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- | Preclinical, Journal: Protective Effect of Vitamin K2 (MK-7) on Acute Lung Injury Induced by Lipopolysaccharide in Mice. (Pubmed Central) - Mar 27, 2024
Compared with the LPS group, VK2 improved histopathological changes; alleviated inflammation, apoptosis, and TJ injury; increased antioxidant enzyme activity; reduced Ca2+ overload; regulated mitochondrial function; and inhibited lung autophagy. These results indicate that VK2 could improve tight junction protein loss, inflammation, and cell apoptosis in LPS-induced ALI by inhibiting the mitochondrial dysfunction and excessive autophagy, indicating that VK2 plays a beneficial role in ALI and might be a potential therapeutic strategy.
- | Niagen (nicotinamide riboside) / ChromaDex
Journal: Nicotinamide ribose ameliorates myocardial ischemia/reperfusion injury by regulating autophagy and regulating oxidative stress. (Pubmed Central) - Mar 27, 2024
The sirt 1 inhibitor EX527 significantly attenuated the ability of NR to inhibit autophagy, but had no significant effect on the ROS content of the H9c2 cells. In summary, the present study suggests that NR protects against autophagy by increasing the NAD+ content in the body via the sirt 1 pathway, although the sirt 1 pathway does not affect oxidative stress.
- | ATG-101 / Antengene
Journal: Subversion of selective autophagy for the biogenesis of tombusvirus replication organelles inhibits autophagy. (Pubmed Central) - Mar 27, 2024
In addition, we observed that several core autophagy proteins, such as ATG1a, ATG4, ATG5, ATG101 and the plant-specific SH3P2 autophagy adaptor proteins were also re-localized to TBSV VROs, suggesting that TBSV hijacks the autophagy machinery in plant cells...We propose that the VRO-associated condensates trap those autophagy proteins, taking them away from the autophagy pathway. Overall, tombusviruses hijack selective autophagy to provide phospholipid-rich membranes for replication and to regulate the antiviral autophagic flux.
- | Journal: Phototoxicity of low doses of light and influence of the spectral composition on human RPE cells. (Pubmed Central) - Mar 26, 2024
We show that exposure to white light at a dose of 3.6 J/cm2 induces an alteration of the global cellular structure, DNA damage and an activation of cellular stress pathways. The exposure to blue light triggers DNA damage and the activation of autophagy, while exposure to red light modulates the inflammatory response and inhibits autophagy.
- || ifosfamide / Generic mfg.
Review, Journal: Methylene blue and its potential in the treatment of traumatic brain injury, brain ischemia, and Alzheimer's disease. (Pubmed Central) - Mar 26, 2024
MB is a well-described treatment for methemoglobinemia, malaria, and encephalopathy caused by ifosfamide. In recent years, this drug has attracted great interest as a potential treatment for a number of neurodegenerative disorders, including the effects of TBI, ischemia, and AD.
- | Journal: Autophagy inhibition-induced cytosolic DNA sensing combined with differentiation therapy induces irreversible myeloid differentiation in leukemia cells. (Pubmed Central) - Mar 26, 2024
Importantly, the combined therapy dramatically reduced the total leukemia cell counts and proportion of blast cells in the spleens of AML mice. Collectively, these findings indicate that the autophagy inhibition-cytosolic DNA-sensor signaling axis can potentiate AML differentiation therapy.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Aucubin alleviates doxorubicin-induced cardiotoxicity through crosstalk between NRF2 and HIPK2 mediating autophagy and apoptosis. (Pubmed Central) - Mar 26, 2024
Collectively, these findings indicate that the autophagy inhibition-cytosolic DNA-sensor signaling axis can potentiate AML differentiation therapy. These collective results innovatively documented that AU regulated the unique crosstalk between NRF2 and HIPK2 to coordinate oxidative stress, autophagy, and apoptosis against DIC without compromising the anti-tumor effect of DOX in vitro.
- | Journal: Gelatin but not type I collagen promotes bacteria phagocytosis in PMA-treated U937 human lymphoma cells. (Pubmed Central) - Mar 25, 2024
Inhibiting autophagy reduced the phagocytosis of bacteria, in cells with gelatin-coating, while stimulating autophagy enhanced phagocytosis. This study finds the bacteria-phagocytosis stimulatory effect of gelatin in PMA-treated U937 cells and reveals the positive regulatory role of autophagy, predicting the potential use of gelatin products in anti-bacterial therapy.
- | LY294002 / Eli Lilly
Journal: Sirt3 Mediates the Cardioprotective Effect of Therapeutic Hypothermia after Cardiac Arrest and Resuscitation by Restoring Autophagic Flux via the PI3K/Akt/mTOR Pathway. (Pubmed Central) - Mar 25, 2024
Sirt3 mediates the cardioprotective effect of TH by restoring autophagic flux via the PI3K/Akt/mTOR pathway. These findings suggest the potential of Sirt3 as a therapeutic target for CA.
- | Preclinical, Journal: Plumbagin Regulates Snail to Inhibit Hepatocellular Carcinoma Epithelial-Mesenchymal Transition in vivo and in vitro. (Pubmed Central) - Mar 25, 2024
In vitro experiments confirmed that PL up-regulated epithelial cell markers, down-regulated mesenchymal cell markers, and inhibited EMT levels in HCC cells. PL inhibits Snail expression, up-regulates E-cadherin expression, and down-regulates N-cadherin and vimentin expression, preventing EMT in HCC cells and reducing lung metastasis.
- | sirolimus / Generic mfg.
Journal: Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death. (Pubmed Central) - Mar 25, 2024
The mechanistic target of rapamycin (mTOR) coordinates metabolism and cell growth with environmental inputs...Genetic inhibition of autophagy, via mutation of the autophagy gene atg7, improved facial phenotypes in atg7;raptor double mutants, relative to raptor single mutants. We conclude that finely regulated levels of autophagy, via mTORC1, are crucial for craniofacial development.
- | Journal: NPS-2143 inhibit glioma progression by suppressing autophagy through mediating AKT-mTOR pathway. (Pubmed Central) - Mar 25, 2024
We conclude that finely regulated levels of autophagy, via mTORC1, are crucial for craniofacial development. The nude mice xenograft model showed NPS-2143 could suppress glioma growth in
- | Journal, IO biomarker: Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies. (Pubmed Central) - Mar 25, 2024
The nude mice xenograft model showed NPS-2143 could suppress glioma growth in These findings confirm that autophagy signaling in B-cell malignancies is essential for the effective cytotoxic function of CAR-T cells and thereby pave the way for the development of autophagy-targeting strategies to improve the clinical efficacy of CAR-T cell immunotherapy.
- | bleomycin / Generic mfg.
Journal: SPAUTIN-1 alleviates LPS-induced acute lung injury by inhibiting NF-?B pathway in neutrophils. (Pubmed Central) - Mar 25, 2024
These findings confirm that autophagy signaling in B-cell malignancies is essential for the effective cytotoxic function of CAR-T cells and thereby pave the way for the development of autophagy-targeting strategies to improve the clinical efficacy of CAR-T cell immunotherapy. SPAUTIN-1 alleviated LPS-induced inflammatory injury by inhibiting the NF-?B pathway in leukocytes and protected epithelial cells from oxidative damage, positioning it as a potential therapeutic candidate for ALI.
- | sirolimus / Generic mfg.
Journal: DMC triggers MDA-MB-231 cells apoptosis via inhibiting protective autophagy and PI3K/AKT/mTOR pathway by enhancing ROS level. (Pubmed Central) - Mar 23, 2024
Moreover, the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and its mechanistic target of rapamycin kinase (mTOR) were also decreased after 30??M DMC incubating for 24?h...The inhibition of autophagy flow and PI3K/AKT/mTOR pathway could be reversed after being treated with ROS scavenger NAC. Altogether, the results of the present study suggest that DMC effectively induces apoptosis and growth inhibition in MDA-MB-231 cells through blocking autophagy flow and regulating the PI3K/AKT/mTOR pathway by increasing ROS level.
- | BMS-345541 / BMS
Journal: Calebin A modulates inflammatory and autophagy signals for the prevention and treatment of osteoarthritis. (Pubmed Central) - Mar 23, 2024
To study the anti-degradative and anti-apoptotic effects of CA in an inflamed joint, an in vitro model of OA-EN was created and treated with antisense oligonucleotides targeting NF-?B (ASO-NF-?B), and I?B kinase (IKK) inhibitor (BMS-345541) or the autophagy inhibitor 3-methyladenine (3-MA) and/or CA to affect chondrocyte proliferation, degradation, apoptosis, and autophagy...However, the preventive properties of CA in OA-EN could be partially abrogated by the autophagy inhibitor 3-MA. The present results reveal for the first time that CA is able to ameliorate the progression of OA by modulating autophagy pathway, inhibiting inflammation and apoptosis in chondrocytes, suggesting that CA may be a novel therapeutic compound for OA.
- | Journal: Xijiao Dihuang decoction combined with Yinqiao powder promotes autophagy-dependent ROS decrease to inhibit ROS/NLRP3/pyroptosis regulation axis in influenza virus infection. (Pubmed Central) - Mar 23, 2024
XDY can promote an intact autophagy flux to eliminate damaged mitochondria, namely mitophagy, which reduces the intracellular ROS accumulation contributing to NLRP3 inflammasome activation, restricting pyroptosis and eventually alleviating the influenza virus-induced inflammatory lesions. The obtained results provide new insights into the mechanism of action of XDY in alleviating influenza virus pneumonia, especially the roles of XDY in anti-oxidation, anti-inflammation and anti-pyroptosis, with potential therapeutic targets for future application in integrative medicine.
- | Journal: Modulation of autophagy affected tumorigenesis induced by the envelope glycoprotein of JSRV. (Pubmed Central) - Mar 23, 2024
Last, mouse xenograft experiments indicated that inhibition of autophagy by 3-methyladenine suppressed both tumor growth and the epithelial-to-mesenchymal transition. In conclusion, JSRV, through JSRV Env, takes advantage of the autophagy process, leading to the development of OPA.
- Renal tubule-derived EVs carrying complement 3 aggravate CKD vascular calcification by downregulating autophagy in vascular smooth muscle cells (Focussed Oral Room 1) - Mar 23, 2024 - Abstract #ERAEDTA2024ERA_EDTA_2197;
This study confirms that tubular-derived EVs carrying C3 downregulate autophagy in VSMCs, mediating CKD- associated VC. These findings provide insights into understanding CKD-associated VC initiation and progression, revealing potential therapeutic targets.
- p120 catenin enhances autophagy in macrophages via modulation of mTOR signaling pathway (Room W176) - Mar 22, 2024 - Abstract #IMMUNOLOGY2024IMMUNOLOGY_122;
Collectively, our findings strongly suggest that p120 plays a pivotal role in fostering autophagy while concurrently hindering apoptosis in macrophages, achieved through modulation of the mTOR/ULK-1 signaling pathway in sepsis. This underscores the potential of targeting macrophage p120 as an innovative therapeutic avenue for treating inflammatory disorders.
- | Journal: Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells. (Pubmed Central) - Mar 22, 2024
Together, these data demonstrate that OPEs have adverse effects on HepG2 cells. Further, OPE-induced dysregulation of autophagy may contribute to the association between OPE exposure and adverse effects on liver lipid homeostasis.
- | Preclinical, Journal: Asprosin improved neuronal survival by suppressing apoptosis and enhancing the activity of the autophagy pathway in the MCAO model in rats. (Pubmed Central) - Mar 22, 2024
Asp has protective and therapeutic effects against CI/R damage. While applying Asp before ischemia activates the autophagy pathway more, applying it after ischemia protects the neuronal death/survival balance by activating the apoptosis pathway more.
- | dorsomorphin (Compound C) / EMD Serono
Preclinical, Journal: Reduced Cx43 Expression Induces Autophagy through Activation of the AMPK-mTOR-ULK1 Signaling Pathway in the Common Bile Duct Ligation Rat Heart. (Pubmed Central) - Mar 22, 2024
CBDL induces myocardial injury in rats and activates autophagy through the AMPK-mTOR-ULK pathway, resulting in decreased Cx43 protein levels. A moderate increase in early autophagy in CBDL can improve cardiac injury, while late inhibition of autophagy can reduce myocardial injury.
- | chloroquine phosphate / Generic mfg.
Journal: MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans. (Pubmed Central) - Mar 21, 2024
Silencing of the autophagy regulators ATG-13, BEC-1 or LGG-2, but not the TOR homolog LET-363, reversed lifespan extension caused by MALT-1 deficiency. These findings suggest that MALT-1 limits the lifespan of C. elegans by acting as an inhibitor of an early step of autophagy in the intestine.
- | sirolimus / Generic mfg.
Preclinical, Journal: AMPK/MTOR/TP53 Signaling Pathway Regulation by Calcitonin Gene-Related Peptide Reduces Oxygen-Induced Lung Damage in Neonatal Rats through Autophagy Promotion. (Pubmed Central) - Mar 19, 2024
Furthermore, hyperoxia increased the expression levels of AMP-activated protein kinase (AMPK) alpha 1 (also known as protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1)) but inhibited TP53 and mechanistic target of rapamycin (MTOR); these expression trends were regulated by CGRP treatment. In conclusion, we showed that CGRP can attenuate hyperoxia-induced lung injury in neonatal rats by enhancing autophagy and regulating the TP53/AMPK/MTOR crosstalk axis.
- | Preclinical, Journal: Ferritinophagy Is Critical for Deoxynivalenol-Induced Liver Injury in Mice. (Pubmed Central) - Mar 19, 2024
Both autophagy inhibition and NCOA4 expression suppression ameliorate DON-induced ferroptosis. Our study concludes that DON facilitates NCOA4-mediated ferritinophagy via the ATM-NCOA4 pathway, subsequently inducing ferroptosis in the liver.
- | chloroquine phosphate / Generic mfg.
Journal: Evaluation of Autophagy in Conjunctival Fibroblasts. (Pubmed Central) - Mar 19, 2024
In our current protocol, we present a robust methodology established in our laboratory for studying autophagy in primary conjunctival fibroblasts. We assess autophagy through techniques like immunocytochemistry, immunoblotting, and qPCR.
- | Preclinical, Journal: Regulation of genes involved in the metabolic adaptation of murine microglial cells in response to elevated HIF-1? mediated activation. (Pubmed Central) - Mar 19, 2024
Together, our findings suggest that the role of HIF-1? in regulating metabolic pathways during hypoxia in microglia is beyond optimization of glucose utilization and distinctly regulates lipid metabolism during pro-inflammatory activation.
- | metformin / Generic mfg.
Journal: Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia. (Pubmed Central) - Mar 18, 2024
Meanwhile, AMPK (AMP-activated protein kinase) inhibition reversed the anti-senescence effects of metformin. Overall, these results suggest that metformin alleviates periodontal damage in db/db mice and cellular senescence in ALCs under high glucose conditions via the AMPK/SIRT1/autophagy pathway.
- | Journal: Autophagy inhibition potentiates energy restriction-induced cell death in hepatocellular carcinoma cells. (Pubmed Central) - Mar 18, 2024
The treatment combination promoted HCC death through apoptosis, cell cycle arrest, and inhibition of AKT and ERK activation, which are known to play a key role in cellular proliferation. Collectively, our findings highlight a potential strategy to combat HCC by combining energy restriction with autophagy inhibition.
- | methotrexate / Generic mfg., aceclofenac / Generic mfg.
Journal, IO biomarker: Co-Delivery of Aceclofenac and Methotrexate Nanoparticles Presents an Effective Treatment for Rheumatoid Arthritis. (Pubmed Central) - Mar 18, 2024
The animals with experimental RA receiving drug treatment were shown to regain the structure of paw bones and joints similar to the control and were comparable with the market formulations. Our findings confirmed the use of co-delivery of drug nanoformulations as the "combination drug regimen" to treat RA.
- | Journal: ALKBH5 facilitates the progression of skin cutaneous melanoma via mediating ABCA1 demethylation and modulating autophagy in an m6A-dependent manner. (Pubmed Central) - Mar 18, 2024
Finally, our data demonstrated that ALKBH5 promoted SKCM via mediating ABCA1 downregulation by reducing ABCA1 mRNA stability in an m6A-dependent manner. Our findings exhibited the functional value of the key demethylase ALKBH5 mediated m6A modification in the progression of SKCM, suggesting the ALKBH5-m6A-ABCA1 axis as a potential therapeutic target in SKCM.
- | Journal: FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA. (Pubmed Central) - Mar 18, 2024
Besides, the mechanism by which FTO blocked SESN2-mediated autophagy activation was associated with the AMPK-mTOR signaling pathway. Taken together, these findings uncover an essential role of the FTO-autophagy-SESN2 axis in NSCLC progression.
- | temozolomide / Generic mfg.
Preclinical, Journal: Lucanthone, a Potential PPT1 inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation and Slows the Growth of Temozolomide-Resistant Gliomas in Vivo. (Pubmed Central) - Mar 18, 2024
It acts as an autophagy inhibitor and its mechanism of action may be via inhibition of palmitoyl protein thioesterase 1. As there are no defined therapies approved for recurrent, TMZ-resistant tumor, lucanthone could emerge as a treatment for glioblastoma tumors that may not be amenable to TMZ both in the newly diagnosed and recurrent settings.
- | MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
Journal: SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination. (Pubmed Central) - Mar 18, 2024
These results reveal that SPHK1 potentiates CRC progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination. SPHK1-TRAF6-ULK1 signaling axis is critical to the progression of CRC and provides a new strategy for the therapeutic control of CRC.
- | Journal: Beneficial Effects of Small-Molecule Oligopeptides Isolated from Panax Ginseng C. A. Meyer on Cellular Fates in Oxidative Stress-Induced Damaged Human Umbilical Vein Endothelial Cells and PC-12. (Pubmed Central) - Mar 17, 2024
Similarly, GOPs positively regulated cell stability in PC-12; notably, the protective effect of GOPs on PC-12 mainly occurred through the inhibition of autophagic cell death of neuronal cells, while the protective effect on mitochondria was weak. In conclusion, it is evident that GOPs demonstrate potential beneficial effects in maintaining cell fate stability, thereby potentially contributing to an enhanced health span and overall well-being.
- EXOSOMES OF GESTATIONAL DIABETES MELLITUS INDUCE OXIDATIVE STRESS AND REGULATE CELL AUTOPHAGY AND APOPTOSIS VIA TRANSFERRING MIR-152-5P () - Mar 17, 2024 - Abstract #ICEEDEC2024ICE_EDEC_1037;
Our findings revealed that peripheral blood-derived exosomes of GDM could affect cell lipid metabolism, increase oxidative stress and regulate cell autophagy and apoptosis. Exosomal miR-152-5p is expected to be a promising target for GDM treatment.
- | doxycycline / Generic mfg., gefitinib / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker: USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy. (Pubmed Central) - Mar 16, 2024
In addition, inhibition of autophagy by bafilomycin-A1 significantly abolished the effect of USP24-i-101 on maintaining genomic integrity, decreasing PD-L1 and inhibiting drug resistance acquired in chemotherapy or targeted therapy. In summary, an increase in the expression of USP24 in cancer cells is beneficial for the induction of drug resistance and targeting USP24 by USP24-i-101 optimized from USP24-i inhibits drug resistance acquired during cancer therapy by increasing PD-L1 protein degradation and genomic stability in an autophagy induction-dependent manner.
- Circulating Acyl-CoA-Binding Protein Abates T-Cell Function in People Living With HIV (Poster hall) - Mar 16, 2024 - Abstract #CROI2024CROI_1062;
Higher plasma ACBP levels in PLWH on ART were associated with inflammation, unfit metabolism, and markers of T-cell dysfunction. Our findings indicate that circulating ACBP directly abates autophagy and anti-HIV T-cell functions, compelling the development of circulating ACBP inhibitors aiming at improving anti-HIV T-cell responses in PLWH, towards an HIV cure.
- | Journal: Oxymatrine protects articular chondrocytes from IL-1?-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition. (Pubmed Central) - Mar 16, 2024
OMT decreases oxidative stress and inhibits the AKT/mTOR signaling pathway to enhance autophagy, thus inhibiting IL-1?-induced damage. Therefore, OMT may be a novel and effective therapeutic agent for the clinical treatment of OA.
- || Review, Journal: The multiple roles of autophagy in uveal melanoma and the microenvironment. (Pubmed Central) - Mar 16, 2024
Therefore, OMT may be a novel and effective therapeutic agent for the clinical treatment of OA. Understanding the molecular mechanisms of how autophagy differentially affects tumor progression may help to design better therapeutic regimens to prevent and treat UM.
- | Journal: Targeting CAMK2N1/CAMK2 inhibits invasion, migration and angiogenesis of non-small cell lung cancer by promoting autophagy and apoptosis via AKT/mTOR signaling pathway. (Pubmed Central) - Mar 16, 2024
The tumorigenic ability of CAMK2N1 overexpressing cells significantly diminished in nude mice. In conclusion, this study demonstrated the cancer suppressive function of CAMK2N1 in NSCLC and showed that CAMK2N1/CAMK2 exerted anti-cancer effects by inhibiting the AKT/mTOR signaling pathway to promote autophagy.
- | ABT-737 / AbbVie
Journal: The inhibition of Beclin1-dependent autophagy sensitizes PTC cells to ABT737-induced death. (Pubmed Central) - Mar 15, 2024
In conclusion, the limited role of ABT737 in PTC cell apoptosis is attributed to its promoting effect on Beclin1-dependent autophagy. Therefore, autophagy inhibition based on Beclin1 downregulation can enhance the sensitivity of PTC cells to ABT737-induced death.
- | chloroquine phosphate / Generic mfg.
Journal: The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol. (Pubmed Central) - Mar 15, 2024
It seems resveratrol-induced cytotoxicity is independent of reactive oxygen species (ROS) generation and accompanied by a significant elevation of caspase-3/7 activity, while pharmacologic ascorbate-induced cytotoxicity shows strong ROS dependence but proved to be caspase-independent. Our results are particularly important since ascorbate and resveratrol are natural compounds without significant harmful effects on normal cells, and chloroquine is a known antimalarial drug that can easily be repurposed.
- | metformin / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Journal: Metformin Inhibits Autophagy, Mitophagy and Antagonizes Doxorubicin-Induced Cardiomyocyte Death. (Pubmed Central) - Mar 15, 2024
In addition, metformin diminished DOX-induced autophagy/mitophagy as well as cardiomyocyte death. Together, these results suggest that the cardioprotective effects of metformin against DOX cardiotoxicity may be mediated by its ability to inhibit autophagy and mitophagy, although the underlying molecular mechanisms remain to be determined.
- thapsigargin / University of Nottingham, Pirbright Institute
AUTOPHAGY AMELIORATES ER STRESS-MEDIATED INTESTINAL TIGHT JUNCTION BARRIER DYSFUNCTION (140AB - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_400;
Our data indicate that persistent ER stress-induced IRE1? activation and downstream signaling pathway inhibits autophagy and escalates TJ barrier defects during chronic inflammatory conditions.
- | Journal, Metastases: HES1 induces ITPR1-mediated autophagy to exert anti-metastatic effects in pituitary adenomas. (Pubmed Central) - Mar 14, 2024
In summary, our research uncovered a complex regulatory interplay among HES1, ITPR1, and autophagy in the context of PA progression. These findings opened up promising avenues for novel therapeutic interventions targeting this intricate network to enhance PA treatment.
- || Review, Journal: The potential anti-tumor effect of anesthetics on cancer by regulating autophagy. (Pubmed Central) - Mar 14, 2024
Herein, we also explore the potential application of the anesthetic/autophagy system in clinical tumor treatment. These findings provide a theoretical basis for the use of anesthetics during the perioperative period to suppress tumor development and provide insights for autophagy-targeted cancer treatment and drug development.
- | Journal: miR-873-5p Suppression Reinvigorates Aging Mesenchymal Stem Cells and Improves Cardiac Repair after Myocardial Infarction. (Pubmed Central) - Mar 14, 2024
miR-873-5p which serves as a pivotal element in mediating MSC aging through its regulation of the Cab39/AMPK signaling pathway. It represents an innovative target for revitalizing AMSCs and enhancing their heart-protective abilities.
- | Journal: miR-193b-5p promotes GCRV replication by inhibiting autophagy via targeting deptor in grass carp (Ctenopharyngodon idellus). (Pubmed Central) - Mar 14, 2024
All the above results indicated that miR-193b-5p was linked to grass carp autophagy and played a vital role in antiviral immunity by targeting deptor. Our study may provide important insights into autophagy-related miRNAs and their roles in defense and immune mechanisms against pathogens in teleost.