| tizanidine / Generic mfg. |
ChiCTR2000039318: Comparison of diclofenac with tramadol, tizanidine or placebo in the treatment of acute low back pain: multi-centre randomised controlled trial |
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| Recruiting | 4 | 369 | | encapsulated tramadol plus encapsulated tizanidine like placebo ;encapsulated tizanidine plus encapsulated tramadol like placebo ;encapsulated tramadol like placebo plus encapsulated tizanidine like placebo | Food and Health Bureau, Hong Kong SAR Government; Level of the institution：, Health and Medical Research Fund | adults aged from 18-65 with acute non-specific low back pain | | | | |
ChiCTR2000040075: Clinical study on prophylactic treatment of migraine with tizanidine |
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| Not yet recruiting | 4 | 150 | | placebo tid ;Tizanidine 1mg tid ;Tizanidine 2mg tid | West China Hospital, Sichuan University; West China Hospital, Sichuan University, 2020JDJQ0018 | Migraine | | | | |
NCT05488847: Opioid-Free Pain Protocol After Shoulder Arthroplasty |
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| Active, not recruiting | 4 | 80 | US | Celecoxib, Celebrex, Pregabalin, Lyrica, Tramadol, Ultram, Dexamethasone, Decadron, Acetaminophen, tylenol, Ropivicaine, naropin, Epinephrine, Ketorolac, Tizanidine, Zanaflex, Magnesium, magnesium oxide, Ibuprofen, Motrin, Oxycodone Hydrochloride 5 Mg, Roxicodone | Henry Ford Health System | Shoulder Arthropathy, Shoulder Pain | 12/24 | 09/26 | | |
ChiCTR2300068058: Effect of drug metabolizing enzyme gene on drug metabolism in migraineurs treated with Tizanidine |
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| Not yet recruiting | 4 | 150 | | Tizanidine hydrochloride tablets(1mg，TID) ;Tizanidine hydrochloride tablets (1mg in the morning and at noon, 2mg in the evening) ;Tizanidine hydrochloride tablets(2mg，TID) | West China Hospital, Sichuan University; West China Hospital, Sichuan University, Major neuropsychiatric diseases - new target for the prevention and treatment of epilepsy (2020JDJQ0018) | migraine | | | | |
NCT06382662: Assess the Effect of Metaxalone 640 mg (M640) Compared to Tizanidine 8 mg on Truck Driving Ability and Cognition |
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| Recruiting | 4 | 20 | US | metaxalone m640, Metaxalone 640, tizanidine, Zanaflex | Primus Pharmaceuticals, Sun Valley Arthritis Center | Cognitive Impairment | 04/25 | 04/25 | | |
NCT06303076: Tizanidine vs. Zolpidem in Primary Insomnia: A Randomized Trial |
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| Not yet recruiting | 4 | 90 | NA | Tizanidine Hcl 4Mg Tab, Zolpidem Tartrate 10 mg | Sultan Qaboos University | Depressive Disorder, Major | 09/26 | 12/26 | | |
ChiCTR2400091102: Effects and safety of Tizanidine in reducing knee pain after total knee arthroplasty. A randomized, double-blind, controlled study |
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| Not yet recruiting | 4 | 120 | | Oral placebo, 2mg tid, was taken on the first day after surgery for 14 days; Oral tizanidine hydrochloride tablets, 2mg tid, were taken on the first day after surgery for 14 days | West China Hospital, Sichuan University; West China Hospital, Sichuan University | knee osteoarthritis | | | | |
ChiCTR2300072407: Safety and efficacy of oral tizanidine hydrochloride in preventing migraine attacks in adults with migraine |
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| Recruiting | 4 | 189 | | Tizanidine hydrochloride 1mg tid, 1mg/ tablet ;Tizanidine hydrochloride 2mg tid, 2mg/ tablet ;Placebo 1 tablet tid | The Second Affiliated Hospital of Zhejiang University School of Medicine; The Second Affiliated Hospital of Zhejiang University School of Medicine, Sichuan Keride Pharmaceutical Co., LTD | migraine | | | | |
NCT05484349: TIzanidine for the Preventive Treatment of Episodic MigrainE （TIME） |
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| Recruiting | 3 | 189 | RoW | Tizanidine Hydrochloride, Tizanidine Hydrochloride Placebo | Second Affiliated Hospital, School of Medicine, Zhejiang University, SICHUAN CREDIT PHARMACEUTICAL CO., LTD. | Migraine Without Aura, Migraine With Aura | 12/25 | 12/25 | | |
NCT06258785: Effect of Tizanidine on Postoperative Urinary Retention After Sacrospinous Suspension |
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| Recruiting | 3 | 30 | US | Tizanidine, Zanaflex | Endeavor Health | Postoperative Urinary Retention, Sacrospinous Vaginal Vault Suspension, Reconstructive Pelvic Surgery | 05/25 | 06/25 | | |
NCT06027099: CARES-Spine (Comprehensive Analgesic, Recovery, and Education Support for Spine Surgery) Trial |
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| Not yet recruiting | 3 | 375 | NA | Tizanidine, MI-Opioid Taper, Placebo, Enhanced Usual Care | Stanford University | Chronic Pain, Back Pain, Neck Pain, Opioid Misuse | 01/28 | 07/28 | | |
2015-003770-32: A Randomized, Double-Blind, Four Treatment, Four period, Crossover Study, with Placebo, Tizanidine Immediate Release and Diphenhydramine to Study the Effect of Tizanidine Extended Release on Simulated Driving Performance, Cognitive, and Psychomotor Functioning |
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| Ongoing | 2 | 24 | Europe | Tizanidine Extended Release Tablets 12 mg, Zanaflex Tablets 4 mg, GALPHARM ONE A NIGHT NIGHTCALM 50MG TABLETS (Diphenhydramine Hydrochloride), Zanaflex Tablets, GALPHARM ONE A NIGHT NIGHTCALM 50MG TABLETS, Zanaflex Tablets, GALPHARM ONE A NIGHT NIGHTCALM 50MG TABLETS | Sun Pharma Advanced Research Company, Sun Pharma Advanced Research Company | healthy volunteers (acute musculoskeletal pain) | | | | |
NCT04429347: Gabapentin and Tizanidine for Insomnia in Chronic Pain |
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| Completed | 2 | 9 | US | Gabapentin, Neurontin, Placebo, Sham, Sugar Pill, Tizanidine, Zanaflex | University of California, San Diego, National Center for Advancing Translational Sciences (NCATS) | Insomnia Due to Medical Condition, Chronic Pain | 12/24 | 12/24 | | |
ACTRN12624001134516: Comparative, Multiple-Dose, Fixed Sequence, Pharmacokinetic Study of 2 Sizes of Daily MRX-4TZT TDS (Tizanidine Transdermal Delivery System) Applied for 3 Days and 2 Dose Levels of Oral Tizanidine in Healthy Adult Subjects |
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| Not yet recruiting | 1 | 24 | | | MEDRx Australia Pty Ltd , MEDRx Australia Pty Ltd | Spasticity | | | | |
NCT06274021: Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury |
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| Recruiting | 1 | 16 | US | Transcutaneous spinal stimulation at 100 Hz, Transcutaneous spinal stimulation at 50 Hz, Transcutaneous spinal stimulation at 50 Hz and single dose of baclofen, Transcutaneous spinal stimulation at 50 Hz and single dose of tizanidine, Sham transcutaneous spinal stimulation | University of Mississippi Medical Center, Methodist Rehabilitation Center, The Craig H. Neilsen Foundation | Spinal Cord Injuries, Spinal Cord Injury, Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic | 12/25 | 12/25 | | |
| Recruiting | 1 | 64 | US | Tizanidine, Zanaflex®, Placebo | Northwestern University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Stroke | 06/29 | 07/29 | | |
NCT05789173: Interaction of CYP2B6 Genotype and Efavirenz with Methadone and Tizanidine PK |
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| Recruiting | 1 | 60 | US | Methadone and Tizanidine, Efavirenz, Methadone and Tizanidine | Indiana University, National Institute of General Medical Sciences (NIGMS) | Drug-Drug Interaction | 04/26 | 04/26 | | |
NCT05852093: Clinical Study on the Effect of Tizanidine on the Function and Pain of Patients After Shoulder Arthroscopy |
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| Not yet recruiting | 1 | 100 | NA | Celecoxib+Buprenorphine Transdermal Patch, Celecoxib+Buprenorphine Transdermal Patch+Tizanidine | Second Affiliated Hospital, School of Medicine, Zhejiang University | Rotator Cuff Tears | 06/26 | 06/27 | | |
NCT04574791: Addition of Muscle Relaxants in a Multimodal Analgesic Regimen for Analgesia After Primary Total Knee Arthroplasty |
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| Enrolling by invitation | N/A | 240 | US | TiZANidine 2 MG Oral Capsule | Rothman Institute Orthopaedics | Pain, Postoperative | 09/21 | 09/21 | | |
ChiCTR2000040107: Clinical study of tizanidine combined with intrathecal analgesic pump on cancer pain |
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| Not yet recruiting | N/A | 20 | | intrathecal analgesic pump ;tizanidine + intrathecal analgesic pump | Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University, Self-pay | cancer pain | | | | |
ChiCTR2000040108: Clinical study of tizanidine combined with pregabalin on post herpes neuralgia |
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| Not yet recruiting | N/A | 40 | | pregabalin ;tizanidine+pregabalin | Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University, Self-pay | post herpes neuralgia | | | | |
ChiCTR2300077964: An exploratory study of clinical efficacy of Tizanidine hydrochloride tablets combined with acreoxib tablets in improving knee osteoarthritis |
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| Not yet recruiting | N/A | 176 | | Tizanidine hydrochloride tablets combined with imrecoxib tablets; Oral imrecoxib tablets | West China Hospital of Sichuan University; West China Hospital of Sichuan University, Beijing Life Oasis public Service Center | knee osteoarthritis | | | | |
| dexmedetomidine / Generic mfg. |
ACTRN12621000547842p: The Dex-Jet Study.
Examining the effects of a sedative medication in healthy adult volunteers with a novel needle-free delivery device. |
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| Not yet recruiting | 4 | 10 | | | Anaesthetic Research Department, Anaesthetic research department- Waikato hospital, | Needle Phobia; Anxiety before an operation | | | | |
ACTRN12620001088932p: The effect of early sedation with dexmedetomidine compared with placebo on 90-day mortality in older critically ill patients |
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| Not yet recruiting | 4 | 3500 | | | Monash University , The Australian National Health and Medical Research Council (NHMRC) | Critically ill patients; Mechanical Ventilation; Sedation | | | | |
ACTRN12612000211864: A comparison of propofol and dexmedetomidine for sedation during hip and knee arthoplasty. |
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| Recruiting | 4 | 40 | | | Dr Mark Suss, Dr Mark Suss | Sedation during hip and knee arthroplasty, which is often associated with a need for airway support due to respiratory depression and reduced airway tone. | | | | |
ACTRN12612000700831: Role of oral ketamine and dexmedetomidine in adults burns dressing. A double blind randomised cross over study. |
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| Recruiting | 4 | 45 | | | Jawaharlal Nehru institute of Medical education and research | Burns | | | | |
ACTRN12612000892819: Dexmedetomidine pharmacodynamics and population pharmacokinetics in elderly intensive care unit (ICU) patients |
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| Recruiting | 4 | 60 | | | Noorjahan Haneem binti Md Hashim, University of Malaya | Intensive Care patients aged 65 and more | | | | |
ACTRN12612000964819: A comparison of dexmedetomidine combined with propofol for conscious sedation during endoscopic retrograde cholangiopancreatography(ERCP) |
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| Recruiting | 4 | 60 | | | Dr Qianbo Chen, Dr Qianbo Chen | Although target controlled infusion(TCI) systems decrease the risk of respiratory during sedation with propofol, the risk persists. | | | | |
ACTRN12612000581864: Comparative evaluation of isobaric ropivacaine (0.75%) with the adjuvants - clonidine and dexmedetomidine administered intrathecally in adult patients undergoing infra-umbilical surgeries |
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| Recruiting | 4 | 90 | | | safdarjung hospital, safdarjung hospital | intrathecal drugs | | | | |
| Recruiting | 4 | 500 | | | Hospital Complex of Navarra, Hospital Complex of Navarra | Postoperative analgesia for elective total knee arthroplasty | | | | |
ACTRN12621000557831: A randomised controlled trial of dexmedetomidine compared to placebo to reduce pain after spinal fusion surgery |
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| Recruiting | 4 | 128 | | | The Royal Melbourne Hospital, The Royal Melbourne Hospital | Pain, Spinal fusion surgery | | | | |
ACTRN12620001088932: The effect of early sedation with dexmedetomidine compared with placebo on 90-day mortality in older critically ill patients |
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| Recruiting | 4 | 3500 | | | Monash University , The Australian National Health and Medical Research Council (NHMRC) | Critically ill patients, Mechanical Ventilation, Sedation | | | | |
ACTRN12624000252516: Does melatonin after tonsillectomy enhance sleep and recovery in children (MATES)? |
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| Recruiting | 4 | 240 | | | Perth Children's Hospital, Perth Children's Hospital | Pain following tonsillectomy surgery | | | | |
ChiCTR-IPR-15007628: Effect of Intraoperative and Postoperative Infusion of Dexmedetomidine on Quality of Postoperative Analgesia and Recovery of Bowel Movements in Normal-weight or Overweight Patients Who are Middle-aged or Aged Undergoing Laparoscopic Nephrectomy. |
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| Recruiting | 4 | 90 | | normal saline ;low-dose dexmedetomidine ;high-dose dexmedetomidine | Department of Anesthesiology, Qilu Hospital of Shandong University; Qilu Hospital of Shandong University, Natural Science Foundation of China | Postoperative Analgesia and Recovery of Bowel Movements | | | | |
ChiCTR-ORC-11001592: A comparison of dexmedetomidine versus flurbiprofen for analgesic effect in thymusectomy patients |
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| Completed | 4 | 40 | | dexmedetomidine ;Flurbiprofen | urgical intensive care unit, The First Affiliated Hospital of Sun Yat-sen University University; Level of the institution：, research funding of SICU | myasthenic gravis with Thymusectomy | | | | |
ChiCTR-TRC-12002788: Postoperative outcomes of dexmedetomidine, propofol or Sevoflurane anesthesia in children with cyanotic complex congenital heart defect undergoing cardiac surgery |
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| Completed | 4 | 90 | | dexmedetomidine ;propofol ;Sevoflurane | First Affiliated Hospital of Anhui Medical University, Department of Anesthesiology; Level of the institution：, 2010 Anhui Provincial Health Department medical research focused Project (Number: 2010A011) | cyanotic congenital heart disease | | | | |
ChiCTR-PRC-12002903: Use of Dexmedetomidine for prophylactic analgesia and sedation in delayed extubation patients after craniotomy: a study protocol and statistical analysis plan for a randomized controlled trial |
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| Completed | 4 | 144 | | Dex group:Dexmedetomidine group patients received a continuous infusion of 0.6μg/kg/h(10ug/ml). ;Saline group:Placebo group patients received a maintenance infusion of 0.9% sodium chloride for injection at a volume and rate equal to that of dexmedetomidine. | ICU, Beijing Tiantan Hospital Affiliated to Capital Medical University; ICU, Beijing Tiantan Hospital Affiliated to Capital Medical University, The study was funded by Beijing Health Bureau (No: 2009-3-28) | delayed extubation patients after craniotomy | | | | |
ChiCTR-TRC-12002743: Dexmedetomidine for sedation of patients in the intensive care unit during intrahospital transports to diagnostic tests |
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| Completed | 4 | 340 | | Dexmedetomidine ;saline | The Second Affiliated Hospital of Harbin Medical University; Level of the institution：, Jiangsu Singch Pharmaceutical co.ltd | Critically disease | | | | |
ChiCTR-TRC-14004208: The effect of dexmedetomidine on laryngeal reflex during recovery in general anesthesia |
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| Completed | 4 | 120 | | dexmedetomidine of 1.0ug/kg+NS 20ml ;dexmedetomidine of 0.6ug/kg+NS 20ml ;dexmedetomidine of 0.3ug/kg+NS 20ml ;NS 20ml | Anesthesiology Department of Zhongshan Hospital Fudan University; Level of the institution：, Anesthesiology Department of Zhongshan Hospital, Fudan University | diseases that need short operations | | | | |
ChiCTR-TRC-14004815: Sevoflurane-sparing degree of dexmedetomidine in patients with gynecological laparoscopy |
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| Completed | 4 | 40 | | intravenously infuse the same amount of normal saline ;Intravenous infusion of dexmedetomidine 1.0 ug/kg by 10 min before anesthesia induction, followed by 0.4 ug/kg/h continuous infusion to the end of the surgery | Anhui Provincial Hospital; Level of the institution：, Self-raised | patients with gynecological laparoscopy | | | | |
ChiCTR-OCH-14004897: Effects of gender on median effective target plasma concentration of propofol inhibiting responses to laryngeal mask airway insertion when combined with dexmedetomidine |
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| Recruiting | 4 | 60 | | propofol+dexmedetomidine ;propofol+dexmedetomidine | Anhui Provincial Hospital; Anhui Provincial Hospital, Self-raised | patients undergoing elective surgeries | | | | |
ChiCTR-TRC-14005048: Dexmedetomidine as an analgesic adjuvant to paravertebral ropivacaine for post-thoracic surgery pain |
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| Recruiting | 4 | 120 | | 0.5% ropivacaine 16ml with DEX 1ug/kg ;0.5% ropivacaine 16ml with DEX 1.5ug/kg in Esophagus cancer/lung cancer surgery ;0.5% ropivacaine 16ml with DEX 1.5ug/kg in the Total knee/hip replacement surgery | Southern District of Anhui Provincial Hospital; Southern District of Anhui Provincial Hospital, Anhui Provincial Hospital | Esophagus cancer/lung cancer | | | | |
ChiCTR-IPR-15006101: Preventive effect of dexmedetomidine on postoperative delirium in elderly oral cancer patients and its impact on postoperative inflammatory cytokines, cortisol and melatonin |
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| Not yet recruiting | 4 | 120 | | Intravenous dexmedetomidine at a dose of 0.2ug/kg/h for 12 hours after operation ;NS | Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, self-funding | postoperative delirium | | | | |
ChiCTR-IIR-15007618: Effect of intraoperative infusion of dexmedetomidine on body temperature in laparoscopic nephrectomy normal-weight or overweight patients who are middle-aged or aged |
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| Recruiting | 4 | 90 | | normal saline ;low-dose dexmedetomidine ;high-dose dexmedetomidine | Qilu Hospital of Shandong University; Qilu Hospical of Shandong University, Natural Science Foundation of China | hypothermia | | | | |
ChiCTR1800015869: Hemotological Mechanisms underlying the Postoperative Analgesia-promoting effect of Dexmedetomidine on Opioids |
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| Recruiting | 4 | 60 | | general anesthesia ;intraoperative use of dexmedetomidine under general anesthesia | The Huai'an First People's Hospital; The Huai'an First People's Hospital, the pulic funding for the department of Anesthesiology | abdonial hysteretomy | | | | |
ChiCTR2000040629: Effect of dexmedetomidine on liver postoperative function following living donor hepatectomy |
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| Recruiting | 4 | 56 | | dexmedetomidine ;normal saline | Beijing Friendship Hospital, Capital Medical University; Beijing Friendship Hospital, Capital Medical University, Self-raised | Hepatic ischemia-reperfusion injury | | | | |
2007-000043-10: Combination of alpha2-adrenoreceptor agonists, opioids and ketamine for improving of perioperative course |
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| Ongoing | 4 | 360 | Europe | Precedex, Rapifen, Dolsin, FENTANYL-JANSSEN, Injection*, Precedex, Rapifen, Dolsin, Fentanyl | Fakultní nemocnice Královské Vinohrady | Praeanaesthetic preparation (premedication) for patients scheduled for laparoscopic cholecystectomy | | | | |
2009-011112-37: Dexmedetomidine versus midazolam til sedasjon av pediatriske intensivpasienter ved Oslo Universitetssykehus. |
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| Ongoing | 4 | 40 | Europe | Midazolam, Concentrate for solution for infusion, Injection*, Precedex 100micrograms/ml, Midazolam Hameln 1mg/ml solution for injection | Dept. of Anaesthesia, Oslo University Hospital, Ullevål | Paediatric patients requiring mecanical ventilation and sedation in PICU. | | | | |
| Completed | 4 | 120 | | the parturients received 20ml intravenous normal saline (NS) after delivery of the fetus, and whose postoperative PCA included sulfentanyl only ;the parturients received 0.5 μg/kg intravenous dexmedetomidine, and whose PCA protocol was the same as group 1 ;the parturients were treated in the same way as group II during operation and received intravenous dexmedetomidine after delivery of the fetus, and whose PCA included sulfentanyl+dexmedetomidine | Shanghai medical college of Fudan University; Shanghai medical college of Fudan University, Backbone Youth Fund of Shanghai medical college of Fudan University | obstetric analgesia | | | | |
ChiCTR-TRC-11001785: Caudal dexmedetomidine combined with bupivacaine inhibit response of hernial sac traction in children undergoing unilateral inguinal hernia repair |
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| Completed | 4 | 60 | | caudal block by 0.25%bupivacaine 1ml/kg ;caudal block by 0.25%bupivacaine 1ml/kg+ dexmedetomidine 1ug/kg | Wuhan medical care center for women and children; Wuhan medical care center for women and children, Scientific research foundation for Ph.D in Wuhan medical care center for women and children | Pediatric caudal block anesthesia | | | | |
ChiCTR-TRC-12001934: Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia in Patients Undergoing Thoracotomy During Anesthesia Recovery Period |
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| Completed | 4 | 60 | | Patients in this group received dexmedetomidine 0. ;Patients in this group received placebo | Department of Anaesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Self sponsored | Pain, Restlessness | | | | |
ChiCTR-TRC-10001610: Total Intravenous Anesthesia in gastrointestinal surgery combined with dexmedetomidine given values of the propofol TCI and the economical effect of intravenous anesthetics |
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| Completed | 4 | 90 | | Control group: (weight in kilograms * 1 / 8) normal saline intravenously in 15 minutes +10 mi / h normal saline until extubation ;Experimental group 1: intravenous infusion of 0.5ug/kg (weight) dexmedetomidine completed 15 minutes of scheduled +0.25 ug / kg / h constant intravenous infusion of dexmedetomidine given to extubation ;Group 2: intravenous infusion of 0.5ug/kg (weight) dexmedetomidine completed 15 minutes of scheduled +0.5 ug / kg / h constant intravenous infusion of dexmedetomidine given to extubation | Department of Anesthesiology, First Affiliated Hospital of Sun Yat-sen Univercity; Department of Anesthesiology, First Affiliated Hospital of Sun Yat-sen Univercity, self-funded | Gastrointestinal disease | | | | |
ChiCTR-TRC-11001530: A comparison of the mechanism and protective effects on liver and distant organs on patients with hepatic carcinoma and cirrhosis after hepatectomy with inflow occlusion among different anesthetics |
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| Completed | 4 | 120 | | propofol+NS, not inflow occlusion ;propofol+dexmedetomidine, inflow occlus ;propofol+dexmedetomidine, not inflow occlus ;sevoflurane, inflow occlus ;propofol+NS, inflow occlusion ;voflurane, not inflow occlus | The First Affiliated Hospital of Sun Yat-sen University; Guangdong Science and Technology Agency, Num171, Lianxin Road, Yuexiu District, Guangzhou, Guangdong Science and Technology Program | hepatic cirrhosis, hepatic carcinoma | | | | |
ChiCTR-TRC-11001714: effect of dexmedetomidine on tourniquet-induced hemodynamic and lung injury in patients undergoing total knee arthroplasty |
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| Completed | 4 | 80 | | infusion of dex 1ug/kg for 20minutes ;equal volume of saline for 20 minutes | Anesthesiology department of Shanghai Changzheng Hospital; Anesthesiology department of Shanghai Changzheng Hospital, self-financing | tourniquet-induced hemodynamic and lung injury | | | | |
ChiCTR-TRC-12002042: Comparison the perioperative effects of the intramuscular Dexmedetomidine and Midazolam Premedication for Suspension Laryngoscopy |
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| Completed | 4 | 30 | | intramuscular Dexmedetomidine before induction of anesthesia ;intramuscular Midazolam before induction of anesthesia | Dept. of Anesthesiology, Guangzhou No.1 People's Hospital; Guangzhou No.1 People's Hospital, Guangzhou No.1 People's Hospital | Vocal cord polyp | | | | |
ChiCTR-TRC-12002388: The clinical research of Dexmedetomidine-Ketamine Anesthesia on children with obstructive sleep apnea after uvulopalatopharyngoplasty |
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| Completed | 4 | 60 | | Anesthesia was maintained by Dexmedetomidine-Ketam ;Anesthesia was maintained by Sevoflurane-sufentanil | Shanghai Children's Medical Center; Shanghai Children's Medical Center, Key Project of Anhui Provincial Health Department medical research | obstructive sleep apnea | | | | |
ChiCTR-TRC-12002714: The Effect of Dexmedetomedine on plasma concentrations of Brain-Derived Neutrophic factor |
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| Completed | 4 | 40 | | Dexmedetomidine vs propofol | Xu JM; the Second XiangYa Hospital, Central South University, the research fund of Professor Xu JM | lumbar disc protrusion | | | | |
ChiCTR-ONC-12002601: The role of ADRA2A genetic variations in responses to selective agonist dexmedetomidine on patients undergoing epidural anesthesia in Han Chinese |
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| Completed | 4 | 113 | | dexmedetomidine | Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Level of the institution：, 2010 Clinical key Disciplines Construction Grant from the Ministry of Health, China | Sedation with dexmedetomidine for epidural anesthesia | | | | |
ChiCTR-TRC-12002766: Dexmedetomidine vs Midazolam for CT Sedation in ICU patients: a Randomized Controlled Trial |
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| Completed | 4 | 100 | | Dexmedetomidine Hydrochloride ;Midazolam | The Second Affiliated Hospital of Harbin Medical University; Level of the institution：, Jiangsu Singch Pharmaceutical co.ltd | Critically disease | | | | |
ChiCTR-PRC-12002426: Dexmedetomidine for the prevention of shivering during epidural anesthesia in children |
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| Completed | 4 | 60 | | Dexmedetomidine is intravenously administered before epidural aneaesthesia ;sanline is intravenously administered before epidural aneaesthesia | Department of Anaesthesiology Hospital 306 of the PLA Beijing City; 306th hospital, PLA, Clinical Use | shivering during epidural anesthesia | | | | |
ChiCTR-TRC-12002376: Effects of dexmedetomidine on performance of bispectral index as an indicator of loss of consciousness during propofol anesthesia |
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| Completed | 4 | 225 | | intravenously infuse saline ;intravenously infuse DEX 0.5 ug/kg ;intravenously infuse DEX 1.0 ug/kg | the First People's Hospital of Zhen Jiang; Level of the institution：, Department of Anesthesiology, the First People's Hospital of Zhenjiang | general anesthesia | | | | |
ChiCTR-TRC-12002750: Dexmedetomidine vs Midazolam for Sedation of ICU Patients during Intrahospital Transports to Diagnostic Tests: A Randomized Trial |
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| Completed | 4 | 660 | | Dexmedetomidine Hydrochloride ;Midazolam | The Second Affiliated Hospital of Harbin Medical University; Level of the institution：, Jiangsu Singch Pharmaceutical co.ltd | Critically disease | | | | |
2013-000122-60: The effect of dexmedetomidine in combination with local anaesthetics after application around nerves in the abdominal wall in pediatric patients. |
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| Ongoing | 4 | 40 | Europe | Dexmedetomidine, EU/1/11/718/001, Concentrate and solvent for solution for infusion, Dexdor | Karolinska University Hospital, Division of Pediatrics/Astrid Lindgren Children´s Hospital, Karolinska University Hospital, Astrid Lindgren Children´s Hospital | Pediatric patients receive ilioinguinal-iliohypogastric nerve blockade with 0.2ml/kg ropivacaine 0.197% and 0.3µg/kg dexmedetomidine or 0.2ml/kg ropivacaine 0.197% and saline as a placebo. Aim of the study is to investigate if dexmedetomidine as an adjuvant to local anaesthetics prolongs the duration of the block and furthermore reduces the postoperative pain therapy or at least delay the first application of analgetic drugs., Paediatric patients receive a special abdominal nerve block as a pain therapy for operations. Dexmedetomidine as an adjuvant to local anesthetics should prolong the blockade and reduce analgesia., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
ChiCTR-TRC-12002974: Effect of dexmedetomidine on elderly hip surgery patients postoperative delirium |
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| Completed | 4 | 60 | | dexmedetomidine ;0.9% NS | The first affiliated hospital of anhui medical university anesthesiology; None, selffinance | postoprative delirium | | | | |
ChiCTR-TRC-13003151: Dexmedetomidine vs Remifentanil infusion for conscious sedation for awake intubation with the Modified Flexible Fiberoptic |
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| Completed | 4 | 60 | | remifentanil ;dexmedetomidine | The First Affiliated Hospital of Guangzhou University of TCM; Level of the institution：, The First Affiliated Hospital of Guangzhou University of Chinese Medicine | difficult airway | | | | |
ChiCTR-TRC-13003216: Effect of dexmedetomidine on remifentanil requirement for inhibiting body movement to skin incision in the same sedative depth |
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| Completed | 4 | 90 | | administrated saline + Propofol ;propofol and dexmedetomidine 0.5 ug/kg ;propofol and dexmedetomidine 1.0 ug/kg | The Affiliated People’s Hospital of Jiangsu University; Level of the institution：, Department of Anesthesiology | mammary tumor patients in general anaesthesia | | | | |
ChiCTR-TRC-13003346: Doxapram hasten the recovery from following total intravenous anesthesia with dexmedetomidine, propofol and remifentanil |
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| Completed | 4 | 60 | | doxapram 1mg/kg iv vs normal saline | Department of Anesthesiology, Qilu Hospital, Shandong University, P.R.China; Qilu Hospital of Shandong University, no | Obstructive sleep apnea syndromes | | | | |
ChiCTR-TRC-10000802: Effects of dexmedetomidine on the incidence of postoperative delirium in critically ill elderly patients |
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| Completed | 4 | 700 | | General anesthesia will be induced and maintained during surgery. Patient controlled analgesia will be provided for postoperative analgesia whenever necessary. Sedation level will be assessed with Richmond Agitation Sedation Scale (RASS) hourly after ICU admission. Study drug will be started when the RASS score is -2 or above. Normal saline will be administered by intravenous infusion at a rate of 0.025 ml/kg/h until 8:00 am on the first day after surgery. ;General anesthesia will be provided during surgery and patient-controlled analgesia will be provided for postoperative analgesia in the same way as those in the placebo group. Sedation level will be assessed with Richmond Agitation Sedation Scale (RASS) hourly after ICU admission. Study drug will be started when the RASS score is -2 or above. Dexmedetomidine will be administered by intravenous infusion at a rate of 0.025 ml/kg/h (0.1 ug/kg/h) until 8:00 am on the first day after surgery. | Peking University First Hospital; Peking University First Hospital, Peking University First Hospital | postoperative delirium in critically ill elderly patients | | | | |
ChiCTR-TQR-14004833: Dexmedetomidine improves intubating conditions in children after induction with propofol and remifentanil without muscle relaxants |
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| Completed | 4 | 60 | | induced by the infusion of dexmedetomidine 1 ug/kg ;0.9% NS | Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College; None, Self -funding | Clinical pharmacology | | | | |
ChiCTR-TRC-14004313: Effect of dexmedetomidine during the perioperative period on the postoperative pain of patients after transabdominal hysterectomy |
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| Completed | 4 | 60 | | sufentanil (continue) ;sufentanil (continue) | Liaocheng hospital, Shandong; Level of the institution：, no | postoperative pain | | | | |
ChiCTR-TRC-14004266: Does dexmedetomidine has cardiac protection effect for non-cardiac surgery: A randomised controlled trial. |
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| Completed | 4 | 80 | | dexmedetomidine ;NS | Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University; Level of the institution：, the Project of Medical Technology, Zhejiang, China (2013KYB193 ） | coronary heart disease | | | | |
ChiCTR-TRC-14004392: The Effect of Intraoperative Infusion of Dexmedetomidine on the Stress Response and Insulin Resistance: A Randomized Controlled Trial |
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| Completed | 4 | 52 | | dexmedetomidine ;normal saline | First Affiliated Hospital of Chongqing Medical University; the First People's Hospital of Jiashan County, Jiaxing, China, Self-financing | major abdominal surgery | | | | |
ACTRN12625000184471: Comparison of the Effects of Propofol-Dexmedetomidine and Propofol-Remifentanil Combinations on the Success of Classical LMA (Laryngeal Mask Airway) Placement, Haemodynamic Response and Pharyngolaryngeal Morbidity in ASA I-II Patients |
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| Completed | 4 | 81 | | | Firat University School of Medicine Hospital, Okmeydani Education and Research Hospital | Anesthesiology
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ChiCTR-TRC-14004732: Dexmedetomidine can provide cardioprotective effect in laparoscopic hysterectomy patients. |
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| Completed | 4 | 40 | | 15ml saline ;15ml saline | Second Affiliated Hospital of Anhui Medical University; Level of the institution：, Graduate Research Fund | Myocardial injury | | | | |
ChiCTR-TRC-14004961: Intrathecal Dexmedetomidine as Adjuvants to Low Dose of Ropivacaine in Hysteroscopic Surgery |
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| Completed | 4 | 108 | | intrathecal ropivacaine supplemented with dexmedet ;intrathecal ropivacaine supplemented with fentanyl ;intrathecal ropivacaine | Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University; Level of the institution：, Shenzhen Maternal and Child Care Hospital, Southern Medical University | Hysteroscopic Surgery | | | | |
ChiCTR-TRC-14004717: Different doses of dexmedetomidine anesthesia given to elderly cardiovascular effects of induction period. |
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| Completed | 4 | 60 | | 0.3ug/kg dexmedetomidine given ;0.6ug/kg dexmedetomidine given ;1ug/kg dexmedetomidine | Second Affiliated Hospital of Anhui Medical University; None, Graduate Research Fund | Anesthesia in elderly patients | | | | |
ChiCTR-TRC-13003731: Clinical research of dexmedetomidine for inhibiting remifentanil-induced hyperalgesia |
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| Completed | 4 | 60 | | given dexmedetomidine 15 min before the induction of anesthesia using up-and-down method ;normal saline was given to the patients in group C,15 min before the induction of anesthesia. | the First People’s Hospital of Zhenjiang; Level of the institution：, Social development fund of Zhenjiang(SH2011036) | cholecystectomy | | | | |
ChiCTR-TRC-12002567: Effects of preventively subsedative dose of dexmedetomidine on the quality of postoperative sleep of elderly critically patients: prospective random controlled trial |
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| Completed | 4 | 60 | | continuous infusion of dexmedetomidine (0.1ug/kg/h for 15 hours) ;continuous infusion of saline (0.1ug/kg/h for 15 hours) | Peking University First Hospital; Peking University First Hospital, Braun Anesthesia Science Study Fund | postoperative delirium | | | | |
ChiCTR-TRC-14004896: Effects of dexmedetomidine analgesia on immune function of patients with abdominal malignant tumor |
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| Recruiting | 4 | 80 | | Fentanyl PCA ;dexmedetomidine | Shandong Provincial Cancer Hospital; Shandong Provincial Cancer Hospital, none | Abdominal malignancies | | | | |
ChiCTR-IPR-15006217: Comparison of Dexmedetomidine and propofol on the inflammatory responses in elderly Patients Undergoing Radical Gastrectomy, a randomized controlled trial |
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| Completed | 4 | 40 | | Dexmedetomidine and propofol | Affiliated Drum Tower Hospital of Medical School of Nanjing University; Affiliated Drum Tower Hospital of Medical School of Nanjing University, the Department of Health of Jiangsu Province of China (XK201140) | gastric cancer | | | | |
2014-002243-17: Conscious sedation for procedures in Dental and Minor Maxillofacial Surgery Unit: optimization of the dexmedetomidine dose (Dexdor®). Sedación consciente para procedimientos de Unidad Dental y Cirugía Maxilofacial Menor: optimización de la dosis de dexmedetomidina (Dexdor®). |
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| Ongoing | 4 | 124 | Europe | Dexdor, Concentrate for solution for infusion, Dexdor | Clínica Universidad de Navarra/Universidad de Navarra, Orion Corporation | Sedation for procedures in Dental and Minor Maxillofacial Surgery Unit Unidad Dental y Cirugía Maxilofacial Menor, Sedation for procedures in Dental and Minor Maxillofacial Surgery Unit Unidad Dental y Cirugía Maxilofacial Menor, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
ChiCTR-TRC-14004592: Dexmedetomidine enhances the efficacy of local anesthetics on sciatic nerve block |
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| Completed | 4 | 60 | | ultrasound-guided sciatic nerve was blocked with lidocaine and ropivacaine combinded with dexmedetomidine ;ultrasound-guided sciatic nerve was blocked with lidocaine and ropivacaine combinded with saline | The First Affiliated Hospital of Wenzhou Medical University; Level of the institution：, The First Affiliated Hospital of Wenzhou Medical University | great saphenouse varicose | | | | |
ChiCTR-TRC-14004191: Effect of dexmedetomidine during the perioperative period on the postoperative pain of patients after thoracotomy |
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| Completed | 4 | 150 | | sufentanil (continue) ;dexmedetomidine (continue) ;dexmedetomidine (continue+single dose) | Liaocheng hospital, Shandong; Level of the institution：, no | postoperative pain | | | | |
ChiCTR-TRC-14004535: Effects of different does of dexmedetomidine on heart rate and blood pressure of critically ill patients in intensive care units |
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| Completed | 4 | 60 | | The patients first received 1.0ug/kg/10min of DEX via an IV infusion pump for 10 min ;The patients first received 0.5ug/kg per 10min of DEX via an IV infusion pump for 10 min | Shanghai First Peoples Hospital; Level of the institution：, the intensive care unit of Shanghai First Peoples Hospital | critical illness | | | | |
2013-003307-20: Evaluation of sedation in intensive therapy Valutazione delle modalita' di sedazione in terapia intensiva |
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| Ongoing | 4 | 4000 | Europe | DEXMEDETOMIDINE, PROPOFOL IBI, MIDAZOLAM, Solution for infusion, Emulsion for infusion, DEXDOR, PROPOFOL, MIDAZOLAM | ANZIC RESEARCH CENTRE, ANZIC RESEARCH CENTRE | adult patients hospitalized in intensive therapy unit undergoing continuous and immediate sedation for at least 24 hours pazienti che necessitano di sedazione immediata e continuativa, Patients undergoing continuous and immediate sedation Pazienti che necessitano di sedazione immediata e continuativa., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Equipment and Supplies [E07] | | | | |
| Completed | 4 | 60 | | dexmedetomidine ;placebo | Hospital of Stomatology of Wuhan University; Level of the institution：, HOSIPTAL | cleft lip and palate | | | | |
ChiCTR-TTRCC-14005065: Studies of Sinus Nodal, Atrioventricular Node function in healthy volunteers based on imbalance of the autonomic nervous system function induced by Dexmedetomidine |
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| Completed | 4 | 48 | | Dexmedetomidine1.0ug/kg load capacity ;Dexmedetomidine1.5ug/kg load capacity ;Dexmedetomidine 2.0ug/kg load capacity | The Affiliated Hospital of Guiyang Medical College; None, Science and technology foundation of Guizhou Health Department | bradycardia and heart block | | | | |
ChiCTR-TRC-14004832: Effect of dexmedetomidine on renal injury in patients undergoing cardiac valve replacement under cardiopulmonary bypass |
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| Completed | 4 | 60 | | Injection of 0.9% saline ;dexmedetomidine | Anhui Provincial Hospital; None, self funded | the renal injury in patients undergoing cardiac valve replacement under | | | | |
ChiCTR-TRC-14005220: Effect of dexmedetomidine on the intraocular pressure changes during laparoscopic hysterectomy in the steep Trendelenburg position |
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| Recruiting | 4 | 80 | | bolus and maintained with only NS ;dexmedetomidine bolus and maintained with only NS | The Second Hospital of Anhui Medical University; The Second Hospital of Anhui Medical University, none | laparoscopic hysterectomy | | | | |
| Recruiting | 4 | 120 | | intrathecal dexmedetomidine ;intrathecal morphine ;intrathecal morphine | Shenzhen Matertinity and Child Healthcare Hospital, Southern Medical University; Shenzhen Matertinity and Child Healthcare Hospital, Shenzhen Maternal and Child Care Hospital, Southern Medical University | cesarean section | | | | |
ChiCTR-PRC-13003802: Dexmedetomidine for the prevention of shivering during epidural anesthesia in the aged people |
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| Completed | 4 | 60 | | Dexmedetomidine is intravenously administered before epidural aneaesthesia ;sanline is intravenously administered before epidural aneaesthesia | Department of Anaesthesiology, 306th Hospital of PLA; 306th Hospital of PLA, Clinical Use | shivering during epidural anesthesia | | | | |
ChiCTR-TRC-14004930: The Effect of Adding Dexmedetomidine to Ropivacaine for Transversus Abdominis Plane (TAP) Block under Ultrasound-guided for Postoperative Pain Management After abdominal surgery |
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| Recruiting | 4 | 120 | | Transversus abdominis plane block with 0.9% saline ;Transversus abdominis plane block with ropivacaine ;Transversus abdominis plane block with dexmedetomi ;Transversus abdominis plane block with dexmedetomidine | The Second Affiliated Hospital of Harbin Medical University; The Second Affiliated Hospital of Harbin Medical University, No | postoperative analgesia | | | | |
ChiCTR-IPR-15006015: the effect of dexmedetomidine combined with fentanil on haemorrhoidectomy postoper-ative patient controlled intravenous analgesia |
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| Not yet recruiting | 4 | 100 | | fentanyl 0.8mg ;fentanyl 1.0mg | Tianjin Union Medical Center; None, self-raised funds | excisional haemorrhoidectomy postoperative pain | | | | |
ChiCTR-TRC-14004766: Effect of dexmedetomidine postconditioning on renal protection in patients undergoing laparoscopic partial nephrectomy:a |
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| Completed | 4 | 90 | | Injection of 0.9% saline ;Injection of 0.6ug/kg dexmedetomidine postconditioning | Second Affiliated Hospital of Anhui Medical University; Level of the institution：, National Natural Science Foundation of China, Project Grant NO.81200089 | Renal ischemia-reperfusion injury | | | | |
ChiCTR-ICC-15006276: Dexmedetomidine reduce post-operative delirium in elderly patients with mild cognitive impairment |
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| Completed | 4 | 200 | | A continuous DEX does infusion at 0.2-0.4 ug/kg/hr until the end of surgery without an initial dose in the DEX group; a placebo infusion of normal saline; A continuous DEX does infusion at 0.2-0.4 ug/kg/hr until the end of surgery without an initial dose in the DEX group; a placebo infusion of normal saline | Beijing Military General Hospital; Beijing Military General Hospital, Department of Anesthesiolgy, Beijing Military General Hospital | post-operative delirium | | | | |
ChiCTR-ORC-12002210: The Effects of Different Drugs on Isolated—Uterine Smooth Muscle in Pregnant Women |
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| Completed | 4 | 78 | | salt water ;Ondansetron ;Granisetron ;metoclopramide+oxytocin ;Hemabate ;Hemabate+oxytocin ;methergine ;methergine+oxytocin ;Dexmedetomidine ;Dexmedetomidine+oxytocin ;oxytocin ;tropisetron ;tropisetron | Department of Anesthesiology, West China Second University Hospital, Sichuan University; Level of the institution：, Self-financing | isolated—uterine smooth muscle in pregnant women | | | | |
ChiCTR-IPR-15006112: Compare recovery period with different doses of anesthetic drugs in cataract surgery in infant |
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| Not yet recruiting | 4 | 150 | | fentany l0.5ug/kg, dexmedetomidine 0.5ug/kg ;fentany l0.5ug/kg, dexmedetomidine 1ug/kg ;fentanyl 1ug/kg, dexmedetomidine 0.5ug/kg ;fentanyl 1ug/kg, dexmedetomidine 1ug/kg ;fentanyl 0.5ug/kg, dexmedetomidine 1ug/kg，Mivacurium Chloride0.2mg/kg | The Eye, Ear, Nose and Throat Hospital, Fudan University; The Eye, Ear, Nose and Throat Hospital, Fudan University, The Eye, Ear, Nose and Throat Hospital, Fudan University | the use of anesthetic drugs in cataract surgery in infant | | | | |
ChiCTR-IPR-15006078: Effect and security of different dosages of dexmedetomidine on sciatic nerve block in elderly patients |
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| Not yet recruiting | 4 | 60 | | ultrasound guided sciatic nerve block with lidocaine and ropivacaine combined with saline ;ultrasound guided sciatic nerve block with lidocaine and ropivacaine combined with 25ug dexmedetomidine ;ultrasound guided sciatic nerve block with lidocaine and ropivacaine combined with 50ug dexmedetomidine ;ultrasound guided sciatic nerve block with lidocaine and ropivacaine combined with 75ug dexmedetomidine | The First Affiliated Hospital of Wenzhou Medical University; Level of the institution：, The First Affiliated Hospital of Wenzhou Medical University | great saphenouse varicose | | | | |
ChiCTR-OPN-15006568: The pharmacokinetics of dexmedetomidine in patients with different levels of obesity |
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| Recruiting | 4 | 24 | | dexmedetomidine ;dexmedetomidine ;dexmedetomidine | Guangzhou General Hospital of PLA; Guangzhou General Hospital of PLA, Supported by the Special Project of the “Twelve Five-year Plan ”for Medical Science Development of PLA (Grant No.CWS11J269) and the Foundation for Sci & Tech Research Project of Guangzhou (Grant No.20 | morbidly obese | | | | |
2015-002210-71: Impact of dexmedetomidine on preventive noninvasive ventilation in thoracic trauma Impact de la dexmedetomidine sur la ventilation non invasive préventive chez le traumatisé thoracique |
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| Ongoing | 4 | 20 | Europe | DEXDOR, Concentrate for solution for infusion, DEXDOR | University Hospital Grenoble, University Hospital Grenoble | Thoracic trauma Traumatisés thoraciques, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | | | | |
