Autophagy inhib 
Welcome,         Profile    Billing    Logout  
  Companies   Products    Products    Diseases    Trials    News 


«12...8687888990919293949596...135136»
  • ||||||||||  Journal:  Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination. (Pubmed Central) -  Oct 13, 2021   
    Furthermore, high-cytochrome c/CPOX mitochondria are preferentially targeted by Parkin, indicating that in the context of reduced MTF, they are mitophagy intermediates regardless of Parkin expression. In sum, Parkin-deficient cells adapt to mitochondrial proteotoxicity through a Drp1-mediated mechanism that involves the severing of the OMM and autophagy targeting ubiquitinated IMM proteins.
  • ||||||||||  imatinib / Generic mfg.
    Journal:  Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells. (Pubmed Central) -  Oct 13, 2021   
    HSPA8 ablation could downregulate BCR-ABL/STAT5 and BCR-ABL/AKT signaling pathways, dramatically induce proliferation inhibition, autophagy, G0/G1 phase cell cycle arrest but not apoptosis in IR-CML cells. Significantly, HSPA8 ablation enhanced the antitumor activity of imatinib via promoting apoptosis in vitro and vivo.These findings unraveled that HSPA8 ablation inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity of imatinib in IR-CML cells, which investigate the role and molecular mechanism of HSPA8 in IR-CML cells and suggest that HSPA8 may be a potential target for IR-CML treatment.
  • ||||||||||  Journal:  BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer's disease. (Pubmed Central) -  Oct 13, 2021   
    BRUCE was the target of miR-204, and partial loss of miR-204 by inhibitor promoted autophagosome-lysosome fusion to prevent axon dystrophy and accumulated BDNF nuclear translocation to rescue BDNF/TrkB signaling deficits in HT22 cells. The overall results demonstrated that inhibition of miR-204 prevents axonal dystrophy by blocking BRUCE interaction with STX17, which unraveled potential novel therapeutic targets for delaying AD.
  • ||||||||||  Clinical, Journal:  Enhanced Autophagy Suppresses Proplatelet Formation in Pediatric Immune Thrombocytopenia (Pubmed Central) -  Oct 12, 2021   
    Autophagy can alter sensitivity of ALL cells to ferroptosis activator Erastin, which suggestes that combining autophagy regulator with ferroptosis activator may be a new strategy for the treatment of chemotherapy-resistant ALL. Enhanced autophagy is the key factor of poor proplatelet formation in megakaryocytes of ITP children.
  • ||||||||||  hydroxychloroquine / Generic mfg.
    Preclinical, Journal:  Autophagy stimulation delayed biological aging and decreased cardiac differentiation in rabbit mesenchymal stem cells. (Pubmed Central) -  Oct 12, 2021   
    Western blotting data showed that the autophagy stimulation response in rabbit MSCs postponed the biological aging and decreased the differentiation potential to the cardiac cells by diminishing α-actinin comparing with control cells (P < 0.05). In summary, for the informants in this study, it could be noted that autophagy inhibition/stimulation could alter rabbit MSCs aging and differentiation capacity.
  • ||||||||||  dapsone / Generic mfg., minocycline / Generic mfg.
    Review, Journal:  Antibiotics with therapeutic effects on spinal cord injury: a review. (Pubmed Central) -  Oct 10, 2021   
    These antibiotics may target similar signaling pathways such as reducing inflammatory microglial activity, promoting autophagy, inhibiting neuronal apoptosis, and modulating the SCI-related mitochondrial dysfunction. In this review paper, we will discuss the mechanisms underlying therapeutic effects of these antibiotics on SCI, which not only could supply vital information for investigators but also guide clinicians to consider administering these antibiotics as part of a multimodal therapeutic approach for management of SCI and its complications.
  • ||||||||||  Preclinical, Journal:  Co-modification with MSC membrane and PDA prevents FeO-induced pulmonary toxicity in mice via AMPK-ULK1 axis. (Pubmed Central) -  Oct 10, 2021   
    Compared with FeO@PDA nanoparticles, co-modification with MSCM and PDA significantly reduced autophagy and apoptosis in mouse lung tissue, and reduced activation of autophagy mediated by the AMPK-ULK1 pathway axis. Thus, co-modification with MSCM and PDA prevents FeO-induced pulmonary toxicity in mice by inhibiting autophagy, apoptosis, and oxidative stress.
  • ||||||||||  Journal:  Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway. (Pubmed Central) -  Oct 8, 2021   
    Inhibiting autophagosomal transport disrupts maturation, and inhibiting autophagosomal maturation perturbs the association and function of dynein effectors; thus, maturation and transport are tightly linked. These results reveal a novel maturation-based dynein effector handoff on neuronal autophagosomes that is key to motility, cargo degradation, and the maintenance of axonal health.
  • ||||||||||  Kadcyla (ado-trastuzumab emtansine) / Roche
    Journal:  Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer. (Pubmed Central) -  Oct 7, 2021   
    Furthermore, autophagic inhibition might increase the fusion of T-DM1 with lysosomes, which might accelerate the release of the cytotoxic molecule emtansine from the T-DM1 conjugate. These findings highlight a promising therapeutic strategy that combines T-DM1 with an autophagy inhibitor to treat HER-positive GC more efficiently.
  • ||||||||||  chloroquine phosphate / Generic mfg., hydroxychloroquine / Generic mfg., sirolimus / Generic mfg.
    Journal:  Attenuation of chloroquine and hydroxychloroquine on the invasive potential of bladder cancer through targeting matrix metalloproteinase 2 expression. (Pubmed Central) -  Oct 7, 2021   
    Moreover, additional data revealed that the migrative and invasive effects of BC cells treated with CQ or HCQ were abolished after treatment with rapamycin, which induces autophagy, demonstrating that CQ and HCQ functions in BC are based on autophagy inhibition. In conclusion, our research demonstrated that CQ and HCQ regulated cell motility in BC through MMP-2 downregulation by targeting autophagy functions, providing a novel therapeutic strategy for BC treatment.
  • ||||||||||  chloroquine phosphate / Generic mfg.
    Journal:  Pva-miR-252 participates in ammonia nitrogen-induced oxidative stress by modulating autophagy in Penaeus vannamei. (Pubmed Central) -  Oct 7, 2021   
    More importantly, overexpression of pva-miR-252 could enhance the activity of antioxidant enzymes and reduced the production of ROS of shrimp under ammonia nitrogen stress. In conclusion, pva-miR-252 could positively regulate autophagy through PvPI3K and improve the antioxidant enzyme activity of P. vannamei under ammonia nitrogen stress, and our study provides a novel theoretical molecular mechanism for further understanding the shrimp cope with a high ammonia nitrogen environment.
  • ||||||||||  pentylenetetrazole (BTD-001) / Balance Therap
    Preclinical, Journal:  Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats. (Pubmed Central) -  Oct 6, 2021   
    In this study, we found that responder and non-responder pentylenetetrazole-induced chronic epileptic rats had no significant differences in VPA concentrations in their plasma and brain tissues...Furthermore, epileptic rats that were previously administered 3-methyadenine (an inhibitor of autophagy) exhibited a slight increase in VPA efficacy. In conclusion, autophagy was associated with the efficacy of VPA.
  • ||||||||||  sirolimus / Generic mfg.
    Preclinical, Journal:  Autophagy is a defense mechanism controlling Streptococcus suis serotype 2 infection in murine microglia cells. (Pubmed Central) -  Oct 6, 2021   
    Autophagy activators, rapamycin, could further promote autophagy in S. suis-infected BV2 cells...This is the first study reporting that the interaction between autophagy and microglia cells in response to S. suis infection. The possible mechanism involved could additionally suggest potential therapeutic approaches for bacterial meningitis.
  • ||||||||||  Journal:  Resolvin D2 suppresses NLRP3 inflammasome by promoting autophagy in macrophages. (Pubmed Central) -  Oct 5, 2021   
    In summary, the present study reported the negative regulation of NLRP3 inflammasome activation by RvD2. The findings from this study may extend the knowledge of the innate regulation of inflammasome and highlight a possible target for inflammasome-related diseases.
  • ||||||||||  sirolimus / Generic mfg.
    Journal:  Autophagy is involved in neurofibromatosis type I gene-modulated osteogenic differentiation in human bone mesenchymal stem cells. (Pubmed Central) -  Oct 5, 2021   
    In addition, the autophagy activator rapamycin (RAPA) and inhibitor 3-methyladenine (3-MA) were used to investigate the effects of autophagy on NF1-modulated osteogenic differentiation in BMSCs...In conclusion, results from the present study suggest at the involvement of autophagy in the NF1-modulated osteogenic differentiation of BMSCs. Furthermore, NF1 may partially regulate the autophagic activity of BMSCs through the PI3K/AKT/mTOR signaling pathway.
  • ||||||||||  Journal:  TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy. (Pubmed Central) -  Oct 3, 2021   
    In accord with previous findings that autophagy plays a critical role in the control of differentiation, we also demonstrated that autophagy inhibited OS cell differentiation, and that the TRIM21/ANXA2/TFEB axis is implicated in OS cell differentiation through the coordination with autophagy. Taken together, our results suggest that the TRIM21/ANXA2/TFEB axis is involved in OS cell autophagy and subsequent differentiation, indicating that targeting this signaling axis might lead to a new clue for OS treatment.
  • ||||||||||  Journal:  Intracellular Staphylococcus aureus inhibits autophagy of bovine mammary epithelial cells through activating p38α. (Pubmed Central) -  Oct 3, 2021   
    Inhibition of p38α promoted intracellular S. aureus-induced autophagy flow, up-regulated the ratio of LC3 II/I, reduced the level of p62 and inhibited the phosphorylation of ULK1ser757, whereas the above results were reversed after activation of p38α. The current study indicated that intracellular S. aureus can inhibit autophagy flow by activating p38α in bovine mammary epithelial cells.
  • ||||||||||  Journal:  NRF2 deficiency sensitizes human keratinocytes to zinc oxide nanoparticles-induced autophagy and cytotoxicity. (Pubmed Central) -  Oct 2, 2021   
    Knock-down of NRF2 (NRF2-KD) sensitized the cells to ZnO NPs-induced autophagy and cytotoxicity while an autophagy inhibitor, 3-methyladenine, protected the cells from ZnO NPs-induced cell death. These results demonstrated that NRF2 deficiency sensitizes human keratinocytes to ZnO NPs induced autophagy and cytotoxicity, and proposed a key role of NRF2 in protecting skin cells against ZnO NPs through regulation of antioxidants and autophagy.
  • ||||||||||  hydroxychloroquine / Generic mfg.
    Interleukin 2(IL-2) Systems Immunology Modeling: Machine Learning for Cancer Immunotherapy (Poster Hall) -  Oct 1, 2021 - Abstract #SITC2021SITC_924;    
    P1/2
    Methods In a completed Phase 2 trial (NCT01550367), the adaptome of 29 patients with metastatic clear cell renal carcinoma (RCC) treated with high dose (HD) IL-2 and the autophagy inhibitor, hydroxychloroquine (HCQ) were measured from peripheral blood samples by DAM-PCR...Conclusions NLP of both TCR and BCR repertoires can provide early predictions of cancer response to treatment. Furthermore, seven-chain longitudinal monitoring across treatment revealed a surprisingly robust repertoire orchestration in responders that was not observed in non-responders, suggesting that the methodology proposed here can be used to gain new mechanistic insight into the role of repertoire evaluation in cancer immunotherapy.
  • ||||||||||  Byetta (exenatide) / AstraZeneca
    Journal:  Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment. (Pubmed Central) -  Oct 1, 2021   
    Furthermore, we found that exenatide activates the AMPK-SKP2-CARM1 and AMPK-mTOR signaling pathways, which likely lead to exenatide's effects on activating TFE3. Overall, our findings suggest that exenatide may be a potent therapy to prevent flap necrosis, and we also reveal novel mechanistic insight into exenatide's effect on flap survival.