| Linzess (linaclotide) / Ironwood Pharma, AbbVie |
2013-004939-73: A STUDY TO EVALUATE THE EFFECT OF LINACLOTIDE ON COLONIC MOTILITY |
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| Ongoing | 4 | 10 | Europe | LINACLOTIDE, Capsule, hard, CONSTELLA | KULEUVEN, KULEUVEN | COLONIC MOTILITY WILL BE STUDIED IN HEALTHY SUBJECTS, HEALTHY SUBJECTS, Body processes [G] - Physiological processes [G07] | | | | |
2014-002017-28: INFLUENCE OF THE TYPE AND SITE OF DISTENSION IN THE EVALUATION OF DRUGS EFFICACY IN MODULATING COLON AND RECTAL FUNCTION IN MAN |
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| Ongoing | 4 | 23 | Europe | Linaclotide, Capsule, hard, CONSTELLA | KULEUVEN, KULEUVEN | HEALTHY SUBJECTS AND PATIENTS WITH IRRITABLE BOWEL SYNDROME, HEALTHY SUBJECTS AND PATIENTS WITH IRRITABLE BOWEL SYNDROME, Body processes [G] - Physiological processes [G07] | | | | |
ChiCTR2100052551: A multi-center, prospective, real-world study of Linaclotide in the treatment of irritable bowel syndrome with predominant constipation |
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| Completed | 4 | 120 | | Nil | The Second Hospital of Shandong University; The Second Hospital of Shandong University, Nil | Irritable Bowel Syndrome | | | | |
ChiCTR2100050437: Develop bowel preparation strategies based on the patient's bowel habits |
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| Not yet recruiting | 4 | 315 | | 3L PEG ;3L PEG +Linaclotide (290ug) ;3L PEG | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Self-financed | N/A | | | | |
NCT05134584: Efficacy of Linaclotide in Patients With Overlapping Functional Gastrointestinal Disorders |
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| Recruiting | 4 | 78 | RoW | Linaclotide, Linzess, Lactulose, Duphalac, Omeprazol, Itopride | RenJi Hospital | Functional Dyspepsia, Constipation-predominant Irritable Bowel Syndrome | 12/21 | 02/22 | | |
ChiCTR2100043303: Clinical efficacy of Linaclotide in treatment of Parkinson′s disease with constipation |
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| Recruiting | 4 | 240 | | Linaclotide ;PEG-4000 | The 988th Hospitail of Joint Logistic Support Force; The 988th Hospitail of Joint Logistic Support Force, Self-raised funds | Constipation | | | | |
ChiCTR2100043302: Clinical efficacy of Linaclotide in treatment of Diabetic patients with constipation |
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| Recruiting | 4 | 400 | | Linaclotide ; PEG-4000 | The 988th Hospital of PLA Joint Logistics Support Force; Level of the institution：, Self-raised funds | Constipation | | | | |
ChiCTR2300069934: Linaclotide Compares with Macrogol 4000 Powder in Treatment of Functional Constipation: A Prospective Cohort Study |
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| Completed | 4 | 141 | | linaclotide ;macrogol 4000 powder | Chengdu Integrated TCM & Western Medicine Hospital; Chengdu Integrated TCM & Western Medicine Hospital, self-finance | functional constipation | | | | |
ChiCTR2100041992: Effect of Linaclotide on bowel preparation for colonoscopy: a multicenter prospective randomized controlled trial |
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| Recruiting | 4 | 838 | | Linaclotide+2L PEG ;3L PEG | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Raise independently | Bowel preparation | | | | |
ChiCTR2300069936: Study on linaclotide in the treatment of Irritable Bowel Syndrome with predominant constipation: a prospective cohort |
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| Completed | 4 | 145 | | linaclotide ;macrogol 4000 powder + Otilonium bromide ;Maren pils +Otilonium bromide | Chengdu Integrated TCM & Western Medicine Hospital; Chengdu Integrated TCM & Western Medicine Hospital, self-finance | Irritable Bowel Syndrome with predominant constipation | | | | |
ChiCTR2200057301: Effect of linaclotide combined with polyethylene glycol electrolytes on bowel cleanliness in patients with chronic constipation |
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| Not yet recruiting | 4 | 100 | | add Linaclotide | The Affiliated People’s Hospital of Ningbo University; The Affiliated People’s Hospital of Ningbo University, the Yinzhou District Science and Technology Bureau | Bowel Preparation | | | | |
ChiCTR2200064244: The effect of linaclotide combined with polyethylene glycol electrolytes powder on bowel preparation for colonoscopy |
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| Not yet recruiting | 4 | 450 | | 1 Linaclotide+2L PEG ;3L PEG ;2 Linaclotide+1L PEG | Chongqing General Hospital; Chongqing General Hospital, Raise independently | Bowel preparation | | | | |
ChiCTR1900027934: Effect of oral linaclotide on gut flora in patients with constipation type irritable bowel syndrome |
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| Completed | 4 | 60 | | Linaclotide | Department of Gastroenterology, the Second Affiliated Hospital of the Army Military Medical University; The second Affiliated Hospital of Army Medical University, Self raising of departments | Irritable bowel syndrome of constipation type | | | | |
ChiCTR2100053273: The effect of linaclotide combined with low-volume polyethylene glycol for bowel preparation in low-risk patients: a multicenter randomized controlled trial |
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| Recruiting | 4 | 596 | | Linaclotide + 1L PEG ;2L PEG | The Third People's Hospital of Chengdu; The Third People's Hospital of Chengdu, Self-funded | Inadequate bowel preparation | | | | |
ChiCTR2200065832: Effect of linalotide combined with compounded polyethylene glycol electrolyte dispersion in bowel preparation prior to colonoscopy: a randomized, controlled, single-blind, single-centre, non-inferiority trial |
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| Not yet recruiting | 4 | 126 | | The day before colonoscopy, 290ug linalotide was taken orally before lunch/dinner, and 2L PEG was taken orally 4~6 hours before the operation on the same day ;Oral administration of 580ug linaclotide before dinner the day before colonoscopy, and oral administration of 2L PEG 4~6 hours before the procedure on the same day ;Take 1L PEG orally the night before colonoscopy, and 2L PEG 4~6 hours before the same-day operation | General Hospital of the Northern Theater of the Chinese People's Liberation Army; General Hospital of the Northern Theater of the Chinese People's Liberation Army, Self-financing | Intestinal diseases | | | | |
ChiCTR2200057368: Study on the Equivalence of Linaclotide +2L-PEG Regimen and Divided dose 3L-PEG Regimen in Bowel Preparation before Colonoscopy |
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| Not yet recruiting | 4 | 330 | | Linaclotide 290ug×1 tablet+compound polyethylene glycol electrolyte powder 68.56g×1 bag (1L) orally (21: 00 the night before colonoscopy)+linaclotide 290ug×1 tablet+compound polyethylene glycol electrolyte powder 68.56g×1 bag (1L) orally (6 hours before colonoscopy) ;Compound polyethylene glycol electrolyte powder 68.56g×2 bags (2L) orally (21: 00 the night before colonoscopy)+compound polyethylene glycol electrolyte powder 68.56g×1 bags (1L) orally (6 hours before colonoscopy) | Department of Gastroenterology, the First Affiliated Hospital of Shantou University Medical College; the First Affiliated Hospital of Shantou University Medical College, Self-financing | Intestinal diseases | | | | |
ChiCTR2200063143: Clinical efficacy of Linaclotide in treatment of mental disease with constipation |
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| Not yet recruiting | 4 | 224 | | Linaclotide ;Polyethylene glycol 4000 powder | 984 Hospitail of Joint Logistic Support Force; 984 Hospitail of Joint Logistic Support Force, Self-raised | Constipation | | | | |
NCT03119584: Efficacy of Linaclotide in Type II Diabetics With Chronic Constipation |
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| Active, not recruiting | 4 | 23 | US | linaclotide or placebo, Linzess | Texas Tech University Health Sciences Center, El Paso | Chronic Constipation, Diabete Mellitus | 10/24 | 01/25 | | |
ChiCTR2400081524: Application of linaclotide in bowel preparation before colonoscopy in patients with constipation |
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| Recruiting | 4 | 320 | | A:Patients need to take 1 capsule of linaclotide (290ug/capsule) 30 minutes before the first meal every day 3 days before colonoscopy for 3 days, and do not take it on the day of colonoscopy. Take 1L of PEG solution at 20 o'clock the night before the examination and finish it within 1-4 hours; Take 2L of PEG solution 6 hours before colonoscopy for routine bowel preparation; B:Patients do not take linacretide. Take 2L of PEG solution at 20 o'clock the night before the examination, and finish within 1-4 hours; Take 2L of PEG solution 6 hours before colonoscopy for routine bowel preparation | The First Bethune Hospital of Jilin University; The First Bethune Hospital of Jilin University, The First Bethune Hospital of Jilin University | bowel preparation | | | | |
ChiCTR2400083515: Effect of linaclotide combined with compound polyethylene glycol electrolyte powder in bowel preparation before colonoscopy in patients with constipation |
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| Recruiting | 4 | 240 | | On the morning of the examination, 2 boxes of compound polyethylene glycol electrolyte powder were taken orally, dissolved in 3000 mL of warm water to make a solution, and taken within 2 hours.; Take 1 tablet of linaclotide at 7:00~8:00 two days before the examination, and then take 2 boxes of compound polyethylene glycol electrolyte powder orally at 7:00~9:00 on the examination day, dissolve in 2000 mL of warm water Make up a solution and take it within 2 hours.; Take 1 tablet of linaclotide each at 7:00~8:00 four days before the examination, and then take 2 boxes of compound polyethylene glycol electrolyte powder orally at 7:00~9:00 on the examination day, dissolve in 2000 mL of warm water Make up a solution and take it within 2 hours. | The First Affiliated Hospital of Chongqing Medical University; The First Affiliated Hospital of Chongqing Medical University, 3000 | bowel preparation | | | | |
ChiCTR2400090039: The effects of combined use of linaclotide and polyethylene glycol electrolyte solution in colonoscopy preparation for patients undergoing endoscopic mucosal resection or endoscopic submucosal dissection |
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| Recruiting | 4 | 450 | | drink 2L PEG the night before the procedure starting at 7 PM, drink 2L PEG at 7Am on the day of the procedure.; take 290ug linaclotide at 7AM the day before the procedure, drink 2L PEG the night before the procedure starting at 7 PM, take 290ug linaclotide at 5AM on the day of the procedure, and drink 1L PEG at 7AM on the day of the procedure; take 290ug linaclotide at 7AM 2 days before the procedure, take 290ug linaclotide at 7AM the day before the procedure, drink 1L PEG the night before the procedure starting at 7 PM, take 290ug linaclotide at 5AM on the day of the procedure, and drink 1L PEG at 7AM on the day of the procedure | Beijing Shijitan Hospital, Capital Medical University; Beijing Shijitan Hospital, Capital Medical University, Youth Fund of Beijing Shijitan Hospital, Capital Medical University | Colonoscopy Cleaning | | | | |
ChiCTR2400083154: A prospective, randomised controlled clinical study of the efficacy, safety and mechanism of action of rupiprostenone in the treatment of diabetic constipation |
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| Not yet recruiting | 4 | 90 | | Rupiprostenone capsules, 24μg/capsule, 1 capsule/dose, 2 times a day, taken orally with food and water with breakfast and dinner, swallowed whole, not to be split or chewed, for 8 weeks.; Linaclotide, 290 μg/capsule, 1 capsule/dose, 1 day, half an hour before breakfast, swallowed whole, not to be split or chewed, for 8 weeks.; Bifidobacterium bifidum Live Bacteria Capsules, 210mg/capsule, 2 capsules/dose, 2 times a day, after breakfast and dinner, swallowed whole, not to be split or chewed, for 8 weeks. | Binzhou Medical University Hospital; Binzhou Medical University Hospital, Funds for the construction of provincial key clinical specialties in Shandong Province | Diabetic constipation | | | | |
2013-001248-67: Evaluation of predictors of response to linaclotide in patients with irritable bowel syndrome and explore the impact on intestinal symptoms Evaluacion de factores predictores de respuesta a linaclotida en pacientes con Síndrome de Intestino Irritable y explorar el impacto sobre los síntomas extraintestinales |
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| Ongoing | 3 | 120 | Europe | Constella, Constella | almirall, Almirall | Irritable bowel syndrome Síndrome de intestino irritable | | | | |
NCT04804267: Evaluation of Clinical Equivalence Between Two Linaclotide Products in the Treatment of Chronic Idiopathic Constipation |
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| Recruiting | 3 | 750 | RoW | Linaclotide, LINZESS®, Placebo | Jiangsu Hansoh Pharmaceutical Co., Ltd. | Chronic Idiopathic Constipation | 08/22 | 08/22 | | |
LINZESS, NCT04026113 / 2019-001500-38: Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC) |
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| Completed | 3 | 438 | Europe, Canada, US, RoW | Linaclotide, Placebo | AbbVie, Ironwood Pharmaceuticals, Inc. | Functional Constipation, Irritable Bowel Syndrome With Constipation | 05/24 | 05/24 | | |
NCT05652205: A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation |
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| Recruiting | 3 | 116 | Europe, US | Linaclotide, Placebo for Linaclotide | AbbVie, Ironwood Pharmaceuticals, Inc. | Functional Constipation (FC), Chronic Idiopathic Constipation (CIC) | 08/25 | 11/25 | | |
| Active, not recruiting | 3 | 389 | Europe, Canada, US, RoW | Irritable Bowel Syndrome with Constipation (IBS-C) participants (LIN-MD-63 completers), Functional Constipation (FC) participants (LIN-MD-62 and LIN-MD-64 completers) | AbbVie, Ironwood Pharmaceuticals, Inc. | Irritable Bowel Syndrome With Constipation, Functional Constipation | 06/25 | 06/25 | | |
NCT03796884: Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer |
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| Active, not recruiting | 2 | 230 | US | Linaclotide, 851199-59-2, Linzess, [9-L-tyrosine]heat-stable enterotoxin (Escherichia coli)-(6-19)-peptide, L-Tyrosine, L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L- asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteiny, cyclic (1->6), (2->10), (5->13)-tris(disulfide), MD-1100, Placebo | Sidney Kimmel Cancer Center at Thomas Jefferson University, United States Department of Defense | Colorectal Adenoma, Stage 0 Colorectal Cancer AJCC v8, Stage I Colorectal Cancer AJCC v8, Stage II Colorectal Cancer AJCC v8, Stage IIA Colorectal Cancer AJCC v8, Stage IIB Colorectal Cancer AJCC v8, Stage IIC Colorectal Cancer AJCC v8, Stage III Colorectal Cancer AJCC v8, Stage IIIA Colorectal Cancer AJCC v8, Stage IIIB Colorectal Cancer AJCC v8, Stage IIIC Colorectal Cancer AJCC v8 | 06/25 | 06/25 | | |
NCT05760313: A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotide |
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| Recruiting | 2 | 30 | Europe, US, RoW | Linaclotide, Linzess, Placebo | AbbVie, Ironwood Pharmaceuticals, Inc. | Functional Constipation | 09/25 | 09/25 | | |
| Not yet recruiting | 1/2 | 10 | US | Use of Linaclotide as a single agent Colonoscopy prep, Linaclotide prep | University of Florida | Patients Scheduled for Colonoscopy | 08/25 | 12/25 | | |
NCT01912079: Trial of Linaclotide to Demonstrate Colorectal Bioactivity in Health Volunteers |
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| Not yet recruiting | 1 | 18 | US | linaclotide, Linzess, Placebo, PLCB | Fox Chase Cancer Center, National Cancer Institute (NCI) | Gastrointestinal Diseases, Gastrointestinal Neoplasms, Digestive System Diseases, Digestive System Abnormalities, Digestive System Neoplasms, Colorectal Neoplasms | 01/14 | | | |
ChiCTR2400088166: A study on the application value of Linalotide capsules in colonoscopy bowel preparation |
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| Completed | 1 | 600 | | 3L of polyethylene glycol +linaclotide; 3L of polyethylene glycol; 2L of polyethylene glycol + linaclotide | Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University, None | none | | | | |
| Recruiting | 1 | 43 | US | Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Esophagogastroduodenoscopy, EGD, Linaclotide, [9-L-tyrosine]heat-stable enterotoxin (Escherichia coli)-(6-19)-peptide, Linzess, MD-1100, Plecanatide, Trulance | National Cancer Institute (NCI) | Barrett Esophagus, Gastroesophageal Reflux Disease, Malignant Digestive System Neoplasm | 02/25 | 02/25 | | |
ChiCTR2100043297: A randomized controlled trial for individudal bowel preparation with Linaclotide and PEG-ELS |
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| Recruiting | N/A | 400 | | Linaclotide ;PEG-ELS | No.988 Hospitail of Joint Logistic Support Force; No.988 Hospitail of Joint Logistic Support Force, self-raised funds | Bowel preparation methods before colonoscopy | | | | |
NCT05137145: Effect and Safety of Polyethylene Glycol Combined With Linaclotide on Colon Cleansing for Patients With Chronic Constipation |
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| Recruiting | N/A | 300 | RoW | Linaclotide, Compound Polyethylene Glycol Electrolyte Powder | Second Affiliated Hospital of Xi'an Jiaotong University | Bowel Preparation | 03/22 | 04/22 | | |
ChiCTR2100049962: The effect of linaclotide combined with compound polyethylene glycol electrolyte powder on the effect of bowel preparation before colonoscopy in the elderly-a prospective, randomized controlled study |
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| Not yet recruiting | N/A | 332 | | Linaclotide combined with 2L PEG ;3L PEG | Chongqing Thirteenth People's Hospital; Chongqing Thirteenth People's Hospital, Science and technology commission of Chongqing | Colon disease | | | | |
ChiCTR2100050281: Effect of linaclopeptide combined with compound polyethylene glycol electrolyte powder on intestinal preparation before colonoscopy in elderly patients |
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| Not yet recruiting | N/A | 333 | | Polyethylene glycol combined with linaclotide ;3L PEG ;2L PEG | Chongqing 13th People's Hospital; Chongqing 13th People's Hospital, Science and technology commission of Chongqing | Colon disease | | | | |
ChiCTR2000039171: Study on the effect of linaclotide on bowel preparation before colonoscopy and the comfort of patients with colonoscopy |
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| Recruiting | N/A | 200 | | Linanotide+ PEG+2L water ;PEG+ 3L water | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital Affiliated with Tongji Medical College of Huazhong University of Science and Technology, self-raised | Colonic diseases | | | | |
NCT05291325: Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy |
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| Completed | N/A | 1607 | RoW | 3L PEG + Linaclotide, 3L PEG, 2L PEG + Linaclotide | Changhai Hospital, Shanxi Provincial People's Hospital, The 900th Hospital of the PLA, Ruijin Hospital, The First Affiliated Hospital of Nanchang University, Qilu Hospital of Shandong University, The Affiliated Hospital of Qingdao University, Ruian People's Hospital, Yueqing People's Hospital, The First Affiliated Hospital of Soochow University, The 7th Medical Center of the PLA General Hospital, The First Hospital of Jilin University, The Second Hospital of Hebei Medical University, Affiliated Hospital of Inner Mongolia Medical University, The Second Affiliated Hospital of Dalian Medical University, Ningxia Medical University General Hospital, Affiliated Hospital of Qinghai University, Yunnan First People's Hospital, Xiangya Second Hospital, Central South University, Zhongnan Hospital Affiliated to Wuhan University, Daping Hospital, Army Military Medical University, Zunyi Medical College, Huizhou Municipal Central Hospital, Affiliated Hospital of Southwest Medical University, The First Hospital of Shihezi University, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Tangdu Hospital of Air Force Military Medical University | Bowel Preparation for Colonoscopy | 08/23 | 04/24 | | |
| Completed | N/A | 3028 | RoW | | AstraZeneca | Irritable Bowel Syndrome-IBS | 02/23 | 02/23 | | |
NCT06608589: CONSTELLATIONS Living Lab: Improving the Care Transitions of Older Adults Living with Neurocognitive Disorders |
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| Recruiting | N/A | 700 | Canada | CoMPAS+ MNCDs Program - Quality improvement program targeting the care transitions of patients living with a major neurocognitive disorder and their caregivers | Laval University, CISSS de Chaudière-Appalaches, Institut national d'excellence en santé et service sociaux | Alzheimer Disease, Dementia, Neurocognitive Decline | 04/26 | 04/26 | | |
NCT05379491: Application of Linaclotide Capsule in Bowel Preparation for Patients at High Risk of Inadequate Bowel Preparation |
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| Completed | N/A | 720 | RoW | 3 L PEG + linaclotide, 3 L PEG + placebo | Zhiguo Liu | Colonoscopy | 06/23 | 07/23 | | |
| Active, not recruiting | N/A | 53 | Europe | System Constellation VR-Seminar | University of Witten/Herdecke, FH Münster University of Applied Sciences, The Witten Institute For Family Business | Psychological and Systems Functioning | 04/25 | 04/25 | | |
NCT06091735: Clinical Study of Bowel Preparation Before Colonoscopy |
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| Completed | N/A | 444 | RoW | OSS, Sodium potassium magnesium sulfate oral concentrated solution, OSS+Linzess, sodium potassium magnesium sulfate oral concentrated solution + linaclotide, PEG-Interferon Alfa, PEG | Jinling Hospital, China | Bowel Preparation | 02/24 | 02/24 | | |
| Recruiting | N/A | 65 | US | Virtual Reality, Linaclotide | Mayo Clinic, Cedars-Sinai Medical Center, AbbVie, Ironwood Pharmaceuticals, Inc. | Irritable Bowel Syndrome With Constipation | 12/24 | 12/24 | | |
ChiCTR2400089466: Clinical study of Disposable Gastrointestinal Vibrating Capsule combined with polyethylene glycol to optimize bowel preparation for colonoscopy |
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| Recruiting | N/A | 90 | | 1500 ml of polyethylene glycol at 8 p.m. the day before the examination + 1500 ml of polyethylene glycol solution 4h before the colonoscopy.; 1 capsule of Linaclotide was taken orally at 6:00 p.m. the day before the examination + 2000 ml of polyethylene glycol solution was taken orally in divided doses before the colonoscopy + 1 capsule of Linaclotide was taken orally again, which has been confirmed by the prior study in terms of its safety and efficacy.; 1 vibrabot capsule was taken at 7 a.m. the day before the examination, and 2,000 ml of polyethylene glycol solution was taken in divided doses before the colonoscopy. | PLA Rocket Force Characteristic Medical Center; PLA Rocket Force Characteristic Medical Center, none | Colon diseases | | | | |
ChiCTR2400080331: Effect of linalotide on intestinal dysfunction in patients with acute pancreatitis: a randomized controlled trial |
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| Not yet recruiting | N/A | 114 | | In the linaclotide group, participants received 1pill linaclotide oral once daily before breakfast in addition of routine treatment,and stopped taking it after 7 days.; 50g raw rhubarb was added into 100ml warm boiled water, twice a day, orally) on the basis of conventional treatment | The First Affiliated Hospital of Nanchang University; The First Affiliated Hospital of Nanchang University, No funding | Acute pancreatitis | | | | |
| Not yet recruiting | N/A | 422 | | 2L polyethylene glycol (PEG) plus linaclotide; 4L polyethylene glycol (PEG) | The First Affiliated Hospital, Zhejiang University School of Medicine; The First Affiliated Hospital, Zhejiang University School of Medicine, self-supporting | intestinal ployps | | | | |
| Trulance (plecanatide) / Bausch Health |
NCT05151328: Efficacy and Safety of Plecanatide Comparing With Placebo in the Treatment of Functional Constipation |
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| Completed | 3 | 648 | RoW | Plecanatide, Placebo | Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. | Functional Constipation | 10/23 | 10/23 | | |
NCT03596905: Efficacy and Safety of Plecanatide in Children 6 to <18 Years of Age With Irritable Bowel Syndrome With Constipation (IBS-C) |
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| Recruiting | 2 | 210 | US | Plecanatide, Trulance, Matching placebo, No other names | Bausch Health Americas, Inc. | Irritable Bowel Syndrome With Constipation | 12/23 | 12/23 | | |
| IW-3300 / Ironwood Pharma |
NCT05740007: A Phase 2 Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrome |
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| Active, not recruiting | 2 | 98 | US | IW-3300 rectal foam, Placebo | Ironwood Pharmaceuticals, Inc. | Interstitial Cystitis, Bladder Pain Syndrome | 01/25 | 02/25 | | |
