Serotonin 

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  • ||||||||||  agomelatine / Generic mfg.
    Journal:  Agomelatine Is Unable to Attenuate Kainic Acid-Induced Deficits in Early Life Communicative Behavior. (Pubmed Central) -  Sep 1, 2024   
    Agomelatine did not attenuate any of the deficits. Our study is the first to assess agomelatine's efficacy to correct USVs and thus provides an important point of context to the literature, indicating that despite its high therapeutic efficacy to attenuate other behavioral comorbidities of seizures, agomelatine's ability to correct neonatal communicative deficits is limited.
  • ||||||||||  Ingrezza (valbenazine) / Neurocrine
    Journal:  Atypical Antipsychotic-Induced Tardive Dyskinesia in a Middle-Aged Schizophrenic Patient: A Case Report. (Pubmed Central) -  Sep 1, 2024   
    Our study is the first to assess agomelatine's efficacy to correct USVs and thus provides an important point of context to the literature, indicating that despite its high therapeutic efficacy to attenuate other behavioral comorbidities of seizures, agomelatine's ability to correct neonatal communicative deficits is limited. It is primarily associated with the long-term use of first-generation (typical) antipsychotics but can also occur with second-generation (atypical) antipsychotics
  • ||||||||||  dexmedetomidine / Generic mfg., clozapine / Generic mfg.
    Preclinical, Journal:  Dexmedetomidine Promotes NREM Sleep by Depressing Oxytocin Neurons in the Paraventricular Nucleus in Mice. (Pubmed Central) -  Sep 1, 2024   
    Electrophysiological results showed that DEX decreased the frequency of action potential (AP) and the spontaneous excitatory postsynaptic current (sEPSC) of PVNOXT neurons through ?2-adrenoceptors. Therefore, these results identify that DEX promotes sleep and maintains sleep homeostasis by inhibiting PVNOXT neurons through the ?2-adrenoceptor.
  • ||||||||||  aripiprazole / Generic mfg.
    Journal:  Covid-19 psychological distress: analysis of antipsychotic drugs' use in an Italian population sample. (Pubmed Central) -  Sep 1, 2024   
    The difficulty in accessing care and medical appointments has probably influenced this data, masking the therapeutic needs of citizens. It will be necessary to assess in the coming years, as normal clinical activity resumes, whether there will be a growing consumption of these medications, which represent one of the main expenditure categories for the National Healthcare System.
  • ||||||||||  lurasidone / Generic mfg.
    Journal:  Unremitting Nausea Due to Lurasidone After Semaglutide Initiation. (Pubmed Central) -  Sep 1, 2024   
    It will be necessary to assess in the coming years, as normal clinical activity resumes, whether there will be a growing consumption of these medications, which represent one of the main expenditure categories for the National Healthcare System. No abstract available
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Changes in chemical characteristics and toxicity of fluoxetine and humic acid during chlorination. (Pubmed Central) -  Sep 1, 2024   
    Further, a combination of chemical analyses and toxicity tests revealed that the FLX?+?HA solution with chlorination conditions of 3?mg/L for 30?min had lower chemical and toxic effects in this experiment. This study provides valuable scientific insights for the safe discharge of chlorinated water containing FLX and dissolved organic matter, as well as guidance for optimizing chlorination parameters in wastewater treatment.
  • ||||||||||  sertraline / Generic mfg.
    Journal:  Sertraline treatment for paroxysmal nonkinesigenic dyskinesia comorbid with anxiety and depression. (Pubmed Central) -  Sep 1, 2024   
    The patient's attacks decreased from two times per week to once every two months, and his State-Trait Anxiety Inventory score decreased by 5-10 points on treatment with clonazepam and sertraline, allowing his condition to become stable enough that he was able to participate in society. Drug therapy with clonazepam and sertraline is the preferred treatment for reducing attacks in PNKD patients with strong anxiety and depression.
  • ||||||||||  pregabalin / Generic mfg., sertraline / Generic mfg.
    Journal:  Comparison Between Pregabalin and Sertraline in the Treatment of Uremic Pruritus in Patients With Maintenance Hemodialysis. (Pubmed Central) -  Sep 1, 2024   
    Conclusion This research concluded that both pregabalin and sertraline significantly improved itching intensity in each treatment group; however, there was no significant difference between the two drugs in reducing UP based on the 5D itching scores. In each domain of the 5D pruritus scale, a significant difference was found in post-follow-up pregabalin and sertraline therapy.
  • ||||||||||  citalopram / Generic mfg., ciprofloxacin oral / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Impact of seawater temperature and physical-chemical properties on sorption of pharmaceuticals, stimulants, and biocides to marine particles. (Pubmed Central) -  Aug 31, 2024   
    The sorption mechanisms between select pharmaceuticals and stimulants and kaolin was assessed through exploring adsorption kinetics (caffeine, ciprofloxacin, citalopram, fluoxetine, and oxolinic acid) and isotherms (ciprofloxacin, citalopram, and fluoxetine). Temperature was shown to have a significant impact on partitioning, and the impact was more pronounced closer to maximum sorption capacity for the individual compounds.
  • ||||||||||  escitalopram / Generic mfg.
    Journal:  Effect of meditation or escitalopram on work performance in patients with anxiety disorders. (Pubmed Central) -  Aug 31, 2024   
    P4
    Our study finds evidence that MBSR improves work performance equivalently to SSRI medication among individuals with anxiety disorders. Given the limitations of SSRIs, MBSR should be considered as an alternative to individuals who desire improved anxiety symptoms and work outcomes.
  • ||||||||||  Doria (risperidone extended release) / ROVI Pharmaceuticals Laboratories
    PK/PD data, Journal:  Development of a population pharmacokinetic model for the novel long-acting injectable antipsychotic risperidone ISM (Pubmed Central) -  Aug 31, 2024   
    Dosage adjustment need was estimated for 10.2% of venlafaxine, 10.0% of paroxetine, 6.4% of sertraline, 30.8% of citalopram, 52.1% of escitalopram, 18.2% of fluvoxamine, 54.1% of tricyclic antidepressants, 16.7% of zuclopenthixol, 10.6% of haloperidol The population PK model adequately described active moiety concentrations from five clinical studies after risperidone ISM
  • ||||||||||  cisplatin / Generic mfg.
    Enrollment closed:  Cisplatin Disposition and Kidney Injury (clinicaltrials.gov) -  Aug 30, 2024   
    P3,  N=72, Active, not recruiting, 
    N=150 --> 0 | Not yet recruiting --> Withdrawn Recruiting --> Active, not recruiting
  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka
    New P4 trial:  Precision Care for Major Depressive Disorder (clinicaltrials.gov) -  Aug 30, 2024   
    P4,  N=150, Not yet recruiting,