Oxidoreductase inhib Trials

Trial + Data / Events

Status

Region

Interventions

Sponsor

Conditions

Primary compl

Study compl

nitazoxanide / Generic mfg.

ACTRN12614000381684: A randomised, placebo-controlled trial of oral nitazoxanide for the empiric treatment of acute gastroenteritis among Australian Indigenous children

Terminated

300

Telethon Kids Institute, National Health and Medical Research Council, CentreCorp Foundation

Acute Gastroenteritis

NILE, NCT05184491: Nitazoxanide and Lansoprazole Based Regimens for H. Pylori Management

Recruiting

500

RoW

Naïve patients - ACO therapy, Naïve patients - LNDL therapy, Naïve patients - MNDL therapy, Treatment-experienced patients- LNDL therapy, Treatment-experienced patients- MNDL therapy

National Liver Institute, Egypt, Future pharmaceutical industries

Helicobacter Pylori

02/22

03/22

PENTZ, NCT04788407: Efficacy and Safety of Nitazoxanide for Post Exposure Prophylaxis of COVID-19 in Household Contacts

Recruiting

456

RoW

Nitazoxanide, Nixoran, Placebo

FundaciÃ³n HuÃ©sped, Ministerio de Salud de Ciudad AutÃ³noma de Buenos Aires, Laboratorios Roemmers S.A.I.C.F.

Covid19, SARS-CoV-2 Infection, Households Contacts

04/22

NCT04359680: Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Pre- and Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers and Others at Increased Risk of SARS-CoV-2 Infection

Completed

1407

Nitazoxanide, NTZ (nitazoxanide), NT-300, Placebo, Vitamin Super B-Complex

Romark Laboratories L.C.

COVID-19, Viral Respiratory Illnesses

04/21

NCT04746937: Nitazoxanide in Prevention of Secondary Spontaneous Peritonitis

Not yet recruiting

Nitazoxanide, NTZ, Norfloxacin

Tanta University

Spontaneous Bacterial Peritonitis

03/22

05/22

NCT04392427: New Antiviral Drugs for Treatment of COVID-19

Not yet recruiting

100

RoW

Treatment group: will receive a combination of Nitazoxanide, Ribavirin and Ivermectin for a duration of seven days :, Nanozoxide, ivermectin and ribavirin 200 mg or 400 mg

Mansoura University

COVID, Drug Effect

05/22

NCT02621359: A Two Week Nitazoxanidebased Quadruple Regimen

Recruiting

100

RoW

Nitazoxanide, Alenia, nitclean, parazoxanide, Levofloxacin, Tavanic, levoxin, venaxan., Doxycyclin, Vibramycin, Doxymycin, Omeprazole, Omepak, Pepzole, Gasec, Risek.

Tanta University

Dyspepsia

12/22

NCT04423861: Efficacy and Safety of Nitazoxanide 600 mg BID Versus Placebo for the Treatment of Hospitalized Patients With COVID-19

Recruiting

380

RoW

Nitazoxanide, Viranitta (Nitazoxanide), Placebo

Azidus Brasil, Farmoquimica S.A.

covid19

03/23

NCT05480878: Role of Nitazoxanide and Escitalopram in Patients With Rheumatoid Arthritis

Completed

RoW

Placebo, Nitazoxanide 500Mg Oral Tablet, Escitalopram 10mg

Tanta University

Rheumatoid Arthritis

03/23

04/23

P-CABs, NCT06101420: Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication

Completed

232

RoW

Vonoprazan, Clarithromycin, Amoxycillin, Esomeprazole, Levofloxacin, Doxycicline, Nitazoxanide

Ain Shams University

Helicobacter Pylori Eradication

06/23

NCT06600711: Nitazoxanide for Treatment of Cryptosporidium in Children

Not yet recruiting

480

Nitazoxanide, Placebo

Johns Hopkins Bloomberg School of Public Health, National Institute of Allergy and Infectious Diseases (NIAID)

Cryptosporidiosis

12/28

05/30

NCT06049901: Nitazoxanide in Patients With Metastatic Colorectal Cancer

Recruiting

RoW

Nitazoxanide, Nanazoxid

Tanta University

Metastatic Colorectal Cancer

03/25

03/26

NCT05157269: Trial to Evaluate Nitazoxanide for Treatment of Mild COVID-19 in Subjects Not at High Risk of Severe Illness

Withdrawn

600

Nitazoxanide, NTZ, NT-300, Placebo, Vitamin Super-B Complex

Romark Laboratories L.C.

COVID-19

03/25

NCT04489381: Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Colds Due to Enterovirus/Rhinovirus Infection

Terminated

214

Nitazoxanide, NTZ (nitazoxanide), NT-300, Placebo, Vitamin Super B-Complex

Romark Laboratories L.C.

Enterovirus, Rhinovirus

01/21

02/21

NCT05157243: Trial to Evaluate Nitazoxanide for Treatment of Mild or Moderate COVID-19 in Subjects at High Risk of Severe Illness

Withdrawn

2000

Nitazoxanide, NTZ, NT-300, Vitamin Super-B Complex, Placebo, Standard of Care, SOC

Romark Laboratories L.C.

COVID-19

05/25

NCT04161053: Efficacy and Safety of Nitazoxanide in Preventing Recurrence of Hepatic Encephalopathy

Recruiting

RoW

Rifaximin, Gastrobiotic, Trencedia, Nitazoxanide, Nanazoxid

Tanta University

Hepatic Encephalopathy

11/28

12/28

NCT04415983: Study of Nitazoxanide (NTZ) for Helicobacter Pylori in Children

Recruiting

100

RoW

Nitazoxanide, nanazoxid, Clarithromycin, Klacid, Metronidazole, Flagyl, Proton pump inhibitor

Tanta University

Helicobacter Pylori Infection

10/30

12/30

NCT04382846: Novel Regimens in COVID-19 Treatment

Recruiting

160

RoW

Nitazoxanide, Parazoxanide, Nanazoxid

Tanta University

COVID, Corona Virus Infection

12/30

NICEGUT, NCT02165813: Oral Nitazoxanide in Acute Gastroenteritis in Australian Indigenous Children

Terminated

2/3

216

RoW

Nitazoxanide, Alinia, placebo

Telethon Kids Institute, The University of Western Australia, Menzies School of Health Research

Gastroenteritis

04/21

06/21

NCT04959786: MANS-NRIZ Trial for COVID-19 Treatment : Extension Study

Recruiting

2/3

100

RoW

Ivermectin,ribavirin ,nitazoxanide and zinc

Mansoura University

COVID-19 Pneumonia

11/22

12/22

COVERAGE-A, NCT04920838: Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection

Recruiting

2/3

600

RoW

Nitazoxanide and CiclÃ©sonide, Telmisartan 20Mg Oral Tablet, Paracetamol, FluoxÃ©tine and BudÃ©sonide

ANRS, Emerging Infectious Diseases, University of Bordeaux, Institut National de la SantÃ© Et de la Recherche MÃ©dicale, France, PACCI Program, Alliance for International Medical Action, Centre Muraz, Barcelona Institute for Global Health

Covid19, Covid19 Drug Treatment, Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV2 Infection

08/23

NCT05897034: Combination Therapy Between Doxycycline, Pentoxifylline, and Nitazoxanide in Sexually Active Men

Not yet recruiting

2/3

100

Doxycyclin, Pentoxifylline, Nitazoxanide 500Mg Oral Tablet

Tanta University, Marwa Ahmed El-Samongy

Sexually Transmitted Diseases

06/24

06/28

NCT03905655: Study of Nitazoxanide Compared to Placebo in Subjects With HBeAG-Negative Chronic Hepatitis B

Completed

RoW

Placebo Oral Tablet, Nitazoxanide, NTZ, NT-300

Romark Laboratories L.C.

Chronic Hepatitis B

03/21

10/21

FANTAZE, NCT04918927: Favipiravir +/- Nitazoxanide: Early Antivirals Combination Therapy in COVID-19

Completed

120

RoW

Favipiravir, Nitazoxanide, Daxon, Nitazoxanide Placebo, Daxon Placebo

Coordinación de Investigación en Salud, Mexico, University College, London, Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional (CINVESTAV), Universidad Autonoma de Guadalajara, Siegfried Rhein S.A. de C.V., Strides Pharma Science Limited, Hakken Enterprise

Covid19

03/23

PLATCOV, NCT05041907: Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19

Recruiting

3800

RoW

Nirmatrelvir/ritonavir (e.g. PAXLOVID™), Nitazoxanide, Molnupiravir and nirmatrelvir/ritonavir (e.g. PAXLOVID™), Hydroxychloroquine, No treatment, Monoclonal antibodies, Fluoxetine, Molnupiravir, Sotrovimab, Ensitrelvir, Favipiravir, Ivermectin, Remdesivir, Atilotrelvir/ritonavir, Metformin, Nirmatrelvir/ritonavir, Nirmatrelvir

University of Oxford

COVID-19

01/27

NCT06010992: Nitazoxanide as Adjuvant Therapy in Type 2 Diabetes Mellitus

Recruiting

RoW

Nitazoxanide

Tanta University, Menoufia University

Diabetes Mellitus, Type 2

10/24

01/25

NCT05453916: Comparing the Efficacy of Nitazoxanide Versus Rifaximin in Adult Patients With Irritable Bowel Syndrome Without Constipation

Recruiting

1/2

RoW

Nitazoxanide 500Mg Oral Tablet, Rifaximin 550Mg Tab

Sadat City University

Irritable Bowel Syndrome With Diarrhea

07/24

12/24

NCT04746183: AGILE (Early Phase Platform Trial for COVID-19)

Jan 2022 - Jun 2022 : Data from AGILE trial for COVID-19

Active, not recruiting

1/2

600

Europe, RoW

CST-2: EIDD-2801, MK-4482, Molnupiravir, CST-2: Placebo, Placebo, Nitazoxanide, VIR-7832, VIR-7831, Sotrovimab, CST-5: Placebo, Favipiravir, Lagevrio, Paxlovid, nirmatrelvir and ritonavir

University of Liverpool, University of Southampton, Liverpool School of Tropical Medicine, Liverpool University Hospitals NHS Foundation Trust, University of Cambridge

Covid19

07/25

NCT03441893: Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis

Active, not recruiting

1/2

300

parasitological diagnostics (coproscopy), Nitazoxanide 500Mg Oral Tablet, Mesalazine 250Mg Tablet and nitazoxanide 500Mg Oral Tablet, Mesalazine 250Mg, Placebo tabletes

Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan

Ulcerative Colitis, Ulcerative Colitis Exacerbation, Protozoan Infections, Helminth Infection

07/25

12/25

NCT04103216: Treatment of Cryptosporidiosis

Completed

N/A

RoW

Nitazoxanide with Lactobacillus Reuteri DSM 17938, Nitazoxanide

International Centre for Diarrhoeal Disease Research, Bangladesh, University of Virginia

Cryptosporidiosis

12/22

08/23

NCT05680792: Pharmacokinetic Interaction Between Nitazoxanide and Atazanavir/Ritonavir in Healthy Volunteers

Completed

N/A

RoW

Nitazoxanide, Netazox, Atazanavir/ritonavir

Obafemi Awolowo University, University of Liverpool

Drug Interaction

01/23

NSS-PC, NCT05648422: Effect of the Nutritional Support System on Neuromotor Alterations in Patients With Cerebral Palsy

Recruiting

N/A

144

RoW

Probiotics, Probiotics (Saccharomyces Boulardii), NSS Nutritional Support System, NSS, Deworming, Nitazoxanide, Specific diet, Conventional diet (WHO)

Anahuac University

Cerebral Palsy, Spastic, Malnutrition

01/25

rifampicin / Generic mfg.

ACTRN12618000332224: Trial of URsodeoxycholic acid versus RIFampicin in severe early onset Intrahepatic Cholestasis of pregnancy: the TURRIFIC study

Recruiting

108

University of Adelaide, MRFF/NHMRC

Severe early-onset intrahepatic cholestasis of pregnancy

2010-021242-22: Etude multicentrique, de non infériorité, randomisée, ouverte, évaluant l’efficacité de deux Durées d’Antibiothérapie (6 semaines versus 12 semaines) dans le Traitement des Infections sur Prothèses Ostéo-articulaires, avec changement prothétique (en 1 temps ou 2 temps long) ou non (lavage articulaire)

Not yet recruiting

410

Europe

Tablet, Powder and solvent for solution for injection, Solution for injection, Powder for solution for injection, Powder for suspension for injection, Powder for solution for infusion, Solution for infusion, Film-coated tablet, Coated tablet, Powder and solvent for solution for infusion, Acide fusidique, Acide Fusidique, Amikacine, Amoxicilline, Cefotaxine, Ceftazidime, Ceftriaxone, Ciprofloxacine, Clindamycine, Cloxacilline, Cotrimoxazole, Fosfomycine, Gentamicine, Ofloxacine, Oxacilline, Péfloxacine, Pipéracilline-tazobactam, Rifampicine, Teicoplanine, Vancomycine

CHRU de Tours

Infection sur prothèse ostéo-articulaire

ChiCTR-TTRCC-12002451: Comparative oral bioavailability of fixed dose combinations of antituberculosis drugs with separate formulations in healthy Chinese volunteers

Completed

Phase I: oral administration of Four FDC tablets (150mg rifampicin, 75mg isoniazid, 275mg ethambutol and 400mg pyrazinamide per tablet). Phase II: oral administration of reference formulations: rifampicin (4×150mg), isoniazid tablets (3×100mg), ethambutol (4×250mg) and pyrazinamide (6×250mg) ;Phase I: oral administration of reference formulations: rifampicin (4×150mg), isoniazid tablets (3×100mg), ethambutol (4×250mg) and pyrazinamide (6×250mg); Phase II: oral administration of Four FDC tablets (150mg rifampicin, 75mg isoniazid, 275mg ethambutol and 400mg pyrazinamide per tablet).

Beijing Tuberculosis and Thoracic Tumor Research Institute; Level of the institution：, National Science and Technology. Grant Number: 2010ZX09102-301 and China - Gates Foundation: China anti-tuberculosis FDC drug quality assurance

tuberculosis

2012-000344-10: A randomised, placebo controlled trial of rifampicin for the treatment of Staphylococcus aureus bacteraemia

Ongoing

940

Europe

Rifadin capsules 300mg, Rifadin infusion, PL 4425/5916R, PL 4425/0051, Capsule, Infusion, Rifadin capsules, Rifadin infusion

Medical Research Council, Kings College London, Health Technology Assessment Clinical Trials Programme, NIHR,

S. aureus bacteraemia, Infection of the blood caused by the Staphylococcus aureus bug, Diseases [C] - Bacterial Infections and Mycoses [C01]

2013-001525-10: Studying the influence of rifampicin administration on the processing of sorafenib in adult patients with cancer

Ongoing

Europe

Tablet, Infusion, Nexavar, Rifampicine, Midazolam

Erasmus MC, Erasmus MC

Cancer, Cancer, Diseases [C] - Cancer [C04]

2005-005843-24: Studie på effekten av rifampicin och ursodeoxycholsyra på gallipider och deras transport och avgiftning hos patienter med kolesterolgallstenar.

Ongoing

Europe

Rifampicin, Ursodeoxycholic acid, Rimactan, Ursofalk, Rimactan, Ursofalk

Hanns-Ulrich Marschall

Gallstone disease

2007-005268-29: Eficacia y seguridad del tratamiento de infecciones nosocomiales graves causadas por Acinetobacter baumannii multirresistente con rifampicina más imipenem.Efficacy and safety to the treatment of severe nosocomial infections caused by multiresistant Acinetobacter baumannii with rifampin plus imipenem.

Ongoing

100

Europe

TIENAM, RILFALDIN, TIENAM, RILFALDIN

University Hospital Virgen del Rocío, Andalousian Health Service

Neumonía, bacteriemia e infección complicada de piel y partes blandas causadas por Acinetobacter baumannii.Pneumonia, bacteremia and complicated skin and soft-tissue infections caused by Acinetobacter baumannii.

2010-023776-52: Optimizing tamoxifen therapy through the induction of CYP3A4, CYP2C and CYP2D6 mediated metabolism

Ongoing

Europe

Tamoxifen, Rifampicin, Dextromethorphan, Nolvadex, Rifadin, Dextromethorphan, Nolvadex, Rifadin, Dextromethorphan

Breast cancer

2012-003067-22: rifampicine bij longontsteking vermindert de ontstekingsreactie

Ongoing

200

Europe

rifampicine, rifampicine rifadin, rifampicine rifadin

LUMC, FESS

Community acquired pneumonia CURB-65 class >1

2014-001276-56: Multicentre, randomised controlled clinical trial to compare minocycline plus rifampicin with linezolid against MRSA in complex skin and skin structure infections (cSSSI).

Ongoing

100

Europe

Rifampicin, minocycline, Zyvoxid 600mg, Rifampicin, minocycline, Zyvoxid, Zyvoxid

European Commission, Hellenic Institute for the Study of Sepsis, European Commisssion, Hellenic Institute for the Study of Sepsis

Complicated Skin and Skin Structure infections caused by Methicillin Resistant Staphylococcus Aureus

ChiCTR1800018833: Randomized, comparative, multi-center clinical trial for new short therapeutic regimen including cycloserine for rifampicin-resistant tuberculosis treatment

Recruiting

390

8ZAm(Cm)Lfx(Mfx)CsPto/12ZLfx(Mfx)CsPto ;4 (+) HZEAmMfxCfzPto/5ZEMfxCfz ;4(+) CsZEAmMfxCfzPto/5ZEMfxCfz

Beijing Chest Hospital affiliated to Capital Medical University; Beijing Tuberculosis & Thoracic Tumor Research Institute, National Health and Family Planning Commission, China

Tuberculosis

2016-001780-37: Prospective randomized controlled study of two antibiotic treatment times (3 versus 6 weeks) of diabetic foot osteomyelitis Étude prospective randomisée contrôlée de deux durées de traitement antibiotique (3 versus 6 semaines) de l’ostéite du pied diabétique

Not yet recruiting

Europe

Bactrim forte, Ciprofloxacine, Clindamycine, Doxycycline, Ceftazidime, Fucidine, Minocycline, Ofloxacine, Rifampicine, Teicoplanine, Levofloxacine, Tablet, Solution for infusion, Bactrim forte, Ciprofloxacine, Clindamycine, Doxyxycline, Ceftazidime, Fucidine, Minocycline, Ofloxacine, Rifampicine, Teicoplanine, Levofloxacine

Centre Hospitalier de Tourcoing, Centre Hospitalier de Tourcoing

Patients de plus de 18 ans et de moins de 80 ans.Présentant une ostéite du pied diabétique., Patients de plus de 18 ans et de moins de 80 ans.Présentant une ostéite du pied diabétique., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]

2020-001024-34: Oral antimicrobial treatment vs. outpatient parenteral for infectiveendocarditis. Tratamiento antimicrobiano oral vs. parenteral ambulatorio para la endocarditis infecciosa

Not yet recruiting

360

Europe

amoxicillin, cefaclor, ciprofloxacin, clindamycin, Dicloxacillin, Fusidic acid, Fusidic Acid, Levofloxacin, levofloxacin, Linezolid, Moxifloxacin, Rifampicin, Sulfamethoxazole/trimethoprim, sulfamethoxazole /trimethoprin, Tedizolid, cefaclor, Dicloxacillin, Dicloxaxillin ev, Rifampicina, septrin, 49708-146-01, 856866-72-3, Tablet, Injection, Solution for injection, Solution for infusion, Capsule, Concentrate for solution for injection/infusion, , Film-coated tablet, Coated tablet, Solution for solution for infusion, Concentrate for solution for infusion, Concentrate and solvent for solution for infusion, Concentrate and solvent for concentrate for solution for infusion, Amoxicillin, ciprofloxacin

Fundació Clínic per a la Recerca Biomèdica, Instituto de Salud Carlos III

infective endocarditis endocarditis infecciosa, infective endocarditis endocarditis infecciosa, Diseases [C] - Cardiovascular Diseases [C14]

NCT04428294: Impact of LTBI Treatment on Glucose Tolerance and Chronic Inflammation

Not yet recruiting

220

Rifampicin 300 Mg Oral Capsule, Isoniazid 300 MG

Herlev and Gentofte Hospital

Latent Tuberculosis, Diabetes Mellitus, Type 2

04/22

05/23

ORCHID, NCT04746547: Pharmacokinetics of Twice or Once Daily DTG (50mg) in Children With HIV and TB

Recruiting

RoW

Dolutegravir 50 MG, Dolutegravir 10 MG

University of KwaZulu, Centre for the AIDS Programme of Research in South Africa

Tuberculosis, Hiv

07/25

RiCOTTA, NCT06172010: Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection

Recruiting

316

Europe

Clindamycin, Rifampicin and levofloxacin

Leiden University Medical Center, University Medical Center Groningen, Onze Lieve Vrouwe Gasthuis, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Medical Centre Leeuwarden, Isala, Martini Hospital Groningen, Radboud University Medical Center, Sint Maartenskliniek, Elisabeth-TweeSteden Ziekenhuis, Erasmus Medical Center, Alrijne Hospital, Spaarne Gasthuis, Reinier Haga Orthopedisch Centrum, Tergooi Hospital, Rijnstate Hospital

Prosthetic-joint Infection, Infection Hip, Infection; Knee, Joint

03/27

03/28

NCT04830462: Impact of LTBI Treatment on Glucose Tolerance and Chronic Inflammation

Completed

Europe

Rifampicin 300 Mg Oral Capsule, Isoniazid 300 Mg ORAL TABLET

Herlev and Gentofte Hospital

Latent Tuberculosis, Diabetes Mellitus, Type 2

05/23

NCT04921943: Hypertonic Saline for MAC

Recruiting

Canada, US

Hypertonic saline, Azithromycin, Ethambutol, Rifampin

Oregon Health and Science University, NTM Info & Research, Inc., University Health Network, Toronto, New York University

Nontuberculous Mycobacterial Lung Disease, Nontuberculous Mycobacterium Infection

06/25

DoRIS, NCT04166474: Drug Interactions Between Dolutegravir and Escalating Doses of Rifampicin

Completed

RoW

Dolutegravir

Helen Reynolds, Infectious Disease Institute, Kampala, Uganda, Desmond Tutu HIV Centre

Hiv, Tuberculosis

02/24

ChiCTR2300071131: A single center study on the interaction of aildenafil citrate tablets with clarithromycin, rifampicin, cimetidine, nifedipine, dapoxetine or alcohol and the pharmacokinetics of continuous multiple administration of aildenafil citrate tablets

Recruiting

118

On the first day, take 60 mg of Eddenafil Citrate tablets. Take clarithromycin tablets 500mg twice a day from the third to the fifth day. On the sixth day, take 500 mg of clarithromycin tablets and 60 mg of aldenafil citrate tablets simultaneously in the morning, and 500 mg of clarithromycin tablets in the afternoon. ;On the first day, take 60 mg of Eddenafil Citrate tablets. Take rifampicin capsules 600 mg once a day from the third to the ninth day. On the tenth day, take both 600 mg of rifampicin capsules and 60 mg of aldinafil citrate tablets. ;On the first day, take 60 mg of Eddenafil Citrate tablets. Take cimetidine tablets 400mg twice a day from the third to the fifth day. On the sixth day, take 400 mg of cimetidine tablets and 60 mg of aldenafil citrate tablets in the morning, and 400 mg of cimetidine tablets in the afternoon. ;On the first day, take 30mg once a day, once a day, and from the second to sixth days, take 30mg three times a day. On the seventh day, take 30mg once a day, once a day. ;60 mg nifedipine controlled-release tablet was taken on the first day, 60 mg nifedipine controlled-release tablet was taken on the morning of the second day, 60 mg aidenafil citrate tablet was taken on the afternoon, 60 mg nifedipine controlled-release tablet was taken on the third to the fourth day, 60 mg nifedipine controlled-release tablet was taken on the morning of the fifth day, 60 mg aidenafil citrate tablet simulant was taken on the afternoon, and 60 mg nifedipine controlled-release tablet was taken on the sixth day. ;60 mg nifedipine controlled-release tablet was taken on the first day, 60 mg nifedipine controlled-release tablet was taken on the morning of the second day, 60 mg aldenafil citrate tablet simulant was taken on the afternoon, 60 mg nifedipine controlled-release tablet was taken on the third to the fourth day, 60 mg nifedipine controlled-release tablet was taken on the morning of the fifth day, 60 mg aldenafil citrate tablet was taken on the afternoon, and 60 mg nifedipine controlled-release tablet was taken on the sixth day. ;On the first day, 60 mg of aldenafil citrate tablets and 200 mL of warm water were taken at the same time. After the washing period (seven days), 60 mg of aldenafil citrate tablets and 200 mL of Baijiu aqueous solution were taken on the ninth day. ;On the first day, 60 mg of adenafel citrate tablets and 200 mL of Baijiu aqueous solution were taken at the same time. After the washing out period (seven days), 60 mg of adenafel citrate tablets and 200 mL of warm water were taken on the ninth day. ;On the first day, take 60 mg of aldenafil citrate tablets. After a 7-day washout period, take 60 mg of dapoxetine hydrochloride tablets on the ninth day. After a 7-day washout period, take 60 mg of aldenafil citrate tablets and 60 mg of dapoxetine hydrochloride tablets on the seventeenth day. ;On the first day, take 60 mg of dapoxetine hydrochloride tablets. After a 7-day washout period, on the ninth day, take both 60 mg of aldenafil citrate tablets and 60 mg of dapoxetine hydrochloride tablets. After a 7-day washout period, take 60 mg of aldenafil citrate tablets at approximately 8:00 on the seventeenth day. ;On the first day, take both 60 mg of aldenafil citrate tablets and 60 mg of dapoxetine hydrochloride tablets. After a 7-day washout period, take 60 mg of aldenafil citrate tablets on the ninth day. After a 7-day washout period, take 60 mg of dapoxetine hydrochloride tablets on the seventeenth day.

Peking University First Hospital; Youcare Pharmaceutical Group Co, Ltd., Provided by Youcare Pharmaceutical Group Co, Ltd.

Erectile dysfunction

VA INTREPID, NCT03012529: Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

Recruiting

880

Rifampin, Riboflavin Placebo

VA Office of Research and Development

Osteomyelitis, Diabetes, Amputation

09/25

COPAT, NCT05977868: Comparing Oral Versus Parenteral Antimicrobial Therapy

Enrolling by invitation

135

Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, metronidazole, moxifloxacin, rifampin, trimethoprim-sulfamethoxazole, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem, meropenem, oritavancin, oxacillin, penicillin, piperacillin-tazobactam, tigecycline, vancomycin

West Virginia University

Endovascular Infection, Bone and Joint Infection, Skin and Soft Tissue Infection, Pulmonary Infection, Gastrointestinal Infection, Genitourinary Infection

08/24

ChiCTR2300074234: Based on the pharmacokinetics study of contezolamide in Rifampicin resistant tuberculosis patients

Recruiting

Treatment of rifampicin-resistant pulmonary tuberculosis with a regimen containing contezolamide; A regimen containing linezolid for the treatment of rifampicin-resistant tuberculosis

Beijing Chest Hospital affiliated to Capital Medical University; Beijing Chest Hospital affiliated to Capital Medical University, self-financing

Drug-resistant tuberculosis

NCT06476210: The Safety and Efficacy of BDL(Bedaquiline Plus Delamanid Plus Linezolid) Regimen in Subjects With Pulmonary Infection of Multi-drug Resistant Tuberculosis (MDR-TB) or Rifampicin-Resistant Tuberculosis (RR-TB)

Recruiting

RoW

BDL regimen

Beijing Chest Hospital, Public Health Clinical Medical Center of Chengdu, Wuhan Institute for Tuberculosis Control, Changsha Central Hospital, Anhui Chest Hospital, Hunan Chest Hospital, Shandong Public Health Clinical Center

Pulmonary Tuberculosis

06/25

06/26

OraPAT-IEGAMES, NCT05398679: Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis

Not yet recruiting

360

Europe

Cefaclor, Ciprofloxacin Tablets, Ciprofloxacin Injection, Clindamycin Oral Capsule, Clindamycin Injection, Dicloxacillin Oral Capsule, Dicloxacillin, Fusidic Acid Only Product in Oral Dose Form, Fusidic Acid Only Product in Parenteral Dose Form, Levofloxacin Oral Tablet, Levofloxacin Injection, Linezolid Oral Tablet, Linezolid Injectable Product, Moxifloxacin tablet, Moxifloxacin Injectable Product, Rifampicin Only Product in Oral Dose Form, Rifampicin Only Product in Parenteral Dose Form, Sulfamethoxazole / Trimethoprim Oral Tablet [Bactrim], Sulfamethoxazole / Trimethoprim Injectable Product, Tedizolid Oral Tablet, Tedizolid Injection, Amoxicillin Capsules, Amoxicillin, Cefaclor Capsules

Fundacion Clinic per a la Recerca Biomédica

Endocarditis Infective

06/24

12/24

OPTIMAL, NCT05156437: Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis

Enrolling by invitation

Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline

Vinay Badhwar

Endocarditis

10/24

ROADMAP, NCT06771050: Randomised Arthroplasty Infection Worldwide Multidomain Adaptive Platform () Trial is an International RCT Evaluating the Effect of a Range of Clinical Surgical and Antibiotic Interventions on Treatment Success 12 Mths Post-platform Entry in Adults With Prosthetic Joint Infection (PJI)

Not yet recruiting

2500

RoW

Debridement and Implant Retention (DAIR), Revision Arthroplasty - Single stage revision, Antibiotic Choice, No intervention: Standard of Care "Backbone antibiotics", Intervention: Standard of care " Backbone antibiotics" + Rifampicin antibiotics, Antibiotic duration Part A - Single stage revision, shorter duration - 6 weeks, longer duration - 12 weeks, Antibiotic Duration Part B - Two stage revision, Extended antibiotic prophylaxis following 2nd stage Revision operation, No extended antibiotic prophylaxis following 2nd stage Revision operation

University of Newcastle, Australia, Hunter Medical Research Institute (HMRI), The University of Western Australia, Michael Garron Hospital, Aotearoa Clinical Trials, Exeter Orthopaedic Trial unit, University of Sydney, University of Melbourne, The Peter Doherty Institute for Infection and Immunity

Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Large Joint Prosthetic Joint Infections

02/28

12/29

ChiCTR2300072703: A prospective, randomized, controlled, open-label clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus doxycycline plus rifampicin in Chinese adults with uncomplicated brucellosis

Recruiting

194

oral sitafloxacin (100mg daily, for 6weeks) ;doxycycline (100 mg po b.i.d.) plus rifampin (10 mg /kg q.d.) for 6 weeks

Qilu Hospital, Shandong University; Qilu Hospital, Shandong University, Self-financing

brucellosis

ChiCTR2400090645: Study on the use of contezolid as alternative therapy in patients with rifampicin-resistant pulmonary tuberculosis for whom linezolid is not applicable

Recruiting

1) For patients with severe adverse reactions due to linezolid, Linezolid should be discontinued, and after symptomatic treatment of adverse reactions (about 7 days), Contezolid (800mg PO 12h) should be used instead of linezolid to continue anti-tuberculosis therapy for at least 12 weeks, while other anti-tuberculosis drugs in the original regimen should continue to be used without adjustment. 2) For patients who are not eligible for linezolid due to specific diseases, Contezolid (800mg PO q12h) should be used instead of linezolid to form an anti-tuberculosis treatment regimen for at least 12 weeks, and other anti-tuberculosis drugs should be selected according to the Guidelines for Chemotherapy of Drug-Resistant Tuberculosis (2019 Simplified Edition).

Guangzhou Chest Hospital; Guangzhou Chest Hospital, Study drug - Contezolid tablets were donated by Shanghai Micurx Pharmaceutical Co.,Ltd.

tuberculosis

2018-004011-44: Trial of URsodeoxycholic acid versus RIFampicin in severe early onset Intrahepatic Cholestasis of pregnancy: the TURRIFIC study

Ongoing

3/4

108

Europe, RoW

Rifampicin, Ursodeoxycholic acid, Film-coated tablet, Capsule, hard

The University of Adelaide, The University Of Adelaide, Department of Health

Intrahepatic Cholestasis of Pregnancy (ICP) is an serious liver condition in pregnancy. The main symptom of this is itching. Ursodeoxycholic acid is routinely used to treat cholestasis but is not effective in reducing itch in all people who take it. Rifampcin has been used to reduce itch in people with Primary Biliary Cholangitis. This study will randomly allocate women with severe early onset ICP to receive either Ursodeoxycholic Acid, or the "Investigational drug" Rifampicin., ICP is a liver condition in pregnancy where women develop severe itching and high concentration of bile acid in their blood. ICP is associated with increased risk of premature delivery and stillbirth., Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]

2013-000219-25: MRSA study. Studio MRSA

Ongoing

100

Europe

Rifampin, Trimethoprim-sulfamethoxazole, minocycline, Tablet

AOU Meyer, Fondazione Italiana per la ricerca sulla fibrosi cistica

Patients affected by cystic fibrosis and who present an initial infection of MRSA. Fibrosi cistica con infezione iniziale da MRSA, Patients with cystic fibrosis with pulmonary first colonization by MRSA. Pazienti affetti da fibrosi cistica con prima colonizzazione polmonare da MRSA, Diseases [C] - Bacterial Infections and Mycoses [C01]

2015-003446-45: Clinical trial to shortening the treatment for pulmonary tuberculosis with rifapentin containing regimen. Ensayo clínico para acortar el tratamiento de la tuberculosis pulmonar con una pauta que incluye rifapentina

Ongoing

2500

Europe

RIFAPENTINE, Rifampicin, Moxifloxacin, Ethambutol, Isoniazide, Pyrazinamide, Tablet, Capsule, Priftin, Rifadin, Moxifloxacin 400mg Film-coated Tablets, Myambutol, Nicotibine, Pyrafat

Unidad de investigación en Tuberculosis de Barcelona, Centers for Disease COntrol and Prevention (CDC)

Pulmonary tuberculosis Tuberculosis pulmonar, Pulmonary infection Infección pulmonar, Diseases [C] - Respiratory Tract Diseases [C08]

2020-000471-20: Rifabutin versus rifampicin, staphylococcal prosthetic joint infection, multicenter randomized, open-label, non-inferiority trial rifabutine versus rifampicine, infections ostéoarticulaires sur prothèse à staphylocoque, essai multicentrique randomisé ouvert de non infériorité

Not yet recruiting

436

Europe

Capsule, RIFABUTINE MYCOBUTIN, RIFAMPICINE

CH Tourcoing, French Ministry of Health PHRC_2019_0328, CH Tourcoing

Adult with an staphylococcal prosthetic joint infection treated with debridement, antibiotics and implant retention (DAIR strategy) Patient adulte traité pour infections ostéoarticulaires sur prothèse à staphylocoque prises en charge par synovectomie-lavage et antibiothérapie, Adult with an staphylococcal prosthetic joint infection Patient adulte traité pour infections ostéoarticulaires sur prothèse à staphylocoque, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02]

2021-003914-38: Different antimicrobial durations for the treatment of infections associated with OsteosynthesisMaterial implanted after long bone fractures DIFERENTES DURACIONES DE TRATAMIENTO ANTIMICROBIANO DE INFECCIONES ASOCIADAS AL MATERIAL DE OSTEOSÍNTESIS TRAS FRACTURA DE HUESO LARGO

Not yet recruiting

378

Europe

Ampicillim, amoxicillin/clavulanic, Cefazolin, Cefepime, Ceftazidime, CEFTRIAXONE, cloxacillin, daptomycin, Meropenem, Teicoplanin, Vancomycin, Amoxicillin, Amoxicillin / clavulanic acid, Ciprofloxacin, Levofloxacin, Linezolid, Moxifloxacin, Rifampicin, Powder and solvent for solution for infusion, Powder and solvent for solution for injection, Powder for solution for injection, Powder and solvent for suspension for injection, Powder for solution for injection/infusion, Tablet, , Capsule, Ampicillim, Amoxicillin/Clavulanic, Cefazolin, Cefepime, ceftazidime, CEFTRIAXONE, cloxacillin, daptomycin, Meropenem, Teicoplanin, Vancomycin, Amoxicillin, Amoxicillin / clavulanic acid, Ciprofloxacin, Clindamycin, Sulfametoxazol trimetoprim, Levofloxacin, Linezolid, Moxifloxacin, Rifampicin

Fundación Pública Andaluza para la Gestión de la Investigación, Instituto de Salud Carlos III. Ministerio de Ciencia e

Patients with long bone fractures who have had osteosynthesis material implanted to stabilize and assist fracturehealing and meet the criteria for Infections associated with osteosynthesis material Pacientes con fracturas de huesos largos a quienes se les ha implantado material de osteosíntesis para estabilizar y ayudar a la curación de la fractura y que cumplen con los criterios de Infecciones asociadas con el material de osteosíntesis., Patients with infections due to the implant used to stabilize a long bone fracture Pacientes con infecciones debidas al implante usado para estabilizar una fractura de hueso largo, Diseases [C] - Bacterial Infections and Mycoses [C01]

2022-000632-27: High dose rifampicin for tuberculosis, PORT

Ongoing

164

Europe

Rifampicin, Tablet, Rifampicin

Radboud University Medical Center, Radboud University Medical Center

Tuberculosis, Tuberculosis, Diseases [C] - Bacterial Infections and Mycoses [C01]

EDOSE, NCT04513379: Efficacy of 400 mg Efavirenz Versus Standard 600 mg Dose in HIV/TB Co-infected Patients

Not yet recruiting

Efavirenz 600mg, Efavirenz 400mg

Shanghai Public Health Clinical Center

HIV Infections, Tuberculosis

10/22

01/23

NCT03662022: Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar

Completed

144000

RoW

Rifampicin

Institute of Tropical Medicine, Belgium, Damien Foundation, Centre d'Infectiologie Charles Mérieux, Fondation Raoul Follereau, Leiden University Medical Center, L'Institut National de la Santé et de la Recherche Médicale, Genoscreen, Instituto Fernandes Figueira

Leprosy

01/23

NCT04062201: Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline, Delamanid and Linezolid) With the Current South African Standard of Care

Completed

402

RoW

Bedaquiline Oral Tablet, Sirturo, Linezolid Oral Tablet, Zyvox, Delamanid in Oral Dosage Form, Deltyba, Clofazimine Oral Product, Lamprene, Levofloxacin Oral Tablet, Isoniazid Oral Product, INH, Ethambutol Oral Product, Pyrazinamide Oral Product

Wits Health Consortium (Pty) Ltd, Regents of the University of California, University of Cape Town, Perinatal HIV Research Unit of the University of the Witswatersrand

Tuberculosis, Pre-XDR-TB, Extensively Drug-Resistant Tuberculosis, Multi Drug Resistant Tuberculosis, Rifampicin Resistant Tuberculosis

04/24

NCT06489431: Irrisept vs Traditional Antibiotic Irrigation for Virgin Penile Prosthesis Placement

Recruiting

100

Chlorhexidine, Irrisept, Gentamicin, Gentak, Rifampin, rifampicin, Rifadin

Rush University Medical Center

Erectile Dysfunction, Penile Prosthesis; Complications, Infection or Inflammation

12/24

12/25

SURE-TB, NCT05824871: A Phase III Study of Oral Sudapyridine (WX-081) Tablets in Rifampicin-Resistant Pulmonary Tuberculosis Patients

Recruiting

450

RoW

Sudapyridine, WX-081, Bedaquiline

Shanghai Jiatan Pharmatech Co., Ltd

Rifampin-Resistant Pulmonary Tuberculosis, Tuberculosis, Multidrug-Resistant (MDR-TB)

12/25

10/26

NCT06191692: 1HP Versus 3HR in the Treatment of Tuberculosis Infection in Vietnam

Not yet recruiting

350

RoW

Isoniazid, INH, Rifapentine, RPT, Rifampicin, RIF

Freundeskreis Für Internationale Tuberkulosehilfe e.V

Tuberculosis Infection

12/24

12/26

NCT02701608: Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus

Recruiting

324

Europe

Levofloxacin, Fluoroquinolones, Rifampicin, Conventional IV treatment of staphylococci IE following European guidelines 2015 including cloxacilline, oxacilline,gentamicine,vancomycine,rifampicine

University Hospital, Tours

Infective Endocarditis

05/24

09/24

NCT06526039: A Short Regimen for Rifampicin-resistant Isoniazid-susceptible TB

Not yet recruiting

100

a novel short regimen

Taipei Medical University WanFang Hospital, Hualien Tzu Chi General Hospital, Chest Hospital, Ministry of Health and Welfare, Taiwan, Chang-Hua Hospital, Taichung Veterans General Hospital, Taichung Hospital, Ministry of Health and Welfare, Taoyuan General Hospital, Kaohsiung Veterans General Hospital., Kaohsiung Medical University Chung-Ho Memorial Hospital

Tuberculosis, Pulmonary

12/28

12/29

2021-006613-10: A Phase 3, Multicenter, Open-label, Rater-blind, Active-controlled Study to Evaluate the Efficacy and Safety of Bedaquiline for the Treatment of Multibacillary Leprosy When Combined With Rifampicin and Clofazimine

Not yet recruiting

386

RoW

Bedaquiline, Rifampicin, Clofazimine, Dapsone, Tablet, Capsule, Rifampicin Sandoz, Lamprene, Dapsone

Janssen Pharmaceutica NV, Janssen Pharmaceutica NV

Multibacillary Leprosy, Leprosy, Diseases [C] - Bacterial Infections and Mycoses [C01]

INSPIRE-BDLL, NCT06649721: Innovating Shorter, All- Oral, Precised Treatment Regimen for Rifampicin Resistant Tuberculosis：BDLL Chinese Cohort

Not yet recruiting

120

RoW

bedaquiline, BDQ, B, delamanid, DLM, D, linezolid, LZD, L, Levofloxacin, LFX, Clofazimine, CFZ, C

Huashan Hospital, Beijing Chest Hospital

Drug-resistant Tuberculosis, Pulmonary Tuberculosis, Rifampin-resistant Tuberculosis

06/27

PRISM-TB, NCT06441006: Program for Rifampicin-Resistant Disease With Stratified Medicine for Tuberculosis

Not yet recruiting

690

RoW

Bedaquiline, Sirturo, Linezolid, Zyvox, Pretomanid, Pretamyl, Moxifloxacin, Avelox, Control Arm FQ-S MDR/RR-TB regimen, designed according to latest WHO guidelines

University of California, San Francisco, Johns Hopkins University

Tuberculosis, Pulmonary, Tuberculosis, Multidrug-Resistant, Tuberculosis, MDR

06/29

11/29

CLAZI, NCT03236987 / 2017-001087-38: CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections

Recruiting

424

Europe

Clarithromycin 1000 MG, ZECLAR, Azithromycin 250 mg, ZITHROMAX, Rifampicin, RIFADINE, Ethambutol, DEXAMBUTOL

Centre Hospitalier Universitaire, Amiens

Lung Infection, Mycobacterium Avium Complex

02/25

DOVETAIL, NCT06497465: Dolutegravir/Lamivudine Dual Therapy for ART-naïve People With HIV and TB Receiving Rifampin-based TB Treatment

Not yet recruiting

150

RoW

Dolutegravir 50mg Tab, TIVICAY 50 mg, TIVICAY PD, Dolutegravir/Lamivudine 50 MG-300mg Oral Tablet [DOVATO], Dolutegravir plus Tenofovir disoproxil fumarate (TDF)/ lamivudine (3TC)

Johns Hopkins University, ViiV Healthcare

Tuberculosis, HIV

01/28

01/29

OptiRiMoxTB, NCT05575518: A Pragmatic Trial With Optimized Dose of Rifampicin and Moxifloxacin for the Treatment of Drug Susceptible Pulmonary Tuberculosis

Recruiting

414

RoW

Optimised rifamycin, 8-methoxy-fluoroquinolone

Stellah Mpagama, University of St Andrews, Radboud University Medical Center

Tuberculosis, Human Immunodeficiency Virus

12/25

03/26

PORT, NCT06057519 / 2022-000632-27: Pragmatic Optimized Rifampicin Trial

Recruiting

164

Europe

Optimised dose rifampicin, Standard dose rifampicin

Radboud University Medical Center

Tuberculosis, Pulmonary

12/25

Co-SAM, NCT05994742: An Adaptive Multi-arm Trial to Improve Clinical Outcomes Among Children Recovering From Complicated SAM

Recruiting

1266

RoW

Rifampicin, Azithromycin, Isoniazid, Pyridoxine Hydrochloride, The Friendship Bench, Care for Child Development, Educational and behaviour-change modules, Reformulated Ready to Use Therapeutic Food, Standard Care

Queen Mary University of London, University of Oxford, KEMRI-Wellcome Trust Collaborative Research Program, University of Washington, Wageningen University, Zvitambo Institute for Maternal & Child Health, Tropical Gastroenterology & Nutrition Group (TROPGAN), University of Cambridge, Kenya Medical Research Institute, National Institute for Health Research, United Kingdom

Severe Acute Malnutrition, HIV, Comorbidities and Coexisting Conditions, Child Malnutrition

07/26

09/27

TB-YOUTH, NCT06022146: TB YOUTH - TB sYstemic Management Using One-month, Ultra-short TPT Regimen for scHool Contacts

Recruiting

3520

RoW

Rifampin and Isoniazid, isoniazid and rifapentine

Huashan Hospital

Tuberculosis, Latent Tuberculosis

09/26

INSPIRE-CODA, NCT06081361: Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis：Contezolid, Delamanid and Bedaquiline Cohort

Recruiting

186

RoW

Bedaquiline, BDQ, Delamanid, DLM, Contezolid, CZD, Levofloxacin, LFX, Moxifloxacin, MFX, Clofazimine, CFZ, Linezolid, LZD, Cycloserine, CS, Prothionamide, Pto, Pyrazinamide, PZA, Para-Aminosalicylic Acid, PAS, Ethambutol, EMB

Beijing Chest Hospital, National Medical Center for Infectious Diseases

Pulmonary Tuberculosis, Rifampicin-resistant Tuberculosis

10/26

12/26

INSHORT, NCT05917340: Intensified Short Course Regimen for TBM in Adults

Not yet recruiting

372

RoW

High dose rifampicin (25mg/kg), Moxifloxacin 400mg, Aspirin 150 mg, Isoniazid, Pyrazinamide, Steroid, Rifampicin, HRZE, HRE

Indian Council of Medical Research, All India Institute of Medical Sciences, Jodhpur, Christian Medical College, Vellore, India, Jawaharlal Institute of Postgraduate Medical Education & Research, North Eastern Indira Gandhi Regional Institute of Health ans Medical Sciences, Madras Medical College, Rural Development Trust Hospital

Tuberculous Meningitis

09/27

RIFAMAB, NCT04672525: Rifabutin Versus Rifampicin for Treatment of Staphylococcal PJI Treated With DAIR

Recruiting

436

Europe

Rifabutin, Rifampicin

Tourcoing Hospital

Prosthetic Infection

11/26

06/27

BE-PEOPLE P3, NCT05597280: Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy

Recruiting

124000

RoW

BE-PEP Bedaquiline, SDR-PEP Rifampicin, BE-PEP Rifampicin

Institute of Tropical Medicine, Belgium

Leprosy

12/26

RIFACute, NCT05902221: Impact of Rifampicin in Treatment Outcome of Cutibacterium Acnes Prosthetic Joint Infections

Not yet recruiting

235

Europe

amoxicillin or moxifloxacin, amoxicillin or moxifloxacin + rifampicin

Centre Hospitalier Universitaire de Nice

Infections Joint Prosthetic

07/27

ATORTUB, NCT04721795: Treating Tuberculosis With the Lipid Lowering Drug Atorvastatin in Nigeria(ATORvastatin in Pulmonary TUBerculosis)

Completed

2/3

150

Europe, RoW

Atorvastatin with standard anti tuberculosis drugs, Atorvastatin, Statins, Standard anti tuberculosis drugs only, Rifampicin, INH, Ethambuthol and Pyrazinamide

Obafemi Awolowo University Teaching Hospital, University Hospital Birmingham NHS Foundation Trust, Cures Within Reach

Tuberculosis, Pulmonary, Tuberculosis

03/22

06/22

DERIVE, NCT04121195: Dose Escalation Study to Determine the Pharmacokinetics of Atazanavir Administered With RIfampicin to HIV Positive Adults on sEcond-line ART Regimen With Suppressed HIV-1 Viral Load

Completed

2/3

RoW

Dose escalation

University of Liverpool, European and Developing Countries Clinical Trials Partnership (Funder), Joint Clinical Research Centre, Kampala, Uganda, University of Cape Town, Cape Town, South Africa, Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda, University of Turin, Turin, Italy

HIV/AIDS, Tuberculosis

05/22

05/23

NCT06498414: An Adaptive Trial to Find the Safest and Shortest TB Preventive Regimens.

Not yet recruiting

2/3

1800

Canada, RoW

rifampin standard arm, 4R10, rifampin double dose, 2R20, levofloxacin and rifapentine, 1LP

McGill University Health Centre/Research Institute of the McGill University Health Centre, Canadian Institutes of Health Research (CIHR)

Tuberculosis Infection, Latent

04/27

06/29

MAC2v3, NCT03672630: Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease

Active, not recruiting

2/3

474

Canada, US

Azithromycin, Zithromax, Ethambutol, Myambutol, Rifampin, Rifadin

Kevin Winthrop, Patient-Centered Outcomes Research Institute, National Jewish Health, The University of Texas Health Science Center at Tyler, University Health Network, Toronto, New York University, Medical University of South Carolina, Mayo Clinic, Louisiana State University Health Sciences Center in New Orleans, University of California, San Diego, Stanford University, University of Kansas, Vancouver Clinic, University of California, San Francisco, University of Washington, Johns Hopkins University, University of Miami, Emory University, University of Iowa, University of North Carolina, Temple University, Loma Linda University, Columbia University, University of Wisconsin, Madison, Northwell Health, Kaiser Permanente Hawaii, James A. Haley Veterans Administration Hospital

Mycobacterium Avium Complex, Nontuberculous Mycobacterium Infection

10/25

ASTERoiD, NCT03474029: Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI

Recruiting

2/3

3400

Canada, US, RoW

Rifapentine daily for 6 weeks, priftin, Rifapentine and Isoniazid weekly for 12 weeks, Rifampin and Isoniazid daily for 12 weeks, Rifampin daily for 16 weeks

Centers for Disease Control and Prevention, British Medical Research Council

Latent Tuberculosis

12/29

ACTRN12606000477527: Rifampicin test as a predictor of Irinotecan toxicity in metastatic colorectal cancer.

Recruiting

Dr Nimit Singhal, Department of Medical Oncology, Royal Adelaide Hospital

Patients with metastatic colorectal cancer

2008-000566-23: A randomized phase 2 double-blind, placebo-controlled study of GK-001 in hepatocellular carcinoma (HCC) in chronic hepatitis C patients after prior curative HCC treatment Estudio aleatorizado de fase 2, doble ciego, controlado con placebo sobre GK-001 en pacientes con carcinoma hepatocelular (CHC) y hepatitis C crónica tras tratamiento curativo para el CHC

Ongoing

Europe

GK-001,

GeneCare Research Institute Co., Ltd.

hepatocellular carcinoma (HCC) in chronic hepatitis C patients after prior curative HCC treatment carcinoma hepatocelular (CHC) en pacientes con hepatitis C crónica tras tratamiento curativo para el CHC

2008-004970-41: Phase II open-label randomized multicenter trial to compare the efficacy and safety of two different doses of raltegravir and efavirenz, all in combination with tenofovir and lamivudine, in naive HIV-1-infected patients receiving rifampin for active tuberculosis.

Ongoing

Europe

Sustiva, Viread, Epivir, MK-0518, BMS-561525, raltegravir, Sustiva, Viread, Epivir, Isentress, Sustiva, Viread, Epivir, Isentress

Agence nationale de recherches sur le sida et les hépatites virales. ANRS.

HIV-1 Infection and tuberculosis

NCT05896930: Study to Evaluate EBA, Safety and Tolerability of Carbapenems in Adults With Pulmonary Tuberculosis

Completed

134

RoW

Meropenem 6g IV over 6 hours, Ertapenem 1g IM, Meropenem 3g IV, Ertapenem 1g IV, Amoxicillin/CA twice daily, Rifampicin 35 mg/kg, Meropenem 6g IV over 60 minutes, Rifafour e-275, Meropenem 4g IV, Amoxicillin/CA once daily

TASK Applied Science

Pulmonary Tuberculosis

01/21

2021-001626-22: New treatment for pulmonary TB with High dose Rifampicin, High dose Moxifloxacin and Linezolid

Ongoing

120

Europe

Capsule, hard, Rifampicin

Vall d'Hebron Institute of Research, Instituto de Salud Carlos III

Smear-positive rifampicin-sensitive pulmonary Tuberculosis, pulmonary Tuberculosis, Diseases [C] - Respiratory Tract Diseases [C08]

2020-004295-18: A trial of two host-directed therapies in patients with drug-resistant tuberculosis (DRTB-HDT)

Not yet recruiting

330

Europe

CC-11050, metformin ratiopharm, CC-11050, Capsule, Tablet, Accord ratiopharm

The Aurum Institute, Horizon 2020 / EC

Rifampin-resistant pulmonary tuberculosis, Drug-resistant tuberculosis, Diseases [C] - Bacterial Infections and Mycoses [C01]



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