Activated protein C receptor mod 
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7 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
SerpinPC (APC-specific serpin) / Centessa
PRESent-6, NCT06568302: The Long-term Safety and Efficacy of SerpinPC in Subjects with Hemophilia Who Completed a Sponsored SerpinPC Clinical Trial

Recruiting
3
150
Europe, Canada, US, RoW
SerpinPC, Activated Protein C (APC) inhibitor
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B, Hemophilia a with Inhibitor, Hemophilia B with Inhibitor
11/28
11/28
PRESent-3, NCT05789537: A Study of SerpinPC in Participants with Hemophilia B (HemB) with Inhibitors

Recruiting
2
12
Europe, US, RoW
SerpinPC, Activated Protein C (APC) inhibitor
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia B with Inhibitor, Hemophilia B
09/25
10/25
PRESent-2, NCT05789524: The Efficacy and Safety of SerpinPC in Participants With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B

Recruiting
2
120
Europe, Canada, US, RoW
SerpinPC, Activated Protein C (APC) inhibitor
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia A, Hemophilia B
03/26
06/26
NCT04073498: The Safety and Tolerability of SerpinPC in Healthy Men and in Men With Severe Blood Disorders (Haemophilia A and B)

Active, not recruiting
1/2
39
Europe, RoW
SerpinPC, Placebo
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia A, Hemophilia B
10/24
10/24
PRESent-5, NCT05605678: Hemophilia Non-Interventional Study Prior to SerpinPC Intervention

Recruiting
N/A
200
Europe, Canada, US, RoW
No Intervention
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia A, Hemophilia B
11/24
11/24
3K3A-APC / ZZ Biotech
RHAPSODY-2, NCT05484154: Efficacy and Safety Evaluation of 3K3A-APC in Ischemic Stroke

Withdrawn
3
1400
NA
3K3A-APC, 3K3A-Activated Protein C, Placebo, Matching Placebo
ZZ Biotech, LLC, National Institute of Neurological Disorders and Stroke (NINDS), University of Southern California, University of Cincinnati, University of South Carolina
Ischemic Stroke
07/26
10/26
ACTRN12621000864820: 3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS)

Completed
2
16
 
Macquarie University, Macquarie University
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
 
 

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