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- | Journal, IO biomarker: Goose astrovirus induces apoptosis and endoplasmic reticulum stress in gosling hepatocytes. (Pubmed Central) - Dec 1, 2024
Correlation analysis further revealed a potential relationship among ERS gene expression, apoptotic gene expression, and liver injury. In summary, GoAstV infection can lead to liver injury by interfering with ER Ca2+ homeostasis, exacerbating ERS and inducing hepatocyte apoptosis.
- | XAV-939 / Novartis
Journal, IO biomarker: ZEB2 reduction contributes to pre-eclampsia via Wnt/?-Catenin pathway. (Pubmed Central) - Nov 30, 2024
In summary, GoAstV infection can lead to liver injury by interfering with ER Ca2+ homeostasis, exacerbating ERS and inducing hepatocyte apoptosis. ZEB2 was involved in the pathological and physiological processes of PE through Wnt/?-Catenin pathway, which may provide a useful perspective for exploring new therapies for PE.
- | Journal: TMBIM6/BI-1 is an intracellular environmental regulator that induces paraptosis in cancer via ROS and Calcium-activated ERAD II pathways. (Pubmed Central) - Nov 29, 2024
In xenograft models, we show TMBIM6 agonism induces rapid cancer cell death with no toxicity, even at high doses of TMBIM6 agonist (>450?mg/kg). In summary, this study shows TMBIM6's functional diversity is only activated by severe ICE change in diseased/injured cells, highlighting its transformative potential as a therapeutic target across various diseases and injuries, including cancer.
- | clemastine / Generic mfg.
Preclinical, Journal, IO biomarker: Clemastine mitigates sepsis-induced acute kidney injury in rats; the role of ?-Klotho/TLR-4/MYD-88/NF-?B/ Caspase-3/ p-P38 MAPK signaling pathways. (Pubmed Central) - Nov 29, 2024
CLM downregulated the levels of the proinflammatory markers, suppressed the expression of cleaved caspase-3, TLR-4 and MYD-88 as well as inactivating NF-?B p-P65 and p-P38 proteins, inhibited Bax, NF-?B, and caspase-3 genes expression, and augmented ?-Klotho protein expression as well as Bcl-2 gene expression. Finally, CLM pretreatment protected against acute kidney injury by preventing TLR-4/ p-P38 pathway-mediated apoptotic cell death in rats.
- | dexamethasone / Generic mfg.
Journal, IO biomarker: Neurotoxic mechanisms of dexamethasone in SH-SY5Y neuroblastoma cells: Insights into bioenergetics, oxidative stress, and apoptosis. (Pubmed Central) - Nov 21, 2024
Assessment of neuronal development genes (GAP43, CAMK2A, CAMK2B, TUBB3, and Wnts) by quantitative PCR assay showed increased expression of CAMK2A, CAMK2B, and Wnt3a with a significant reduction in GAP43 mRNA levels. Collectively, this study proved that DEX was cytotoxic to SH-SY5Y via bioenergetic disruption, mitochondrial dysfunction, oxidative stress, and apoptosis.
- | Journal: Salivary effector DcE1 suppresses plant defense and facilitates the successful feeding of Asian citrus psyllid, Diaphorina citri. (Pubmed Central) - Nov 17, 2024
These results indicate that DcE1 is a novel effector that promotes plant susceptibility and enables D.?citri feeding. These findings enhance our understanding of D.?citri-plant interactions and offer a potential new target gene for the development of citrus protection strategies.
- | Journal, IO biomarker: Jing-Si Herbal Tea Suppresses H2O2-Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG-82 Synoviocytes. (Pubmed Central) - Nov 16, 2024
Interestingly, the cytoprotective effect of JS treatment was attributed to a decreased mitochondrial localization of Bax and a reduction of Cytochrome C release into the cytoplasm of H2O2-treated HIG-82 cells. Collectively, our results suggest a novel protective mechanism of JS for RA treatment, which could be potentially applied as a complementary treatment or as an alternative therapeutic approach to mitigate inflammatory diseases.
- | Journal, IO biomarker: Changes in meat quality of Esox Lucius during postmortem storage: Based on the lysosomal-mitochondrial apoptotic pathway. (Pubmed Central) - Nov 13, 2024
Moreover, TUNEL staining confirmed the occurrence of apoptosis. We concluded that the lysosome- mitochondrial apoptosis pathway was active during the storage of Esox Lucius, in which ferritin degradation and increased lysosomal iron were key factors inducing lysosomal damage, and cathepsin D released by lysosomes was a key factor connecting lysosomes and mitochondria.
- ASTX029 / Otsuka
ERK1/2 Inhibition Mediates Bax Dependent Proteolysis of OPA1 and Induces Mitochondrial Cristae Remodeling to Overcome Resistance to Venetoclax (Halls G-H (San Diego Convention Center)) - Nov 6, 2024 - Abstract #ASH2024ASH_5276;
P1/2
Inhibition of ERK1/2, results in mitochondrial dysfunction and mediates Bax dependent proteolysis of Opa1 in AML, which alters mitochondrial cristae width and releases cytochrome C to overcome ABT199 resistance. The findings in this study provide a strong rationale for combining Bcl-2 and ERK1/2 inhibitors as part of an AML treatment protocol.
- | Preclinical, Journal, IO biomarker: m6A methyltransferase ZC3H13 improves pulmonary fibrosis in mice through regulating Bax expression. (Pubmed Central) - Oct 30, 2024
Bax inhibition ameliorated BLM-induced MLE-12 cell dysfunction and partially abrogated the inhibition of MLE-12 cell function by ZC3H13 downregulation. In conclusion, m6A methyltransferase ZC3H13 impedes lung epithelial cell apoptosis and thus improves pulmonary fibrosis by promoting Bax mRNA m6A methylation and down-regulating Bax expression through reading protein YTHDC1.
- | Journal, IO biomarker: GRK2 Protein Mediates the ANRIL, a lncRNA, to Affect the Proliferation and Apoptosis of Kasumi-1 Cells. (Pubmed Central) - Oct 30, 2024
In conclusion, m6A methyltransferase ZC3H13 impedes lung epithelial cell apoptosis and thus improves pulmonary fibrosis by promoting Bax mRNA m6A methylation and down-regulating Bax expression through reading protein YTHDC1. The GRK2 protein-mediated ANRIL, increasing Kasumi-1 cell proliferation and inhibiting apoptosis by activating the PI3K/AKT/BCL-2 pathway.
- | mirabegron / Generic mfg.
Preclinical, Journal: Unveiling the protective potential of mirabegron against thioacetamide-induced hepatic encephalopathy in rats: Insights into cAMP/PPAR-?/p-ERK1/2/p S536 NF-?B p 65 and p-CREB/BDNF/TrkB in parallel with oxidative and apoptotic trajectories. (Pubmed Central) - Oct 26, 2024
Mira showed anti-apoptotic activity through inhibition of Bax immunoreactivity and elevation of Bcl2. To summarize, Mira exhibited a hepato-and neuroprotective effect against TAA-induced HE in rats via shielding antioxidant defense and mitigation of the pathological inflammatory and apoptotic axis besides upregulation of neuroprotective signaling pathways.
- | Preclinical, Journal, IO biomarker: Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway. (Pubmed Central) - Oct 18, 2024
Mechanistically, OA activated the Nrf2/HO-1 signalling pathway, which is crucial for regulating the expression of antioxidant-related targets in IVM porcine oocytes. Our findings indicated that OA improved antioxidant capacity by activating the Nrf2/HO-1 signalling pathway, thereby promoting porcine oocyte maturation.
- | Journal: CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis. (Pubmed Central) - Oct 6, 2024
Moreover, inhibition of miR-107-3p suppressed HG-induced proliferation and fibrosis, which were attenuated by Tmbim6 knockdown in MCs. CircRNA Arf3 could suppress HG-evoked mesangial cell proliferation and fibrosis via miR-107-3p/Tmbim6 axis, indicating the potential involvement of this axis in DN progression.
- | LY294002 / Eli Lilly
Journal, IO biomarker: Role of PI3K/AKT signaling pathway involved in self-renewing and maintaining biological properties of chicken primordial germ cells. (Pubmed Central) - Sep 28, 2024
Our findings indicated that although supplementation with the PI3K/AKT activator IGF-1 failed to promote proliferation under the assessed culture conditions, the PI3K/AKT inhibitor LY294002 resulted in retarded cell proliferation and reduced expression of germ cell-related markers...These findings indicated that the PI3K/AKT pathway is required for cell renewal, apoptosis, and maintenance of the reproductive potential in chicken PGCs. This study aimed to provide a theoretical basis for the optimization and improvement of a culture system for chicken PGCs and provide insights into the self-renewal of vertebrate PGCs as well as potential evolutionary changes in this unique cell population.
- | Journal: Characterization of the Bax Inhibitor-1 Family in Cauliflower and Functional Analysis of BobBIL4. (Pubmed Central) - Sep 14, 2024
The functional characterization of this gene in Arabidopsis revealed that it enhances root growth and salinity tolerance. These findings provide insights into BI-1 gene functions in cauliflower while also highlighting the potential utility of BobBIL4 for improving crop stress resistance.
- | Journal: Alleviating protein-condensation-associated damage at the endoplasmic reticulum enhances plant disease tolerance. (Pubmed Central) - Sep 12, 2024
These findings suggest that the ER is a crucial hub for maintaining cellular homeostasis and establishing disease tolerance. They also highlight the potential of engineering disease tolerance as a defense strategy to complement established resistance mechanisms in combating plant diseases.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Journal, IO biomarker: Picornavirus VP3 protein induces autophagy through the TP53-BAD-BAX axis to promote viral replication. (Pubmed Central) - Aug 24, 2024
This study provides insight for developing broad-spectrum antivirals and genetic engineering attenuated vaccines against picornaviruses.Abbreviations: 3-MA, 3-methyladenine; ATG, autophagy related; BAD, BCL2 associated agonist of cell death; BAK1, BCL2 antagonist/killer 1; BAX, BCL2 associated X, apoptosis regulator; BBC3/PUMA, BCL2 binding component 3; BCL2, BCL2 apoptosis regulator; BID, BH3 interacting domain death agonist; BIP-V5, BAX inhibitor peptide V5; CFLAR/FLIP, CASP8 and FADD like apoptosis regulator; CPE, cytopathic effects; CQ, chloroquine; CV, coxsackievirus; DAPK, death associated protein kinase; DRAM, DNA damage regulated autophagy modulator; EV71, enterovirus 71; FMDV, foot-and-mouth disease virus; HAV, hepatitis A virus; KD, knockdown; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MOI, multiplicity of infection; MTOR, mechanistic target of rapamycin kinase; PML, promyelocytic leukemia; PV, poliovirus; SVA, Seneca Valley virus; TCID50, 50% tissue culture infectious doses; TOR, target of rapamycin. TP53/p53, tumor protein p53; WCL, whole-cell lysate.
- | Journal: Virulent Effector Hasp155 of Puccinia striiformis f. sp. tritici Suppresses Plant Immunity and Promotes Fungus Infection. (Pubmed Central) - Aug 23, 2024
Furthermore, transgenic overexpression of Hasp155 significantly renders wheat resistance susceptible, resulting in a decreased defense response and increased Pst pathogenicity. Overall, these results indicate that Hasp155 is an important effector of Pst pathogenicity by suppressing plant immunity.
- | doxorubicin hydrochloride / Generic mfg.
Journal, IO biomarker: Anethole Alleviates Doxorubicin-Induced Cardiac and Renal Toxicities: Insights from Network Pharmacology and Animal Studies. (Pubmed Central) - Aug 18, 2024
AN also enhanced Bcl-2 levels and inhibited Bax and the cleavage of caspase-3 and 9. AN countered the lipid peroxidation, oxidative stress, inflammation, and apoptosis induced by Dox, marking it as a potential preventive strategy against Dox-induced nephrotoxic and cardiotoxic injuries.
- | Journal, IO biomarker: Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicle miR-208a-3p Alleviating Spinal Cord Injury via Regulating the Biological Function of Spinal Cord Neurons. (Pubmed Central) - Aug 12, 2024
Moreover, BMSCs-Exo-rno-miR-208a-3p promoted cyclin D1, CDK6, and Bcl-2 and inhibited Bax expression in a cell model of SCI. In conclusion, BMSCs-Exo-carried rno-miR-208a-3p significantly protects rats from SCI via regulating the Cdkn1a pathway.
- | Journal, IO biomarker: Nobiletin restores HFD-induced enteric nerve injury by regulating enteric glial activation and the GDNF/AKT/FOXO3a/P21 pathway. (Pubmed Central) - Aug 3, 2024
In conclusion, BMSCs-Exo-carried rno-miR-208a-3p significantly protects rats from SCI via regulating the Cdkn1a pathway. Nobiletin restored HFD-induced enteric nerve injury, which may be associated with inhibiting enteric nerve apoptosis, promoting enteric nerve survival and regulating the GDNF/AKT/FOXO3a/P21 pathway.
- | Journal: Lung decellularized matrix-derived 3D spheroids: Exploring silicosis through the impact of the Nrf2/Bax pathway on myofibroblast dynamics. (Pubmed Central) - Jul 23, 2024
The results demonstrate that the spheroid model can mimic the development process of silicotic nodules, and silica stimulation leads to an apoptosis-resistant phenotype in myofibroblasts in the model, acting through the Nrf2/Bax pathway. This research establishes a new methodology for silicosis study, identifies therapeutic targets for silicosis, and opens new avenues for studying the mechanisms of silicosis fibrosis.
- | Journal: BI1 Activates Autophagy and Mediates TDP43 to Regulate ALS Pathogenesis. (Pubmed Central) - Jul 2, 2024
The findings indicate that BI1 can inhibit pathological TDP43 morphology and initially stimulate autophagy through interaction with TDP43. This study establishes a solid theoretical foundation for understanding the regulation of autophagy by BI1 and TDP43 while shedding light on the pathogenesis of ALS through their interaction - offering new concepts and targets for clinical implementation and drug development.
- | Preclinical, Journal: Cytoprotective Small Compound M109S Attenuated Retinal Ganglion Cell Degeneration Induced by Optic Nerve Crush in Mice. (Pubmed Central) - Jun 19, 2024
The present study suggests that M109S is effective in rescuing damaged RGCs. Since M109S is an orally bioactive small compound, M109S may become the basis for a portable patient-friendly medicine that can be used to prevent blindness by rescuing damaged optic nerve cells from death.
- | Journal: Systematic identification and functional characterization of the CFEM proteins in fishscale bamboo rhombic-spot pathogen Neostagonosporella sichuanensis. (Pubmed Central) - Jun 17, 2024
This study lays a foundation for elucidating the role of CFEM proteins in the pathogen of fishscale bamboo rhombic-spot caused by N. sichuanensis. In particular, the functional studies of NsCFEM1 and NsCFEM2 revealed their potential roles in the interaction between N. sichuanensis and the host Phyllostachys heteroclada.
- | baxdrostat (CIN-107) / AstraZeneca
Journal: Aldosterone synthase inhibitor "Baxdrostat" for resistant hypertension: A clinical approach or futuristic idea? (Pubmed Central) - Jun 14, 2024
In particular, the functional studies of NsCFEM1 and NsCFEM2 revealed their potential roles in the interaction between N. sichuanensis and the host Phyllostachys heteroclada. No abstract available
- | Journal: bZIP60 and Bax inhibitor 1 contribute IRE1-dependent and independent roles to potexvirus infection. (Pubmed Central) - Jun 10, 2024
This is the first demonstration of a potato bZIP transcription factor complementing genetic defects in Arabidopsis. Evidence indicates that the three IRE1 isoforms regulate the initial stages of virus replication and gene expression, while bZIP60 and BI-1 contribute separately to virus cell-to-cell and systemic movement.
- | colchicine / Generic mfg.
Journal, IO biomarker: Discovery of novel octahydroquinazoline scaffolds endowed with dual inhibition of tubulin polymerization/Eg5 against HCC: Apoptotic and radio-chemotherapeutic studies. (Pubmed Central) - Jun 6, 2024
Octahydroquinazoline 10 displayed an increase in caspase-3 by 1.12 folds compared to standard colchicine and induce apoptosis and demonstrated cell cycle arrest in G2/M phase arrest by targeting p53 pathway. Analogue 10 has considerably promoted cytotoxic radiation activity and boosted apoptotic induction in HepG-2 cells by 1.5 fold higher than standard colchicine.
- | Journal, IO biomarker: Licochalcone A Protects Vaginal Epithelial Cells Against Candida albicans Infection Via the TLR4/NF-?B Signaling Pathway. (Pubmed Central) - May 31, 2024
Furthermore, TLR4 overexpression partially abated LA-mediated protection, further highlighting the role of the TLR4/NF-?B pathway. LA holds the potential to safeguard VECs against C. albicans infection, potentially offering therapeutic avenues for VVC management.
- | Journal: A Colletotrichum tabacum effector Cte1 targets and stabilizes NbCPR1 to suppress plant immunity. (Pubmed Central) - May 30, 2024
Cte1 stabilizes NbCPR1 in N. benthamiana. Together, our study showed that Cte1 suppresses plant immunity to facilitate C. tabacum infection by intervening in the native function of NbCPR1.
- | Preclinical, Journal: Potential Hepatoprotective Effects of Allicin on Carbon Tetrachloride-Induced Acute Liver Injury in Mice by Inhibiting Oxidative Stress, Inflammation, and Apoptosis. (Pubmed Central) - May 24, 2024
The in vitro study of the LPS-induced RAW264.7 inflammatory cell model confirmed that allicin can inhibit important inflammation-related factors and alleviate inflammation. This research firstly clarified that allicin has a significant protective effect on CCl4-induced liver injury via inhibiting the inflammatory response and hepatocyte apoptosis, alleviating oxidative stress associated with the progress of liver damage, highlighting the potential of allicin as a hepatoprotective agent.
- | STF-083010 / Shanghai Jiao Tong University
Journal: Bax Inhibitor-1 preserves pancreatic ?-cell proteostasis by limiting proinsulin misfolding and programmed cell death. (Pubmed Central) - May 15, 2024
These results uncover a new protective role for BI-1 in pancreatic ?-cell physiology as a stress integrator to modulate the UPR triggered by accumulating unfolded proinsulin in the ER, as well as autophagy and programmed cell death, with consequences on ?-cell function and insulin secretion. In pancreatic ?-cells, BI-1-/- deficiency perturbs proteostasis with proinsulin misfolding, ER stress, terminal UPR with overwhelmed IRE1?/XBP1s/CHOP activation, inflammation, ?-cell programmed cell death, and diabetes.
- | Journal: BAX/MLKL signaling contributes to lipotoxicity-induced lysosomal membrane permeabilization in alcohol-associated liver disease. (Pubmed Central) - Apr 29, 2024
Importantly, the pharmacological or genetic inhibition of BAX or MLKL protects hepatocytes from lipotoxicity-induced LMP. Thus, our study reveals a novel molecular mechanism that activation of BAX/MLKL signaling contributes to the pathogenesis of ALD through mediating lipotoxicity-induced LMP.
- | Journal, IO biomarker: QiDongNing induces lung cancer cell apoptosis via triggering P53/DRP1-mediated mitochondrial fission. (Pubmed Central) - Apr 29, 2024
Thus, our study reveals a novel molecular mechanism that activation of BAX/MLKL signaling contributes to the pathogenesis of ALD through mediating lipotoxicity-induced LMP. Additionally, QDN inhibited tumour growth with acceptable safety in
- | Journal, PD(L)-1 Biomarker, IO biomarker: GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling. (Pubmed Central) - Apr 12, 2024
Furthermore, we also showed that YY1 could decrease GHITM level via binding to its promoter. Taken together, our study revealed that GHITM was a promising therapeutic target for KIRC, which could modulate malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling pathway.
- || baxdrostat (CIN-107) / AstraZeneca
P1 data, PK/PD data, Journal: Results from a Phase 1 Study Assessing the Pharmacokinetics of the Aldosterone Synthase Inhibitor Baxdrostat in Participants with Varying Degrees of Renal Function. (Pubmed Central) - Apr 5, 2024
Inadequate urine production in the kidney failure group resulted in minimal urinary baxdrostat excretion. Renal impairment had no significant impact on systemic exposure or clearance of baxdrostat, suggesting that dose adjustment due to PK differences in patients with kidney disease is unnecessary.
- | donepezil / Generic mfg.
Journal, IO biomarker: Donepezil promotes skin flap survival through activation of the HIF-1?/VEGF signalling pathway. (Pubmed Central) - Mar 29, 2024
Finally, it had anti-inflammatory effects by reducing the levels of IL-1?, IL-6, and TNF-?. The results suggest that donepezil can enhance the viability of randomly generated skin flaps by upregulating HIF-1?/VEGF signalling pathway, facilitating vascularization, inducing autophagy, suppressing cell apoptosis, and mitigating inflammation within the flap tissue.
- dexamethasone / Generic mfg.
IL-6 INTERFERES WITH APOPTOSIS-INDUCTION OF RHEUMATOID ARTHRITIS FIBROBLAST-LIKE SYNOVIAL CELLS BY AFFECTING BCL-2 FAMILY OF PROTEINS (Poster View) - Mar 29, 2024 - Abstract #EULAR2024EULAR_2466;
The results suggest that donepezil can enhance the viability of randomly generated skin flaps by upregulating HIF-1?/VEGF signalling pathway, facilitating vascularization, inducing autophagy, suppressing cell apoptosis, and mitigating inflammation within the flap tissue. Synovial cells were treated with dexamethasone (DEX; 0, 0.1, 1.0,10,100,300,500,1000
- Urinary extracellular vesicle proteins as signatures for cribriform and intraductal prostate carcinoma (221C) - Mar 12, 2024 - Abstract #AUA2024AUA_867;
Bax inhibitor-1 specific down-regulation by RNA interference leads to cell death in human PCa cells. TMBIM1 has also been previously identified as up-regulated in urinary EVs in patients with high-grade prostate cancer (poor prognosis).
- | Journal: The Activation of GABAAR Alleviated Cerebral Ischemic Injury via the Suppression of Oxidative Stress, Autophagy, and Apoptosis Pathways. (Pubmed Central) - Feb 24, 2024
These data suggest that GABAAR activation exerts neuroprotective effects during cerebral ischemia through improving oxidative stress and inhibiting autophagy and apoptosis. Our findings indicate that GABAAR serves as a target for treating cerebral ischemia and highlight the GABAAR-mediated autophagy signaling pathway.
- | Journal: A cysteine-rich receptor-like kinase CRK10 targeted by Coniella diplodiella effector CdE1 contributes to white rot resistance in grapevine. (Pubmed Central) - Feb 6, 2024
The activity of the VdCRK10 promoter is induced by C. diplodiella and is higher than that of VvCRK10, indicating the involvement of transcriptional regulation in CRK10 gene expression. Taken together, our results highlight the potential of VdCRK10 as a resistant gene for enhancing white rot resistance in grapevines.
- | Journal: Small secreted effector protein from Fusarium sacchari suppresses host immune response by inhibiting ScPi21-induced cell death. (Pubmed Central) - Feb 1, 2024
These results suggest that Fs00367 is a core pathogenicity factor that suppresses plant immunity through inhibiting ScPi21-induced cell death. The findings of this study provide new insights into the molecular mechanisms of effectors in regulating plant immunity.
- | Journal: Dexpanthenol exhibits antiapoptotic and anti-inflammatory effects against nicotine-induced liver damage by modulating Bax/Bcl-xL, Caspase-3/9, and Akt/NF-?B pathways. (Pubmed Central) - Jan 21, 2024
Nicotine-induced liver injury resulted in oxidative stress, inflammation, and apoptosis, mediated by Bax/Bcl-xL, Caspase-3, Caspase-9, and Akt/NF-?B pathways. Conversely, DEX effectively attenuated nicotine-induced liver injury by modulating apoptosis through NF-?B, Caspase-3, Caspase-9, Bax inhibition, and Bcl-xL activation.
- | cisplatin / Generic mfg.
Journal, IO biomarker: The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis. (Pubmed Central) - Jan 16, 2024
Many cancer types display high mitochondrial cholesterol levels, and oesophageal adenocarcinoma tumours show a correlation between chemotherapy resistance and STARD1 expression which is supported by our findings. This establishes an important role for Itch in regulation of extrinsic and intrinsic apoptosis, mitochondrial cholesterol levels and provides insight to mechanisms that contribute to TRAIL, Bcl-2 inhibitor and cisplatin resistance in cancer cells.
- | Journal: A new labdane diterpenoid from Scoparia dulcis improving pancreatic function against islets cell apoptotic by Bax/Bcl-2/Caspase-3 pathway. (Pubmed Central) - Jan 15, 2024
This establishes an important role for Itch in regulation of extrinsic and intrinsic apoptosis, mitochondrial cholesterol levels and provides insight to mechanisms that contribute to TRAIL, Bcl-2 inhibitor and cisplatin resistance in cancer cells. We demonstrated the new diterpenoid scoparicol E could protect islet cells apoptosis by modulating the Bax/Bcl-2/Caspase-3 pathway.
- || Kerendia (finerenone) / Bayer, aprocitentan (ACT-132577) / J&J, baxdrostat (CIN-107) / AstraZeneca
Review, Journal: Taming Resistant Hypertension - the promise of novel pharmacologic approaches and renal denervation. (Pubmed Central) - Jan 15, 2024
Furthermore, the evidence base for consideration of catheter-based renal denervation as a safe and effective adjunct therapeutic approach across the clinical spectrum of hypertension has been further substantiated. This narrative review will summarise the recently published evidence on novel antihypertensive agents and renal denervation in the context of resistant hypertension.
- | atorvastatin / Generic mfg.
Preclinical, Journal, IO biomarker: Atorvastatin calcium ameliorates cognitive deficits through the AMPK/mTOR pathway in rats with vascular dementia. (Pubmed Central) - Jan 15, 2024
This narrative review will summarise the recently published evidence on novel antihypertensive agents and renal denervation in the context of resistant hypertension. This study found that AC may relieve learning and memory deficits as well as neuronal damage in VD rats by changing the expression of apoptosis/autophagy-related genes and activating the AMPK/mTOR signalling pathway in neurons.
- | setanaxib (GKT831) / Calliditas
Journal, IO biomarker: Setanaxib mitigates oxidative damage following retinal ischemia-reperfusion via NOX1 and NOX4 inhibition in retinal ganglion cells. (Pubmed Central) - Jan 10, 2024
This inhibition further prevents the activation of apoptosis and senescence related factors in RGCs, ultimately protecting them against retinal I/R injury. Consequently, setanaxib exhibits promising potential as a therapeutic intervention for glaucoma.
- | Journal, IO biomarker: Exosomes from adipose-derived stem cells restore fibroblast function and accelerate diabetic wound healing. (Pubmed Central) - Jan 3, 2024
In addition, we verified that ADSC exosomes downregulated high glucose induced increased apoptosis rate in fibroblast and the protein expression of Bax as well as cleaved caspases 3. This study indicated that ADSC exosomes alleviated high glucose induced damage to fibroblasts and accelerate diabetic wound healing by inhibiting Bax/caspase 3.