifacial spasm without compromising their likelihood of achieving spasm-freedom with future surgical decompression. Therefore, surgical decompression of the facial nerve is an effective therapy for elderly patients with hemifacial spasm refractory to botulinum toxin.
- |||||||||| ondansetron / Generic mfg., haloperidol / Generic mfg.
Journal: The Incidence of Torsades de Pointes With Perioperative Triple Antiemetic Administration. (Pubmed Central) - Aug 16, 2024 No episodes of TdP were identified in patients receiving triple antiemetic therapy perioperatively, though the cause of death in 1 patient could not be determined. This suggest that low-dose triple antiemetic therapy is low risk for the development of TdP.
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