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- | atorvastatin / Generic mfg.
Preclinical, Journal: Dysregulation of autophagy activation induced by atorvastatin contributes to new-onset diabetes mellitus in western diet-fed mice. (Pubmed Central) - Mar 4, 2024
These results indicate that high doses of ATO induced hyperactivated autophagy in pancreatic cells, leading to impaired insulin storage, decreased cell viability, and reduced functional cell mass, ultimately resulting in NOD development.
- | montelukast / Generic mfg.
Journal, IO biomarker: Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-?B, NLRP3 inflammasome, and autophagy pathways. (Pubmed Central) - Mar 4, 2024
Montelukast show an inhibitory effect on HMGB1, TLR4, NF-?B, NLRP3, and IL-1? and has autophagy stimulating characteristics indicating its potential renoprotective effect.
- | sirolimus / Generic mfg.
Journal: The mechanism of nickel-induced autophagy and its role in nephrotoxicity. (Pubmed Central) - Mar 3, 2024
Autophagy inhibition with 3-MA could inhibit cell viability and increase apoptosis in the TCMK-1 cells, however, autophagy promotion with rapamycin relieved cytotoxicity and decreased apoptosis...Mitophagy inhibition could inhibit cell viability and increase apoptosis in the TCMK-1 cells, whereas, promotion of mitophagy could increase cell viability and decrease apoptosis. In summary, above-mentioned results showed that NiCl2 induces autophagy in TCMK-1 cells through oxidative stress-dependent AMPK/AKT-mTOR pathway, autophagy plays a role in reducing NiCl2-induced renal toxicity, and a major mechanism in autophagy's inhibitory effect on NiCl2-induced apoptosis may be mitophagy.
- | Journal: BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response. (Pubmed Central) - Mar 2, 2024
In addition, the mRNA level of BOP1 was negatively correlated with antral follicle count (AFC), body-mass index (BMI), serum androgen levels, and anti-Mullerian hormone (AMH) in patients with PCOS. In summary, our study demonstrates that BOP1 downregulation inhibits mTOR phosphorylation through activation of the p53-dependent nucleolus stress response, which subsequently contributes to aberrant autophagy in granulosa cells, revealing that BOP1 may be a key target for probing the mechanisms of PCOS.
- | Journal: Fisetin orchestrates neuroinflammation resolution and facilitates spinal cord injury recovery through enhanced autophagy in pro-inflammatory glial cells. (Pubmed Central) - Mar 2, 2024
Fisetin orchestrates enhanced autophagy in pro-inflammatory microglial cells through the AMPK-mTOR signaling pathway, thereby mitigating neuroinflammation and reducing the apoptotic effects of neuroinflammation on neurons. This mechanistic insight significantly contributes to the protection and recovery of neurological function following spinal cord injury, underscoring the vital nature of Fisetin as a potential therapeutic agent.
- | sirolimus / Generic mfg.
Journal: Interplay between autophagy and CncC regulates dendrite pruning in Drosophila. (Pubmed Central) - Mar 1, 2024
Furthermore, the metabolic regulator AMP-activated protein kinase and the insulin-target of rapamycin pathway act upstream to regulate autophagy during dendrite pruning...Conversely, CncC also indirectly affects autophagic activity via proteasomal degradation, as impaired CncC results in the inhibition of autophagy through sequestration of Atg8a into ubiquitinated protein aggregates. Thus, this study demonstrates the important role of autophagy in activating CncC prior to dendrite pruning, and further reveals an interplay between autophagy and CncC in neuronal pruning.
- Plasma exosomal miR-3926 regulates CD4+ T cell apoptosis and activation in SLE through inhibiting autophagy by targeting ATG12-5/16L1 (Room 31B) - Mar 1, 2024 - Abstract #AAD2024AAD_3522;
- | Journal, IO biomarker: Deregulation of circRNA hsa_circ_0009109 promotes tumor growth and initiates autophagy by sponging miR-544a-3p in gastric cancer. (Pubmed Central) - Mar 1, 2024
The autophagy status was altered under the regulation of the hsa_circ_0009109-targeted miR-544a-3p/bcl-2 axis. The hsa_circ_0009109 mediated a novel autophagy regulatory network through targeting the miR-544a-3p/bcl-2 axis, which may shed new light on the exploration of therapeutic targets for the clinical treatment of GC.
- | Journal: Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer. (Pubmed Central) - Mar 1, 2024
The hsa_circ_0009109 mediated a novel autophagy regulatory network through targeting the miR-544a-3p/bcl-2 axis, which may shed new light on the exploration of therapeutic targets for the clinical treatment of GC. This study laid the foundation for further research on the combination of CDK9 inhibitors and autophagy inhibitors in the treatment of patients with CRC.
- | methotrexate / Generic mfg.
Journal: Ferritinophagy-mediated ferroptosis facilitates methotrexate-induced hepatotoxicity by high-mobility group box (Pubmed Central) - Mar 1, 2024
Our study shows the significant roles of autophagy-dependent ferroptosis and HMGB1 in MTX-induced hepatotoxicity. It emphasizes that the inhibition of ferritinophagy and HMGB1 may have potential as a therapeutic approach for preventing and treating MTX-induced liver injury.
- | sirolimus / Generic mfg.
Journal: Enriched environment ameliorates fear memory impairments induced by sleep deprivation via inhibiting PIEZO1/calpain/autophagy signaling pathway in the basal forebrain. (Pubmed Central) - Mar 1, 2024
It emphasizes that the inhibition of ferritinophagy and HMGB1 may have potential as a therapeutic approach for preventing and treating MTX-induced liver injury. EE combats sleep deprivation-induced fear memory impairments by inhibiting the BF PIEZO1/calpain/autophagy pathway.
- | cisplatin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Phytohemagglutinin from (Pubmed Central) - Feb 29, 2024
Besides, the combination of PHA and ADM increased the ADM concentration in the multidrug-resistant strain A549-R cells and achieved the drug sensitization effect. Our results suggest that PHA combined with chemotherapy can be applied in the treatment of lung cancer cells and lung cancer multidrug-resistant strains, and provide a novel strategy for clinical tumor chemotherapy and a new idea to solve the problem of drug resistance in clinical lung cancer.
- | Preclinical, Journal, IO biomarker: Secretory Clusterin Inhibits Dopamine Neuron Apoptosis in MPTP Mice by Preserving Autophagy Activity. (Pubmed Central) - Feb 29, 2024
Activation of PI3K/AKT/mTOR signaling with MPTP inhibited autophagy in the SN of MPTP mice; however, sCLU treatment activated autophagy in MPTP-induced PD mice by inhibiting PI3K/AKT/mTOR signaling. These data indicated that sCLU treatment had a neuroprotective effect in an MPTP-induced model of PD.
- | sirolimus / Generic mfg.
Journal: New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis. (Pubmed Central) - Feb 28, 2024
In contrast, compound 8 decreased the levels of both LC3B-I and LC3B-II, and a similar effect was observed following treatment with rapamycin, an autophagy inducer. Our findings provide experimental evidence for new potential autophagy modulators in the hallucinogenic poisonous mushroom G. orientispectabilis.
- | Preclinical, Journal: Effect of Blueberry Supplementation on a Diet-Induced Rat Model of Prediabetes-Focus on Hepatic Lipid Deposition, Endoplasmic Stress Response and Autophagy. (Pubmed Central) - Feb 28, 2024
BJ-treated animals presented a reduction in fecal SCFAs, increased markers of arrested iBAT thermogenesis and energy expenditure, together with an aggravation of HFD-induced lipotoxicity and hepatic steatosis, which were accompanied by the inhibition of autophagy and ER stress responses in the liver. In conclusion, despite the improvement of glucose tolerance, BJ supplementation promoted a major impact on lipid management mechanisms at liver and AT levels in prediabetic animals, which might affect disease course.
- | Journal, PARP Biomarker, IO biomarker: Carnosic Acid against Lung Cancer: Induction of Autophagy and Activation of Sestrin-2/LKB1/AMPK Signalling. (Pubmed Central) - Feb 28, 2024
Overall, these data indicate that CA can inhibit NSCLC cell viability and that the underlying mechanism of action of CA involves the induction of autophagy through a Sestrin-2/LKB1/AMPK signaling cascade. Future experiments will use siRNA and small molecule inhibitors to better elucidate the role of these signaling molecules in the mechanism of action of CA as well as tumor xenograft models to assess the anticancer properties of CA in vivo.
- | Preclinical, Journal: Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy. (Pubmed Central) - Feb 28, 2024
Future experiments will use siRNA and small molecule inhibitors to better elucidate the role of these signaling molecules in the mechanism of action of CA as well as tumor xenograft models to assess the anticancer properties of CA in vivo. Hydrogen exerts protective effect against SIC, which may be achieved through the promotion of autophagy and mitophagy.
- ||| temuterkib (LY3214996) / Eli Lilly
Trial completion, Combination therapy, Metastases: LY3214996 +/- HCQ in Pancreatic Cancer (clinicaltrials.gov) - Feb 28, 2024
P2, N=52, Completed, Sponsor: Kimberly Perez, MD
Hydrogen exerts protective effect against SIC, which may be achieved through the promotion of autophagy and mitophagy. Active, not recruiting --> Completed
- | Journal: Neuronal waste management: new roles for autophagy genes in the extrusion of protein aggregates and in longevity. (Pubmed Central) - Feb 27, 2024
We found that the ATG-16.2 WD40 domain, a conserved domain critical for at least some noncanonical autophagy functions of ATG16L1 in mammalian cells, is required for the increased exopher biogenesis, reduction in polyQ aggregate load, and lifespan extension induced by neuronal inhibition of early-acting autophagy genes. Our study suggests that noncanonical functions of ATG-16.2, and potentially other early-acting autophagy genes, may play a role in neuronal exopher formation and in C. elegans aging, extending beyond their canonical degradative functions in the autophagy process.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPK?2 activation. (Pubmed Central) - Feb 26, 2024
However, erastin (ferroptosis inducer), 3-methyladenine (autophagic inhibitor), adenovirus-mediated AMPK?2 downregulation, and AMPK?2 inhibition by compound C significantly diminished these effects, both in vivo and in vitro...Overall, this study highlighted the pivotal role of mitochondria in myocardial DIC-induced ferroptosis and shows how E-Exe preconditioning activated AMPK?2 against myocardial DIC injury. This suggests that E-Exe preconditioning could be a viable strategy for patients undergoing cardiac rehabilitation.
- | Journal: Bone marrow mesenchymal stem cells suppress activated CD4+ T cells proliferation through TGF-beta and IL10 dependent of autophagy in pathological hypoxic microenvironment. (Pubmed Central) - Feb 26, 2024
This suggests that E-Exe preconditioning could be a viable strategy for patients undergoing cardiac rehabilitation. Our findings reveal that BMSCs possess significant immunosuppression on CD4+T cell through IL-10 and TGF-?1 dependent of autophagy in hypoxic microenvironment.
- | bleomycin / Generic mfg.
Journal: Qingfei xieding prescription ameliorates mitochondrial DNA-initiated inflammation in bleomycin-induced pulmonary fibrosis through activating autophagy. (Pubmed Central) - Feb 26, 2024
QF alleviated bleomycin-induced pulmonary fibrosis by activating autophagy, inhibiting mtDNA-cGAS-STING pathway-mediated inflammation. This research recognizes the protection role of QF on bleomycin-induced mouse model, and offers evidence for the potentiality of QF in clinical application for pulmonary fibrosis treatment.
- | Focus V (anlotinib) / Advenchen, Sino Biopharm
Journal: Inhibition of anlotinib-induced autophagy attenuates invasion and migration by regulating epithelial-mesenchymal transition and cytoskeletal rearrangement through ATG5 in human osteosarcoma cells. (Pubmed Central) - Feb 25, 2024
Our results demonstrated that anlotinib can induce protective autophagy in osteosarcoma cells and that inhibition of anlotinib-induced autophagy enhanced the inhibitory effects of anlotinib on osteosarcoma metastasis. Thus, the therapeutic effect of anlotinib treatment can be improved by combination treatment with autophagy inhibitors, which provides a new direction for the treatment of metastatic osteosarcoma.
- | fenofibrate / Generic mfg.
Journal: Ppar? activation stimulates autophagic flux through lipid catabolism-independent route. (Pubmed Central) - Feb 24, 2024
These data show that Ppar? activation-induced autophagic flux should be independent of lipid catabolism.
- | Preclinical, Journal: GPNMB Modulates Autophagy to Enhance Functional Recovery After Spinal Cord Injury in Rats. (Pubmed Central) - Feb 24, 2024
Inhibiting autophagy reversed the effects of GPNMB. These findings suggest that GPNMB promotes neural injury repair after SCI, potentially through attenuating the inflammatory response, reducing oxidative stress, and inhibiting cell apoptosis.
- | Journal: YAP knockdown repressed autophagy in fibroblasts to accelerate wound healing through regulating En1/mTOR axis. (Pubmed Central) - Feb 24, 2024
These findings suggest that GPNMB promotes neural injury repair after SCI, potentially through attenuating the inflammatory response, reducing oxidative stress, and inhibiting cell apoptosis. YAP knockdown repressed autophagy in fibroblasts to accelerate wound closure by regulating the En1/mTOR axis.
- | Journal: The Activation of GABAAR Alleviated Cerebral Ischemic Injury via the Suppression of Oxidative Stress, Autophagy, and Apoptosis Pathways. (Pubmed Central) - Feb 24, 2024
These data suggest that GABAAR activation exerts neuroprotective effects during cerebral ischemia through improving oxidative stress and inhibiting autophagy and apoptosis. Our findings indicate that GABAAR serves as a target for treating cerebral ischemia and highlight the GABAAR-mediated autophagy signaling pathway.
- | chloroquine phosphate / Generic mfg.
Journal: Activation of adenosine A2B receptor alleviates myocardial ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress and restoring autophagy flux. (Pubmed Central) - Feb 24, 2024
The A2BAR agonist also alleviated the blockage of autophagic flux, coupled with augmented ERS in the IR/OGDR group, which was reassured by using an autophagy inhibitor chloroquine (CQ) and ERS inhibitor (4-PBA) in vitro...We observed that the positive efficacy of Bay 60-6583 was inhibited by H89. Collectively, our findings demonstrate that the A2BAR/cAMP/PKA signaling pathway exerts a protective role in MIRI by mitigating impaired autophagic flux and excessive ERS.
- | hydroxychloroquine / Generic mfg.
Journal: MYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1. (Pubmed Central) - Feb 23, 2024
The addition of hydroxychloroquine, an autophagy inhibitor, reduced autophagy and increased apoptosis in DLBCL cells...MiR-7-5p also suppressed autophagy and apoptosis by targeting AMBRA1 in DLBCL cells. Therefore, these data suggest that targeting miR-7-5p may be a promising strategy in DLBCL therapy.
- | GSK3036656 / GSK
Journal: Targeting PERK-ATF4-P21 axis enhances the sensitivity of osteosarcoma HOS cells to Mpp?-PDT. (Pubmed Central) - Feb 22, 2024
In conclusion, we found that the combination of MPP?-PDT and GSK2656157 enhanced apoptosis in HOS cells by inhibiting autophagy. Mechanistically, this autophagy is p21-dependent and can be suppressed by GSK2656157, thereby enhancing sensitivity to MPP?-PDT.
- | Journal: Perfluorooctanoic acid induces Leydig cell injury via inhibition of autophagosomes formation and activation of endoplasmic reticulum stress. (Pubmed Central) - Feb 22, 2024
Taken together, these results demonstrate that PFOA induces cell injury through inhibition of autophagosomes formation and induction of ER stress in Leydig cells. Thus, our study sheds light on the cellular mechanisms of PFOA-induced Leydig cell injury, which may be suggestive to human male reproductive health risk assessment and prevention from PFOA exposure-induced reproductive toxicity.
- | MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
Journal: Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction. (Pubmed Central) - Feb 21, 2024
Our study demonstrates that defects in p62 within endothelium cells induce multi-organ fibrosis and cardiac dysfunction in mice. Our findings indicate that FN1 and LAMC2, as markers of (EndoMT), have detrimental effects on HUVECs and elucidate the autophagy-lysosome degradation mechanism of FN1 and LAMC2.
- | bleomycin / Generic mfg.
Preclinical, Journal: Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats. (Pubmed Central) - Feb 20, 2024
Male SD rats were randomly divided into the following groups: control, model, CQ?+?QFTL (84?mg/kg chloroquine (CQ)?+?3.64?g/kg QFTL), QFTL-L, M, H (3.64, 7.28, and 14.56?g/kg, respectively) and pirfenidone (PFD 420?mg/kg)...Immunohistochemistry and Western blotting were performed to observe changes in proteins related to pulmonary fibrosis (?-smooth muscle actin (?-SMA) and matrix metalloproteinase 12 (MMP12)) and autophagy (P62 and mechanistic target of rapamycin (mTOR))...In conclusion, QFTL could effectively attenuate bleomycin-induced inflammation and pulmonary fibrosis through mTOR-dependent autophagy in rats. Therefore, QFTL has the potential to be an alternative treatment for IPF in clinical practice.
- | Preclinical, Journal: Autophagy inhibitors 3-MA and BAF may attenuate hippocampal neuronal necroptosis after global cerebral ischemia-reperfusion injury in male rats by inhibiting the interaction of the RIP3/AIF/CypA complex. (Pubmed Central) - Feb 20, 2024
These findings suggest that after global cerebral I/R injury, RIP3, AIF, and CypA translocated into the nuclei and formed the DNA degradation complex RIP3/AIF/CypA in hippocampal CA1 neurons. Pretreatment with autophagy inhibitors could reduce neuronal necroptosis by preventing the formation of the RIP3/AIF/CypA complex and its nuclear translocation.
- | Journal: Effects of autophagy-inhibiting chemicals on sialylation of Fc-fusion glycoprotein in recombinant CHO cells. (Pubmed Central) - Feb 20, 2024
- | Journal: Mitophagy regulates mitochondrial number following pharmacological induction of mitochondrial biogenesis in renal proximal tubule cells. (Pubmed Central) - Feb 20, 2024
Also, ROC-325 treatment sustained the elevated mitochondrial number after LY344864 pre-treatment and removal. These data revealed that inhibition of autophagy extends elevated mitochondrial number and function by preventing the lysosomal degradation of mitochondria after the removal of LY344864.
- | chloroquine phosphate / Generic mfg., cyclosporin A microemulsion / Generic mfg.
Journal: Ginsenoside Rb1 alleviates 3-MCPD-induced renal cell pyroptosis by activating mitophagy. (Pubmed Central) - Feb 20, 2024
Therefore, we conclude that 3-MCPD damages mitochondria and leads to ROS accumulation, which causes NLRP3 activation and pyroptosis in ICR mice and NRK-52E cells, while Gs-Rb1 mitigates this phenomenon via the TFEB-mitophagy pathway. Our findings may provide new insights for understanding the molecular mechanisms by which Gs-Rb1 mitigates renal injury.
- hydroxychloroquine / Generic mfg.
T2/IL-13-induced Autophagy Promotes RV-A16 Infection in Human Airway Epithelial Cells (San Diego Convention Center, Area C (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4222;
IL-13/T2 conditions decrease ICAM-1 expression reducing initial RV-A16 attachment, while promoting replication post-attachment. Enhancement of autophagy/mitophagy under T2- conditions may contribute to this increase in replication, while only modestly increasing cell death.
- MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
Ubiquitin Ligase HRD1 Facilitates Degradation of the Type I Collagen in Idiopathic Pulmonary Fibrosis (San Diego Convention Center, Room 30C-E (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3183;
HRD1 contributes to preserving lung structure and function in a mouse model of IPF. Further investigation is needed to understand Col I metabolic regulation.
- bleomycin / Generic mfg.
Tryptophan Metabolite Indole-3-acetic Acid Ameliorates Pulmonary Fibrosis by Regulating Lung Microbiota and Inducing Autophagy Via Inhibition of the PI3K/AKT/MTOR Pathway (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_2029;
In vivo, mice were used to build the PF animal model induced by bleomycin(BLM) treated with or without IAA in different doses... Tryptophan metabolite indole-3-acetic acid could improve pulmonary fibrosis by maintaining lung flora homeostasis and promoting autophagy via inhibition of the PI3K/Akt/mTOR pathway in lung fibroblasts.
- | Journal: Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells. (Pubmed Central) - Feb 19, 2024
Thus, AECs and CTCs respond differently to OS via differential autophagy response, partly mediated via p38 MAPK. Besides senescence, OS-induced autophagy dysregulation in amniochorion cells may play a mechanistic role in pPROM pathophysiology.
- | Journal: Grass carp peroxiredoxin 5 and 6-mediated autophagy inhibit grass carp reovirus replication and mitigate oxidative stress. (Pubmed Central) - Feb 19, 2024
Significantly, these functions of CiPrx5 and CiPrx6 in GCRV replication and ROS mitigation were abolished upon treatment with an autophagy inhibitor. In summation, our findings suggest that grass carp Prx5 and Prx6 promote autophagy to inhibit GCRV replication, decrease intracellular ROS, and provide protection against oxidative stress.
- | busulfan / Generic mfg.
Preclinical, Journal: Ferritinophagy-mediated ferroptosis of spermatogonia is involved in busulfan-induced oligospermia in the mice. (Pubmed Central) - Feb 19, 2024
The results displayed that inhibition of autophagy relieves busulfan-induced FTH1 degradation and then blocks the occurrence of ferroptosis in GC-1 spg cells and testicular spermatogonia, which subsequently alleviates busulfan-caused testicular damage and spermatogenesis disorders. In summary, these data collectively indicated that ferroptosis of spermatogonia is involved in busulfan-induced oligospermia and mediated by autophagy-dependent FTH1 degradation, identifying a new target for the therapy of busulfan-induced male infertility.
- | 5-fluorouracil / Generic mfg.
Journal: 5-FU promotes HBV replication through oxidative stress-induced autophagy dysfunction. (Pubmed Central) - Feb 19, 2024
In summary, these data collectively indicated that ferroptosis of spermatogonia is involved in busulfan-induced oligospermia and mediated by autophagy-dependent FTH1 degradation, identifying a new target for the therapy of busulfan-induced male infertility. Together, our results indicate that ROS-induced autophagosome formation and autophagic degradation play a critical role in 5-FU-induced HBV reactivation.
- | Journal: Combined administration of anisodamine and neostigmine alleviated colitis by inducing autophagy and inhibiting inflammation. (Pubmed Central) - Feb 18, 2024
Furthermore, 3-methyladenine (3-MA) and the ?7nAChR antagonist methyllycaconitine (MLA) weakened the ANI/NEO-induced protection on DSS-induced colitis in mice. Overall, these results indicate that the ANI/NEO combination exerts therapeutic effects through autophagy and ?7nAChR in a DSS-induced colitis mouse model.
- | Journal: UDP-glucose dehydrogenase supports autophagy-deficient PDAC growth via increasing hyaluronic acid biosynthesis. (Pubmed Central) - Feb 17, 2024
Using an orthotopic mouse model of PDAC, we find that inhibition of HA synthesis by targeting UGDH in PDAC reduces tumor weight. Thus, the combined inhibition of HA and autophagy might be an attractive strategy for PDAC treatment.
- gemcitabine / Generic mfg.
Isoliquiritigenin attenuated metastatic development of pancreatic cancer by regulation of the tumor microenvironment and reactivation from chemoresistance () - Feb 16, 2024 - Abstract #ITOC2024ITOC_69;
ISL had exhibited synergistic cell growth inhibition of PANC1 and Mia PaCa2 with gemcitabine. Conclusions Our results reveal that ISL attenuated metastatic development of pancreatic cancer by reprogramming of the tumor immunity and reactivation from gemcitabine chemoresistance.
- | sirolimus / Generic mfg.
Journal: A cardiomyocyte-based biosensing platform for dynamic and quantitative investigation of excessive autophagy. (Pubmed Central) - Feb 16, 2024
Different concentrations of rapamycin-mediated autophagy were administrated in the culture environment to simulate the autophagy model...Our study confirms the possibility of visualizing and characterizing the process of cardiomyocyte autophagy using cardiomyocyte-based biosensing platform, allowing to monitor the whole autophagy process in a non-invasive, real-time, and continuous way. We believe it will pave a promising avenue to precisely study the autophagy-related cardiovascular diseases.
- | Journal: Yapping at the autophagy door? The answer is flowing in the kidney proximal tubule. (Pubmed Central) - Feb 16, 2024
When simulating in vitro a pathological urinary flow in murine proximal tubule kidney epithelial cells, we observe the nuclear retention of YAP1 and, consequently, high expression of RUBCN and inhibition of autophagic flux. Importantly, these findings were confirmed in biopsies of patients suffering from diabetic nephropathy, a major cause of chronic kidney disease.
- | Journal: Metabolic rewiring and autophagy inhibition correct lysosomal storage disease in mucopolysaccharidosis IIIB. (Pubmed Central) - Feb 16, 2024
Indeed, metabolomic analyses revealed defects of mitochondrial activity accompanied by anaerobic metabolism and inhibition of AMP-activated protein kinase (AMPK), which acts on metabolism and autophagy, rescues lysosomal defects. These results provide insights into the molecular mechanisms of MPS IIIB physiopathology, supporting the development of new promising approaches based on autophagy inhibition and metabolic rewiring to correct lysosomal pathology in MPSs.