Serotonin 

 448 Products   448 Products   1070 Diseases   113911 News 


12345678910111213...11171118»
  • ||||||||||  clozapine / Generic mfg.
    Trial primary completion date:  Clozapine CHAMPION-ECHO Educational Study to Improve Clozapine Use. (clinicaltrials.gov) -  Oct 4, 2024   
    P=N/A,  N=300, Active, not recruiting, 
    Trial primary completion date: Aug 2024 --> Apr 2025 Trial primary completion date: Jun 2024 --> Jan 2024
  • ||||||||||  Clinical, Review, Journal:  Preventive drug treatments for adults with chronic migraine: a systematic review with economic modelling. (Pubmed Central) -  Oct 4, 2024   
    The adverse events review included 40 randomised controlled trials with 25,891 participants; 3 additional drugs, amitriptyline, atogepant and rimegepant, were included...Consensus was reached on the top three recommendations for future research on medications to prevent chronic migraine: (1) calcitonin gene-related peptide monoclonal antibodies and Botox versus calcitonin gene-related peptide monoclonal antibodies, (2) candesartan versus placebo and (3) flunarizine versus placebo...63. See the NIHR Funding and Awards website for further award information.
  • ||||||||||  Biomarker, Journal, Real-world evidence, Real-world:  Value of Pharmacogenetic Testing Assessed with Real-World Drug Utilization and Genotype Data. (Pubmed Central) -  Oct 4, 2024   
    In a 2-year follow-up, 60.4% of the patients in the nationwide cohort purchased at least one pharmacogenetically actionable drug, most commonly ibuprofen (25.0%) and codeine (19.4%)...The cost-benefit model included frequently dispensed drugs in the university hospital cohort, comprising ondansetron (19.4%), simvastatin (7.4%), clopidogrel (5.0%), warfarin (5.1%), (es)citalopram (5.3%), and azathioprine (0.5%). For untargeted pre-emptive pharmacogenetic testing of all university hospital patients, the model indicated saving
  • ||||||||||  gabapentin / Generic mfg., nortriptyline / Generic mfg.
    Review, Journal:  8. Herpes zoster and post herpetic neuralgia. (Pubmed Central) -  Oct 4, 2024   
    Besides the conventional treatment for PHN, interventional management is considered a new treatment option. PRF of DRG seems to be the most promising interventional management.
  • ||||||||||  risperidone / Generic mfg., sertraline / Generic mfg.
    Journal:  Delusional Parasitosis in Comorbidity With Shared Paranoid Disorder in a Marriage. (Pubmed Central) -  Oct 4, 2024   
    The wife was asked to sleep in a separate room, and she reported that the sensory hallucinations disappeared as soon as she slept in a different room. We conclude that the pharmacological approach, the intervention in the family life, and the gradual reintegration of marital habits once the patient improves are crucial in the therapy of delusional disorder.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Long-term Outcomes of Periurethral Sphincter Botulinum Toxin in Female Chronic Urinary Retention. (Pubmed Central) -  Oct 4, 2024   
    In addition, clinicians may want to consider changing the type of treatment early on for these patients, rather than encouraging them to persist with their current medication. Sphincter botulinum toxin through the periurethral approach is safe and effective following repeat injections, and offers a low-cost, minimally invasive alternative to managing female chronic urinary retention due to Fowler syndrome, particularly when there was a high baseline MUCP.
  • ||||||||||  clozapine / Generic mfg.
    Journal:  Dentate gyrus is needed for memory retrieval. (Pubmed Central) -  Oct 3, 2024   
    One study used Designer Receptors Exclusively Activated by Designer Drugs (DREADD)-mediated clozapine N-oxide (CNO)-induced hyperpolarization and reported that the previously formed memory was erased, thus concluding that denate gyrus is needed for memory maintenance...Our work shows that the DG output is required for memory retrieval. Based on previous and recent findings, we propose that the actively functional anterograde and retrograde neuronal signaling is necessary to preserve synaptic memory engrams along the entorhinal cortex to the hippocampal trisynaptic circuit.
  • ||||||||||  citalopram / Generic mfg., imipramine / Generic mfg.
    Journal:  Norharmane potentiated anxiolytic- and antidepressant-like responses induced by imipramine and citalopram: an isobologram analysis. (Pubmed Central) -  Oct 3, 2024   
    When citalopram and norharmane were coinjected, norharmane augmented the anxiolytic- and antidepressant-like effects induced by citalopram by increasing %OAT and reducing immobility time. These results indicated additive anxiolytic- and antidepressant-like effects between norharmane and antidepressant drugs such as imipramine and citalopram on the modulation of anxiety and depression processes in mice.
  • ||||||||||  olanzapine / Generic mfg.
    Journal, Adverse events:  Black Hairy Tongue: A Rare Adverse Effect of Olanzapine. (Pubmed Central) -  Oct 3, 2024   
    These results indicated additive anxiolytic- and antidepressant-like effects between norharmane and antidepressant drugs such as imipramine and citalopram on the modulation of anxiety and depression processes in mice. No abstract available
  • ||||||||||  quetiapine / Generic mfg.
    PK/PD data, Journal:  Pharmacokinetic interaction of quetiapine and lamotrigine - victim and perpetrator? (Pubmed Central) -  Oct 3, 2024   
    The combination of quetiapine IR with lamotrigine is associated with significantly lower drug concentrations of quetiapine, potentially impacting quetiapine effectiveness. For quetiapine ER, a significant interaction is less likely.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Botulinum Toxin for the Treatment of Postmenopausal Craniofacial Hyperhidrosis. (Pubmed Central) -  Oct 3, 2024   
    The patient was successfully treated with 100 units of onabotulinum toxin A along the forehead, frontal hairline, and periauricular scalp and reported significant improvement in symptoms and quality of life as a result. We review the literature describing targeted intradermal injection of botulinum neurotoxin as an alternative to medical therapy for craniofacial hyperhidrosis.
  • ||||||||||  clozapine / Generic mfg.
    Journal:  Clozapine monitoring requirements: is it time for an update? (Pubmed Central) -  Oct 3, 2024   
    Their research suggests that stringent monitoring may unnecessarily limit access to clozapine, a crucial treatment for resistant schizophrenia. The editorial supports calls for international consensus to carefully weigh the pros and cons of relaxing monitoring guidelines while ensuring comprehensive care for patients.
  • ||||||||||  sildenafil / Generic mfg.
    Journal, Machine learning:  Harnessing machine learning for efficient large-scale interatomic potential for sildenafil and pharmaceuticals containing H, C, N, O, and S. (Pubmed Central) -  Oct 3, 2024   
    Specifically, the study focuses on the application of Allegro, a novel machine learning algorithm, running on high-performance GPUs for training potentials...To assess the efficacy of the approach, the sildenafil citrate, iso-sildenafil, aspirin, ibuprofen, mebendazole and urea, representing all five relevant elements, serve as the test bed...Visualization of the results confirms the scientific accuracy of each structure's relaxation. The findings of this study demonstrate strong scaling and the potential for applications in pharmaceutical research, allowing the exploration of larger molecular structures not previously amenable to computational analysis at this level of accuracy The success of the machine learning approach underscores its potential to revolutionize computational solid-state physics.
  • ||||||||||  amitriptyline / Generic mfg.
    Preclinical, Journal:  Amitriptyline protects afferent synapses in the cochlea against excitotoxic trauma in vitro. (Pubmed Central) -  Oct 3, 2024   
    Furthermore, we found that the protective effects of amitriptyline are likely mediated by suppressing apoptosis factors that were upregulated during excitotoxic trauma. In conclusion, our results suggest that amitriptyline could protect afferent synapses in the cochlea from NICS, making it a potential drug candidate for hearing protection.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda, Viibryd (vilazodone) / AbbVie
    Review, Journal:  A Proposed Algorithm for the Pharmacological Treatment of Generalized Anxiety Disorder in the Older Patient. (Pubmed Central) -  Oct 3, 2024   
    Acknowledging that the median age of onset of GAD is in early adulthood, many patients with GAD will have been started on benzodiazepines (or other medications that require caution in the elderly) for GAD at a younger age. These medications may be continued with regular observation to see if the potential harms are starting to exceed the benefits and a switch to other recommended agents may be justified.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda
    Clinical, Journal:  Impact of Elevated Body Mass Index (BMI) on Cognitive Functioning and Inflammation in Persons with Post-COVID-19 Condition: A Secondary Analysis. (Pubmed Central) -  Oct 2, 2024   
    Genetic variations in ERBB4 and TACR1 might contribute to experienced dryness of mouth among patients treated with clozapine. We observed a significant negative correlation between BMI and cognitive functioning, and a significant positive correlation between BMI and inflammation in persons with PCC, suggesting a bidirectional interplay between BMI, PCC, and cognitive function; individuals with an elevated BMI may be at a greater risk of developing PCC and/or presenting with greater cognitive deficits mediated by chronic systemic inflammation.
  • ||||||||||  ketamine / Generic mfg.
    Review, Journal:  The Pharmacological Management of Ketamine Use Disorder: A Systematic Review. (Pubmed Central) -  Oct 2, 2024   
    There is a paucity of research into pharmacological management of ketamine use disorder. The limited very low-quality evidence suggests benzodiazepine regimens may be most salient for future exploration in management of ketamine intoxication and withdrawal, whereas case reports suggest naltrexone, lamotrigine, and paliperidone palmitate plus bupropion may potentially merit further investigation with regard to craving/relapse prevention.
  • ||||||||||  clozapine / Generic mfg.
    Journal:  Psychiatrists' views on clozapine prescribing in Ireland. (Pubmed Central) -  Oct 2, 2024   
    Tertiary service or clinical advice service would assist in clozapine rechallenge cases or in managing significant adverse events. More structured patient education regarding clozapine effectiveness and professional development programmes focused on managing side effects and rechallenge may promote clozapine use.
  • ||||||||||  clozapine / Generic mfg.
    Journal:  Mortality associated with clozapine: what is the evidence? (Pubmed Central) -  Oct 2, 2024   
    Clozapine actually lowers mortality, partly by reducing schizophrenia-related suicides, but preventable deaths still occur. Clozapine should be used earlier and more widely, but there should be better monitoring and better management of toxicity.
  • ||||||||||  The Disease of 1000 Faces: A Case Report of Multisystem Progression of Systemic Lupus Erythematosus (Poster Hall: Hyatt Regency Orlando, Plaza International Ballroom) -  Oct 2, 2024 - Abstract #AAPNCE2024AAP_NCE_681;    
    SLE can present as a diagnostic challenge, with pediatric patients often exhibiting a more acute and severe presentation... This case highlights the swift disease progression and the need for close management of pediatric SLE patients guided by a multidisciplinary approach to care.
  • ||||||||||  rizatriptan / Generic mfg.
    Migrainosus Misadventure, A Crisis in Disguise (Poster Hall: Hyatt Regency Orlando, Plaza International Ballroom) -  Oct 2, 2024 - Abstract #AAPNCE2024AAP_NCE_658;    
    We present this case to identify a unique and early pediatric presentation of Polyglandular Autoimmune Syndrome. While headache is a common presenting complaint for pediatric healthcare encounters, normal imaging, lack of symptomatic relief with routine abortive medications, systemic symptoms, and persistent electrolyte changes should prompt pediatric providers to broaden their differential to include adrenal and endocrine pathologies.
  • ||||||||||  Calcium channel and beta blocker intoxication: A management challenge in an overmedicated psychiatric patient. (Poster Hall: Hyatt Regency Orlando, Plaza International Ballroom) -  Oct 2, 2024 - Abstract #AAPNCE2024AAP_NCE_483;    
    This case emphasizes the intricate interplay between pharmacotherapy for mental illness and acute medical complications in adolescents following suicide attempts. Mental health providers must inform parents/guardians about the risks and benefits of multiple pharmacotherapy approaches for common adolescent mental illnesses like MDD and GAD.