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- | sirolimus / Generic mfg.
Journal: ?-Hydroxybutyrate impairs the directionality of migrating neutrophil through inhibiting the autophagy-dependent degradation of Cdc42 and Rac1 in ketotic cows. (Pubmed Central) - Aug 29, 2023
Additionally, rapamycin (RAPA), a specific autophagy activator, was used with or without BHB treatment in vitro...Overall, the present study revealed that pathological concentration of BHB impairs neutrophil migration directionality through inhibiting the autophagy-mediated degradation of Cdc42 and Rac1. These findings help explain the immunosuppression caused by ketosis.
- | Preclinical, Journal: MATN3 delivered by exosome from synovial mesenchymal stem cells relieves knee osteoarthritis: Evidence from in vitro and in vivo studies. (Pubmed Central) - Aug 28, 2023
In addition, SMSCExo, as a novel drug carrier, has great potential for treating and diagnosing other diseases. With further research, these findings will provide new directions for developing personalized and innovative treatment options.
- || chloroquine phosphate / Generic mfg., hydroxychloroquine / Generic mfg.
Review, Journal: Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines. (Pubmed Central) - Aug 28, 2023
The nanocarrier-based drug delivery systems for autophagy inhibitors and their distinct advantages are also described. The progress of autophagy inhibitors for clinical applications is finally introduced, and their future perspectives are discussed.
- | sirolimus / Generic mfg.
Journal: Treponema pallidum promoted microglia apoptosis and prevented itself from clearing by human microglia via blocking autophagic flux. (Pubmed Central) - Aug 27, 2023
Transcription factor EB (TFEB) is a master regulator of lysosome biogenesis, Tp activates the mechanistic target of rapamycin complex 1 (mTORC1) signaling to inhibit the nuclear translocation of TFEB, leading to decreased lysosomal biogenesis and accumulated autophagosome...This study offers novel perspectives on the potential mechanism of immune evasion employed by Tp within CNS. The results not only establish the pivotal role of autophagy dysregulation in the detrimental effects of Tp on microglial cells but also bear considerable implications for the development of therapeutic strategies against Tp, specifically involving mTORC1 inhibitors and autophagosome formation inhibitors, in the context of neurosyphilis patients.
- | Journal: MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy. (Pubmed Central) - Aug 27, 2023
Mechanistically, we show that ubiquitinated ATG14 has fewer interactions with STX17, leading to the inhibition of autophagy flux. Collectively, our study reveals a mechanism in regulating autophagy and suggests a potential strategy for the treatment of autophagy-related diseases.
- | Journal: Autophagy Alters the Susceptibility of Candida albicans Biofilms to Antifungal Agents. (Pubmed Central) - Aug 26, 2023
The ALP activity and ROS level of C. albicans biofilms increased with the treatment of antifungal agents, and autophagosomes could be observed in C. albicans biofilms. Autophagy was involved in the susceptibility of C. albicans biofilms to antifungal agents.
- | Journal: The Chicken cGAS-STING Pathway Exerts Interferon-Independent Antiviral Function via Cell Apoptosis. (Pubmed Central) - Aug 26, 2023
In addition, chSTING lost its antiviral function in IRF7-knockout chicken macrophages, indicating that IRF7 is not only essential for the production of IFN, but also participates in the other activities of chSTING, such as the apoptosis. Collectively, our results showed that chSTING exerts an antiviral function independent of IFN, likely via apoptosis.
- | Journal, IO biomarker: Zingerone-Induced Autophagy Suppresses IL-1? Production by Increasing the Intracellular Killing of Aggregatibacter actinomycetemcomitans in THP-1 Macrophages. (Pubmed Central) - Aug 26, 2023
Finally, zingerone alleviated alveolar bone absorption in an A. actnomycetemcomitans-induced periodontitis mice model. Our data suggested that zingerone has potential use as a treatment for periodontal inflammation induced by A. actinomycetemcomitans.
- | salubrinal / Soochow University
Journal: Ischemic preconditioning attenuates endoplasmic reticulum stress-dependent apoptosis of hepatocytes by regulating autophagy in hepatic ischemia-reperfusion injury. (Pubmed Central) - Aug 25, 2023
The autophagy inhibitor 3-methyladenine significantly attenuated the protective effects of IPC on ERS-dependent apoptosis and liver function, whereas the autophagy activator rapamycin mimicked the protective effects of IPC on ERS-dependent apoptosis in vivo and in vitro, suggesting a regulatory role of autophagy in ERS-dependent apoptosis. These results demonstrated that IPC could induce moderate autophagy and upregulate a few molecular chaperones to strengthen endogenous defense mechanisms, which is beneficial for alleviating ERS-dependent apoptosis and protecting hepatocytes from HIRI.
- | Preclinical, Journal: Targeting ANXA7/LAMP5-mTOR axis attenuates spinal cord injury by inhibiting neuronal apoptosis via enhancing autophagy in mice. (Pubmed Central) - Aug 24, 2023
In summary, our findings clarify the new role of ANXA7 and LAMP5 in SCI, provided a new specific target of neuronal repair and discovered new molecular mechanisms of ANXA7 to regulate autophagy and apoptosis. Targeting ANXA7 may be a prospective therapeutic strategy for SCI in future.
- | LY294002 / Eli Lilly
Journal: Tenuigenin activates the IRS1/Akt/mTOR signaling by blocking PTPN1 to inhibit autophagy and improve locomotor recovery in spinal cord injury. (Pubmed Central) - Aug 24, 2023
Targeting ANXA7 may be a prospective therapeutic strategy for SCI in future. This study demonstrates that TEN suppresses autophagy to promote function recovery in SCI rats by blocking PTPN1 and rescuing the IRS1/Akt/mTOR signaling.
- | Journal, Tumor cell: Antitumor Effects of ?-Elemene Through Inducing Autophagy-Mediated Apoptosis in Ewing Sarcoma Family Tumor Cells. (Pubmed Central) - Aug 23, 2023
In addition, autophagy was found to be important in the toxic effects induced by the combination treatment of ?-elemene and IGF1R inhibition in ESFT cells. Our data suggested an essential role of autophagy in ?-elemene-induced apoptosis in ESFT cells, which is anticipated to provide novel insights to the development of ESFT treatments.
- | Journal: Bidirectional negative feedback actions of DNMT3A and miR-145 in regulating autophagy in cardiac fibroblasts and affecting myocardial fibrosis. (Pubmed Central) - Aug 23, 2023
In summary, myocardial fibroblast autophagy can be regulated by bidirectional negative feedback actions of DNMT3A and miR-145, thus affecting myocardial fibrosis. This finding will provide a potential target for the clinical treatment of myocardial fibrosis.
- | SP600125 / BMS
Journal: Banxia Xiexin Decoction Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via JNK/SIRT1/Foxo3a Signaling Pathway. (Pubmed Central) - Aug 23, 2023
It modulates the JNK/SIRT1/Foxo3a signaling pathway to mitigate autophagy inhibition and apoptotic damage in HT22 cells induced by HG. These findings provide valuable perspectives and concepts for future clinical trials and fundamental research.
- thapsigargin / University of Nottingham, Pirbright Institute
The Ferroptosis Induced by Palmitic Acid via CD36 Activating ER Stress to Break Calcium-Iron Balance in Colon Cancer Cells (Hall B2; In Person Only; Screen: 12) - Aug 22, 2023 - Abstract #ASTRO2023ASTRO_1031;
In general, we report for the first time that PA can selectively induce ferroptosis in colon cancer cells with high expression of CD36 by activating ER stress/ER calcium release/transferrin-dependent ferroptosis. This provides a new strategy and basis for the precise treatment of tumors.
- EZM2302 / GSK, Ipsen
Carm1 Inhibition Potentiates Irradiation-Induced Antitumor Immunity via Tumor Intrinsic STING Pathway Activation (Hall B2; In Person Only; Screen: 2) - Aug 22, 2023 - Abstract #ASTRO2023ASTRO_990;
This provides a new strategy and basis for the precise treatment of tumors. Finally, Carm1 inhibitor EZM2302 was applied in combination with radiotherapy in vitro , and it
- | Journal, Stroma: Exosomes from TNF-? preconditioned human umbilical cord mesenchymal stromal cells inhibit the autophagy of acinar cells of severe acute pancreatitis via shuttling bioactive metabolites. (Pubmed Central) - Aug 22, 2023
In summary, our study demonstrated that exosomes from TNF-?-preconditioned HUMSCs inhibit the autophagy of acinar cells of SAP by shuttling 3,4-dihydroxyphenylglycol and inhibiting the mTOR pathway. This study revealed the vital role and therapeutic potential of metabolite-derived exosomes in SAP, providing a new promising method to prevent and therapy SAP.
- | Journal: Protein components of maple syrup as a potential resource for the development of novel anti?colorectal cancer drugs. (Pubmed Central) - Aug 22, 2023
These results suggested that AGEs in MSpf suppressed cell proliferation and epithelial?mesenchymal transition through inhibition of the STAT3 signaling pathway through decreased RAGE expression. Therefore, AGEs in MSpf may be potential compounds for the development of antitumor drugs for the treatment of CRC with fewer adverse effects compared with existing antitumor drugs.
- | chloroquine phosphate / Generic mfg., tamoxifen / Generic mfg.
Journal, IO biomarker: HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury. (Pubmed Central) - Aug 22, 2023
Treatment with the autophagy inhibitor chloroquine during the acute stage or delayed induction of HSPB2 remarkably impeded HSPB2's long-term reparative function, indicating the importance of acute-stage autophagy in long-term neuro-regeneration. Our findings highlight the beneficial role of HSPB2 in neuro-regeneration and functional recovery following acute CNS injury, thereby emphasizing the therapeutic potential of autophagy regulation for enhancing neuro-regeneration.
- | chloroquine phosphate / Generic mfg.
Journal, IO biomarker: Anticancer effect of Dihydroartemisinin via dual control of ROS-induced apoptosis and protective autophagy in prostate cancer 22Rv1 cells. (Pubmed Central) - Aug 22, 2023
The underlying mechanism may involve the regulation of ROS/AMPK/mTOR signaling pathways and the interaction between Beclin-1 and Bcl-2 proteins. Additionally, the combination of DHA and CQ may enhance the efficacy of DHA in inhibiting tumor cell activity.
- | Journal, Checkpoint inhibition, PD(L)-1 Biomarker, IO biomarker, Checkpoint block: Tumor acidity-activatable macromolecule autophagy inhibitor and immune checkpoint blockade for robust treatment of prostate cancer. (Pubmed Central) - Aug 22, 2023
levels, and elicited the robust anti-tumor immune memory effect. This study demonstrated that the pH-sensitive PDPA macromolecule could serve as a carrier for the aPD-L1 delivery and as an efficient autophagy inhibitor to boost the immunotherapy of prostate cancer.
- | sirolimus / Generic mfg.
Preclinical, Journal: Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes. (Pubmed Central) - Aug 21, 2023
This study demonstrated that the pH-sensitive PDPA macromolecule could serve as a carrier for the aPD-L1 delivery and as an efficient autophagy inhibitor to boost the immunotherapy of prostate cancer. RPMTG showed potent therapeutic effects on AIA rats and induced apoptosis, inhibited autophagy mainly through activating the p38 MAPK and PI3K/Akt/mTOR pathways in RA-FLS.
- | Mekinist (trametinib) / Novartis, BeiGene
Trial termination: Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC). (clinicaltrials.gov) - Aug 21, 2023
P2, N=2, Terminated, Sponsor: National Cancer Institute (NCI)
RPMTG showed potent therapeutic effects on AIA rats and induced apoptosis, inhibited autophagy mainly through activating the p38 MAPK and PI3K/Akt/mTOR pathways in RA-FLS. Completed --> Terminated; Slow accrual
- | chloroquine phosphate / Generic mfg.
Journal: A biodegradable hollow nanoagent enables a boosted chemodynamic therapy by simultaneous autophagy inhibition and macrophage reeducation. (Pubmed Central) - Aug 21, 2023
The chloroquine (CQ) was used to inhibit autophagy in cancer cells and reset TAMs from the M2 phenotype to the M1 phenotype, eliminating the resistance of cancer cells and realizing an augmented therapeutic effect. This work provides a promising way for augmenting therapeutic efficiency by simultaneously interfering with two critical therapeutic resistance mechanisms.
- | hydroxychloroquine / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal, IO biomarker: A "bulldozer" driven by anoxic bacteria for pancreatic cancer chemo-immunotherapy. (Pubmed Central) - Aug 21, 2023
Meanwhile, HCQ can amplify DOX induced ICD effect by inhibiting tumor autophagy, which further increase cell surface expression of major histocompatibility complex class I (MHC-I) and augment recruitment of CD8 T cell to improve immunosuppressive TME. This study provides a new strategy for PDAC chemo-immunotherapy.
- | chloroquine phosphate / Generic mfg.
Journal: Helicobacter pylori infection induces autophagy via ILK regulation of NOXs-ROS-Nrf2/HO-1-ROS loop. (Pubmed Central) - Aug 20, 2023
Stable low expression of ILK with further knockdown of Beclin1 or ATG5 significantly reduced LC3B-II levels in GES-1 cells, while with the addition of the autophagy inhibitor chloroquine (CQ), LC3B-II and p62 protein levels were both remarkably upregulated...pylori accelerated the accumulation of ROS and further led to the induction of ROS-mediated autophagy by inhibiting ILK levels. Together, these results indicate that H. pylori infection manipulates the NOX-ROS-Nrf2/HO-1-ROS loop to control intracellular oxygen stress and further induced ROS-mediated autophagy by inhibiting ILK levels.
- | docetaxel / Generic mfg.
Journal: Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer. (Pubmed Central) - Aug 20, 2023
Our findings demonstrated that the cuproptosis-regulated DLAT/mTOR pathway inhibited autophagy and promoted cells in G2/M phase retention, thus enhancing the chemosensitivity to docetaxel. This discovery may provide an effective therapeutic option for treating advanced prostate cancer by inhibiting the chemotherapeutic resistance to docetaxel.
- | Journal, PARP Biomarker, IO biomarker: Macrophage targeted polymeric curcumin nanoparticles limit intracellular survival of Mycobacterium tuberculosis through induction of autophagy and augment anti-TB activity of isoniazid in RAW 264.7 macrophages. (Pubmed Central) - Aug 20, 2023
Adjunct action of ISCurNP and CMN in combination with isoniazid (INH) revealed >99% decrease in intracellular survival of MTB in macrophage as compared to ISCurNP, CMN or INH alone. In conclusion, our findings suggest the role of ISCurNP as novel host directed formulation to combat both sensitive and MDR strains of MTB by induction of autophagy.
- | Tagrisso (osimertinib) / AstraZeneca
Journal: Cezanne promoted autophagy through PIK3C3 stabilization and PIK3C2A transcription in lung adenocarcinoma. (Pubmed Central) - Aug 19, 2023
In the Cezanne-overexpressing cells, autophagy was activated even in the absence of autophagy inducers rapamycin and Earle's Balanced Salt Solution (EBSS)...Based on these results, Cezanne also accelerates EGFR recycling which may explain the mechanism mediating Cezanne expression and Osimertinib resistance. In conclusion, this study establishes a new model connecting Cezanne, autophagy, and Osimertinib resistance, opening new avenues to explore the effect of Cezanne and autophagy in LUAD.
- || Review, Journal: Targeting autophagy with small-molecule activators for potential therapeutic purposes. (Pubmed Central) - Aug 19, 2023
Thus, in this perspective, we focus on summarizing the complicated relationships between defective autophagy and human diseases, and further discuss the updated progress of a series of small-molecule activators targeting autophagy in human diseases. Taken together, these inspiring findings would provide a clue on discovering more small-molecule activators of autophagy as targeted candidate drugs for potential therapeutic purposes.
- | Journal: Swainsonine inhibits autophagic degradation and causes cytotoxicity by reducing CTSD O-GlcNAcylation. (Pubmed Central) - Aug 18, 2023
In summary, these findings suggest that SW inhibits the O-GlcNAcylation of CTSD, affecting its maturation and leading to the impairment of lysosome function. Consequently, it inhibits autophagy degradation, and causes cytotoxicity, providing a new theoretical basis for SW toxicological mechanism.
- | sirolimus / Generic mfg.
Journal: Inhibition of autophagy and RIP1/RIP3/MLKL-mediated necroptosis by edaravone attenuates blood spinal cord barrier disruption following spinal cord injury. (Pubmed Central) - Aug 17, 2023
Moreover, rapamycin (Rapa) treatment deteriorated the protective effect of edaravone while aggravating the phosphorylation of RIP1/RIP3/MLKL expression...The possible underlying mechanism is that edaravone is capable of protecting angiogenic activity and improving autophagy and the phosphorylation of RIP1/RIP3/MLKL, as well as their mutual deterioration. Accordingly, edaravone can be a favorable option for the treatment of SCI.
- || Review, Journal: Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia. (Pubmed Central) - Aug 16, 2023
These findings indicate the importance of natriuretic peptide signaling in pregnancy. This review discusses the role of ANP in uterine biology and potential implications of impaired ANP signaling in preeclampsia.
- | hydroxychloroquine / Generic mfg.
Journal: Autophagy Inhibition via Hydroxychloroquine or 3-Methyladenine Enhances Chemotherapy-Induced Apoptosis in Neuro-Blastoma and Glioblastoma. (Pubmed Central) - Aug 16, 2023
Supplementing cisplatin or temozolomide with autophagy activator rapamycin stabilized cancer cell mitochondria, despite having little effect on apoptosis or oxidative stress. Importantly, combining hydroxychloroquine with 0.5
- | trichostatin A (VTR-297) / Vanda
Journal, Epigenetic controller: Dysregulation of Histone Deacetylases Inhibits Trophoblast Growth during Early Placental Development Partially through TFEB-Dependent Autophagy-Lysosomal Pathway. (Pubmed Central) - Aug 16, 2023
Specifically, overactivated autophagy is involved in the TSA-driven growth inhibition of trophoblast, which can be partially reversed by the autophagy inhibitor chloroquine (CQ) or RNA interference of TFEB. In summary, our results reveal that abnormal acetylation and autophagy levels during early gestation may be associated with RSA and suggest the potential novel molecular target TFEB for RSA treatment.
- | Journal: Inhibiting autophagy by miR-19a-3p/PTEN regulation protected retinal pigment epithelial cells from hyperglycemic damage. (Pubmed Central) - Aug 16, 2023
Our findings suggest that upregulation of miR-19a-3p inhibits aberrant autophagy by directly targeting PTEN, thus protecting RPE cells against DR damage. miR-19a-3p may represent a novel therapeutic target for inducing protective autophagy in early DR.
- | methotrexate / Generic mfg.
Preclinical, Journal: Aucubin alleviates methotrexate-induced enteritis in rats by inducing autophagy. (Pubmed Central) - Aug 15, 2023
These findings prompted the hypothesis that aucubin alleviates MTX-induced enteritis by aggravating autophagy. This study might provide evidence for further investigation on the therapeutic role of aucubin in MTX-resulted enteritis.
- | Preclinical, Journal: FGF-18 Protects the Injured Spinal cord in mice by Suppressing Pyroptosis and Promoting Autophagy via the AKT-mTOR-TRPML1 axis. (Pubmed Central) - Aug 15, 2023
A mechanistic study revealed that after stimulation of the protein kinase B (AKT)-transient receptor potential mucolipin 1 (TRPML1)-calcineurin signalling pathway, the FGF-18-induced increase in autophagy was mediated by the dephosphorylation and nuclear translocation of transcription factor E3 (TFE3). Together, these findings indicated that FGF-18 is a robust autophagy modulator capable of accelerating functional recovery after SCI, suggesting that it may be a promising treatment for SCI in the clinic.
- | Journal: Pepino mosaic virus antagonizes plant mA modification by promoting the autophagic degradation of the mA writer HAKAI. (Pubmed Central) - Aug 15, 2023
This study uncovers that the PepMV RdRP exploits the autophagy pathway by interacting with SlBeclin1 to promote the autophagic degradation of the SlHAKAI protein, thereby inhibiting the mA modification-mediated plant defense responses. The online version contains supplementary material available at 10.1007/s42994-023-00097-6.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Dioscin ameliorates doxorubicin-induced heart failure via inhibiting autophagy and apoptosis by controlling the PDK1-mediated Akt/mTOR signaling pathway. (Pubmed Central) - Aug 14, 2023
The mTOR inhibitor (rapamycin) could counteract the therapeutic impact of Dioscin in vitro. Taken together, Dioscin could relieve cardiac function through blocking apoptosis and autophagy by activating the PDK1-elicited Akt/mTOR pathway.
- Xpovio (selinexor) / Karyopharm, Menarini, FORUS Therap
XPO1 inhibitor Selinexor induces heme oxygenase-1 mediated p53-dependent ferroptosis in chronic lymphocytic leukemia () - Aug 14, 2023 - Abstract #IWCLL2023IWCLL_145;
Silencing HMOX1 decreased lipid ROS levels in CLL cells after Selinexor treatment (Figure 2(E)). Our data thus indicated that targeting XPO1 by Selinexor increased HMOX1 expression in a p53-dependent pathway and upregulated the lipid ROS to trigger ferroptosis in CLL (Figure 2(F)).
- | chloroquine phosphate / Generic mfg., temozolomide / Generic mfg.
Journal: Temozolomide and chloroquine co-loaded mesoporous silica nanoparticles are effective against glioma. (Pubmed Central) - Aug 14, 2023
In addition, TMZ/CQ@MSN-RGD therapy enhanced the apoptosis effect of the RGD-MSNs in glioma. Therefore, the combination of autophagy inhibitor with chemotherapy drugs in nanocarriers may promote therapeutic efficacy in treating glioma.
- | sirolimus / Generic mfg.
Journal: Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway. (Pubmed Central) - Aug 14, 2023
Furthermore, TQ decreased the phosphorylation levels of phosphatidylinositol-4,5-bisphosphate 3 kinase (PI3K), protein kinase B (Akt), and mechanistic target of rapamycin (mTOR)...TQ inhibits the proliferation of GC cells and induces apoptosis and protective autophagy by inhibiting the PI3K/Akt/mTOR pathway. The results suggest that the combination of TQ and autophagy inhibitors might be a potential chemotherapeutic strategy for GC.
- | Journal: Hsa_circRNA_103124 upregulation in Crohn's disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-?B pathways. (Pubmed Central) - Aug 12, 2023
In summary, the results of this study indicated that hsa_circRNA_103124 promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the TLR4/NF-?B pathway in a hsa-miR-650/AKT2 dependent manner. Hsa_circRNA_103124 could serve as a potential biomarker and a novel therapeutic target in CD progression.
- | Journal: Hyperoside Attenuates Sepsis-Induced Acute Lung Injury (ALI) through Autophagy Regulation and Inflammation Suppression. (Pubmed Central) - Aug 11, 2023
Inhibiting autophagy or silencing Atg13 reversed the protective effect of HYP against sepsis-induced ALI. Taken together, we conclude that HYP attenuated sepsis-induced ALI by regulating autophagy and inhibiting inflammation.
- | Journal: Transformed cells maintain survival by downregulating autophagy at a high cell confluency. (Pubmed Central) - Aug 11, 2023
These results imply that once a cell has switched from a proliferative state to a senescent state, the inhibition of autophagy has only a minimal effect. Taken together, our results suggest that autophagy can be differentially regulated in cells at different stages of tumorigenesis under stressful conditions.
- | Preclinical, Journal: Matrix stiffness regulates neovascular homeostasis through autophagy in nude mice. (Pubmed Central) - Aug 11, 2023
Furthermore, we found that cell autophagy levels decreased in stiffer matrices, and autophagy inhibition attenuated neovascular homeostasis. A soft matrix is conducive to maintaining neovascular homeostasis through autophagy in nude mice.
- | 5-fluorouracil / Generic mfg.
Journal: CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c in HCT116 colorectal cancer cells: comprehensive characterization after exposure to 5-FU reveals EMT and autophagy as key processes regulated by miR-34. (Pubmed Central) - Aug 9, 2023
Inhibition of autophagy by depletion of ATG9A or chloroquine re-sensitized miR-34a/b/c-deficient HCT116 cells to 5-FU. In summary, our findings show a complementary role of miR-34a and miR-34b/c in the regulation of EMT and autophagy which may be relevant for CRC therapy in the future.
- | chloroquine phosphate / Generic mfg.
Journal: Autophagy modulates the stability of Wee1 and cell cycle G2/M transition. (Pubmed Central) - Aug 7, 2023
In addition, the half-life of Wee1 is extended by the addition of chloroquine, an autophagy inhibitor...Furthermore, overexpression of Wee1 leads to G2/M arrest both in vitro and in vivo. Collectively, our data indicate that autophagy could degrade Wee1-a gatekeeper of the G2/M transition, whereas the inhibition of autophagy leads to the accumulation of Wee1 and causes G2/M arrest in mouse liver.
- | Journal: Protective effects of Radix Stellariae extract against Alzheimer's disease via autophagy activation in Caenorhabditis elegans and cellular models. (Pubmed Central) - Aug 7, 2023
Collectively, our study presents novel discoveries that RSE alleviates AD pathology and toxicity primarily by inducing autophagy, both in vivo and in vitro. These findings open up new avenues for exploring the therapeutic potential of RSE and its active component, Dichotomine B, in treating neurodegenerative diseases like AD.