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- Autophagy as a target for therapy in ovarian cancer: A phase II randomized trial with biomarker correlation (ATOC Trial) (Exhibition / Poster Area) - Oct 9, 2022 - Abstract #ESMOAsia2022ESMO_Asia_735;
Hydroxychloroquine (HCQ) is an autophagy inhibitor that inhibits the autophagosome's fusion with the lysosome...Standard Therapy: 3 weekly Carboplatin+ paclitaxel/gemcitabine or weekly paclitaxel+carboplatin Objectives: 1...5. To assess the quality of life at baseline and after 3 cycles.
- | MRT68921 / University of Dundee
Journal: Inhibition of mTOR signaling protects human glioma cells from hypoxia-induced cell death in an autophagy-independent manner. (Pubmed Central) - Oct 8, 2022
We analyzed autophagic activity, cell growth, viability and oxygen consumption following (co-)treatment with the mTOR inhibitors torin2 or rapamycin, and autophagy inhibitors bafilomycin A1 or MRT68921...Our proteomic findings suggest that the pharmacological inhibition of autophagy induces extensive changes in the cellular proteome that can support glioma cell survival under nutrient-deplete and hypoxic conditions. These findings provide a novel perspective on the complex role of autophagy in gliomas.
- | Journal, IO biomarker: The circadian clock gene ARNTL overexpression suppresses oral cancer progression by inducing apoptosis via activating autophagy. (Pubmed Central) - Oct 8, 2022
An in vivo tumorigenesis assay also showed ARNTL overexpression inhibited tumor growth, and autophagy-related protein expressions were consistent with the in vitro data. The research demonstrated for the first time that ARNTL induced apoptosis and inhibited cell proliferation dependent on autophagy in oral cancer, which provides theoretical basis for potential therapeutic targets.
- Role of adenylate cyclase 6 autophagy complex in the rescue and function of F508del cystic fibrosis transmembrane conductance regulator protein (Exhibition Hall) - Oct 8, 2022 - Abstract #NACFC2022NACFC_1209;
The research demonstrated for the first time that ARNTL induced apoptosis and inhibited cell proliferation dependent on autophagy in oral cancer, which provides theoretical basis for potential therapeutic targets. This study will help identify one of the causes of reducedautophagy in CF and a modifying pathway for most efficient rescue ofF508del CFTR protein.
- | Journal: Triterpenoid saponins of Ilex pubescens against TNF-α induced inflammation and apoptosis in human umbilical vein endothelial cells via autophagy pathway. (Pubmed Central) - Oct 8, 2022
This study will help identify one of the causes of reducedautophagy in CF and a modifying pathway for most efficient rescue ofF508del CFTR protein. This study preliminarily confirmed that IPTS ameliorated HUVECs' inflammation and apoptosis by increasing autophagy.
- | moxidectin / Generic mfg.
Journal: Moxidectin induces autophagy arrest in colorectal cancer. (Pubmed Central) - Oct 7, 2022
It was found that MOX can induce autophagy arrest, promote autophagy initiation, inhibit autophagic flux and cell proliferation, simultaneously PI3K-Akt-mTOR signaling pathway and microtubule acetylation. Furthermore, MOX suppressed the growth of xenograft tumors, which was consistent with the in vitro results.
- | sorafenib / Generic mfg.
Journal: The natural medicinal fungus Huaier promotes the anti-hepatoma efficacy of sorafenib through the mammalian target of rapamycin-mediated autophagic cell death. (Pubmed Central) - Oct 7, 2022
The mTOR activator MHY1485 attenuated the effect of HUA-SOR combination by inhibiting autophagy, suggesting HUA may potentiate the sensitivity of HCC cells to SOR by partially inducing mTOR-mediated autophagic cell death. These findings might provide a rationale experimental foundation for clinical applications of HUA with SOR.
- | Journal, IO biomarker: Combining autophagy and immune characterizations to predict prognosis and therapeutic response in lung adenocarcinoma. (Pubmed Central) - Oct 7, 2022
The expression of the four genes was assessed in clinical specimens and cell lines. The autophagy-immune-based gene signature represents a promising tool for risk stratification in patients with lung adenocarcinoma, guiding individualized targeted therapy or immunotherapy.
- | cisplatin / Generic mfg., paclitaxel / Generic mfg.
Journal: Autophagy promotes recurrence of nasopharyngeal carcinoma via inducing the formation of dormant polyploid giant cancer cells (Pubmed Central) - Oct 7, 2022
The mechanism of dormant polyploid giant cancer cells formation is related to autophagy. Inhibition of autophagy can inhibit the formation of PGCC and thus prevent the recurrence of nasopharyngeal carcinoma.
- | Journal: Dual effect of ultraviolet B on cholesterol efflux and regulated by ultraviolet radiation resistance-associated gene-mediated autophagy. (Pubmed Central) - Oct 7, 2022
In conclusion, our research proves that UVB exhibits a dual role in foam cell formation by regulating cholesterol efflux. Further more, we also reveal that UVRAG-mediated autophagy is the underlying mechanism of UVB-induced cholesterol efflux.
- | Preclinical, Journal: Methylprednisolone Inhibits Autophagy of Vascular Endothelial Cells in Rat Femoral Head Via PI3K/Akt/mTOR Pathway. (Pubmed Central) - Oct 6, 2022
Further more, we also reveal that UVRAG-mediated autophagy is the underlying mechanism of UVB-induced cholesterol efflux. The steroid inhibited the physiological protective effect of autophagy on SANFH by increasing the expression of PI3K/Akt/mTOR signaling pathway related factors and decreasing the expression of Beclin1 and MAP1LC3 in the femoral head VEC.
- | Preclinical, Journal: Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition. (Pubmed Central) - Oct 6, 2022
Collectively, LBW plus high-fat intervention increased the risk of glucose metabolism disorders, which may be related to the alteration of TRPC5 expression level and its regulation of the AMPKα/mTOR autophagy pathway. This study may provide a fundamental basis for the molecular mechanism of glucose metabolism disorders induced by LBW with high-fat diets in adulthood and a new target for the treatment of metabolic diseases in LBW individuals.
- | Journal: PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish. (Pubmed Central) - Oct 6, 2022
Mechanistically, PLAAT1 interacts with IRF3 and IRF7 to initiate degradation of IRF3 and IRF7, which can be attenuated by 3-methyladenine, an inhibitor of autophagosome. Our study provides novel insights into the functions of PLAAT1 in host immune response to viral infection.
- | Preclinical, Journal: FOXD1-mTOR Signaling Pathway on Oral Squamous Cell Carcinoma and Its Inhibition by Rosemary Extract (Invitro-Study). (Pubmed Central) - Oct 6, 2022
FOXD1 can be considred a diagnostic biomarker for OSCC. RE inhibits autophagy of oral human cancer cells via mTOR/LC3I/II-dependent pathways and decrease caspase -3 apoptotic level.
- | Journal, Checkpoint inhibition: Cardio-, hepato- and pneumoprotective effects of autophagy checkpoint inhibition by targeting DBI/ACBP. (Pubmed Central) - Oct 6, 2022
We conclude that a-DBI-mediated neutralization of extracellular DBI/ACBP mediates potent autophagy-dependent organ protection by on-target effects, hence unravelling a novel and potentially useful strategy for autophagy enhancement. "Autophagy checkpoint inhibition" (ACI) can be achieved by targeting DBI/ACBP.
- Opdivo (nivolumab) / Ono Pharma, BMS, NG-350A / PsiOxus, Yervoy (ipilimumab) / Ono Pharma, BMS
Exploratory Platform Trial to Evaluate Immunotherapy Combinations with Chemotherapy for the Treatment of Patients with Previously Untreated Metastatic Pancreatic Adenocarcinoma (REVOLUTION) (Hall C) - Oct 6, 2022 - Abstract #SITC2022SITC_977;
Cohort B: high-dose hydroxychloroquine (HCQ), an autophagy inhibitor, + ipilimumab + gem/nP...The same mechanisms of action for chemotherapy and ipilimumab as Cohorts A and B are hypothesized, with NG-350A re-programming the tumor microenvironment, activating antigen-presenting cells, and facilitating immune priming...5 Results Cohorts A and B are fully enrolled for Stage 1 and accumulating data to support an expansion decision. Cohort C is in development.
- metformin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Metformin Inhibits Autophagy/Mitophagy and Antagonizes Doxorubicin-Induced Cardiomyocyte Death (Virtual Only) - Oct 5, 2022 - Abstract #AHA2022AHA_8029;
Together, these results suggest that the cardioprotective effects of metformin against DOX cardiotoxicity may be mediated by its ability to inhibit autophagy and mitophagy. Future studies are needed to understand the molecular mechanisms by which metformin suppresses autophagy and mitophagy.
- | doxorubicin hydrochloride / Generic mfg.
Journal: A self-assembled leucine polymer sensitizes leukemic stem cells to chemotherapy by inhibiting autophagy in acute myeloid leukemia. (Pubmed Central) - Oct 5, 2022
Furthermore, doxorubicin (DOX) treatment stimulated autophagy in LSC by repressing the mTOR pathway, and pharmaceutical inhibition of autophagy rendered chemoresistant LSC sensitive to DOX treatment in MLL-AF9 induced murine AML...Consequently, Leu-DOX efficiently reduced LSCs and prolonged the survival of AML mice, with limited myeloablation and tissue damage side effects than DOX treatment. Overall, we proposed that the newly developed Leu-DOX is an effective autophagy inhibitor and an ideal drug to efficiently eliminate LSCs, thus serving as a revolutionary strategy to enhance the chemotherapy efficacy in AML.
- | chloroquine phosphate / Generic mfg.
Journal, IO biomarker: Lipopolysaccharide reduces melanin synthesis in vitiligo melanocytes by regulating autophagy. (Pubmed Central) - Oct 5, 2022
Inhibiting autophagy with 3-methyladenine or chloroquine blocked these effects. This suggests that LPS inhibits skin pigmentation by modulating autophagy, thus providing novel insights into the pathogenesis of vitiligo.
- | sirolimus / Generic mfg.
Journal: AT2 Receptor Stimulation Inhibits Vascular Smooth Muscle Cell Senescence Induced by Angiotensin II and Hyperglycemia. (Pubmed Central) - Oct 5, 2022
This suggests that LPS inhibits skin pigmentation by modulating autophagy, thus providing novel insights into the pathogenesis of vitiligo. Ang II and hyperglycemia synergistically promoted VSMC senescence, at least partly through the participation by autophagy, oxidative stress, and p21-pRb pathway, which could be inhibited by C21.
- | Journal: RBM3 interacts with Raptor to regulate autophagy and protect cardiomyocytes from ischemia-reperfusion-induced injury. (Pubmed Central) - Oct 5, 2022
We confirmed that RBM3 interacts with Raptor to regulate the autophagy pathway. Taken together, these findings illustrate the protective effects of RBM3 against I/R-induced myocardial apoptosis through the autophagy pathway.
- | Journal, IO biomarker: Cineole regulates Wnt/β-catenin pathway through Nrf2/keap1/ROS to inhibit bisphenol A-induced apoptosis, autophagy inhibition and immunosuppression of grass carp hepatocytes. (Pubmed Central) - Oct 5, 2022
Therefore, these results indicated that CIN could inhibit BPA-induced apoptosis, autophagy inhibition and immunosuppression in grass carp hepatocytes by regulating the Wnt/β-catenin pathway with Nrf2/keap1/ROS. This study provided further information to the risk assessment of the neuroendocrine disruptor BPA on aquatic organisms and offered suggestions and resources for further research into the function of natural extracts in the body's detoxification process.
- | cyclosporin A microemulsion / Generic mfg.
Journal: P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy. (Pubmed Central) - Oct 4, 2022
P-gp-specific siRNA and pharmacological inhibitor cyclosporine A were used to inhibit P-gp, whereas pcDNA3.1 was utilized to overexpress P-gp...Additionally, treatment with an autophagy inhibitor (3-methyladenine) abolished protections against ischemic stroke and tight junction proteins reduction followed by P-gp silence. In conclusion, increased P-gp expression after ischemic injury resulted in BBB dysfunction and hyperpermeability by suppressing Akt/mTOR-induced endothelial autophagy.
- | SP600125 / BMS
Journal: Snake venom induces an autophagic cell death via activation of the JNK pathway in colorectal cancer cells. (Pubmed Central) - Oct 4, 2022
Pretreatment with SP600125, a JNK inhibitor, reversed snake venom-induced autophagy and cell death, indicating that JNK plays a critical role in snake venom-induced autophagy. This study demonstrated that snake venom can function as an anticarcinogenby induction autophagy.
- | Journal, IO biomarker: Functional components of Chinese rice wine can ameliorate diabetic cardiomyopathy through the modulation of autophagy, apoptosis, gut microbiota, and metabolites. (Pubmed Central) - Oct 4, 2022
The biosynthesis of primary bile acids was enhanced by the presence of RWPH. Both RWPH and RWPE provided a protective effect against DCM by promoting autophagy, inhibiting apoptosis, and reversing both gut microbiota dysbiosis and metabolic dysregulation.
- ACBP and control of HIV in progressors and elite controllers () - Oct 4, 2022 - Abstract #HIVGlasgow2022HIV_Glasgow_342;
High circulating ACBP levels were associated with innate inflammation (IL-1β) and low IL-21 plasma levels. Our findings indicate that high intracellular ACBP levels might promote IL-21 production and persistent anti-HIV T-cell response.
- || Review, Journal: Sepsis-induced AKI: From pathogenesis to therapeutic approaches. (Pubmed Central) - Oct 4, 2022
Hence, understanding the pathophysiology of sepsis-induced AKI may help to develop novel therapeutics to attenuate the complications of sepsis and lower the mortality rate. This review updates the recent progress of underlying pathophysiological mechanisms of sepsis-associated AKI, focuses specifically on autophagy, and summarizes the potential therapeutic effects of phytochemicals and pharmacological inhibitors.
- | Journal: Suppression of endoplasmic reticulum stress-dependent autophagy enhances cynaropicrin-induced apoptosis via attenuation of the P62/Keap1/Nrf2 pathways in neuroblastoma. (Pubmed Central) - Oct 4, 2022
Overall, our findings suggested that CYN may be a promising candidate for the treatment of NB, and the combination of pharmacological inhibitors of autophagy may hold novel therapeutic potential for the treatment of NB. Our paper will contribute to the rational utility and pharmacological studies of CYN in future anticancer research.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Journal: Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions. (Pubmed Central) - Oct 4, 2022
Furthermore, in an IUA-like mouse model, the autophagy in endometrium was defective accompanied by EEC-EMT, and CQ could inhibit autophagy and aggravate endometrial fibrosis, whereas rapamycin or T3 treatment could improve the autophagic levels and blunt endometrial fibrosis. Together, we demonstrated that defective autophagy played an important role in EEC-EMT in IUA via the DIO2-MAPK/ERK-MTOR pathway, which provided a potential target for therapeutic implications.Abbreviations: ACTA2/α-SMA: actin alpha 2, smooth muscle; AMPK: adenosine 5'-monophosphate-activated protein kinase; AKT/protein kinase B: AKT serine/threonine kinase; ATG: autophagy related; CDH1/E-cadherin: cadherin 1; CDH2/N-cadherin: cadherin 2; CQ: chloroquine; CTSD: cathepsin D; DIO2: iodothyronine deiodinase 2; DEGs: differentially expressed genes; EECs: endometrial epithelial cells; EMT: epithelial-mesenchymal transition; FN1: fibronectin 1; IUA: intrauterine adhesions; LAMP1: lysosomal associated membrane protein 1; LPS: lipopolysaccharide; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAPK: mitogen-activated protein kinase; MTOR: mechanistic target of rapamycin kinase; Rapa: rapamycin; SQSTM1/p62: sequestosome 1; T3: triiodothyronine; T4: tetraiodothyronine; TFEB: transcription factor EB; PBS: phosphate-buffered saline; TEM: transmission electron microscopy; TGFB/TGFβ: transforming growth factor beta.
- || Review, Journal: AMPK's double-faced role in advanced stages of prostate cancer. (Pubmed Central) - Oct 4, 2022
This study reveals that there are numerous pathways other than cell metabolism by which AMPK exerts its effects in the advanced stages of PCa, making it a priceless treatment target. Finally, we mention some drugs developed to treat the advanced stages of PCa by acting on AMPK.
- | Journal: Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart. (Pubmed Central) - Oct 4, 2022
Moreover, inhibition of IGF1R signaling by means of a dominant-negative phosphoinositide 3-kinase (PI3K) mutant induces cardioprotective autophagy, restores myocardial bioenergetics and improves late-life survival. Hence, our results demonstrate that IGF1R exerts a dual biphasic impact on cardiac health, and that autophagy mediates the late-life geroprotective effects of IGF1R inhibition in the heart.
- | Journal: BMI1 promotes the proliferation and inhibits autophagy of breast cancer cells by activating COPZ1. (Pubmed Central) - Oct 4, 2022
To sum up, BMI1 exhibited promotive effects on the malignant progression of breast cancer through the activation of COPZ1. These findings might offer a preliminary theoretical basis for COPZ1 participation in autophagy in breast cancer cells.
- | Journal: Mutual antagonism between aryl hydrocarbon receptor and hypoxia-inducible factor-1α (AhR/HIF-1α) signaling: Impact on the aging process. (Pubmed Central) - Oct 4, 2022
For instance, (i) AhR and HIF-1α factors heterodimerize with the same factor, ARNT/HIF-1β, leading to their competition for DNA-binding, (ii) AhR and HIF-1α signaling exert antagonistic effects on autophagy, and (iii) co-chaperone p23 exhibits specific functions in the signaling of AhR and HIF-1α factors. One might speculate that it is the competition between the AhR and HIF-1α signaling pathways that is a driving force in the aging process.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Journal: Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone induces calcium signaling-dependent crosstalk between autophagy and apoptosis in human macrophages. (Pubmed Central) - Oct 4, 2022
Furthermore, inhibiting autophagy with chloroquine attenuated 3oc-induced apoptosis, while autophagy induction with rapamycin aggravated cell death, suggesting autophagy plays a role in cell death in 3oc-treated macrophages. In conclusion, our findings indicate that 3oc activates a multifaceted death signaling by activating autophagy and apoptosis through Ca signaling, and we propose pharmacological modulation of Ca signaling may act as a combinatorial therapeutic intervention in patients with Pseudomonas aeruginosa-associated infections.
- | Xospata (gilteritinib) / Astellas, crenolanib besylate (ARO-002) / AROG, Vanflyta (quizartinib) / Daiichi Sankyo
Journal: Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia. (Pubmed Central) - Oct 4, 2022
In mice xenografted with FLT3-ITD + AML cells, co-treatment with oral FLT3 and autophagy inhibitors synergistically impaired leukemia progression and extended overall survival. Our findings identify a molecular mechanism responsible for primary FLT3i treatment resistance and demonstrate the pre-clinical efficacy of a rational combination treatment strategy targeting both FLT3 and autophagy induction.
- | chloroquine phosphate / Generic mfg., sirolimus / Generic mfg.
Journal: Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy. (Pubmed Central) - Oct 4, 2022
In conclusion, BBH inhibited BVDV infection by inhibiting BVDV-induced autophagy in cells, and its inhibitory effect was obvious in the viral attachment and release stages. Therefore, our study provides a new idea for exploring novel anti-BVDV drugs.
- | Preclinical, Journal: Mouse dendritic cells in the steady state: Hypoxia, autophagy, and stem cell factor. (Pubmed Central) - Oct 4, 2022
Gene expression microarrays and gene set enrichment analysis supported the hypothesis that SCF had an impact on hypoxia response and inhibited autophagy-related gene sets. Our results suggest that hypoxic response and autophagy, and their modulation by SCF, can play a role in DC homeostasis at the steady state, in agreement with our previous findings on SCF's role in DC survival.
- | gefitinib / Generic mfg.
Journal: FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy. (Pubmed Central) - Oct 1, 2022
This study reveals that FOXO3 mutation, leading to autophagic imbalance, plays important role in gefitinib-induced hepatotoxicity, especially for patients with high concentration of gefitinib. In conclusion, FOXO3 mutation is an effective predictor and erlotinib might be an appropriately and well-tolerated treatment option for patients carrying rs4946935 AA.
- | Journal: Peli1 contributes to myocardial ischemia/reperfusion injury by impairing autophagy flux via its E3 ligase mediated ubiquitination of P62. (Pubmed Central) - Oct 1, 2022
In addition, Peli1 deficiency also decreased cardiomyocyte apoptosis. Together, our work demonstrated a critical link between increased expression and activity of Peli1 and autophagy flux blockage in M-I/R injury, providing insight into a promising strategy for treating myocardium M-I/R injury.
- | morphine sulphate / Generic mfg.
Journal: Morphine Prevents Ischemia/Reperfusion-Induced Myocardial Mitochondrial Damage by Activating δ-opioid Receptor/EGFR/ROS Pathway. (Pubmed Central) - Oct 1, 2022
Morphine may prevent I/R-induced myocardial mitochondrial damage by activating EGFR through δ-opioid receptors, in turn increasing RISK and SAFE pathway activity via intracellular ROS. Moreover, morphine may reduce myocardial injury by regulating autophagy but not apoptosis.
- | Flumadine (rimantadine) / AbbVie
Journal: Amantadine and Rimantadine Inhibit Hepatitis A Virus Replication through the Induction of Autophagy. (Pubmed Central) - Oct 1, 2022
In addition, amantadine and its derivative rimantadine suppress HAV replication partly by enhancing autophagy at the post-entry phase of HAV infection in human hepatocytes. Amantadine may be useful for the control of acute HAV infection by inhibiting cellular autophagy pathways during HAV infection processes.
- | Journal: Polyphenolic Compounds Inhibit Osteoclast Differentiation While Reducing Autophagy through Limiting ROS and the Mitochondrial Membrane Potential. (Pubmed Central) - Oct 1, 2022
In addition, we found that by decreasing intracellular calcium and decreasing ROS levels, along with decreasing mitochondrial membrane potential, polyphenolic compounds inhibit osteoclast differentiation. Together, this study provides evidence that polyphenolic compounds inhibit osteoclast differentiation by reducing ROS production, autophagy, intracellular Ca level, and mitochondrial membrane potentials.
- || 5-fluorouracil / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Review, Journal, Combination therapy: Combination Therapy Using Polyphenols: An Efficient Way to Improve Antitumoral Activity and Reduce Resistance. (Pubmed Central) - Oct 1, 2022
Co-administration of EGCG and doxorubicin induced the death of liver cancer cells. EGCG has the ability to inhibit autophagic activity and stop hepatoma Hep3B cell proliferation This symbiotic approach is well-known in medical practice including in multiple chemotherapy.
- | Journal: TRIM22 actives PI3K/Akt/mTOR pathway to promote Psoriasis through enhancing cell proliferation and inflammation and inhibiting autophagy. (Pubmed Central) - Oct 1, 2022
TRIM22 deficiency blocked M5-induced activation of PI3K/Akt/mTOR pathway in HaCat cells. TRIM22 facilitates cell proliferation and inflammation, and suppresses autophagy in M5-treated HaCat cells through activating PI3K/Akt/mTOR pathway, and inhibition of TRIM22 can be a novel potential treatment for psoriasis.
- | Journal: Resolvin D1 Prevents Epithelial-to-Mesenchymal Transition and Reduces Collagen Deposition by Stimulating Autophagy in Intestinal Fibrosis. (Pubmed Central) - Sep 30, 2022
TRIM22 facilitates cell proliferation and inflammation, and suppresses autophagy in M5-treated HaCat cells through activating PI3K/Akt/mTOR pathway, and inhibition of TRIM22 can be a novel potential treatment for psoriasis. Our results suggested that RvD1 reduces autophagy-induced EMT in intestinal epithelial cells and ameliorates intestinal fibrosis by disrupting epithelial-fibroblast crosstalk.
- | LY294002 / Eli Lilly
Journal: Cholesterol inhibits autophagy in RANKL-induced osteoclast differentiation through activating the PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - Sep 30, 2022
Therefore, our results demonstrated that CHO could inhibit autophagy during osteoclast differentiation by activating the PI3K/AKT/mTOR signaling pathway. These findings provided important theoretical basis for CHO in bone resorption and formation.
- | Preclinical, Journal: Involvement of Mitophagy in Primary Cultured Rat Neurons Treated with Nanoalumina. (Pubmed Central) - Sep 30, 2022
Observation under a transmission electron microscope and a fluorescence microscope revealed mitophagy characteristics induced by nanoalumina. Additionally, the neurotoxicological effects induced by nanoalumina were more significant than those induced by aluminum and in a particle size-dependent manner.
- | Journal: Targeting the ATG5-ATG16L1 Protein-Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition. (Pubmed Central) - Sep 30, 2022
Thus, targeting ATG5-ATG16L1 protein-protein interactions (PPIs) might inhibit early stage autophagy with high specificity. In this paper, we report that a stapled peptide derived from ATG16L1 exhibits potent binding affinity to ATG5, striking resistance to proteolysis, and significant autophagy inhibition activities in cells.
- | Journal: Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells. (Pubmed Central) - Sep 30, 2022
Atg13 serves as a mediator between autophagy and proteasome. Modulation of Atg13 or proteasome activity might be a novel strategy for treating HSC inflammation.
- | cisplatin / Generic mfg.
Journal: Calcitriol potentially alters HeLa cell viability via inhibition of autophagy. (Pubmed Central) - Sep 30, 2022
Treatment with Calcitriol produced protein carbonyl levels similar to those in the cisplatin-treated and control groups...The inhibition of HIF1α partially rescued the HeLa cells from the toxic effects of Calcitriol treatment. We suggest that Calcitriol may shut down mitochondrial homeostasis in HeLa cells by inducing the PI3K-AKT-mTOR pathway and inhibiting autophagy, which leads to cell death.