Serotonin 

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  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal, Surgery:  Granulosis rubra nasi from plastic surgery perspective. (Pubmed Central) -  Sep 9, 2024   
    The case was successfully managed with Botox injections, though we suggested our theory of undercutting the glands through aggressive defatting as part of open rhinoplasty to the patient; he declined our suggested modality. It remains an untested option and caution should be exercised in high-risk patients to avoid compromising blood supply to the skin and risking skin necrosis.
  • ||||||||||  rizatriptan / Generic mfg., eletriptan / Generic mfg., zolmitriptan / Generic mfg.
    Retrospective data, Journal:  Triptan non-response in a London tertiary headache centre: What can we learn? A retrospective study. (Pubmed Central) -  Sep 9, 2024   
    Our findings highlight an alarming prevalence of triptan non-response among adult migraineurs receiving treatment in a London-based tertiary headache service. It is imperative for clinicians to explore methods to optimize acute medication efficacy, whether this comprises changing to a triptan with a superior response rate, advocating for early intervention or considering alternative acute medication classes, such as gepants or ditans.
  • ||||||||||  venlafaxine / Generic mfg., fluoxetine / Generic mfg.
    Retrospective data, Journal:  Partial Residual Plots as an Integrated Model Diagnostic Tool in Model-Based Meta-Analysis. (Pubmed Central) -  Sep 9, 2024   
    Normalizing observed data addressed this, providing a "like-to-like" comparison with model predictions in PRP when assessing the effect of one covariate (dose) after normalizing for other covariates/effects (placebo response and mean baseline). PRPs provide a robust integrated diagnostic tool in MBMA that uses all data to show the correlation between response and any covariate while controlling for other covariates included in the model.
  • ||||||||||  risperidone / Generic mfg.
    Biomarker, Journal, Machine learning:  Identification of Immune-Related Biomarkers of Schizophrenia in the Central Nervous System Using Bioinformatic Methods and Machine (Pubmed Central) -  Sep 7, 2024   
    Lastly, in a schizophrenia rat model, the EIF4A2 expression levels were reduced in the model rat brains in a brain-regional dependent manner, but can be reversed by risperidone. In conclusion, by using various bioinformatic and biological methods, this study found 17 immune-related signature genes and a hub gene of schizophrenia that might be potential diagnostic biomarkers and therapeutic targets of schizophrenia.
  • ||||||||||  Veozah (fezolinetant) / Astellas
    Journal:  Cooling the flames: Navigating menopausal vasomotor symptoms with nonhormone medications. (Pubmed Central) -  Sep 7, 2024   
    However, treatment of these symptoms is underutilized due to real and perceived drawbacks of therapy. Pharmacists are ideally suited to bridge this gap, but first it is important for pharmacists to be knowledgeable about and comfortable with the evidence supporting all treatment options.
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Rexulti (brexpiprazole) / Lundbeck, Otsuka, Caplyta (lumateperone) - Intra / Cellular Therapies
    Review, Journal:  Advances in Mood Disorder Pharmacotherapy: Evaluating New Antipsychotics and Mood Stabilizers for Bipolar Disorder and Schizophrenia. (Pubmed Central) -  Sep 7, 2024   
    The potential of new mood stabilizer candidates lumateperone and brexpiprazole is also presented...The results underscore the importance of ongoing and future research to better understand the action and efficacy of these mood stabilizers and their implications in the treatment of mood disorders, aiming to achieve euthymia and improve the quality of life of affected patients. In this article, we aim to review current drug treatments for the management of mood disorders, including bipolar disorder and schizophrenia.
  • ||||||||||  ketamine / Generic mfg., clozapine / Generic mfg.
    Biomarker, Journal:  Next-generation precision medicine for suicidality prevention. (Pubmed Central) -  Sep 7, 2024   
    Lastly, we compared that to machine learning approaches, to optimize predictive ability and identify key features. We propose that our findings and comprehensive approach can have transformative clinical utility.
  • ||||||||||  mirtazapine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Effect of Antidepressants on Non-Alcoholic Fatty Liver Disease and their Underlying Mechanism. (Pubmed Central) -  Sep 6, 2024   
    Furthermore, mirtazapine can cause steatosis in both AML-12 and MIHA cell lines and may promote the development of NAFLD through the TLR4/MyD88/NF-?B signaling pathway. This study lays a solid foundation for further research on depression and NAFLD and can contribute to the prevention and treatment of these two diseases.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  "The peace that I wanted, I got": Qualitative insights from patient experiences of SMART DAPPER interventions for major depression and traumatic stress disorders in Kenya. (Pubmed Central) -  Sep 5, 2024   
    P=N/A
    We report on patient experiences in a study using a Sequential, Multiple Assignment Randomized Trial (SMART) design to test first and second line non-specialist treatment using psychotherapy (Interpersonal Psychotherapy [IPT] or medication (fluoxetine [FLX]), integrated within public sector primary care in western Kenya...The findings demonstrate the potential of the SMART DAPPER intervention for depression and trauma-related disorder treatments and underscore the challenges and barriers that must be addressed when scaling similar interventions. Trial registration: ClinicalTrials.gov identifier: NCT03466346.
  • ||||||||||  memantine / Generic mfg.
    Journal:  AMPA receptors in Alzheimer disease: Pathological changes and potential therapeutic targets. (Pubmed Central) -  Sep 5, 2024   
    However, the therapeutic potential of the NMDA receptor antagonist memantine in rescuing synaptic damage is limited...Understanding the impact of AMPA receptors on AD pathogenesis and exploring the potential for the development of AMPA receptor-targeting drugs are crucial. This review aims to consolidate recent research findings on AMPA receptors in AD, elucidate the current state of AMPA receptor research and lay the foundation for future basic research and drug development.
  • ||||||||||  venlafaxine / Generic mfg., gentamicin sulfate / Generic mfg.
    Clinical, Journal:  Efficacy of a Serotonin-Norepinephrine Reuptake Inhibitor as a Treatment for Meniere Disease: A Randomized Clinical Trial. (Pubmed Central) -  Sep 5, 2024   
    P2/3
    To determine the efficacy of a serotonin-norepinephrine reuptake inhibitor, venlafaxine, compared to placebo in treating patients with Meniere disease...Participants were eligible if they were 18 years or older, had definite Meniere disease criteria as defined by Barany criteria, had at least 2 episodes in the last month, had not received intratympanic gentamycin, skull base surgery, or radiation therapy to the head or neck, not currently taking diuretics for Meniere disease, not currently taking oral steroids, and not currently taking serotonin-modulating medication...Future studies may benefit from different dosing regimens, larger cohorts, and longer lengths of therapy. ClinicalTrials.gov Identifier: NCT04218123.
  • ||||||||||  quetiapine / Generic mfg.
    Journal:  Quetiapine-induced urinary retention. (Pubmed Central) -  Sep 5, 2024   
    Normal urinary function returned three days after the last dose of quetiapine 25 mg. This case report shows that patients with a low BMI may be more receptive of the anticholinergic effects of quetiapine.
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie
    Journal:  Cariprazine and clozapine combination for the treatment of psychosis in a young, female patient with schizophrenia: a case report. (Pubmed Central) -  Sep 5, 2024   
    The efficacy of cariprazine, which affects D3 receptors as a D3/D2 receptor partial agonist, has been extensively studied and is one of the first medication choices by practicing psychiatrists when treating patients with negative symptomatology. In this clinical case, we demonstrate the effective and safe treatment of a patient's positive and affective symptoms using a combination of cariprazine, clozapine, and venlafaxine.
  • ||||||||||  trazodone ER / Generic mfg.
    Retrospective data, Review, Journal:  Effects of Trazodone on Sleep: A Systematic Review and Meta-analysis. (Pubmed Central) -  Sep 5, 2024   
    Trazodone is associated with adverse effects, necessitating a careful risk-benefit assessment. Limited data restrict generalizability, underscoring the need for more research.
  • ||||||||||  olanzapine / Generic mfg.
    Journal:  In situ-gelling hydrophobized starch nanoparticle-based nanoparticle network hydrogels for the effective delivery of intranasal olanzapine to treat brain disorders. (Pubmed Central) -  Sep 5, 2024   
    The hydrogel shows high in vitro cytocompatibility in mouse striatal neuron and human primary nasal cell lines and in vivo efficacy in an amphetamine-induced pre-clinical rat schizophrenia model, with IN-delivered NNH hydrogels maintaining successful attenuation of locomotor activity for up to 4?h while all other tested treatments (drug-only IN or conventional intraperitoneal delivery) failed to attenuate at any time point past 0.5?h. As such, in situ-gelling NNHs represent a safe excipient for the IN delivery of hydrophobic drugs directly to the brain using customized SNPs that exhibit high penetration and drug complexing properties to maximize effective drug delivery.
  • ||||||||||  aripiprazole / Generic mfg., chlorpromazine / Generic mfg., haloperidol / Generic mfg.
    Journal:  Recent Advances in representative small-molecule DRD2 inhibitors: Synthetic Routes and clinical applications. (Pubmed Central) -  Sep 5, 2024   
    Additionally, newer classes of inhibitors, such as aripiprazole, exhibit partial agonist activity at DRD2, offering a unique therapeutic profile...Advances in the development of second-generation antipsychotics aim to balance efficacy with a better side effect profile by targeting additional neurotransmitter receptors. This review aims to deliver an overview of the synthesis and clinical applications of representative small-molecule DRD2 inhibitors across various clinical phases, thereby offering strategic insights for the advancement of DRD2 inhibitor development.
  • ||||||||||  memantine / Generic mfg.
    Preclinical, Journal:  Liposomal Formulations of Anti-Alzheimer Drugs and siRNA for Nose-to-Brain Delivery: Design, Safety and Efficacy In Vitro. (Pubmed Central) -  Sep 4, 2024   
    The current study aims to prepare, characterize, and evaluate in vitro liposomal forms of donepezil, memantine, BACE-1 siRNA, and their combination for possible treatment of AD via NtB delivery...The Calu-3 Transwell model was used as an in vitro system for mimicking the anatomical and physiological conditions of the nasal epithelium and studying the suitability of the proposed formulations for possible NtB delivery. The investigation results show that liposomes provided the effective intracellular delivery of therapeutics, the potential to overcome tight junctions in BBB, reduced beta-amyloid plaque accumulation and pro-inflammatory cytokine expression, supporting the therapeutic potential of our approach.