Bile acid binding protein mod 
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15 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
colesevelam / Generic mfg.
2018-003575-34: Treatment of bile acid malabsorption with liraglutid Behandling af galdesyremalabsorption med liraglutid

Ongoing
4
44
Europe
Injection, Tablet, Victoza, Cholestagel
Professor, Ph.d. MD. Filip Krag Knop, Novo Nordisk
Bile acid malabsoprtion is a disease in which there is a large spill-over of bileacids to the larger intestines. This causes watery diarrheas and abdominal symptoms. Galdesyremalabsorption er en sygdom, hvos der er mere galdesyre i tarmsystemet end hos raske individer. Dette giver vandige diarrere og abdominale gener, Bile acid malabsoprtion is a disease in which there is a large spill-over of bileacids to the larger intestines. This causes watery diarrheas and abdominal symptoms. Galdesyremalabsorption er en sygdom, hvos der er mere galdesyre i tarmsystemet end hos raske individer. Dette giver vandige diarrere og abdominale gener, Diseases [C] - Nutritional and Metabolic Diseases [C18]
 
 
2021-000667-74: The effect of bile acid binding with colesevelam on blood sugar levels in patients after gastric bypass surgery and galbladder surgery : meal test study Het effect van galzuurbinding met Colesevelam op glucose waarden in het bloed bij patiënten die een gastric bypass en een galblaasoperatie hebben gehad: maaltijd test

Ongoing
4
20
Europe
Tablet, Cholestagel
Medisch Centrum Leeuwarden BV, stichting CON-VOLUME research
Post Bariatric Hypoglycemia post bariatrie hypoglycaemie, development of low blood sugar levels after gastric bypass surgery and galbladder surgery lage bloedsuikers (hypoglycaemie) welke ontstaan na een maagverkleiningsoperatie en galblaasoperatie, Body processes [G] - Metabolic Phenomena [G03]
 
 
ACTRN12620000755932: The impact of assessing and treating bile acid malabsorption on function and quality of life in patients with major Low Anterior Resection Syndrome (LARS).

Not yet recruiting
3/4
45
 
University of Otago, Lottery Health Research Grants Board, Health Care Otago Charitable Trust
Low Anterior Resection, Bile Salt Malabsorption, High anterior resection, Ultra-low anterior resection, Rectal cancer, Colorectal cancer
 
 
2012-001638-33: Heredity and treatment of increased cholesterol concentration Dědičnost a léčba zvýšené koncentrace cholesterolu

Ongoing
3
66
Europe
Film-coated tablet, Cholestagel 625 mg film-coated tablets
Institute for Clinical and Experimental Medicine, Institute for Clinical and Experimental Medicine, Ministry of Health
hypercholesterolemia hypercholesterolémie, high cholesterol in blood vysoký cholesterol v krvi, Diseases [C] - Nutritional and Metabolic Diseases [C18]
 
 
2009-010163-16: Bile salt manipulation as a novel treatment for Crohn’s disease: a single centre open label pilot study of atorvastatin and colesevalam in patients with active ileal Crohn’s disease

Ongoing
2
13
Europe
Lipitor, Cholestagel, Lipitor, Cholestagel
University College London
Active Crohn\'s disease affecting the ileum
 
 
2019-001559-38: Phase II study to evaluate diarrhoea discontinuations at 3 cycles in patients with early-stage HER2 positive, hormone receptor positive breast cancer treated with neratinib plus loperamide versus neratinib dose escalation plus loperamide administered as needed versus neratinib plus loperamide plus colesevelam Estudio fase II para evaluar la incidencia de abandono debida a diarrea en 3 ciclos de tratamiento en pacientes con cáncer de mama estadio temprano HER2 positivo, receptor hormonal positivo tratados con neratinib más loperamida frente a neratinib con escalada de dosis más loperamida administrada solamente según necesidad frente a neratinib más loperamida más colesevelam

Not yet recruiting
2
315
Europe
Neratinib, Loperamide, Colesevelam, PB-272; HKI-272, Film-coated tablet, Capsule, hard, Nerlynx, Sindiar, Cholestagel
GEICAM (Fundación Grupo Español de Investigación en Cáncer de Mama), PUMA BIOTECHNOLOGY, INC
HER2+, HR+ Early stage Breast Cancer Cáncer de Mama Precoz HER2+, RH+, HER2 positive, Hormone Receptor positive Early-stage Breast Cancer Cáncer de mama precoz HER2 positivo, receptor hormonal positivo, Diseases [C] - Cancer [C04]
 
 
DIANER, NCT05252988: Three Antidiarrheal Strategies in HER2+/HR+ Early Breast Cancer Patients Treated With Extended Adjuvant Neratinib

Recruiting
2
315
Europe
Neratinib, Nerlynx, Loperamide, Sindiar, Colesevelam, Cholestagel
Spanish Breast Cancer Research Group, Puma Biotechnology, Inc., Pierre Fabre Laboratories
Early-stage Breast Cancer, HER2 Positive Breast Cancer, Hormone Receptor Positive
03/25
01/30
NCT03767257: A Study of Colesevelam for Lenalidomide-Associated Diarrhea

Completed
2
25
US
Colesevelam Pill
Memorial Sloan Kettering Cancer Center
Multiple Myeloma, Diarrhea
11/24
11/24
MYSTIC, NCT06197763: Impact of Therapy Using Colesevelam Treatment Reducing Bile Acids in Patients With Fontan Circulation.

Not yet recruiting
1/2
50
NA
Colesevelam, Control Arm
St. Boniface Hospital
Fontan Circulation
11/25
05/26
ACTRN12621000877886: More or less? Bile acids and glycaemic control in type 2 diabetes

Recruiting
1
25
 
The University of Adelaide, Diabetes Australia
Type 2 diabetes
 
 
PERI-DYS, NCT03110432: Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry

Active, not recruiting
N/A
1713
Europe
PCSK9 Inhibitor [EPC], Repatha, Praluent, Standard lipid lowering therapy, Statins, ezetimibe, nicotinic acid, fibrates, cholestagel, omega-3 fatty acids
GWT-TUD GmbH
Dyslipoproteinemias
03/24
06/24
cholestyramine (A3384) / Ipsen
2007-002863-28: Investigation into the use of colestyramine as a therapy for patients with erythropoietic protoporphyria

Ongoing
4
21
Europe
Questran, Questran, Questran
Guy\'s & St Thomas\' NHS Foundation Trust
Erythropoietic protoporphyria (EPP)
 
 
NCT05014646: Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients

Recruiting
2
56
US
Cholestyramine, Cholybar, Colestyramine, Duolite AP143 Resin, Questran, Questran Light, Leflunomide, Arava, SU101
City of Hope Medical Center, National Cancer Institute (NCI)
Smoldering Plasma Cell Myeloma
12/25
12/25
NCT06454383: Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer

Recruiting
1
19
US
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cholestyramine, Cholybar, Colestyramine, Duolite AP143 Resin, Questran, Questran Light, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Diagnostic Imaging, Medical Imaging, Gemcitabine, dFdC, dFdCyd, Difluorodeoxycytidine, Leflunomide, Arava, SU101, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI
City of Hope Medical Center, National Cancer Institute (NCI)
Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8, Unresectable Pancreatic Ductal Adenocarcinoma
11/26
11/26
NCT05443425: Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies

Recruiting
1
18
US
Cholestyramine, Cholybar, Colestyramine, Duolite AP143 Resin, Questran, Questran Light, Leflunomide, Arava, SU101, Steroid Therapy
City of Hope Medical Center, National Cancer Institute (NCI)
Acute Graft Versus Host Disease, Hematopoietic and Lymphoid System Neoplasm
07/25
07/25

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