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705 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Daytrana (methylphenidate transdermal system) / Hisamitsu
NCT03420339: Stimulant Effects on Disruptive Behavior

Recruiting
4
10
US
Stimulant, Adderall, Concerta, Aptensio, Daytrana, Metadate, Quillivant, Ritalin, Focalin, Vyvanse
Matthew J O'Brien, PhD, BCBA-D
Attention Deficit Hyperactivity Disorder, Problem Behavior
03/27
08/27
NCT04419272 / 2012-004406-10: Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits

Recruiting
4
226
US
Methylphenidate, Concerta, Ritalin, Daytrana, Aptensio XR, Metadate CD, Methylin, Quillivant XR, Jornay PM, Adhansia XR, Cotempla, Placebo, sugar pill, lactose
VA Office of Research and Development, VA New York Harbor Healthcare System, Portland VA Medical Center, Miami VA Healthcare System, VA Boston Healthcare System
Epilepsy
09/27
09/27
NCI-2018-00698, NCT03525873: A Study of Cancer Related Fatigue in Patients With Metastatic Cancer Receiving Anti-PD1 Immunotherapy

Active, not recruiting
3
212
US
Laboratory Biomarker Analysis, Methylphenidate, Daytrana, Physical Activity, Placebo, placebo therapy, PLCB, sham therapy, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm, Recurrent Malignant Neoplasm
12/26
12/26
NCI-2018-02527, NCT03772834: Methylphenidate and Exercise in Reducing Cancer-Related Fatigue in Patients with Prostate Cancer

Recruiting
2/3
200
US
Exercise Intervention, Methylphenidate, Daytrana, Placebo, placebo therapy, PLCB, sham therapy, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Stretching
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Prostate Carcinoma
11/26
11/26
droxidopa / Generic mfg.
SCI, NCT05839652: Treatment of Orthostatic Hypotension in

Recruiting
4
25
US
Midodrine Hydrochloride, Droxidopa
James J. Peters Veterans Affairs Medical Center, Kessler Foundation
Hypotension
06/26
06/26
2007-005673-60: A MULTI-CENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP WITHDRAWAL-DESIGN STUDY TO ASSESS THE CLINICAL EFFECT OF DROXIDOPA IN SUBJECTS WITH PRIMARY AUTONOMIC FAILURE, DOPAMINE BETA HYDROXYLASE DEFICIENCY OR NON-DIABETIC NEUROPATHY AND SYMPTOMATIC NEUROGENIC ORTHOSTATIC HYPOTENSION

Ongoing
3
30
Europe
Droxidopa, DOPS, DOPS
Chelsea Therapeutics Inc
Symptomatic neurogenic orthostatic hypotension (NOH) in patients with Primary Autonomic Failure (PD, MSA and PAF), DBH deficiency and Non-Diabetic Neuropathy.
 
 
2013-003433-15: Effets du L-ThreoDOPS à long terme sur l’hypotension orthostatique et certains symptômes non moteurs dans l’atrophie multisystématisée

Not yet recruiting
3
108
Europe
Droxidopa, Capsule
CHU de Toulouse, PHRC
l’atrophie multisystématisée (AMS), maladie neurologique due à une perte de neurones (atrophie) dans plusieurs régions du cerveau, Diseases [C] - Nervous System Diseases [C10]
 
 
NCT02558972: Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS)

Active, not recruiting
2
30
US
Northera (Droxidopa), Placebo
New York Medical College, Lundbeck LLC
Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS), Fainting
12/22
12/22
NCT01370512: Droxidopa / Pyridostigmine in Orthostatic Hypotension

Enrolling by invitation
2
30
US
Droxidopa, Pyridostigmine, Placebo
Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)
Orthostatic Hypotension
05/26
05/26
DROP-AKI, NCT06937307: DROXIDOPA TO INCREASE MEAN ARTERIAL PRESSURE IN DECOMPENSATED CIRRHOSIS PATIENTS WITH ACUTE KIDNEY INJURY

Not yet recruiting
2
75
US
Droxidopa capsules, L-threo-3,4-dihydroxyphenylserine, Placebo
Giuseppe Cullaro, MD
Acute Kidney Injury, Cirrhosis, Decompensated Cirrhosis of Liver
12/26
12/27
NCT04977388: NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Occipital Horn Syndrome

Recruiting
1/2
6
US
Droxidopa, Northera, Placebo
Stephen G. Kaler, MD
Menkes Disease, Occipital Horn Syndrome
06/25
06/26
NCT02897063: Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Recruiting
1
34
US
Droxidopa, Northera, Midodrine, Placebo
Vanderbilt University Medical Center
Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease, Orthostatic Hypotension
09/25
12/25
Nucynta (tapentadol) / Collegium Pharma, Grunenthal
2010-023175-26: Influence of Tapentadol on endogenous modulation of pain in chronic neuropathic pain patients and healthy volunteers

Ongoing
4
24
Europe
Tapentadol, morphine, Tapentadol, morphine, Tapentadol, morphine
Leiden University Medical Center
Chronic pain patients/ mhealthy volunteers
 
 
2015-005259-28: A study on the efefct of the analgesic tapentadol on pain scores in patients with low back pain

Ongoing
4
40
Europe
Tapentadol, N02AX06, Tablet, Palexia
LUMC, LUMC, Grunenthal
Low back pain, pain in the back, Diseases [C] - Musculoskeletal Diseases [C05]
 
 
2015-005258-37: Effect of treatment with the painkiller tapentadol on pain in patients with fibromyalgia

Ongoing
4
40
Europe
Tapenatdol, N02AX06, Tablet, Pallexia
LUMC, LUMC, Grunenthal GmbH
Fibromyalgia, Fibromyalgia, Diseases [C] - Musculoskeletal Diseases [C05]
 
 
2018-003515-22: Breathing effects of two opioid pain killers in healthy volunteers

Not yet recruiting
4
24
Europe
Tapentadol, Oxycodone, N02AX06, RVG110728, Tablet, Pallexia, Oxycodone
Leiden University Medical Center, Grunenthal
Chronic pain, Chronic pain, Body processes [G] - Physiological processes [G07]
 
 
2018-004804-21: The prevention of chronic postoperative pain.

Not yet recruiting
4
540
Europe
Tapentadol, Tablet, Tapentadol
Leiden University Medical Center, Grunenthal
Chronic pain after inguinal hernia surgery and knee replacement surgery., Chronic pain after surgery., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
NCT06269770: Tapentadol vs Tramadol in Total Knee Arthroplasty

Recruiting
4
96
Europe
Tapentadol, Tramadol
University of Thessaly
Total Knee Replacement, Post-operative Pain, Chronic Pain
05/25
06/25
2006-004514-40: A Randomized, Double-Blind, Active- And Placebo-Controlled, Parallel Group, Multicenter Study To Evaluate The Efficacy And Safety of Multiple Doses of CG5503 Immediate Release Formulation In Subjects Awaiting Primary Joint Replacement Surgery for End-Stage Joint Disease

Ongoing
3
100
Europe
CG5503; R331333, OxyNorm, CG5503; R331333, n.a., OxyNorm 5, 10, 20 mg, OxyNorm 5, 10, 20 mg
Johnson & Johnson Pharamceutical Research & Development, L.L.C.
Pain
 
 
ChiCTR2300069799: Efficacy and Safety of Tapentadol Hydrochloride Tablets in Subjects with Moderate to Severe Pain after Orthopedic Surgery: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Phase III Study

Not yet recruiting
3
286
 
Oral administration Tapentadol Hydrochloride tablets ;Oral administration Oxycodone hydrochloride capsules
The Third Xiangya Hospital of Central South University; Third Xiangya Hospital of Central South University, Jiangsu Enhua Pharmaceutical Co., LTD., National Natural Science Foundation of China, Hunan Natural Science Foundation, Self-funded
Postoperative pain
 
 
2019-000755-14: Trial in healthy subjects to investigate the effect of analgesic drug on pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. Studio su soggetti sani volto ad indagare gli effetti di farmaci analgesici sulla elaborazione del dolore mediante misure neurofisiologiche del'attività del midollo del midollo spinale e del tronco dell'encefalo

Ongoing
2
56
Europe
pregabalin, lacosamide, tapentadol, [N03AX16], [N/A], [N02AX06], Capsule, hard, Film-coated tablet, Tablet, LYRICA - 75 MG CAPSULA RIGIDA - USO ORALE 100 CAPSULE IN BLISTER IN UNITA' SEPARABILI PERFORATO (PVC/ALU), VIMPAT - 100 MG - COMPRESSE RIVESTITE CON FILM - USO ORALE - BLISTER (PVC/PVDC/ALU) 14 COMPRESSE, PALEXIA - 50 MG COMPRESSE RIVESTITE CON FILM 10 COMPRESSE IN BLISTER PVC/PVDC/AL
UMBERTO I - POLICLINICO DI ROMA, Teva Pharmaceutical Industries LTD, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmbH
Healthy volunteers (intended indication: pain) soggetti sani (indicazione: dolore), Healthy volunteers (intended indication: pain) soggetti sani (indicazione: dolore), Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
2019-000942-36: The effects of lacosamide, pregabalin and tapentadol on biomarkers of peripheral pain processing

Not yet recruiting
2
60
Europe
lacosamide, Pregabalin, Tapentadol, [N02AX06], [N/A], [N03AX16], Tablet, Capsule, Vimpat 100 mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets
Aarhus University, UMBERTO I - POLICLINICO DI ROMA, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmbH, Teva Pharmaceutical Industries LTD
Healthy volunteers (intended indication: pain), Study in healthy volunteers to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
2019-001204-37: The effects of lacosamide, pregabalin and tapentadol on biomarkers of pain processing

Not yet recruiting
2
56
Europe
lacosamide, pregabalin, tapentadol, [N02AX06], [N03AX16], [N/A], Film-coated tablet, Capsule, Tablet, Vimpat 100mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets
Institute of Neuroscience (IoNS), Université catholique de Louvain, UMBERTO I - POLICLINICO DI ROMA, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under Grant Agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmBH, Teva Pharmaceutical Industries LTD
Healthy subjects (intended indication: pain), Study in healthy subjects to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
lisdexamfetamine / Generic mfg.
ACTRN12624001061527: Oral Lisdexamfetamine for the treatment of Acute Methamphetamine withdrawal (the OLAM trial): A randomised controlled trial

Not yet recruiting
4
184
 
St Vincent's Hospital Sydney, NHMRC
Acute methamphetamine withdrawal
 
 
ACTRN12618000623291: Neural mechanisms of lisdexamfetamine in binge eating disorder.

Recruiting
4
62
 
University of Sydney, Shire International GmbH
Binge-Eating Disorder
 
 
NCT01413165: Phase 4, Open Label, Multicentre, 2 Year Safety Study of Lisdexamfetamine Dimesylate in Children/Adolescents With ADHD

Not yet recruiting
4
12
Europe
Lisdexamfetamine dimesylate, SPD 489
Maastricht University Medical Center, Shire Development LLC
Attention Deficit Disorder With Hyperactivity
08/13
12/13
ACTRN12621000045819: An open-label trial of oral lisdexamfetamine for the treatment of acute methamphetamine withdrawal

Completed
4
15
 
St Vincent's Hospital Sydney, The National Centre for Clinical Research on Emerging Drugs
Acute methamphetamine withdrawal
 
 
NCT03337646: Evaluation of the Effect and Safety of Lisdexamfetamine in Children Aged 6-12 With ADHD and Autism

Completed
4
48
Canada
Lisdexamfetamine Dimesylate, Vyvanse
JPM van Stralen Medicine Professional, Shire
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
03/23
03/23
ACTRN12617000657325: Lisdexamfetamine for the treatment of methamphetamine addiction

Completed
3
180
 
University of New South Wales , National Health and Medical Research Council, Curran Foundation
Addiction, Methamphetamine dependence
 
 
NCT03924193: Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Acute Treatment

Completed
3
141
US
Lisdexamfetamine Dimesylate, Cognitive-Behavioral Therapy, Combination LDX and Cognitive-Behavioral Therapy
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Binge-Eating Disorder, Obesity
09/23
09/23
NCT03926052: Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Maintenance Treatment

Completed
3
61
US
Lisdexamfetamine Dimesylate, Placebo
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Binge-Eating Disorder, Obesity
11/24
11/24
NCT04599504: Pharmacological and Behavioral Treatment After Bariatric Surgery: Medication Change for Non-Responders (Stage 2b)

Enrolling by invitation
2/3
60
US
Lisdexamfetamine Dimesylate (Medication), Vyvanse, Placebo
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Loss-of-control Eating, Obesity/Overweight
05/27
05/27
2017-001490-16: Treatment of Bulimia Nervosa, with and without simultaneous probable ADHD, with the stimulant medicine Lisdexamphetamin . Behandling av Bulimia Nervosa, med och utan samtidig sannolik ADHD, med den psykostimulerande medicinen Lisdexamfetamin.

Ongoing
2
50
Europe
Capsule, hard, Elvanse vuxen
Stockholms läns landsting, Stiftelsen Söderström-Königska sjukhemmet, Petrus och Augusta Hedlunds stiftelse
Bulimia Nervosa with and without simultaneous Attention Deficit Hyperactivity Disorder. Bulimia Nervosa med och utan samtidig Attention Deficit Hyperactivity Disorder., Bulimia Nervosa with and without simultaneous ADHD Bulimia Nervosa med och utan samtidig ADHD, Psychiatry and Psychology [F] - Mental Disorders [F03]
 
 
2022-001906-24: LAMAinDiab - comparison of 2 pharmacological therapies (lisdexamphetamine vs methylphenidate) for pediatric patients with ADHD and type 1 diabetes - a randomized crossover clinical trial   LAMAinDiab – porównanie 2 terapii farmakologicznych (lisdeksamfetamina vs metylfenidat) dla pacjentów pediatrycznych z zespołem ADHD i cukrzycą typu 1 - randomizowane krzyżowe badanie kliniczne .

Not yet recruiting
2
150
Europe
Elvanse, Concerta, Capsule, hard, Prolonged-release tablet
Medical University in Lodz, Agencja Badań Medycznych
Patients with ADHD and type I diabetes. Pacjenci z ADHD i Cukrzycą typu I., Patients with ADHD and type I diabetes. Pacjenci z ADHD i Cukrzycą typu I., Not possible to specify
 
 
LIBERATE, NCT06847399: Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder

Not yet recruiting
2
105
US
Tirzepatide, Lisdexamfetamine Dimesylate, Guided self-help cognitive behavioral therapy, Placebo (oral), Placebo (injection)
Johns Hopkins University, Eli Lilly and Company
Obesity and Overweight, Binge Eating Disorder
12/27
12/27
NCT05854667: Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users

Recruiting
2
440
Canada
Treatment as Usual plus Placebo, Contingency Management, Treatment as Usual plus Placebo plus Contingency Management, Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
Centre hospitalier de l'Université de Montréal (CHUM), Canadian Institutes of Health Research (CIHR)
Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
11/25
11/25
LAMAinDiab, NCT05957055: Lisdexamphetamine Vs Methylphenidate for Pediatric Patients with ADHD and Type 1 Diabetes

Recruiting
2
150
Europe
parental training in behavior management, PT training, Lisdexamfetamine, LDX, Methylphenidate, MPH
Medical University of Lodz, Medical University of Silesia, Medical University of Gdansk, Institute of Medical Sciences of the University of Opole, Pediatric Center of the Central Clinical Hospital of the Medical University of Lodz
Attention Deficit Disorder with Hyperactivity, Diabetes Mellitus, Type 1
12/27
12/27
NCT05416125: Vyvanse in Children Aged 6 to 12 Years

Recruiting
1
40
US
Lisdexamfetamine Dimesylate, Lifestyle therapy
University of Minnesota
Obesity, Childhood
11/28
11/29
ADAPT, NCT02136147: ADHD Medication and Predictors of Treatment Outcome

Completed
N/A
632
Europe
methylphenidate medication, N06BA04, Concerta, Ritalin, Equasym, Medikinet, atomoxetine medication, N06BA09, Strattera, lisdexamphetamine medication, N06BA12, Elvanse, guanfacine medication, C02AC02, Intuniv
Karolinska Institutet
Attention Deficit Disorder With Hyperactivity (ADHD)
07/21
06/22
NCT04727476: The Use of Lisdexamfetamine for Children Aged 7-13 With Attention Deficit Disorders

Active, not recruiting
N/A
413
Europe
Lisdexamfetamine
Aarhus University Hospital, Takeda
Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Hyperkinetic Disorder
08/21
05/22
IDEAL, NCT04946461: The Day-time Response Variation of (Lis)Dexamphetamine

Completed
N/A
16
Europe
Dexamfetamine Sulfate 5 Mg Oral Tablet, Tentin, Lisdexamfetamine Dimesylate, Elvanse, blood samples, vena puncture
Amsterdam UMC, location VUmc, ADHDcentraal
Adhd
12/21
06/22
NCT05551689: FOCUS ADHD Mobile Health App for Adult ADHD Patients

Completed
N/A
73
RoW
Psychostimulant, Methilphenidate, Lisdexamfetamine, FOCUS ADHD App, mhealth app
Hospital de Clinicas de Porto Alegre, University of Sao Paulo
ADHD
09/22
03/23
AGUALIS, NCT03333668: Experimental fMRI Study of Guanfacine and Lisdexamfetamine in ADHD Adolescents

Active, not recruiting
N/A
20
Europe
Lisdexamfetamine dimesylate, Vyvanse (Shire Pharmaceuticals Ltd.), Guanfacine Extended Release Oral Tablet, Intuniv (Shire Pharmaceuticals Ltd.), Placebo
King's College London, Shire
ADHD
12/22
03/25
NCT03497169: Bariatric Surgery and Pharmacokinetics of Lisdexamphetamine

Completed
N/A
12
Europe
Lisdexamfetamine Dimesylate, Lisdexamfetamine, Vyvanse, Elvanse
Norwegian University of Science and Technology, St. Olavs Hospital, Volvat Medisinsk Senter Stokkan, Namsos Hospital, Alesund Hospital
Obesity, Morbid
09/20
09/20
Savella (milnacipran) / AbbVie, Pierre Fabre
NCT05737511: Efficacy of Hydroxyzine for Patients With Panic Disorder

Not yet recruiting
4
80
NA
Hydroxyzine, Atarax, Vistaril, Escitalopram Oxalate, citalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR,, Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine, Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine
Sultan Qaboos University
Panic Disorder
12/26
12/26
2006-003658-47: Exploratory study of the efficacy and safety of flexible doses of Milnacipran and Venlafaxine administered in out patients with Major Depressive Disorder.

Ongoing
3
180
Europe
Milnacipran, Venlafaxine, IXEL 25 mg, IXEL 50 mg, EFFEXOR 25 mg, EFFEXOR 50 mg, IXEL 25 mg, IXEL 50 mg, EFFEXOR 25 mg, EFFEXOR 50 mg
Pierre Fabre Médicament - IRPF
Major Depressive Disorder
 
 
KETAPAL, NCT02783430: Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease

Recruiting
2/3
80
Europe
Ketamine, Milnacipran, Placebo
University Hospital, Lille
Depression
09/24
09/24
SPR, NCT01026077: The Savella Pregnancy Registry

Terminated
N/A
350
US
Syneos Health, AbbVie
Fibromyalgia
10/24
10/24
NCT05384210: Effect of Milnacipran / Gabapentin in Fibromyalgia

Enrolling by invitation
N/A
75
RoW
Milnacipran, Gabapentin, Combined gabapentin/milnacipran
Mansoura University
Fibromyalgia
10/23
11/23
ChiCTR2400083771: Randomized, double-blind, and placebo-controlled clinical study of Milnacipran hydrochloride tablets combined with transcranial magnetic stimulation in the treatment of somatic cough disorders

Not yet recruiting
N/A
98
 
receiving both Milnacipran and true rTMS; receiving both Milnacipran and false rTMS
Shanghai Tongji Hospital; Shanghai Tongji Hospital, Project supported by Clinical Research Project of Tongji Hospital of Tongji University (Grant No.ITJ(QN)2303)
somatic cough disorders
 
 
duloxetine / Generic mfg.
ACTRN12624000919516: Duloxetine for chronic sciatica (DREAM): an adaptive randomised placebo-controlled trial

Recruiting
4
332
 
The University of Sydney, National Health and Medical Research Council (NHMRC)
Sciatica
 
 
2008-006558-17:

Ongoing
4
100
Europe
cymbalta, sipralexa, aspegic, Buccal tablet, Tablet, , cymbalta, sipralexa, aspegic
cliniques universitaire de mont godinne
major depression
 
 
2014-005701-20: Het verschuiven van pijn modulatie naar pijnstilling: mechanisme-specifieke farmacologische preventie van post-sternotomie pijn: de MASTER studie

Ongoing
4
300
Europe
Capsule, Cymbalta, Lyrica
Leiden University Medical Center, LUMC
chronic pain chronische pijn, chronic pain chronische pijn, Body processes [G] - Physiological processes [G07]
 
 
2005-003846-33: Efecto de la duloxetina en la respuesta nociceptiva cerebral en el trastorno depresivo mayor. Estudio mediante resonancia magnética funcional (RMf)

Ongoing
4
72
Europe
Duloxetina, Duloxetina (DCI), Cymbalta 30 mg cápsulas duras gastrorresistentes, Cymbalta 30 mg cápsulas duras gastrorresistentes
Dr. Narcís Cardoner
Trastorno depresivo mayor
 
 
2008-005695-27: Comparing Problem Solving Treatment combined with duloxetine with Problem Solving Treatment alone for patients with major depressive disorder in primary care

Ongoing
4
160
Europe
duloxetine, Cymbalta, Cymbalta, Cymbalta
Eli Lilly Nederland
Major depressive disorder (episode or recurrent), moderately severe as principal DSM-IV diagnosis.
 
 
2009-011893-13: Adherence of antidepressants during pregnancy

Ongoing
4
50
Europe
Paroxetine, Amitriptyline, Clomipramine, Imipramine, Nortriptyline, escitalopram, Citalopram, Fluoxetine, Fluvoxamine, Sertraline, Duloxetine, venlafaxine, EU/1/04/296/002, Seroxat, Tryptizol, Anafranil, Imipramine, Nortrilen, Lexapro, Cipramil, prozac, Fevarin, Zoloft, Cymbalta, Efexor, Seroxat, Tryptizol, Anafranil, Imipramine, Nortrilen, Lexapro, Cipramil, prozac, Fevarin, Zoloft, Cymbalta, Efexor
Isala Klinieken
Pregnant women with psychiatric morbidity and an strong indication for using antidepressants
 
 
2009-010188-18: Effectiveness of the treatment of depressive disorder and comorbid pain symptoms

Ongoing
4
219
Europe
duloxetine, Cymbalta, Cymbalta, Cymbalta
Eli Lilly Nederland, Eli Lilly Nederland BV, GGz Breburg, Arkin, GGz inGeest
Major depressive disorder (episode or recurrent), as principal DSM-IV diagnosis combined with (sub)chronic pain symptoms as defined bij score of >3 on BPI painlist for at least six weeks.
 
 
2014-001550-42: Combined molecular and functional brain imaging (PET/MR) to predict treatment response to neuropharmacological treatment Kombinierte molekulare und funktionelle Bildgebung des Gehirns (PET/MR) zur Vorhersage des Therapieerfolgs von Neuropharmaka

Ongoing
4
80
Europe
Seropram, Cymbalta, Efectin, Cipralex, Seropram, Cymbalta, Efectin, Cipralex, Seropram, Cymbalta, Efectin
Medizinische Universität Wien, Medizinische Universität Wien
Major depressive disorder Depression
 
 
ChiCTR1900027181: Efficacy and Safety of Doloxetine in the Treatment of Subacute Herpes Zoster Neuralgia

Completed
4
43
 
duloxetine with Oral administration of gabapentin, pregabalin and Mecobalamin ;Oral administration of gabapentin, pregabalin and Mecobalamin
Fujian Provincial Geriatric Hospital; None, self-funding
Subacute Herpes Zoster Neuralgia
 
 
NCT03249311: Levomilnacipran in Healthy Males

Active, not recruiting
4
36
Canada
Levomilnacipran, Fetzima, Duloxetine, Cymbalta, Placebos
University of Ottawa, Allergan
None (i.e. Healthy Volunteers)
12/19
05/22
ChiCTR1900027004: Role of SERTRALINE (SSRI) Versus DULOXETINE (SSNRI) among depressed total knee arthroplasty candidates: a prospective, randomized, patient selective, double blind study

Not yet recruiting
4
180
 
DULOXETINE ;SERTRALINE ;placebo
Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University; West China Hospital, Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total knee arthroplasty
 
 
ChiCTR1900027005: Compare the effect of DULOXETINE Versus SERTRALINE in THA patients with anxiety and depression: a prospective, randomized, double-blinded study

Recruiting
4
180
 
DULOXETINE ;SERTRALINE ;placebo
West China Hospital, Sichuan University; West China Hospital, Sichuan University, Ministry of Health Special Scientific Research Projects of China
THA
 
 
ChiCTR-RPC-17012990: Functional magnetic resonance study of brain network mechanism in persistent somatoform pain disorder

Recruiting
4
80
 
duloxetine sustained-release capsules ;none
Department of Psychology, The affiliated Drum Tower hospital of Nanjing university medical school; The affiliated Drum Tower hospital of Nanjing university medical school, Nanjing General course of medical science and technology development
persistent somatoform pain disorder
 
 
ChiCTR2000033606: The effect of duloxetine on pain and functional rehabilitation after total hip replacement: a randomized controlled trial.

Recruiting
4
100
 
Duloxetine ;Placebo
West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total hip arthroplasty
 
 
ChiCTR2000033910: The Effects of Duloxetine on Pain and Hip Function after Total Knee Arthroplasty: a Randomized Controlled Trial.

Recruiting
4
100
 
Duloxetine ;Placebo
West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total knee arthroplasty
 
 
NCT06837012: Duloxetine As an Analgesic in Patients Without Central Sensitivity After Same Sitting Bilateral Total Knee Arthroplasty

Completed
4
106
RoW
Duloxetine - low dose, Placebo
Orthopaedic Arthroscopy Knee and Shoulder Clinic, The Grant Medical College & Sir J.J. Group of Hospitals
Osteoarthritis of Knee, Central Sensitization, Central Sensitisation
07/22
07/22
ChiCTR2000033605: The Effects of Duloxetine on Pain and Emotional Function Following Total Hip Arthroplasty in Patients With Anxiety and Depression: a Randomized Controlled Trial

Recruiting
4
100
 
Duloxetine ;Placebo
West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total hip arthroplasty
 
 
NCT04117893: Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients

Completed
4
150
RoW
Duloxetine, intra-articular injection of corticosteroid and hyaluronic acid
Beijing Tiantan Hospital
Osteoarthritis, Knee, Chronic Pain
06/21
12/21
ChiCTR2000033903: The Effects of Duloxetine on Pain and Emotional Function Following Total Knee Arthroplasty in Patients with Depression Symptoms: a Randomized Controlled Trial.

Recruiting
4
100
 
Duloxetine 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery). ;Placebo 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery).
West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total knee arthroplasty
 
 
ChiCTR2000030195: Duloxetine reduces postoperative pain and improves quality of life after single-segment lumbar fusion procedures in centrally sensitized patients: a prospective randomized controlled study

Recruiting
4
100
 
duloxetine 60mg/day with standard analgesic regimen ;standard analgesic regimen
The Third People's Hospital of Chengdu; The Third People's Hospital of Chengdu, Self-financing
single-segment lumbar fusion
 
 
ChiCTR2000035105: Duloxetine Reduces Pain and Improves Quality of Recovery Following the Repair of Rotator Cuff Injury

Recruiting
4
120
 
duloxetine 30mg bid ;without duloxetine
West China Hospital of Sichuan University; West China Hospital of Sichuan University, 135 key fund of West China Hospital
Rotator cuff injury
 
 
NCT04782310: Duloxetine vs Pregabalin for Thoracotomy Pain

Recruiting
4
75
RoW
Pregabalin, Duloxetine
Cairo University
Postoperative Pain
08/21
09/21
ChiCTR1900027038: Synergistic Analgesia of Duloxetine in Phantom Limb Pain: a Randomized Controlled Trial.

Recruiting
4
120
 
administration of duloxetine 60mg ;administration of placebo
Cancer Hospital of China Medical University; Cancer Hospital of China Medical University, self-financing
Phantom Limb Pain
 
 
ChiCTR2100042981: Efficacy, safety and compliance of integrated traditional Chinese and Western medicine in patients with depression in the community: a multi-center, randomized controlled study

Not yet recruiting
4
300
 
Use escitalopram or duloxetine ;Use Shu-Gan Jie-Yu capsule ;Use Shu-Gan Jie-Yu capsule combined with escitalopram or duloxetine
Shandong Mental Health Center; Shandong Mental Health Center, Shandong Province Integrated Traditional Chinese and Western Medicine Depression Prevention Project
Major depressive disorder
 
 
ChiCTR2100047183: Investigation of the effect of duloxetine on the treatment of primary frozen shoulder

Recruiting
4
102
 
Daily oral duloxetine 60mg ;Before treatment, 1 week, 2 week, 4 week, 8 week, 1 month after oral placebo or duloxetine
Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, NSFC scientific research funds
Frozen shoulder
 
 
ChiCTR2200056163: Effects of Pregabalin, Duloxetine and NSAIDs on Joint Pain and Function in Osteoarthritis Patients after Total Joint Arthroplasty

Not yet recruiting
4
84
 
200mg celecoxib b.i.d. (morning and night) p.o. for 4 weeks ; 75mg pregabalin b.i.d. (morning and night) p.o. for 4 weeks ; 30mg duloxetine b.i.d. (morning and night) p.o. for 4 weeks
West China Hopital of Sichuan University; West China Hopital of Sichuan University, 1.3.5 Project of West China Hospital [No. 2021YFQ0028]
Osteoarthritis
 
 
ChiCTR2100046144: Combining multimodal magnetic resonance imaging and machine learning technology to explore the central mechanism of chronic primary frozen shoulder pain and the central analgesic mechanism of duloxetine

Recruiting
4
60
 
Daily oral duloxetine 60mg
Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, NSFC scientific research funds
Frozen shoulder
 
 
ChiCTR2100054802: Effect of duloxetine administration in patients with depressive symptoms undergoing total knee arthroplasty: A randomized controlled trial

Recruiting
4
70
 
Duloxetine 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery) ;Placebo 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery)
West China Hospital, Sichuan University; West China Hospital, Sichuan University, 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18039)
Total knee arthroplasty
 
 
ChiCTR2100054655: Effect of duloxetine administration in patients with depressive symptoms undergoing total hip arthroplasty: a randomized controlled trial

Not yet recruiting
4
70
 
Duloxetine ;Placebo
West China Hospital, Sichuan University; West China Hospital, Sichuan University, 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18039)
N/A
 
 
2022-002780-30: Efficacy of patient education and duloxetine, alone and in combination, for patients with multiorgan bodily distress syndrome: a partial-factorial randomized controlled trial Patientundervisning og medicinsk behandling (duloxetin/aktiv placebo) til patienter med svær funktionel lidelse: et randomiseret, kontrolleret forsøg

Not yet recruiting
4
212
Europe
Cymbalta, Benztropine, Capsule, Tablet, Cymbalta, Benztropine
Aarhus University Hospital, The Research Clinic for Functional Disorders and Psychosomatics, The Tryg Foundation
Multiorgan Functional somatic disorders (FSD) / bodily disstress syndrome (BDS) multiorgan Funktionel lidelse, Functional somatic disorder Funktionel lidelse, Not possible to specify
 
 
NCT05510856: Comparative Clinical Study Evaluating the Possible Efficacy of Duloxetine, Gabapentin and Lacosamide on Oxaliplatin-Induced Peripheral Neuropathy in Cancer Patients

Completed
4
93
RoW
Duloxetine, Gabapentin, Lacosamide
Tanta University
Oncology
09/24
10/24
ChiCTR2100054831: Clinical efficacy and safety of duloxetine hydrochloride and amitriptyline combined with pregabalin in patients with herpes zoster neuralgia

Recruiting
4
80
 
Duloxetine combined with pregabalin ;Amitriptyline combined with pregabalin
Nanjing Drum Tower Hospital, School of Medicine, Nanjing University; Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University
Herpes zoster neuralgia
 
 
NCT05563038: Scrambler Therapy for Post-Stroke Pain

Recruiting
4
40
US
Scrambler Therapy, Calmare Therapy, Standard Medication Management
Johns Hopkins University
Post Stroke Pain
12/26
12/26
NCT05086393: Duloxetine RCT on Postop TKA Outcomes

Recruiting
4
504
US
Duloxetine, Placebos
Rush University Medical Center
Pain, Postoperative, Total Knee Arthroplasty
05/25
06/25
EDULOX, NCT06232473 / 2022-002780-30: Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder

Recruiting
4
424
Europe
Patient Education, Duloxetine, Cymbalta, SNRI, Benztropine Mesylate 0.5 MG and passive placebo RAP, Enhanced usual care
Aarhus University Hospital, Central Denmark Region, University of Aarhus, Vejle Hospital, Aalborg University Hospital, TrygFonden, Denmark, Independent Research Fund Denmark
Functional Disorder
11/27
11/29
PREDICT, NCT06245109: Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

Recruiting
4
180
US
Duloxetine, Cymbalta, Celecoxib, Celebrex, Placebo
Northwestern University, Brigham and Women's Hospital
Knee Osteoarthritis
03/28
03/28
BEST, NCT05396014: The Trial: Biomarkers for Evaluating Spine Treatments

Completed
4
1014
US
Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM), Duloxetine, Cymbalta
University of North Carolina, Chapel Hill, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Chronic Low-back Pain
07/24
10/24
NCT06087211: Pain Relieving Potentials of Combination of Oral Duloxetine and Intravenous Magnesium Sulphate in Post Mastectomy Pain

Recruiting
4
90
RoW
Duloxetine and magnesium sulphate, cymbalta and magnesium sulphate, Duloxetine, cymbalta, placebo, control
National Cancer Institute, Egypt
Post-mastectomy Pain Syndrome
04/24
04/24
RELIFE, NCT06423716: Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty

Not yet recruiting
4
150
Canada
Duloxetine, Placebo
Sunnybrook Health Sciences Centre
Knee Osteoarthritis
07/26
12/26
PRECICE, NCT04395001: Pain Response Evaluation of a Combined Intervention to Cope Effectively

Completed
4
345
US
duloxetine, Irenka, Cymbalta, Web-based Cognitive Behavioral Therapy (CBT), Nurse-delivered Motivational Interviewing
Wake Forest University Health Sciences, National Institute of Nursing Research (NINR)
Chronic Pain
07/24
07/24
AtLAS-A, NCT04245436: Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety

Recruiting
4
60
US
Duloxetine, Cymbalta, Irenka, Escitalopram, Lexapro
University of Cincinnati
Anxiety, Depressive Symptoms
07/25
08/25
DOTS-AD, NCT04245748: Determining Optimal Treatment Sequences in Anxious Depression

Recruiting
4
84
US
Escitalopram, Lexapro, Duloxetine, Cymbalta
University of Cincinnati
Anxious Depression, Depression
07/25
12/25
ChiCTR2400079841: Analysis of the efficacy of duloxetine and pregabalin for analgesia after total knee arthroplasty: a prospective, randomized controlled study

Not yet recruiting
4
120
 
Oral duloxetine 60 mg/dose once daily beginning two days before surgery and continuing through 14 days postoperatively; Oral pregabalin 150 mg/dose twice daily beginning two days before surgery and continuing through 14 days postoperatively; Oral duloxetine 60 mg/dose once a day and oral pregabalin 150 mg/dose twice a day starting two days prior to surgery and continuing until 14 days postoperatively; After the 6h postoperative fasting period, oral erixib tablets 0.1g, codeine 500mg, starting on the second postoperative day and up to 14 days postoperatively, oral erixib tablets 0.1g/dose, 2 times/day, oral codeine 500mg/dose, 2 times/day
Honghui Hospital, Xi'an Jiaotong University; Honghui Hospital, Xi'an Jiaotong University, self-finance
osteoarthritis of the knee
 
 
ChiCTR2400087090: A randomized double-blind multicenter psychiatric imaging study of Jiuwei Zhenxin granules in the treatment of patients with generalized anxiety disorder

Not yet recruiting
4
100
 
Duloxetine (60mg qd) + Jiuwei Zhenxin granules placebo; Jiuwei Zhenxin granules (6g tid) + Duloxetine placebo; None
West China Hospital of Sichuan University; West China Hospital of Sichuan University, BEIJING BEILU PHARMACEUTICAL CO.,LTD
generalized anxiety disorder (GAD)
 
 
SNRI, NCT05851898: Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures

Recruiting
4
100
US
Duloxetine 30 mg, Common brands: Irenka, Cymbalta
Wake Forest University Health Sciences
Depression in Old Age, Fragility Fracture
12/26
12/26
NCT06807866: Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT

Recruiting
4
64
US
Duloxetine, Placebo
University of Miami
THA
04/26
04/26
NCT03548454: Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization

Recruiting
4
320
US
Duloxetine, Cymbalta, Desipramine, Norpramin
Stanford University
Chronic Pain
07/25
07/25
NCT02670161: Quality Improvement and Practice Based Research in Neurology Using the EMR

Enrolling by invitation
4
3300
US
Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description), (too many characters to list in this field; see Intervention Description)
NorthShore University HealthSystem
Brain Tumors, Epilepsy, Migraine, Mild Cognitive Impairment, Concussion, Multiple Sclerosis, Neuropathy, Parkinson's, Restless Legs Syndrome, Stroke
12/25
12/26
NCT05976347: Identifying and Treating Depression in the Orthopaedic Trauma Population

Not yet recruiting
4
100
US
Fluoxetine 20 MG, Prozac Weekly, Sarafem, Prozac, Duloxetine 30 MG, Irenka and Cymbalta, Observation, Referral to behavioral health and resources
Wake Forest University Health Sciences
Depression
05/26
05/26
Neuromodulators in IBS treatment, ChiCTR2400084241: Neuromodulators in the treatment of irritable bowel syndrome: a multicenter real-world study in China

Not yet recruiting
4
800
 
Escitalopram oxalate; Paroxetine; Sertraline; Duloxetine; Mirtazapine; Shugan Jieyu capsule
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Project of National Key R&D Program of China (2022YFC2504004)
irritable bowel syndrome
 
 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Daytrana (methylphenidate transdermal system) / Hisamitsu
NCT03420339: Stimulant Effects on Disruptive Behavior

Recruiting
4
10
US
Stimulant, Adderall, Concerta, Aptensio, Daytrana, Metadate, Quillivant, Ritalin, Focalin, Vyvanse
Matthew J O'Brien, PhD, BCBA-D
Attention Deficit Hyperactivity Disorder, Problem Behavior
03/27
08/27
NCT04419272 / 2012-004406-10: Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits

Recruiting
4
226
US
Methylphenidate, Concerta, Ritalin, Daytrana, Aptensio XR, Metadate CD, Methylin, Quillivant XR, Jornay PM, Adhansia XR, Cotempla, Placebo, sugar pill, lactose
VA Office of Research and Development, VA New York Harbor Healthcare System, Portland VA Medical Center, Miami VA Healthcare System, VA Boston Healthcare System
Epilepsy
09/27
09/27
NCI-2018-00698, NCT03525873: A Study of Cancer Related Fatigue in Patients With Metastatic Cancer Receiving Anti-PD1 Immunotherapy

Active, not recruiting
3
212
US
Laboratory Biomarker Analysis, Methylphenidate, Daytrana, Physical Activity, Placebo, placebo therapy, PLCB, sham therapy, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm, Recurrent Malignant Neoplasm
12/26
12/26
NCI-2018-02527, NCT03772834: Methylphenidate and Exercise in Reducing Cancer-Related Fatigue in Patients with Prostate Cancer

Recruiting
2/3
200
US
Exercise Intervention, Methylphenidate, Daytrana, Placebo, placebo therapy, PLCB, sham therapy, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Stretching
M.D. Anderson Cancer Center, National Cancer Institute (NCI)
Prostate Carcinoma
11/26
11/26
droxidopa / Generic mfg.
SCI, NCT05839652: Treatment of Orthostatic Hypotension in

Recruiting
4
25
US
Midodrine Hydrochloride, Droxidopa
James J. Peters Veterans Affairs Medical Center, Kessler Foundation
Hypotension
06/26
06/26
2007-005673-60: A MULTI-CENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PARALLEL-GROUP WITHDRAWAL-DESIGN STUDY TO ASSESS THE CLINICAL EFFECT OF DROXIDOPA IN SUBJECTS WITH PRIMARY AUTONOMIC FAILURE, DOPAMINE BETA HYDROXYLASE DEFICIENCY OR NON-DIABETIC NEUROPATHY AND SYMPTOMATIC NEUROGENIC ORTHOSTATIC HYPOTENSION

Ongoing
3
30
Europe
Droxidopa, DOPS, DOPS
Chelsea Therapeutics Inc
Symptomatic neurogenic orthostatic hypotension (NOH) in patients with Primary Autonomic Failure (PD, MSA and PAF), DBH deficiency and Non-Diabetic Neuropathy.
 
 
2013-003433-15: Effets du L-ThreoDOPS à long terme sur l’hypotension orthostatique et certains symptômes non moteurs dans l’atrophie multisystématisée

Not yet recruiting
3
108
Europe
Droxidopa, Capsule
CHU de Toulouse, PHRC
l’atrophie multisystématisée (AMS), maladie neurologique due à une perte de neurones (atrophie) dans plusieurs régions du cerveau, Diseases [C] - Nervous System Diseases [C10]
 
 
NCT02558972: Northera Improves Postural Tachycardia Syndrome (POTS) and Postural Vasovagal Syncope (VVS)

Active, not recruiting
2
30
US
Northera (Droxidopa), Placebo
New York Medical College, Lundbeck LLC
Postural Tachycardia Syndrome (POTS), Vasovagal Syncope (VVS), Fainting
12/22
12/22
NCT01370512: Droxidopa / Pyridostigmine in Orthostatic Hypotension

Enrolling by invitation
2
30
US
Droxidopa, Pyridostigmine, Placebo
Mayo Clinic, National Institute of Neurological Disorders and Stroke (NINDS)
Orthostatic Hypotension
05/26
05/26
DROP-AKI, NCT06937307: DROXIDOPA TO INCREASE MEAN ARTERIAL PRESSURE IN DECOMPENSATED CIRRHOSIS PATIENTS WITH ACUTE KIDNEY INJURY

Not yet recruiting
2
75
US
Droxidopa capsules, L-threo-3,4-dihydroxyphenylserine, Placebo
Giuseppe Cullaro, MD
Acute Kidney Injury, Cirrhosis, Decompensated Cirrhosis of Liver
12/26
12/27
NCT04977388: NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Occipital Horn Syndrome

Recruiting
1/2
6
US
Droxidopa, Northera, Placebo
Stephen G. Kaler, MD
Menkes Disease, Occipital Horn Syndrome
06/25
06/26
NCT02897063: Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Recruiting
1
34
US
Droxidopa, Northera, Midodrine, Placebo
Vanderbilt University Medical Center
Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy, Parkinson Disease, Orthostatic Hypotension
09/25
12/25
Nucynta (tapentadol) / Collegium Pharma, Grunenthal
2010-023175-26: Influence of Tapentadol on endogenous modulation of pain in chronic neuropathic pain patients and healthy volunteers

Ongoing
4
24
Europe
Tapentadol, morphine, Tapentadol, morphine, Tapentadol, morphine
Leiden University Medical Center
Chronic pain patients/ mhealthy volunteers
 
 
2015-005259-28: A study on the efefct of the analgesic tapentadol on pain scores in patients with low back pain

Ongoing
4
40
Europe
Tapentadol, N02AX06, Tablet, Palexia
LUMC, LUMC, Grunenthal
Low back pain, pain in the back, Diseases [C] - Musculoskeletal Diseases [C05]
 
 
2015-005258-37: Effect of treatment with the painkiller tapentadol on pain in patients with fibromyalgia

Ongoing
4
40
Europe
Tapenatdol, N02AX06, Tablet, Pallexia
LUMC, LUMC, Grunenthal GmbH
Fibromyalgia, Fibromyalgia, Diseases [C] - Musculoskeletal Diseases [C05]
 
 
2018-003515-22: Breathing effects of two opioid pain killers in healthy volunteers

Not yet recruiting
4
24
Europe
Tapentadol, Oxycodone, N02AX06, RVG110728, Tablet, Pallexia, Oxycodone
Leiden University Medical Center, Grunenthal
Chronic pain, Chronic pain, Body processes [G] - Physiological processes [G07]
 
 
2018-004804-21: The prevention of chronic postoperative pain.

Not yet recruiting
4
540
Europe
Tapentadol, Tablet, Tapentadol
Leiden University Medical Center, Grunenthal
Chronic pain after inguinal hernia surgery and knee replacement surgery., Chronic pain after surgery., Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
NCT06269770: Tapentadol vs Tramadol in Total Knee Arthroplasty

Recruiting
4
96
Europe
Tapentadol, Tramadol
University of Thessaly
Total Knee Replacement, Post-operative Pain, Chronic Pain
05/25
06/25
2006-004514-40: A Randomized, Double-Blind, Active- And Placebo-Controlled, Parallel Group, Multicenter Study To Evaluate The Efficacy And Safety of Multiple Doses of CG5503 Immediate Release Formulation In Subjects Awaiting Primary Joint Replacement Surgery for End-Stage Joint Disease

Ongoing
3
100
Europe
CG5503; R331333, OxyNorm, CG5503; R331333, n.a., OxyNorm 5, 10, 20 mg, OxyNorm 5, 10, 20 mg
Johnson & Johnson Pharamceutical Research & Development, L.L.C.
Pain
 
 
ChiCTR2300069799: Efficacy and Safety of Tapentadol Hydrochloride Tablets in Subjects with Moderate to Severe Pain after Orthopedic Surgery: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Phase III Study

Not yet recruiting
3
286
 
Oral administration Tapentadol Hydrochloride tablets ;Oral administration Oxycodone hydrochloride capsules
The Third Xiangya Hospital of Central South University; Third Xiangya Hospital of Central South University, Jiangsu Enhua Pharmaceutical Co., LTD., National Natural Science Foundation of China, Hunan Natural Science Foundation, Self-funded
Postoperative pain
 
 
2019-000755-14: Trial in healthy subjects to investigate the effect of analgesic drug on pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. Studio su soggetti sani volto ad indagare gli effetti di farmaci analgesici sulla elaborazione del dolore mediante misure neurofisiologiche del'attività del midollo del midollo spinale e del tronco dell'encefalo

Ongoing
2
56
Europe
pregabalin, lacosamide, tapentadol, [N03AX16], [N/A], [N02AX06], Capsule, hard, Film-coated tablet, Tablet, LYRICA - 75 MG CAPSULA RIGIDA - USO ORALE 100 CAPSULE IN BLISTER IN UNITA' SEPARABILI PERFORATO (PVC/ALU), VIMPAT - 100 MG - COMPRESSE RIVESTITE CON FILM - USO ORALE - BLISTER (PVC/PVDC/ALU) 14 COMPRESSE, PALEXIA - 50 MG COMPRESSE RIVESTITE CON FILM 10 COMPRESSE IN BLISTER PVC/PVDC/AL
UMBERTO I - POLICLINICO DI ROMA, Teva Pharmaceutical Industries LTD, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmbH
Healthy volunteers (intended indication: pain) soggetti sani (indicazione: dolore), Healthy volunteers (intended indication: pain) soggetti sani (indicazione: dolore), Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
2019-000942-36: The effects of lacosamide, pregabalin and tapentadol on biomarkers of peripheral pain processing

Not yet recruiting
2
60
Europe
lacosamide, Pregabalin, Tapentadol, [N02AX06], [N/A], [N03AX16], Tablet, Capsule, Vimpat 100 mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets
Aarhus University, UMBERTO I - POLICLINICO DI ROMA, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmbH, Teva Pharmaceutical Industries LTD
Healthy volunteers (intended indication: pain), Study in healthy volunteers to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
2019-001204-37: The effects of lacosamide, pregabalin and tapentadol on biomarkers of pain processing

Not yet recruiting
2
56
Europe
lacosamide, pregabalin, tapentadol, [N02AX06], [N03AX16], [N/A], Film-coated tablet, Capsule, Tablet, Vimpat 100mg film coated tablets, Lyrica 75 mg hard capsules, Palexia 50 mg film-coated tablets
Institute of Neuroscience (IoNS), Université catholique de Louvain, UMBERTO I - POLICLINICO DI ROMA, Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under Grant Agreement, Eli Lilly and Company LTD, Esteve Pharmaceuticals SA, Grünenthal GmBH, Teva Pharmaceutical Industries LTD
Healthy subjects (intended indication: pain), Study in healthy subjects to examine drug effects on biomarkers in experimental pain, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
 
 
lisdexamfetamine / Generic mfg.
ACTRN12624001061527: Oral Lisdexamfetamine for the treatment of Acute Methamphetamine withdrawal (the OLAM trial): A randomised controlled trial

Not yet recruiting
4
184
 
St Vincent's Hospital Sydney, NHMRC
Acute methamphetamine withdrawal
 
 
ACTRN12618000623291: Neural mechanisms of lisdexamfetamine in binge eating disorder.

Recruiting
4
62
 
University of Sydney, Shire International GmbH
Binge-Eating Disorder
 
 
NCT01413165: Phase 4, Open Label, Multicentre, 2 Year Safety Study of Lisdexamfetamine Dimesylate in Children/Adolescents With ADHD

Not yet recruiting
4
12
Europe
Lisdexamfetamine dimesylate, SPD 489
Maastricht University Medical Center, Shire Development LLC
Attention Deficit Disorder With Hyperactivity
08/13
12/13
ACTRN12621000045819: An open-label trial of oral lisdexamfetamine for the treatment of acute methamphetamine withdrawal

Completed
4
15
 
St Vincent's Hospital Sydney, The National Centre for Clinical Research on Emerging Drugs
Acute methamphetamine withdrawal
 
 
NCT03337646: Evaluation of the Effect and Safety of Lisdexamfetamine in Children Aged 6-12 With ADHD and Autism

Completed
4
48
Canada
Lisdexamfetamine Dimesylate, Vyvanse
JPM van Stralen Medicine Professional, Shire
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
03/23
03/23
ACTRN12617000657325: Lisdexamfetamine for the treatment of methamphetamine addiction

Completed
3
180
 
University of New South Wales , National Health and Medical Research Council, Curran Foundation
Addiction, Methamphetamine dependence
 
 
NCT03924193: Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Acute Treatment

Completed
3
141
US
Lisdexamfetamine Dimesylate, Cognitive-Behavioral Therapy, Combination LDX and Cognitive-Behavioral Therapy
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Binge-Eating Disorder, Obesity
09/23
09/23
NCT03926052: Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity: Maintenance Treatment

Completed
3
61
US
Lisdexamfetamine Dimesylate, Placebo
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Binge-Eating Disorder, Obesity
11/24
11/24
NCT04599504: Pharmacological and Behavioral Treatment After Bariatric Surgery: Medication Change for Non-Responders (Stage 2b)

Enrolling by invitation
2/3
60
US
Lisdexamfetamine Dimesylate (Medication), Vyvanse, Placebo
Yale University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Loss-of-control Eating, Obesity/Overweight
05/27
05/27
2017-001490-16: Treatment of Bulimia Nervosa, with and without simultaneous probable ADHD, with the stimulant medicine Lisdexamphetamin . Behandling av Bulimia Nervosa, med och utan samtidig sannolik ADHD, med den psykostimulerande medicinen Lisdexamfetamin.

Ongoing
2
50
Europe
Capsule, hard, Elvanse vuxen
Stockholms läns landsting, Stiftelsen Söderström-Königska sjukhemmet, Petrus och Augusta Hedlunds stiftelse
Bulimia Nervosa with and without simultaneous Attention Deficit Hyperactivity Disorder. Bulimia Nervosa med och utan samtidig Attention Deficit Hyperactivity Disorder., Bulimia Nervosa with and without simultaneous ADHD Bulimia Nervosa med och utan samtidig ADHD, Psychiatry and Psychology [F] - Mental Disorders [F03]
 
 
2022-001906-24: LAMAinDiab - comparison of 2 pharmacological therapies (lisdexamphetamine vs methylphenidate) for pediatric patients with ADHD and type 1 diabetes - a randomized crossover clinical trial   LAMAinDiab – porównanie 2 terapii farmakologicznych (lisdeksamfetamina vs metylfenidat) dla pacjentów pediatrycznych z zespołem ADHD i cukrzycą typu 1 - randomizowane krzyżowe badanie kliniczne .

Not yet recruiting
2
150
Europe
Elvanse, Concerta, Capsule, hard, Prolonged-release tablet
Medical University in Lodz, Agencja Badań Medycznych
Patients with ADHD and type I diabetes. Pacjenci z ADHD i Cukrzycą typu I., Patients with ADHD and type I diabetes. Pacjenci z ADHD i Cukrzycą typu I., Not possible to specify
 
 
LIBERATE, NCT06847399: Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder

Not yet recruiting
2
105
US
Tirzepatide, Lisdexamfetamine Dimesylate, Guided self-help cognitive behavioral therapy, Placebo (oral), Placebo (injection)
Johns Hopkins University, Eli Lilly and Company
Obesity and Overweight, Binge Eating Disorder
12/27
12/27
NCT05854667: Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users

Recruiting
2
440
Canada
Treatment as Usual plus Placebo, Contingency Management, Treatment as Usual plus Placebo plus Contingency Management, Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
Centre hospitalier de l'Université de Montréal (CHUM), Canadian Institutes of Health Research (CIHR)
Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
11/25
11/25
LAMAinDiab, NCT05957055: Lisdexamphetamine Vs Methylphenidate for Pediatric Patients with ADHD and Type 1 Diabetes

Recruiting
2
150
Europe
parental training in behavior management, PT training, Lisdexamfetamine, LDX, Methylphenidate, MPH
Medical University of Lodz, Medical University of Silesia, Medical University of Gdansk, Institute of Medical Sciences of the University of Opole, Pediatric Center of the Central Clinical Hospital of the Medical University of Lodz
Attention Deficit Disorder with Hyperactivity, Diabetes Mellitus, Type 1
12/27
12/27
NCT05416125: Vyvanse in Children Aged 6 to 12 Years

Recruiting
1
40
US
Lisdexamfetamine Dimesylate, Lifestyle therapy
University of Minnesota
Obesity, Childhood
11/28
11/29
ADAPT, NCT02136147: ADHD Medication and Predictors of Treatment Outcome

Completed
N/A
632
Europe
methylphenidate medication, N06BA04, Concerta, Ritalin, Equasym, Medikinet, atomoxetine medication, N06BA09, Strattera, lisdexamphetamine medication, N06BA12, Elvanse, guanfacine medication, C02AC02, Intuniv
Karolinska Institutet
Attention Deficit Disorder With Hyperactivity (ADHD)
07/21
06/22
NCT04727476: The Use of Lisdexamfetamine for Children Aged 7-13 With Attention Deficit Disorders

Active, not recruiting
N/A
413
Europe
Lisdexamfetamine
Aarhus University Hospital, Takeda
Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, Hyperkinetic Disorder
08/21
05/22
IDEAL, NCT04946461: The Day-time Response Variation of (Lis)Dexamphetamine

Completed
N/A
16
Europe
Dexamfetamine Sulfate 5 Mg Oral Tablet, Tentin, Lisdexamfetamine Dimesylate, Elvanse, blood samples, vena puncture
Amsterdam UMC, location VUmc, ADHDcentraal
Adhd
12/21
06/22
NCT05551689: FOCUS ADHD Mobile Health App for Adult ADHD Patients

Completed
N/A
73
RoW
Psychostimulant, Methilphenidate, Lisdexamfetamine, FOCUS ADHD App, mhealth app
Hospital de Clinicas de Porto Alegre, University of Sao Paulo
ADHD
09/22
03/23
AGUALIS, NCT03333668: Experimental fMRI Study of Guanfacine and Lisdexamfetamine in ADHD Adolescents

Active, not recruiting
N/A
20
Europe
Lisdexamfetamine dimesylate, Vyvanse (Shire Pharmaceuticals Ltd.), Guanfacine Extended Release Oral Tablet, Intuniv (Shire Pharmaceuticals Ltd.), Placebo
King's College London, Shire
ADHD
12/22
03/25
NCT03497169: Bariatric Surgery and Pharmacokinetics of Lisdexamphetamine

Completed
N/A
12
Europe
Lisdexamfetamine Dimesylate, Lisdexamfetamine, Vyvanse, Elvanse
Norwegian University of Science and Technology, St. Olavs Hospital, Volvat Medisinsk Senter Stokkan, Namsos Hospital, Alesund Hospital
Obesity, Morbid
09/20
09/20
Savella (milnacipran) / AbbVie, Pierre Fabre
NCT05737511: Efficacy of Hydroxyzine for Patients With Panic Disorder

Not yet recruiting
4
80
NA
Hydroxyzine, Atarax, Vistaril, Escitalopram Oxalate, citalopram, fluoxetine, fluvoxamine, paroxetine, paroxetine CR, sertraline, venlafaxine XR,, Alprazolam, clomipramine, clonazepam, diazepam, imipramine, lorazepam, mirtazapine, reboxetine, Bupropion SR, divalproex, duloxetine, gabapentin, levetiracetam, milnacipran, moclobemide, olanzapine, phenelzine, quetiapine, risperidone, tranylcypromine
Sultan Qaboos University
Panic Disorder
12/26
12/26
2006-003658-47: Exploratory study of the efficacy and safety of flexible doses of Milnacipran and Venlafaxine administered in out patients with Major Depressive Disorder.

Ongoing
3
180
Europe
Milnacipran, Venlafaxine, IXEL 25 mg, IXEL 50 mg, EFFEXOR 25 mg, EFFEXOR 50 mg, IXEL 25 mg, IXEL 50 mg, EFFEXOR 25 mg, EFFEXOR 50 mg
Pierre Fabre Médicament - IRPF
Major Depressive Disorder
 
 
KETAPAL, NCT02783430: Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease

Recruiting
2/3
80
Europe
Ketamine, Milnacipran, Placebo
University Hospital, Lille
Depression
09/24
09/24
SPR, NCT01026077: The Savella Pregnancy Registry

Terminated
N/A
350
US
Syneos Health, AbbVie
Fibromyalgia
10/24
10/24
NCT05384210: Effect of Milnacipran / Gabapentin in Fibromyalgia

Enrolling by invitation
N/A
75
RoW
Milnacipran, Gabapentin, Combined gabapentin/milnacipran
Mansoura University
Fibromyalgia
10/23
11/23
ChiCTR2400083771: Randomized, double-blind, and placebo-controlled clinical study of Milnacipran hydrochloride tablets combined with transcranial magnetic stimulation in the treatment of somatic cough disorders

Not yet recruiting
N/A
98
 
receiving both Milnacipran and true rTMS; receiving both Milnacipran and false rTMS
Shanghai Tongji Hospital; Shanghai Tongji Hospital, Project supported by Clinical Research Project of Tongji Hospital of Tongji University (Grant No.ITJ(QN)2303)
somatic cough disorders
 
 
duloxetine / Generic mfg.
ACTRN12624000919516: Duloxetine for chronic sciatica (DREAM): an adaptive randomised placebo-controlled trial

Recruiting
4
332
 
The University of Sydney, National Health and Medical Research Council (NHMRC)
Sciatica
 
 
2008-006558-17:

Ongoing
4
100
Europe
cymbalta, sipralexa, aspegic, Buccal tablet, Tablet, , cymbalta, sipralexa, aspegic
cliniques universitaire de mont godinne
major depression
 
 
2014-005701-20: Het verschuiven van pijn modulatie naar pijnstilling: mechanisme-specifieke farmacologische preventie van post-sternotomie pijn: de MASTER studie

Ongoing
4
300
Europe
Capsule, Cymbalta, Lyrica
Leiden University Medical Center, LUMC
chronic pain chronische pijn, chronic pain chronische pijn, Body processes [G] - Physiological processes [G07]
 
 
2005-003846-33: Efecto de la duloxetina en la respuesta nociceptiva cerebral en el trastorno depresivo mayor. Estudio mediante resonancia magnética funcional (RMf)

Ongoing
4
72
Europe
Duloxetina, Duloxetina (DCI), Cymbalta 30 mg cápsulas duras gastrorresistentes, Cymbalta 30 mg cápsulas duras gastrorresistentes
Dr. Narcís Cardoner
Trastorno depresivo mayor
 
 
2008-005695-27: Comparing Problem Solving Treatment combined with duloxetine with Problem Solving Treatment alone for patients with major depressive disorder in primary care

Ongoing
4
160
Europe
duloxetine, Cymbalta, Cymbalta, Cymbalta
Eli Lilly Nederland
Major depressive disorder (episode or recurrent), moderately severe as principal DSM-IV diagnosis.
 
 
2009-011893-13: Adherence of antidepressants during pregnancy

Ongoing
4
50
Europe
Paroxetine, Amitriptyline, Clomipramine, Imipramine, Nortriptyline, escitalopram, Citalopram, Fluoxetine, Fluvoxamine, Sertraline, Duloxetine, venlafaxine, EU/1/04/296/002, Seroxat, Tryptizol, Anafranil, Imipramine, Nortrilen, Lexapro, Cipramil, prozac, Fevarin, Zoloft, Cymbalta, Efexor, Seroxat, Tryptizol, Anafranil, Imipramine, Nortrilen, Lexapro, Cipramil, prozac, Fevarin, Zoloft, Cymbalta, Efexor
Isala Klinieken
Pregnant women with psychiatric morbidity and an strong indication for using antidepressants
 
 
2009-010188-18: Effectiveness of the treatment of depressive disorder and comorbid pain symptoms

Ongoing
4
219
Europe
duloxetine, Cymbalta, Cymbalta, Cymbalta
Eli Lilly Nederland, Eli Lilly Nederland BV, GGz Breburg, Arkin, GGz inGeest
Major depressive disorder (episode or recurrent), as principal DSM-IV diagnosis combined with (sub)chronic pain symptoms as defined bij score of >3 on BPI painlist for at least six weeks.
 
 
2014-001550-42: Combined molecular and functional brain imaging (PET/MR) to predict treatment response to neuropharmacological treatment Kombinierte molekulare und funktionelle Bildgebung des Gehirns (PET/MR) zur Vorhersage des Therapieerfolgs von Neuropharmaka

Ongoing
4
80
Europe
Seropram, Cymbalta, Efectin, Cipralex, Seropram, Cymbalta, Efectin, Cipralex, Seropram, Cymbalta, Efectin
Medizinische Universität Wien, Medizinische Universität Wien
Major depressive disorder Depression
 
 
ChiCTR1900027181: Efficacy and Safety of Doloxetine in the Treatment of Subacute Herpes Zoster Neuralgia

Completed
4
43
 
duloxetine with Oral administration of gabapentin, pregabalin and Mecobalamin ;Oral administration of gabapentin, pregabalin and Mecobalamin
Fujian Provincial Geriatric Hospital; None, self-funding
Subacute Herpes Zoster Neuralgia
 
 
NCT03249311: Levomilnacipran in Healthy Males

Active, not recruiting
4
36
Canada
Levomilnacipran, Fetzima, Duloxetine, Cymbalta, Placebos
University of Ottawa, Allergan
None (i.e. Healthy Volunteers)
12/19
05/22
ChiCTR1900027004: Role of SERTRALINE (SSRI) Versus DULOXETINE (SSNRI) among depressed total knee arthroplasty candidates: a prospective, randomized, patient selective, double blind study

Not yet recruiting
4
180
 
DULOXETINE ;SERTRALINE ;placebo
Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University; West China Hospital, Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total knee arthroplasty
 
 
ChiCTR1900027005: Compare the effect of DULOXETINE Versus SERTRALINE in THA patients with anxiety and depression: a prospective, randomized, double-blinded study

Recruiting
4
180
 
DULOXETINE ;SERTRALINE ;placebo
West China Hospital, Sichuan University; West China Hospital, Sichuan University, Ministry of Health Special Scientific Research Projects of China
THA
 
 
ChiCTR-RPC-17012990: Functional magnetic resonance study of brain network mechanism in persistent somatoform pain disorder

Recruiting
4
80
 
duloxetine sustained-release capsules ;none
Department of Psychology, The affiliated Drum Tower hospital of Nanjing university medical school; The affiliated Drum Tower hospital of Nanjing university medical school, Nanjing General course of medical science and technology development
persistent somatoform pain disorder
 
 
ChiCTR2000033606: The effect of duloxetine on pain and functional rehabilitation after total hip replacement: a randomized controlled trial.

Recruiting
4
100
 
Duloxetine ;Placebo
West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total hip arthroplasty
 
 
ChiCTR2000033910: The Effects of Duloxetine on Pain and Hip Function after Total Knee Arthroplasty: a Randomized Controlled Trial.

Recruiting
4
100
 
Duloxetine ;Placebo
West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total knee arthroplasty
 
 
NCT06837012: Duloxetine As an Analgesic in Patients Without Central Sensitivity After Same Sitting Bilateral Total Knee Arthroplasty

Completed
4
106
RoW
Duloxetine - low dose, Placebo
Orthopaedic Arthroscopy Knee and Shoulder Clinic, The Grant Medical College & Sir J.J. Group of Hospitals
Osteoarthritis of Knee, Central Sensitization, Central Sensitisation
07/22
07/22
ChiCTR2000033605: The Effects of Duloxetine on Pain and Emotional Function Following Total Hip Arthroplasty in Patients With Anxiety and Depression: a Randomized Controlled Trial

Recruiting
4
100
 
Duloxetine ;Placebo
West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total hip arthroplasty
 
 
NCT04117893: Duloxetine Combined With Intra-articular Injection of Corticosteroid and Hyaluronic Acid Reduces Pain in the Treatment of Knee Osteoarthritis Patients

Completed
4
150
RoW
Duloxetine, intra-articular injection of corticosteroid and hyaluronic acid
Beijing Tiantan Hospital
Osteoarthritis, Knee, Chronic Pain
06/21
12/21
ChiCTR2000033903: The Effects of Duloxetine on Pain and Emotional Function Following Total Knee Arthroplasty in Patients with Depression Symptoms: a Randomized Controlled Trial.

Recruiting
4
100
 
Duloxetine 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery). ;Placebo 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery).
West China Hospital of Sichuan University; West China Hospital of Sichuan University, Ministry of Health Special Scientific Research Projects of China
Total knee arthroplasty
 
 
ChiCTR2000030195: Duloxetine reduces postoperative pain and improves quality of life after single-segment lumbar fusion procedures in centrally sensitized patients: a prospective randomized controlled study

Recruiting
4
100
 
duloxetine 60mg/day with standard analgesic regimen ;standard analgesic regimen
The Third People's Hospital of Chengdu; The Third People's Hospital of Chengdu, Self-financing
single-segment lumbar fusion
 
 
ChiCTR2000035105: Duloxetine Reduces Pain and Improves Quality of Recovery Following the Repair of Rotator Cuff Injury

Recruiting
4
120
 
duloxetine 30mg bid ;without duloxetine
West China Hospital of Sichuan University; West China Hospital of Sichuan University, 135 key fund of West China Hospital
Rotator cuff injury
 
 
NCT04782310: Duloxetine vs Pregabalin for Thoracotomy Pain

Recruiting
4
75
RoW
Pregabalin, Duloxetine
Cairo University
Postoperative Pain
08/21
09/21
ChiCTR1900027038: Synergistic Analgesia of Duloxetine in Phantom Limb Pain: a Randomized Controlled Trial.

Recruiting
4
120
 
administration of duloxetine 60mg ;administration of placebo
Cancer Hospital of China Medical University; Cancer Hospital of China Medical University, self-financing
Phantom Limb Pain
 
 
ChiCTR2100042981: Efficacy, safety and compliance of integrated traditional Chinese and Western medicine in patients with depression in the community: a multi-center, randomized controlled study

Not yet recruiting
4
300
 
Use escitalopram or duloxetine ;Use Shu-Gan Jie-Yu capsule ;Use Shu-Gan Jie-Yu capsule combined with escitalopram or duloxetine
Shandong Mental Health Center; Shandong Mental Health Center, Shandong Province Integrated Traditional Chinese and Western Medicine Depression Prevention Project
Major depressive disorder
 
 
ChiCTR2100047183: Investigation of the effect of duloxetine on the treatment of primary frozen shoulder

Recruiting
4
102
 
Daily oral duloxetine 60mg ;Before treatment, 1 week, 2 week, 4 week, 8 week, 1 month after oral placebo or duloxetine
Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, NSFC scientific research funds
Frozen shoulder
 
 
ChiCTR2200056163: Effects of Pregabalin, Duloxetine and NSAIDs on Joint Pain and Function in Osteoarthritis Patients after Total Joint Arthroplasty

Not yet recruiting
4
84
 
200mg celecoxib b.i.d. (morning and night) p.o. for 4 weeks ; 75mg pregabalin b.i.d. (morning and night) p.o. for 4 weeks ; 30mg duloxetine b.i.d. (morning and night) p.o. for 4 weeks
West China Hopital of Sichuan University; West China Hopital of Sichuan University, 1.3.5 Project of West China Hospital [No. 2021YFQ0028]
Osteoarthritis
 
 
ChiCTR2100046144: Combining multimodal magnetic resonance imaging and machine learning technology to explore the central mechanism of chronic primary frozen shoulder pain and the central analgesic mechanism of duloxetine

Recruiting
4
60
 
Daily oral duloxetine 60mg
Tianjin Medical University General Hospital; Tianjin Medical University General Hospital, NSFC scientific research funds
Frozen shoulder
 
 
ChiCTR2100054802: Effect of duloxetine administration in patients with depressive symptoms undergoing total knee arthroplasty: A randomized controlled trial

Recruiting
4
70
 
Duloxetine 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery) ;Placebo 60 mg daily for 7 days, starting on the day of surgery (2 hours before surgery)
West China Hospital, Sichuan University; West China Hospital, Sichuan University, 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18039)
Total knee arthroplasty
 
 
ChiCTR2100054655: Effect of duloxetine administration in patients with depressive symptoms undergoing total hip arthroplasty: a randomized controlled trial

Not yet recruiting
4
70
 
Duloxetine ;Placebo
West China Hospital, Sichuan University; West China Hospital, Sichuan University, 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18039)
N/A
 
 
2022-002780-30: Efficacy of patient education and duloxetine, alone and in combination, for patients with multiorgan bodily distress syndrome: a partial-factorial randomized controlled trial Patientundervisning og medicinsk behandling (duloxetin/aktiv placebo) til patienter med svær funktionel lidelse: et randomiseret, kontrolleret forsøg

Not yet recruiting
4
212
Europe
Cymbalta, Benztropine, Capsule, Tablet, Cymbalta, Benztropine
Aarhus University Hospital, The Research Clinic for Functional Disorders and Psychosomatics, The Tryg Foundation
Multiorgan Functional somatic disorders (FSD) / bodily disstress syndrome (BDS) multiorgan Funktionel lidelse, Functional somatic disorder Funktionel lidelse, Not possible to specify
 
 
NCT05510856: Comparative Clinical Study Evaluating the Possible Efficacy of Duloxetine, Gabapentin and Lacosamide on Oxaliplatin-Induced Peripheral Neuropathy in Cancer Patients

Completed
4
93
RoW
Duloxetine, Gabapentin, Lacosamide
Tanta University
Oncology
09/24
10/24
ChiCTR2100054831: Clinical efficacy and safety of duloxetine hydrochloride and amitriptyline combined with pregabalin in patients with herpes zoster neuralgia

Recruiting
4
80
 
Duloxetine combined with pregabalin ;Amitriptyline combined with pregabalin
Nanjing Drum Tower Hospital, School of Medicine, Nanjing University; Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University
Herpes zoster neuralgia
 
 
NCT05563038: Scrambler Therapy for Post-Stroke Pain

Recruiting
4
40
US
Scrambler Therapy, Calmare Therapy, Standard Medication Management
Johns Hopkins University
Post Stroke Pain
12/26
12/26
NCT05086393: Duloxetine RCT on Postop TKA Outcomes

Recruiting
4
504
US
Duloxetine, Placebos
Rush University Medical Center
Pain, Postoperative, Total Knee Arthroplasty
05/25
06/25
EDULOX, NCT06232473 / 2022-002780-30: Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder

Recruiting
4
424
Europe
Patient Education, Duloxetine, Cymbalta, SNRI, Benztropine Mesylate 0.5 MG and passive placebo RAP, Enhanced usual care
Aarhus University Hospital, Central Denmark Region, University of Aarhus, Vejle Hospital, Aalborg University Hospital, TrygFonden, Denmark, Independent Research Fund Denmark
Functional Disorder
11/27
11/29
PREDICT, NCT06245109: Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

Recruiting
4
180
US
Duloxetine, Cymbalta, Celecoxib, Celebrex, Placebo
Northwestern University, Brigham and Women's Hospital
Knee Osteoarthritis
03/28
03/28
BEST, NCT05396014: The Trial: Biomarkers for Evaluating Spine Treatments

Completed
4
1014
US
Enhanced Self-Care (ESC), Acceptance and Commitment Therapy (ACT), Evidence-Based Exercise and Manual Therapy (EBEM), Duloxetine, Cymbalta
University of North Carolina, Chapel Hill, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Chronic Low-back Pain
07/24
10/24
NCT06087211: Pain Relieving Potentials of Combination of Oral Duloxetine and Intravenous Magnesium Sulphate in Post Mastectomy Pain

Recruiting
4
90
RoW
Duloxetine and magnesium sulphate, cymbalta and magnesium sulphate, Duloxetine, cymbalta, placebo, control
National Cancer Institute, Egypt
Post-mastectomy Pain Syndrome
04/24
04/24
RELIFE, NCT06423716: Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty

Not yet recruiting
4
150
Canada
Duloxetine, Placebo
Sunnybrook Health Sciences Centre
Knee Osteoarthritis
07/26
12/26
PRECICE, NCT04395001: Pain Response Evaluation of a Combined Intervention to Cope Effectively

Completed
4
345
US
duloxetine, Irenka, Cymbalta, Web-based Cognitive Behavioral Therapy (CBT), Nurse-delivered Motivational Interviewing
Wake Forest University Health Sciences, National Institute of Nursing Research (NINR)
Chronic Pain
07/24
07/24
AtLAS-A, NCT04245436: Acute and Long-Term Antidepressant Treatment Success in Adolescents With Anxiety

Recruiting
4
60
US
Duloxetine, Cymbalta, Irenka, Escitalopram, Lexapro
University of Cincinnati
Anxiety, Depressive Symptoms
07/25
08/25
DOTS-AD, NCT04245748: Determining Optimal Treatment Sequences in Anxious Depression

Recruiting
4
84
US
Escitalopram, Lexapro, Duloxetine, Cymbalta
University of Cincinnati
Anxious Depression, Depression
07/25
12/25
ChiCTR2400079841: Analysis of the efficacy of duloxetine and pregabalin for analgesia after total knee arthroplasty: a prospective, randomized controlled study

Not yet recruiting
4
120
 
Oral duloxetine 60 mg/dose once daily beginning two days before surgery and continuing through 14 days postoperatively; Oral pregabalin 150 mg/dose twice daily beginning two days before surgery and continuing through 14 days postoperatively; Oral duloxetine 60 mg/dose once a day and oral pregabalin 150 mg/dose twice a day starting two days prior to surgery and continuing until 14 days postoperatively; After the 6h postoperative fasting period, oral erixib tablets 0.1g, codeine 500mg, starting on the second postoperative day and up to 14 days postoperatively, oral erixib tablets 0.1g/dose, 2 times/day, oral codeine 500mg/dose, 2 times/day
Honghui Hospital, Xi'an Jiaotong University; Honghui Hospital, Xi'an Jiaotong University, self-finance
osteoarthritis of the knee
 
 
ChiCTR2400087090: A randomized double-blind multicenter psychiatric imaging study of Jiuwei Zhenxin granules in the treatment of patients with generalized anxiety disorder

Not yet recruiting
4
100
 
Duloxetine (60mg qd) + Jiuwei Zhenxin granules placebo; Jiuwei Zhenxin granules (6g tid) + Duloxetine placebo; None
West China Hospital of Sichuan University; West China Hospital of Sichuan University, BEIJING BEILU PHARMACEUTICAL CO.,LTD
generalized anxiety disorder (GAD)
 
 
SNRI, NCT05851898: Serotonin-norepinephrine Reuptake Inhibitor in Prophylaxis of Depression Following Fragility Fractures

Recruiting
4
100
US
Duloxetine 30 mg, Common brands: Irenka, Cymbalta
Wake Forest University Health Sciences
Depression in Old Age, Fragility Fracture
12/26
12/26
NCT06807866: Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT

Recruiting
4
64
US
Duloxetine, Placebo
University of Miami
THA
04/26
04/26
NCT03548454: Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization

Recruiting
4
320
US
Duloxetine, Cymbalta, Desipramine, Norpramin
Stanford University
Chronic Pain
07/25
07/25
NCT02670161: Quality Improvement and Practice Based Research in Neurology Using the EMR

Enrolling by invitation
4
3300
US
Listed for each disorder below, up to three drugs per disorder (too many characters to list in this field; see Intervention Description), (too many characters to list in this field; see Intervention Description)
NorthShore University HealthSystem
Brain Tumors, Epilepsy, Migraine, Mild Cognitive Impairment, Concussion, Multiple Sclerosis, Neuropathy, Parkinson's, Restless Legs Syndrome, Stroke
12/25
12/26
NCT05976347: Identifying and Treating Depression in the Orthopaedic Trauma Population

Not yet recruiting
4
100
US
Fluoxetine 20 MG, Prozac Weekly, Sarafem, Prozac, Duloxetine 30 MG, Irenka and Cymbalta, Observation, Referral to behavioral health and resources
Wake Forest University Health Sciences
Depression
05/26
05/26
Neuromodulators in IBS treatment, ChiCTR2400084241: Neuromodulators in the treatment of irritable bowel syndrome: a multicenter real-world study in China

Not yet recruiting
4
800
 
Escitalopram oxalate; Paroxetine; Sertraline; Duloxetine; Mirtazapine; Shugan Jieyu capsule
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Project of National Key R&D Program of China (2022YFC2504004)
irritable bowel syndrome
 
 
 

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