| piromelatine (Neu P11) / Neurim |
| Active, not recruiting | 2/3 | 225 | Canada, US | Piromelatine 20 mg, Neu-P11, Placebo | Neurim Pharmaceuticals Ltd., Syneos Health | Alzheimer's Disease | 06/25 | 06/25 | | |
| Circadin (melatonin prolonged release) / Lundbeck, Neurim, Flynn Pharma, Grupo Insud, Biocodex, Kuhnil Pharma |
| Ongoing | 4 | 702 | Europe | melatonin, none, Circadin, Circadin | Academic Medical Centre | Delirium in elderly patients (65 yrs and older) acutely admitted to the ward of internal medicine. | | | | |
| Ongoing | 4 | 150 | Europe | Ritalin, Circadin, Ritalin, Circadin, Ritalin, Circadin | Parnassia Bavo Groep - PsyQ, PsyQ The Hague | Adults with ADHD and suboptimal eye functioning. Volwassenen met ADHD en een afwijkende oogfunctie. | | | | |
| Recruiting | 4 | 190 | Europe | Melatonin (Circadin ®), Placebo, Oral tablet | University Hospital, Basel, Switzerland | Hypoactive Delirium | 12/26 | 12/27 | | |
2004-000914-37: A DOUBLE-BLIND, PARALLEL GROUP, RANDOMISED, PLACEBO CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF CIRCADIN® 2MG IN THE IMPROVEMENT OF SLEEP QUALITY IN PATIENTS WITH INSOMNIA AGED 55-80 YEARS. |
|
|
| Ongoing | 3 | 520 | Europe | CIRCADIN ®, N/A, | Neurim Pharmaceuticals (1991) Ltd | Primary Insomnia in adults over 55 years | | | | |
2012-002436-82: Melatonin effects on visual and sleep patterns anomalies in subjects diagnosed with Retinitis Pigmentosa Efecto de la melatonina sobre las alteraciones visuales y del sueño en enfermos afectos de Retinosis Pigmentaria |
|
|
| Ongoing | 3 | 80 | Europe | Circadin 2 mg, CIRCADIN 2 mg comprimidos de liberación prolongada, CIRCADIN 2 mg comprimidos de liberación prolongada | Isabel Pinilla Lozano, Ministerio de Sanidad, PolÃtica Social e Igualdad | To evaluate the sleep quality in patients with Retinitis Pigmentosa Evaluar la calidad del sueño en pacientes con RP | | | | |
| Ongoing | 2 | 90 | Europe | Circadin, Circadin, Circadin | University of Oxford | Bipolar Disorder (mania and hypomania) | | | | |
2008-001689-97: Etude de la relation dose-effet de la mélatonine dans l\'autisme infantile. |
|
|
| Ongoing | 2 | 36 | Europe | circadin LP, circadin LP | CHU de Rennes | Autisme infantile, notamment les troubles du sommeil et de la communication | | | | |
| Ongoing | 2 | 80 | Europe | Circadin, N/A, Circadin, Circadin | North Bristol NHS Trust | Nocturia; Multiple Sclerosis | | | | |
2012-005255-17: The effects of melatonin treatment on risk for diabetes and heart disease |
|
|
| Not yet recruiting | 2 | 160 | Europe | melatonin, Prolonged-release tablet, Circadin | University of Leeds, European Commission, clinical researc local network | first-degree relatives of individuals with type 2 diabetes., Diabetes is a common condition and in the majority it is due to insulin resistance. The current work investigates the role of melatonin on insulin resistance and glucose metabolism., Body processes [G] - Metabolic Phenomena [G03] | | | | |
2012-001960-31: Combined drug approach to prevent liver injury during transplantation. Toediening geneesmiddelen om lever beschadiging tijdens transplantatie te verminderen. Réduction de dommage en transplantation hépatique après administration séquentielle de médicaments. |
|
|
| Not yet recruiting | 2 | 82 | Europe | Circadin, Flolan, Atenativ, NeoRecormon, Cetor, Vitamin E suspension, Apotransferrin, Remicade/Infliximab, Tationil 600, Cinryze, Prolonged-release tablet, Powder and solvent for solution for infusion, Solution for injection in pre-filled syringe, Powder and solvent for solution for injection, Oral suspension, Solution for infusion, Powder and solvent for concentrate for solution for infusion, Circadin, Flolan, Atenativ, NeoRecormon solution for injection in pre-filled syringe, Cetor 100E/ml poeder en oplosmiddel voor oplossing voor injectie, Vitamin E Suspension 100 mg/ml, Apotransferrin, Remicade, Tationil 600, Cinryze 500 eenheden poeder en oplosmiddel voor oplossing voor injectie | UZ Leuven, IWT-TBM | Investigation of the ischemia-reperfusion injury in patients who will undergo a liver transplantation after receiving a drug combination/multifactorial modulation beoordeling vermindering van de ischemie-reperfusie schade bij patiënten die een combinatie aan geneesmiddelen tijdens levertranplantatie hebben toegediend gekregen, Investigation of liver injury in patients who will undergo a liver transplantation after receiving a drug combination/multifactorial modulation beoordeling vermindering van leverschade bij patiënten die een een combinatie aan geneesmiddelen tijdens een levertransplantatie hebben toegediend gekregen, Body processes [G] - Biological Phenomena [G16] | | | | |
| Not yet recruiting | 2 | 60 | Europe | Circadin, Tablet, Circadin | University of Aberdeen, NHS Grampian, , National Institute of Academic Anaesthesia | Sleep disturbance in patients with chronic pain, Sleep disturbance in patients with chronic pain, Diseases [C] - Symptoms and general pathology [C23] | | | | |
NCT01628029: Cognitive Behavioral Therapy and Multimodal Therapy in Treating Sleep Disturbance in Patients With Cancer |
|
|
| Active, not recruiting | 2 | 68 | US | Counseling, Counseling Intervention, Methylphenidate Hydrochloride, Concerta, Quillivant XR, Ritalin, Phototherapy, Actinotherapy, Bright Light Therapy, light therapy, Placebo Administration, Quality-of-Life Assessment, Quality of Life Assessment, Sham Intervention, Sham Comparator, Therapeutic Melatonin, Circadin, Melatonin, Melaxen | M.D. Anderson Cancer Center, National Cancer Institute (NCI) | Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Sleep Disorder | 12/25 | 12/25 | | |
Mela-Nia, NCT06801379: A Novel Inhaled Formulation of Melatonin to Treat Adults with Insomnia: Pharmacokinetic Study |
|
|
| Not yet recruiting | 1 | 5 | RoW | Inhaled Melatonin (100 μg), Melatonin, N-Acetyl-5-methoxytryptamine, Oral Melatonin (4 mg), Circadin | Woolcock Institute of Medical Research | Insomnia | 12/25 | 05/26 | | |
| Not yet recruiting | 1 | 10 | RoW | Inhaled Melatonin (100 μg), Melatonin, Oral Melatonin (4 mg), N-Acetyl-5-methoxytryptamine, Circadin | Woolcock Institute of Medical Research | Insomnia | 12/25 | 05/26 | | |
NCT06355687: Melatonin in Obese Patients in Laparoscopic Cholecystectomy |
|
|
| Not yet recruiting | N/A | 60 | NA | Melatonin, Circadin, Vitamin Supplement | Ain Shams University | Anesthesia | 04/25 | 04/25 | | |
NCT06489327: Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery |
|
|
| Recruiting | N/A | 120 | RoW | melatonin (Circadin ®) 0.2 mg/kg, melatonin (Circadin ®) 0.4 mg/kg, placebo group | Al-Azhar University, Al-Ayen Iraqi University | Preoperative Anxiety | 12/24 | 12/24 | | |
| Hetlioz (tasimelteon) / Vanda |
2015-003198-14: A multicenter, randomized, double-blind, placebo-controlled, parallel study to investigate the efficacy and safety of multiple oral doses of tasimelteon and matching placebo in travelers with Jet Lag Disorder |
|
|
| Ongoing | 3 | 400 | Europe | Tasimelteon (HELTLIOZ®), VEC-162, Capsule, HELTLIOZ® | Vanda Pharmaceuticals Inc, Vanda Pharmaceuticals Inc | Jet Lag Disorder (JLD), Not possible to specify | | | | |
NCT01218789 / 2010-020912-12: Safety Study of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder in Blind Individuals With No Light Perception |
|
|
| Active, not recruiting | 3 | 140 | Europe | tasimelteon, VEC-162 | Vanda Pharmaceuticals | Non 24 Hour Sleep Wake Disorder | 12/24 | 12/24 | | |
2021-005475-40: A multicenter, double-blind, randomized study to evaluate the effects of tasimelteon vs. placebo in participants with Delayed Sleep-Wake Phase Disorder (DSWPD) |
|
|
| Not yet recruiting | 3 | 300 | Europe | Tasimelteon, VEC-162, Capsule, hard | Vanda Pharmaceuticals Inc., Vanda Pharmaceuticals Inc. | Delayed Sleep-Wake Phase Disorder (DSWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT05361707: Evaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbances |
|
|
| Recruiting | 3 | 100 | US | Tasimelteon Oral Capsule, Tasimelteon Liquid Suspension | Vanda Pharmaceuticals | Autism Spectrum Disorder, Sleep Disorder, Neurological Disorder, Sleep Disturbance | 07/25 | 07/25 | | |
| Recruiting | 3 | 70 | Europe, US | Tasimelteon, Placebo | Vanda Pharmaceuticals, Vanda Pharmaceuticals Inc. | Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders | 12/25 | 12/25 | | |
NCT06701396: Evaluating the Effects of Tasimelteon Vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD) and the CRY1Δ11 Variant |
|
|
| Recruiting | 3 | 60 | RoW | Tasimelteon, Placebo | Vanda Pharmaceuticals | Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders, Gene Mutations and Other Alterations Nec | 06/25 | 06/25 | | |
NCT06323655: Evaluation of Next-Day Residual Effects of Tasimelteon Compared With Placebo and Active Control in Healthy Subjects |
|
|
| Completed | 1 | 48 | Canada | Tasimelteon, Active Control Placebo, Tasimelteon Placebo, Active Control | Vanda Pharmaceuticals | Healthy Volunteers | 08/18 | 08/18 | | |
NCT05572281: Bioequivalence Study Between Tasimelteon Capsule Formulation and Liquid Suspension Formulation in Healthy Volunteers |
|
|
| Completed | 1 | 36 | US | Tasimelteon Oral Capsule, Tasimelteon Oral Suspension | Vanda Pharmaceuticals | Healthy | 06/22 | 06/22 | | |
RBD, NCT05922995: The Effects of Tasimelteon in Participants With REM Behavior Disorder |
|
|
| Not yet recruiting | 1 | 20 | US | Tasimelteon, Hetlioz | Brigham and Women's Hospital, Vanda Pharmaceuticals | REM Behavior Disorder | 09/26 | 12/28 | | |
| buspirone/melatonin (BCI-952) / BrainCells |
NCT04400266: Buspirone and Melatonin for Depression Following Traumatic Brain Injury |
|
|
| Recruiting | 4 | 10 | US | Buspirone, Mealatonin | Massachusetts General Hospital | Depression, Brain Injuries, Traumatic | 07/26 | 07/26 | | |
| Melatobel (melatonin) / Nobelpharma |
| No trials found |
