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- | Journal: Qizhi Jiangtang capsule activates podocyte autophagy in diabetic kidney disease by inhibiting phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathways. (Pubmed Central) - Jul 20, 2023
These results showed that the QZJT can enhance podocyte autophagy and ameliorate podocyte injury in DKD by inhibiting the PI3K/AKT/mTOR signaling pathway.
- | Ibrance (palbociclib) / Pfizer
New P1/2 trial: A Phase Ib/II Study Confirmed Inhibition of Autophagy Synergizes Anti-tumor Effect of High Dose CDK4/6i (clinicaltrials.gov) - Jul 20, 2023
P1/2, N=32, Recruiting, Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- | LY294002 / Eli Lilly
Preclinical, Journal: 1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro. (Pubmed Central) - Jul 19, 2023
1-Mono induced cytoprotective autophagy since autophagy inhibitor Chloroquine dramatically enhanced 1-Mono-induced cytotoxicity. In summary, our results showed 1-Mono kills lung cancer through PI3K/Akt pathway, providing novel options for lung cancer administration.
- | Journal: Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis. (Pubmed Central) - Jul 18, 2023
These results suggest that RSV inhibits urinary fibrosis and autophagy via the miR-192-5p/TGF?R1/Smad4 pathway. RAV may be a potential drug for alleviating urethral fibrosis.
- | sirolimus / Generic mfg., piceatannol / New York Medical College, Kyushu University
Journal: Piceatannol Protects PC-12 Cells against Oxidative Damage and Mitochondrial Dysfunction by Inhibiting Autophagy via SIRT3 Pathway. (Pubmed Central) - Jul 18, 2023
In addition, the autophagy activator (rapamycin) abrogated the protective effects of piceatannol on PC-12 cell death. These findings demonstrated that piceatannol could alleviate PC-12 cell oxidative damage and mitochondrial dysfunction by inhibiting autophagy via the SIRT3 pathway.
- | gemcitabine / Generic mfg.
Preclinical, Journal, Combination therapy: A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice. (Pubmed Central) - Jul 18, 2023
Our data suggest that a KG results in preservation of skeletal muscle mass. Additional research is warranted to explore whether this diet-treatment combination can be clinically effective in combating CAC in PDAC patients.
- | Journal: ARL6IP5 Ameliorates ?-Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12. (Pubmed Central) - Jul 18, 2023
ARL6IP5 enhances Rab1-dependent autophagosome initiation and elongation by stabilizing free ATG12. We report for the first time that ?-synuclein downregulates ARL6IP5 to inhibit autophagy-dependent clearance of toxic aggregates that exacerbate neurodegeneration.
- | Journal: Potent New Targets for Autophagy Enhancement to Delay Neuronal Ageing. (Pubmed Central) - Jul 18, 2023
Molecules that specifically inhibit Rab2 or Arl8 serve as potent drug candidates to modulate the activity of the autophagic process in treating neurodegenerative pathologies. In the future, it would be reasonable to investigate which GAP enzyme can inhibit Rab2 or Arl8 specifically, but not affect Rab7, with similar medical purposes.
- || ezurpimtrostat (GNS561) / Genoscience Pharma, Genfit, Avastin (bevacizumab) / Roche, Tecentriq (atezolizumab) / Roche
Review, Journal, Checkpoint inhibition: Update on Autophagy Inhibitors in Cancer: Opening up to a Therapeutic Combination with Immune Checkpoint Inhibitors. (Pubmed Central) - Jul 18, 2023
GNS561, a PPT1 inhibitor, is a promising autophagy modulator as it has started a phase 2 clinical trial in liver cancer indication, combined with atezolizumab and bevacizumab, an assessment without precedent in the field. This approach paves a new road, leading to the resurgence of anticancer autophagy inhibitors as an attractive therapeutic target in cancer.
- | Journal: Fluorescence-On Imaging of Reticulophagy Enabled by an Acidity-Reporting Solvatochromic Probe. (Pubmed Central) - Jul 18, 2023
This imaging method was successfully employed to discern reticulophagy induced by various pharmacological agents. These results show the potential of ER-targeted pH probes, as exemplified by ER-Green-proRed, to image reticulophagy and to identify reticulophagy inducers.
- | Journal: Hesperidin inhibits methylation and autophagy in LPS and high glucose-induced human villous trophoblasts. (Pubmed Central) - Jul 18, 2023
GDM with obesity followed the increase of autophagy proteins and m6A levels. Hesperidin inhibited the autophagy proteins and m6A level in LPS and glucose-induced human villous trophoblasts.
- | sirolimus / Generic mfg.
Journal, IO biomarker: DR1-CSE/HS pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose. (Pubmed Central) - Jul 18, 2023
In addition, AICAR (an agonist of AMPK) and Rapamycin (an inhibitor of mTOR) increased the production of autophagosomes but decreased the p-mTOR/t-mTOR ratio, which was similar to the effects of SKF38393 and 3MA. Our findings suggest that DR1 reduces the HG-induced cardiomyocyte damage via up-regulating the CSE/HS pathway, which increases cell autophagy by inhibiting the activation of mTOR.
- | chloroquine phosphate / Generic mfg.
Journal: Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction. (Pubmed Central) - Jul 17, 2023
Compound 189 has the potential to be developed into a therapeutic drug and its discovery documents the power of targeting PPIs for acquiring specific and selective compound inhibitors of autophagy.Abbreviations: ANOVA: analysis of variance; ATG: autophagy related; CQ: chloroquine; GFP: green fluorescent protein; GLuc: Gaussia Luciferase; HEK: human embryonic kidney; IL1B: interleukin 1 beta; LPS: lipopolysaccharide; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; PCA: protein-fragment complementation assay; PDAC: pancreatic ductal adenocarcinoma; PMA: phorbol 12-myristate 13-acetate; PPI: protein-protein interaction. VCL: vinculin.
- | Verzenio (abemaciclib) / Eli Lilly
Journal: CDK4/6 and autophagy inhibitors synergize to suppress the growth of human head and neck squamous cell carcinomas. (Pubmed Central) - Jul 17, 2023
Our results show that the specific CDK4/6 inhibitor, abemaciclib, inhibited cell growth, and induced apoptosis in HNSCC cell lines...Coinhibition of CDK4/6 and autophagy synergistically decreased cell viability, induced apoptosis, and inhibited tumor growth in both in vitro and in vivo preclinical HNSCC models. These results reveal a potential therapeutic strategy that supports the rationale for further clinical development of a combination of CDK4/6 and autophagy inhibitors in HNSCC.
- | Preclinical, Journal, Surgery: 3-Methyladenine ameliorates surgery-induced anxiety-like behaviors in aged mice by inhibiting autophagy-induced excessive oxidative stress. (Pubmed Central) - Jul 17, 2023
3-MA improved anxiety-like behaviors in aged mice undergoing abdominal exploratory laparotomy by inhibiting excessive autophagy-induced oxidative stress. These results suggest that 3-MA could be an effective treatment for postoperative anxiety.
- | chloroquine phosphate / Generic mfg., pegylated liposomal doxorubicin / Generic mfg.
Journal: Exercise improves the outcome of anticancer treatment with ultrasound-hyperthermia-enhanced nanochemotherapy and autophagy inhibitor. (Pubmed Central) - Jul 16, 2023
Results showed that HIIT+PLD+pUH+CQ significantly reduced the tumor volumes and brought about longer survival of tumor-bearing mice than PLD+pUH+CQ did. Blood cell components were analyzed and showed that neutrophil and reticulocytes decreased while lymphocytes increased after exercise.
- | Journal: Effect of Nano-selenium on Biological Mechanism of Goblet Cells of the Small Intestine Within Laying Hen. (Pubmed Central) - Jul 16, 2023
Besides that, immunostaining of IHC, IF and WB showed that autophagy enhanced the secretion of Mucin2 (Muc2) protein in nano-selenium-treated group. This work illustrates that the nano-selenium particle might enhance the mucosal immune-defense mechanism via the protective role of GCs for intestinal homeostasis through autophagy.
- | Journal: Polystyrene microplastics with different sizes induce the apoptosis and necroptosis in liver through the PTEN/PI3K/AKT/autophagy axis. (Pubmed Central) - Jul 15, 2023
More interestingly, inhibition of autophagy not only alleviated PS-MPs-triggered cell death, but also changed the form of death injury to a certain extent. This uncovered crosstalk relationship opens up a new avenue for investigating the biological and toxicological effects of MPs, and may provide important insights for preventing and limiting of health hazards from MPs.
- | Preclinical, Journal: TMT-based quantitative proteomics revealed protective efficacy of Icariside II against airway inflammation and remodeling via inhibiting LAMP2, CTSD and CTSS expression in OVA-induced chronic asthma mice. (Pubmed Central) - Jul 15, 2023
The study demonstrated IS could ameliorate AHR, airway inflammation, remodeling and EMT in OVA-induced chronic asthma mice. Our research was the first to reveal that inhibition of LAMP2, CTSD and CTSS expression in autophagy contributed to the therapeutic efficacy of IS to asthma.
- | Targretin oral (bexarotene oral) / ReXceptor
Preclinical, Journal: Bexarotene improves motor function after spinal cord injury in mice. (Pubmed Central) - Jul 15, 2023
Intravenous injection of transcription factor E3 shRNA or intraperitoneal injection of compound C, an AMP-activated protein kinase blocker, inhibited the effects of bexarotene. These findings suggest that bexarotene regulates nuclear translocation of transcription factor E3 through the AMP-activated protein kinase-S-phase kinase-associated protein 2-coactivator-associated arginine methyltransferase 1 and AMP-activated protein kinase-mammalian target of rapamycin signal pathways, promotes autophagy, decreases reactive oxygen species level, inhibits pyroptosis, and improves motor function after spinal cord injury.
- | Journal, IO biomarker: Yiqi Jiedu decoction attenuates radiation injury of spermatogenic cells via suppressing I?B?/NF-?B pathway-induced excessive autophagy and apoptosis. (Pubmed Central) - Jul 14, 2023
The research results indicate that ionizing radiation can activate the I?B?/NF-?B signaling pathway in spermatocytes, promote cell autophagy and apoptosis by regulating the expression of Beclin-1 and Bcl-2 factors. The YQJD decoction inhibits the I?B?/NF-?B signaling pathway so as to regulate Beclin-1 and Bcl-2.
- | chloroquine phosphate / Generic mfg.
Preclinical, Journal: Neurobehavioral, biochemical and histological assessment of the effects of resveratrol on cuprizone-induced demyelination in mice: role of autophagy modulation. (Pubmed Central) - Jul 14, 2023
These effects are mediated, at least in part, via activating autophagic pathways that may involve SIRT1/FoxO1 activation. This study verified that resveratrol dampens cuprizone-induced demyelination, and partially enhances myelin repair through modulation of the autophagic flux, since interruption of the autophagic machinery by chloroquine reversed the therapeutic potential of resveratrol.
- | Journal: IL-22 promotes occludin expression by activating autophagy and treats ulcerative colitis. (Pubmed Central) - Jul 13, 2023
Importantly, inhibiting autophagy in vitro by 3-Methyladenine (3-MA) attenuated the occludin protective effects of IL-22. In summary, our findings demonstrate that IL-22 ameliorates DSS-induced ulcerative colitis, which may be attributable to activating autophagy and then promoting occludin expression.
- | Journal: Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy. (Pubmed Central) - Jul 12, 2023
and BDNF) and induced the release of proinflammatory cytokines (IL-1?, IL-2 and TNF-?) by STS-treated microglia, thereby inducing mitochondrial dysfunction and apoptosis of STS-treated neurons. STS exerts protection against neuron injury, and the PP2A gene plays a crucial role in improving mitochondrial function and inhibiting neuronal apoptosis by regulating autophagy and inflammation in microglia.
- | Journal: Dietary Apigenin Relieves Body Weight and Glycolipid Metabolic Disturbance via Pro-Browning of White Adipose Mediated by Autophagy Inhibition. (Pubmed Central) - Jul 12, 2023
STS exerts protection against neuron injury, and the PP2A gene plays a crucial role in improving mitochondrial function and inhibiting neuronal apoptosis by regulating autophagy and inflammation in microglia. The findings highlight that autophagy inhibition promotes the browning of white adipocytes and suggest that AP would prevent and treat obesity and the associated metabolic disorders.
- | MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
Preclinical, Journal: Development of KEAP1-targeting PROTAC and its antioxidant properties: In vitro and in vivo. (Pubmed Central) - Jul 12, 2023
Summarizing, we described the synthesis of a KEAP1-targeting PROTAC (SD2267) and its efficacy and mode of action in vitro and in vivo. The results obtained suggest that SD2267 could be used to treat hepatic diseases related to oxidative stress.
- | Preclinical, Journal: Zinc Oxide Nanoparticles Trigger Autophagy in the Human Multiple Myeloma Cell Line RPMI8226: an In Vitro Study. (Pubmed Central) - Jul 11, 2023
We further validated the results using the autophagy inhibitor 3-methyladenine (3?MA). Overall, we observed that ZnO NPs can trigger autophagy signaling in RPMI8226 cells, which may be a potential therapeutic approach for MM.
- | 5-fluorouracil / Generic mfg.
Journal: KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer. (Pubmed Central) - Jul 11, 2023
Accumulating studies demonstrated that resistance of colon cancer (CC) to 5-fluorouracil (5-FU) contributes to adverse prognosis...Autophagy activator Rapamycin or sh-RAB26 treatment reversed the impact of KLF4 overexpression on 5-FU resistance...Rescue experiments revealed that KLF4 targeted RAB26 to inhibit CC cell autophagy, resulting in decreasing the resistance to 5-FU. KLF4 strengthened the sensitivity of CC cells to 5-FU by targeting RAB26 to restrain autophagy pathway.
- | Journal: Ethanol inhibits pancreatic acinar cell autophagy through upregulation of ATG4B, mediating pathologic responses of alcoholic pancreatitis. (Pubmed Central) - Jul 11, 2023
The results reveal a novel mechanism whereby ethanol inhibits autophagosome formation and thus sensitizes to pancreatitis, and a key role of ATG4B in ethanol's effects on autophagy. Enhancing pancreatic autophagy, particularly by down-regulating ATG4B, could be beneficial in mitigating the severity of alcoholic pancreatitis.
- | chloroquine phosphate / Generic mfg.
Journal: Berberine enhances autophagic flux by activating the Nrf2 signaling pathway in bovine endometrial epithelial cells to resist LPS-induced apoptosis. (Pubmed Central) - Jul 10, 2023
BEECs were first preconditioned with an inhibitor of autophagic flux (chloroquine [CQ]) for 1?h, treated with berberine for 2?h, and then incubated with LPS for 3?h...In conclusion, berberine enhances autophagic flux to allow resistance to LPS-induced apoptosis by activating the Nrf2 signaling pathway in BEECs. The present study may provide new insight into the antiapoptotic mechanism of berberine in LPS-induced BEECs.
- | FDA event, Preclinical, Journal: Cardiovascular Protective Effects of NP-6A4, a Drug with the FDA Designation for Pediatric Cardiomyopathy, in Female Rats with Obesity and Pre-Diabetes. (Pubmed Central) - Jul 10, 2023
Cardiac autophagy impairment underlies heart disease induced by obesity and pre-diabetes, and there are no drugs to re-activate autophagy. We propose that NP-6A4 can be an effective drug to reactivate cardiac autophagy and treat obesity- and pre-diabetes-induced heart disease, particularly for young and obese women.
- | Journal: Hepatic COX1 loss leads to impaired autophagic flux and exacerbates nonalcoholic steatohepatitis. (Pubmed Central) - Jul 10, 2023
In conclusion, we demonstrated a novel role of COX1 in hepatic autophagy that protected against NASH by interacting with WIPI2. Targeting the COX1-WIPI2 axis may be a novel therapeutic strategy for NASH.
- | Journal: Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 via biosensors. (Pubmed Central) - Jul 10, 2023
In summary, high-potency schisandrin A and two potential targets were identified, through which schisandrin A could reverse the apoptosis caused by excessive autophagy during oligoasthenospermia. Our study provides promising insights into the discovery of effective compounds and potential targets via a well-established in
- | Erbitux (cetuximab) / Eli Lilly, EMD Serono
Journal: Osthole inhibits malignant phenotypes and induces ferroptosis in KRAS-mutant colorectal cancer cells via suppressing AMPK/Akt signaling. (Pubmed Central) - Jul 10, 2023
Our results suggested that the natural product osthole exerted its anticancer effects in KRAS-mutant CRC cells via inducing ferroptosis, and this was partially through inhibiting AMPK/Akt/mTOR signaling. Our results may expand our current knowledge for the use of osthole as an anticancer agent.
- | sorafenib / Generic mfg.
Journal: Polyphyllin D "Punctures" Hypertrophic Lysosomes to Reverse Drug Resistance of Hepatocellular Carcinoma by Targeting Acid Sphingomyelinase. (Pubmed Central) - Jul 10, 2023
Furthermore, PD-enhanced lysosomal membrane permeabilization to release sorafenib, augmenting the anticancer effect of sorafenib both in vivo and in vitro. Overall, our study suggests that PD can potentially be further developed as a novel autophagy inhibitor, and a combination of PD with classical chemotherapeutic anticancer drugs could represent a novel therapeutic strategy for HCC intervention.
- | Selzentry (maraviroc) / ViiV Healthcare
Journal: Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration. (Pubmed Central) - Jul 10, 2023
CCR5 upregulation is self-sustaining, as CCL5-CCR5 autophagy inhibition impairs CCR5 degradation itself. Finally, pharmacological or genetic inhibition of CCR5 rescues mTORC1 hyperactivation and autophagy dysfunction, which ameliorates HD and tau pathologies in mouse models.
- AUF1 PROMOTES THE DEVELOPMENT OF HELICOBACTER PYLORI-ASSOCIATED GASTRITIS BY INHIBITING THE AUTOPHAGIC DEGRADATION OF CAGA (Auditorium 11) - Jul 8, 2023 - Abstract #UEGW2023UEGW_1286;
- | doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines. (Pubmed Central) - Jul 7, 2023
Doxorubicin (DOX) is the only drug approved for anaplastic thyroid cancer treatment, but its clinical use is restricted due to irreversible tissue toxicity...Furthermore, BER and DOX cooperated to promote apoptosis and autophagy in ATC cells. Taken together, the present findings indicated that BER induces apoptosis and autophagic cell death by activating ROS and regulating the PI3K/AKT/mTOR signaling pathway.
- | Journal: PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells. (Pubmed Central) - Jul 7, 2023
Based on these findings, we conclude that PIF1 inhibits the apoptosis of HPAECs by accelerating the autophagy pathway. Therefore, PIF1 plays a crucial role in HPAEC dysfunction in chronic hypoxia-induced PAH and may be a potential target for the treatment of PAH.
- | sirolimus / Generic mfg.
Journal: Peroxinredoxin 6 reduction accelerates cigarette smoke extract?induced senescence by regulating autophagy in BEAS?2B cells. (Pubmed Central) - Jul 7, 2023
Furthermore, autophagy inhibition by 3-Methyladenine increased P16 and P21 expression levels, while autophagy activation by rapamycin reduced P16 and P21 expression levels in CSE-treated BEAS-2B cells...In conclusion, the present study demonstrated a novel protective role for PRDX6 in COPD. Furthermore, a reduction in PRDX6 could accelerate senescence by inducing autophagy impairment in CSE-treated BEAS-2B cells.
- | Journal: SNRPD1 inhibition suppresses the proliferation of hepatocellular carcinoma and promotes autophagy through the PI3K/AKT/mTOR/4EBP1 pathway. (Pubmed Central) - Jul 7, 2023
Furthermore, a reduction in PRDX6 could accelerate senescence by inducing autophagy impairment in CSE-treated BEAS-2B cells. SNRPD1 may serve as an oncogene in HCC and promote tumor proliferation via inhibiting autophagy induced through the PI3K/Akt/mTOR/4EBP1 pathway.
- | Cosentyx (secukinumab) / Novartis
Journal, IO biomarker: Secukinumab plays a synergistic role with starvation therapy in promoting autophagic cell death of hepatocellular carcinoma via inhibiting IL-17A-increased BCL2 level. (Pubmed Central) - Jul 7, 2023
In conclusion, the antagonism of IL-17A with secukinumab, due to the upregulation on BCL2-related autophagic cell death, can cooperate with starvation therapy in inhibiting HCC carcinogenesis. Our data suggested that secukinumab can become an effective adjuvant for the treatment of HCC.
- | Journal: HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition. (Pubmed Central) - Jul 7, 2023
RBM15 could bind to c-myc mRNA, resulting in an increase to m6A level and protein expression of c-myc, which could be blocked by cycloeucine. HPV-E6 can downregulate autophagy, inhibit the degradation of RBM15 protein, induce the accumulation of intracellular RBM15, and increase the m6A modification on c-myc mRNA, resulting in an increase of c-myc protein and a growth promotion for cervical cancer cells.
- || Mektovi (binimetinib) / Ono Pharma, Pierre Fabre, Pfizer
P2 data, Journal, Metastases: A Phase II Open-Label Trial of Binimetinib and Hydroxychloroquine in Patients With Advanced KRAS-Mutant Non-Small Cell Lung Cancer. (Pubmed Central) - Jul 7, 2023
P2
The combination of B + HCQ in second- or later-line treatment of patients with advanced KRAS-mutant NSCLC did not show significant antitumor activity. (ClinicalTrials.gov Identifier: NCT04735068).
- A study on the cell death mode of ? cells under hypoxia and the protective effect of huc-MSC-CM (Indigo H) - Jul 7, 2023 - Abstract #IPITAIXACTRMS2023IPITA_IXA_CTRMS_67;
cells from hypoxia-induced apoptosis and pyroptosis by inducing autophagy, and enhance cell survival. This result shows that pyroptosis can also be used as a target for ?-cell protection, and huc-MSCs-CM can simultaneously target multiple cell death pathways to protect ?-cells and may improve the effect of islet transplantation.
- Deficiency of methylmalonyl-CoA mutase correlates with higher autophagy in HEK cells (Pincus (ICC)) - Jul 6, 2023 - Abstract #SSIEM2023SSIEM_262;
An involvement of autophagy is also underlined by elevated LC3 levels in MMUT KO cells, both under basal and starvation conditions, and that higher MMUT protein levels are detected upon treatment with the autophagy inhibitor Bafilomycin A1. Conclusion The reduced expression of MMUT variants indicates a decreased stability and potentially faster degradation, while inhibition of autophagy yields higher MMUT protein levels.
- gabapentin / Generic mfg.
Tau as the missing link between persistent pain and increased risk for dementia- preclinical evidence (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_8333;
Molecular understanding experiments also included the analgesic drug, gabapentin or virus-driven overexpression of Rab35, a regulator of Tau degradation... Our findings reveal that exposure to chronic pain triggers Tau-related neuronal pathology in hippocampus and may be relevant for understanding how chronic pain precipitates memory loss leading to dementia as recently suggested by clinical studies.
- Evaluating dynamic autophagic responses to tau inclusions (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_8315;
With this tool we can now dynamically assess autophagy in ex vivo BSCs and characterize changes in response to tau and other pathologies. Overall, understanding the mechanisms that enable tau turnover may guide therapies for Alzheimer
- sirolimus / Generic mfg.
GM1 modulates amyloid-beta activation of NLRP3 inflammasome in microglia through Akt/mTOR-mediated regulation of autophagy (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_4045;
GM1 ganglioside is protective against amyloid-mediated microglia inflammation by suppressing NLRP3 inflammasome priming and restoring autophagy via Akt/mTOR signalling pathways. GM1 upregulation of autophagy demonstrates a promising therapeutic target to resolve neuroinflammation and halt the accelerated progression of AD.
- | Preclinical, Journal: In vivo measurement of autophagic flux by fluorescence correlation spectroscopy. (Pubmed Central) - Jul 6, 2023
This new method was able to evaluate autophagy inducers, early-stage autophagy inhibitors, and late-stage autophagy inhibitors. Compared with current methods, our method shows high spatiotemporal resolution and very high sensitivity for autophagosomes in low EGFP-LC3B expressing cells and will become an attractive and alternative method for biological and medical studies, some drug screening, and disease treatment.