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- || Review, Journal, IO Biomarker: Autophagy as a Potential Therapy for Malignant Glioma. (Pubmed Central) - Jul 28, 2020
Modulating the autophagic pathway as a death mechanism for cancer cells has prompted the use of both inhibitors and autophagy inducers. The autophagic process, either as a cancer suppressing or inducing mechanism in high-grade gliomas is discussed in this review, along with therapeutic approaches to inhibit or induce autophagy in pre-clinical and clinical studies, aiming to increase the efficiency of conventional treatments to remove glioma neoplastic cells.
- || sirolimus / Generic mfg., celecoxib oral / Generic mfg.
Preclinical, Review, Journal: Autophagy modulation in animal models of corneal diseases: a systematic review. (Pubmed Central) - Jul 28, 2020
Protective effects of autophagy activators were demonstrated, including rapamycin for DED and keratitis, lithium for FECD, LYN-1604 for DED, cysteamine and miR-34c antagomir for damaged corneal epithelium. Three autophagy suppressors were also found to have therapeutic effects, such as aminoimidazole-4-carboxamide-riboside (AICAR) for corneal allogeneic transplantation, celecoxib and chloroquine for DED.
- | Journal, IO biomarker: IL-17A promotes human disc degeneration by inhibiting autophagy through the activation of the PI3K/Akt/Bcl2 signaling pathway. (Pubmed Central) - Jul 28, 2020
Three autophagy suppressors were also found to have therapeutic effects, such as aminoimidazole-4-carboxamide-riboside (AICAR) for corneal allogeneic transplantation, celecoxib and chloroquine for DED. These data suggest that IL-17A promotes IDD by inhibiting autophagy through the activation of the PI3K/Akt/Bcl-2 signaling pathway and may offer new insights for targeted therapy of this disease.
- | Journal: Apoptin Regulates Apoptosis and Autophagy by Modulating Reactive Oxygen Species (ROS) Levels in Human Liver Cancer Cells. (Pubmed Central) - Jul 28, 2020
ROS appears to be the key factor linking apoptin-induced autophagy and apoptosis through the mitochondria in liver cancer cells. Therefore, evaluating the interaction between apoptin-induced apoptosis and autophagy is a promising step for the development of alternate tumor therapies.
- | Preclinical, Journal: miR-214-3p Attenuates Sepsis-Induced Myocardial Dysfunction in Mice by Inhibiting Autophagy through PTEN/AKT/mTOR Pathway. (Pubmed Central) - Jul 28, 2020
This study showed that miR-214-3p attenuated SIMD through myocardial autophagy inhibition by silencing PTEN expression and activating the AKT/mTOR pathway. The present findings supported that miR-214-3p may be a potential therapeutic target for SIMD.
- | Preclinical, Journal: Bafilomycin A1 Accelerates Chronic Refractory Wound Healing in db/db Mice. (Pubmed Central) - Jul 28, 2020
However, there were no significant changes in the expression levels of TNF-α and IL-10 in the db/db group. Therefore, Baf A1 may accelerate diabetic chronic refractory wound healing by promoting cell proliferation, collagen production, and regulating the inflammatory balance.
- [VIRTUAL] Inhibition of Histone Deacetylase 6 Protects Human Induced Pluripotent Stem Cells-derived Cardiomyocytes Through Inhibition of Autophagy () - Jul 26, 2020 - Abstract #BCVS2020BCVS_245;
Therefore, Baf A1 may accelerate diabetic chronic refractory wound healing by promoting cell proliferation, collagen production, and regulating the inflammatory balance. Our report indicates for the first time that the AngII-induced cardiac hypertrophy-mediated autophagy is effectively inhibited by the suppression of HDAC6 in human iCMCs.
- | chloroquine phosphate / Generic mfg.
Biomarker, Preclinical, Journal: Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model. (Pubmed Central) - Jul 25, 2020
In this study, we investigated the effect of PPARα activation by its agonist, WY14643, on the protein expression level of Aggrecan and ADAMTS5, and the protein expression level of autophagy biomarkers, including LC3B and P62, using Western blotting analysis in isolated mouse chondrocytes pre-treated with lipopolysaccharides (LPS, mimicking OA chondrocytes) with or without the autophagy inhibitor chloroquine diphosphate salt...The results indicated that PPARα activation by WY14643 promoted proteoglycan synthesis by autophagy enhancement in OA chondrocytes in vivo and in vitro concomitant with the elevation of Akt and ERK phosphorylation. Therefore, autophagy could contribute to the chondroprotection of PPARα activation by WY14643, with the implication that PPARα activation by WY14643 may be a potential approach for OA therapy.
- | sirolimus / Generic mfg.
Journal: Endoplasmic reticulum stress-dependent autophagy inhibits glycated high-density lipoprotein-induced macrophage apoptosis by inhibiting CHOP pathway. (Pubmed Central) - Jul 25, 2020
Administration of diabetic apoE mice with rapamycin attenuated MOMA-2 and CHOP up-regulation and apoptosis in atherosclerotic lesions. These data indicate that gly-HDL may induce macrophage apoptosis through activating ER stress-CHOP pathway and ER stress mediates gly-HDL-induced autophagy, which in turn protects macrophages against apoptosis by alleviating CHOP pathway.
- | Journal: Glycochenodeoxycholic acid impairs transcription factor E3 -dependent autophagy-lysosome machinery by disrupting reactive oxygen species homeostasis in L02 cells. (Pubmed Central) - Jul 24, 2020
Specifically, the decreased expression of TFE3 was closely related to the disruption of reactive oxygen species (ROS) homeostasis, which could be prevented by inhibiting intracellular ROS with N-acetyl cysteine (NAC). In summary, our study is the first to demonstrate that manipulation of ROS/TFE3 signaling may be a therapeutic approach for antagonizing GCDCA-induced hepatotoxicity.
- | Journal: The interplay between autophagy and apoptosis mediates toxicity triggered by synthetic cathinones in human kidney cells. (Pubmed Central) - Jul 24, 2020
Importantly, these antioxidant agents significantly aggravated renal cell death induced by cathinone derivatives, most likely due to their autophagy-blocking properties. Taken together, our results support an intricate control of cell survival/death modulated by oxidative stress, apoptosis and autophagy in synthetic cathinones-induced renal injury.
- | Journal: ATF4-mediated autophagy-dependent glycolysis plays an important role in attenuating apoptosis induced by Cr (VI) in A549 cells. (Pubmed Central) - Jul 24, 2020
ER stress was involved in facilitating glycolysis, whose induction was mediated by ATF4. These findings open a window for the development of therapeutic interventions to prevent Cr (VI)-induced toxicity.
- irinotecan / Generic mfg.
[VIRTUAL] The autophagy-depended PXR regulation in colorectal cancer (On-Demand) - Jul 21, 2020 - Abstract #ESMO2020ESMO_778;
Legal entity responsible for the study: Theocharis Stamatios. Funding: Has not received any funding.
- [VIRTUAL] Targeting mitochondria as a novel therapeutic strategy in biliary tract cancer (On-Demand) - Jul 21, 2020 - Abstract #ESMO2020ESMO_417;
Legal entity responsible for the study: The authors. Funding: TIGEM - Telethon Institute of Genetics and Medicine.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Endurance Exercise Attenuates Doxorubicin-induced Cardiotoxicity. (Pubmed Central) - Jul 21, 2020
Our data provide novel findings that EXE-induced auto/mitophagy promotion and NOX2 downregulation are linked to cardioprotection against DOX-induced cardiotoxicity. Importantly, our study shows that EXE postconditioning intervention is effective and efficacious to prevent DOX-induced cardiac injuries.
- | Aplidin (plitidepsin) / PharmaMar, Roche
Journal: Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells. (Pubmed Central) - Jul 21, 2020
Other anti-myeloma drugs like bortezomib, which target the proteasome, also inhibit the degradation of misfolded proteins through alternate pathways and a synergistic anticancer effect of the PLD plus bortezomib combination has been previously disclosed. The present results extend this synergy to in vivo experiments and provide a mechanistic rationale for this synergy.
- | chloroquine phosphate / Generic mfg.
Journal: Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine. (Pubmed Central) - Jul 21, 2020
Caspase-1/11 signaling affects the response to ischemia in muscle and effects are variably modulated by CQ. This may be critically important for disease treated with CQ and its derivatives, including novel viral diseases (e.g. COVID-19) that are expected to affect patients with comorbidities like cardiovascular disease.
- | Journal: Morphine induces dysfunction of PINK1/Parkin-mediated mitophagy in spinal cord neurons implying involvement in antinociceptive tolerance. (Pubmed Central) - Jul 19, 2020
The deficiency of PINK1/Parkin-mediated clearance of damaged mitochondria is crucial for the generation of excessive ROS and important to the development of analgesic tolerance. These findings suggest that the compounds capable of stabilizing PINK1 or restoring mitophagy may be utilized to prevent or reduce opioid tolerance during chronic pain management.
- | urocortin II (NBI-69734) / Renova Therapeutics
Journal: Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII. (Pubmed Central) - Jul 19, 2020
The effect of CRHRs ligands on paxillin resulted in the suppression of cell migration. Altogether, these data reveal a new link between CRHRs signaling and autophagy, and may help to envisage therapeutic strategies in cancer cell invasion.
- | Journal: Lactate accelerates calcification in VSMCs through suppression of BNIP3-mediated mitophagy. (Pubmed Central) - Jul 19, 2020
In addition, BNIP3-mediated mitophagy played a protective role against VSMC calcification in the presence of lactate. This study suggests that lactate accelerates osteoblastic phenotype transition of VSMC and calcium deposition partly through the BNIP3-mediated mitophagy deficiency induced oxidative stress and apoptosis.
- | chloroquine phosphate / Generic mfg.
Journal: Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation. (Pubmed Central) - Jul 19, 2020
Addition of late stage autophagy inhibitor, chloroquine (CQ), further enhanced LC3-II and p62 level, as well as increased autophagosome accumulation, suggesting a blockage of autophagic flux by GLP in CRC cells...Finally, GLP inhibited tumor growth and also inhibited autophagic flux in vivo. These results unveil new molecular mechanism underlying anti-cancer effects of GLP, suggesting that GLP is a potent autophagy inhibitor and might be useful in anticancer therapy.
- | Journal: Nerve growth factor induced farnesoid X receptor upregulation modulates autophagy flux and protects hepatocytes in cholestatic livers. (Pubmed Central) - Jul 19, 2020
These findings support that NGF modulates autophagy flux via FXR upregulation and protects hepatocytes against BA-induced cytotoxicity. NGF/FXR axis is a novel therapeutic target for treatment of cholestatic liver diseases.
- | Journal: Systematic investigation of intracellular trafficking behavior of one-dimensional alumina nanotubes. (Pubmed Central) - Jul 19, 2020
Blocking endolysosomal pathways using autophagy inhibitors prevented the degradation of AANTs through lysosomes. Our results add new insights into the pathways and mechanisms of intracellular trafficking of AANTs, and suggest that intracellular trafficking and lysosomal degradation are highly interdependent and important for efficient drug delivery, and should be evaluated together for drug carrier development.
- | paclitaxel / Generic mfg.
Journal, Cancer stem cells: The nanoparticle-facilitated autophagy inhibition of cancer stem cells for improved chemotherapeutic effects on glioblastomas. (Pubmed Central) - Jul 19, 2020
More importantly, it was found that the combined delivery system FA-BSA-NP exhibited the most effective cell apoptosis. Our findings demonstrated that drug-loaded albumin nanoparticles could facilitate a combination of chemotherapy and autophagy inhibition for effective glioma therapy.
- | sirolimus / Generic mfg.
Journal: Singapore Grouper Iridovirus (SGIV) Inhibited Autophagy for Efficient Viral Replication. (Pubmed Central) - Jul 19, 2020
Moreover, activation of autophagy by rapamycin or overexpressing LC3 decreased SGIV replication. These results provide an antiviral strategy from the perspective of autophagy.
- [VIRTUAL] THE INTERPLAY OF ATG16L1 AND XBP-1 CRUCIALLY COORDINATES EPITHELIAL DNA DAMAGE RESPONSES AND PROTECTS FROM INTESTINAL CARCINOGENESIS (Hall 1) - Jul 19, 2020 - Abstract #UEGW2020UEGW_5846;
We conclude that dysfunctional macro-autophagy, which is associated with IBD, can promote DNA-damage induced cell death but also increase epithelial proliferation. In addition we show that UPR and autophagy mutually fine tune p53-dependent DNA damage response to protect from intestinal carcinogenesis.
- [VIRTUAL] GASTRIC NON-HELICOBACTER COMMENSAL BACTERIA AND THEIR PRODUCTS, SHORT-CHAIN FATTY ACIDS, COULD ENHANCE CD44V9-POSITIVE GASTRIC CANCER STEM-LIKE CELL DEVELOPMENT IN H. PYLORI-INFECTION (Hall 6) - Jul 19, 2020 - Abstract #UEGW2020UEGW_1977;
In addition we show that UPR and autophagy mutually fine tune p53-dependent DNA damage response to protect from intestinal carcinogenesis. Butyrate-releasing gastric commensal bacteria could influence the risk of gastric cancer through promotion of the development of CAPZA1-overexpressing epithelial cells in the gastric mucosa with H. pylori infection.
- | Preclinical, Journal: Plumbagin induces autophagy and apoptosis of SMMC-7721 cells in vitro and in vivo. (Pubmed Central) - Jul 18, 2020
In contrast, administration of the apoptosis inhibitor Z-VAD did not affect PL-induced autophagy. Taken together, our findings strongly suggest that PL is a promising drug with significant antitumor activity in HCC.
- | hydroxychloroquine / Generic mfg.
Journal, Cytokine storm: Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage. (Pubmed Central) - Jul 18, 2020
Taken together, our findings strongly suggest that PL is a promising drug with significant antitumor activity in HCC. These results suggest that autophagy plays an important role in the pathogenesis of sepsis and could serve as a potential therapeutic target for sepsis.
- | modafinil / Generic mfg., sirolimus / Generic mfg.
Preclinical, Journal: Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation. (Pubmed Central) - Jul 18, 2020
These results suggest that autophagy plays an important role in the pathogenesis of sepsis and could serve as a potential therapeutic target for sepsis. The novel mechanism may deepen our knowledge of modafinil in the clinical therapy of impaired memory caused by sleep loss.
- | Journal: Inhibition of autophagy by 3-MA promotes hypoxia-induced apoptosis in human colorectal cancer cells. (Pubmed Central) - Jul 18, 2020
The novel mechanism may deepen our knowledge of modafinil in the clinical therapy of impaired memory caused by sleep loss. Autophagy might play a role as a self-defense mechanism in hypoxia-treated colon cancer cells, and its inhibition could be a promising strategy for the adjuvant chemotherapy of colon cancer.
- | Journal: Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis. (Pubmed Central) - Jul 15, 2020
Furthermore, we demonstrated that echinatin had a significant antitumor effect in the tumor xenograft model and markedly suppressed cell migration and invasion abilities of ESCC cells in a dose-dependent manner. Our findings provide the first evidence that echinatin could be a novel therapeutic strategy for treating ESCC.
- | chloroquine phosphate / Generic mfg.
Journal: Sphingosine-1-phosphate promotes pulmonary artery smooth muscle cells proliferation by stimulating autophagy-mediated E-cadherin/CDH1 down-regulation. (Pubmed Central) - Jul 15, 2020
Prior silencing TRAF2 or BECN1 using siRNA or pre-incubation of cells with autophagy inhibitor chloroquine phosphate (CQ) suppressed S1P-induced autophagy activation and subsequent CDH1 degradation and further PASMCs proliferation. Taken together, our study indicates that S1P promotes the activation of autophagy by accelerating TRAF2-mediated BECN1 up-regulation and ubiquitination, which in turn results in CDH1 reduction and contributes to PASMCs proliferation.
- | Journal: Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p. (Pubmed Central) - Jul 15, 2020
Our findings disclose a novel autophagy/apoptosis-regulatory pathway that is composed of mir-20a-5p, circ-ADAM9, PTEN, and ATG7. Circ-ADAM9 is a potential novel target for regulating the function of diabetic EPCs and angiogenesis.
- azathioprine orodispersible / Generic mfg.
[VIRTUAL] Homozygous mutations of ARFGAP1 gene in severe sarcoidosis (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_3737;
RAC1 is one of the main targets of azathioprine (AZA), an immunosuppressive drug used in corticosteroid (CS) refractory sarcoidosis...We would hypothesize that ARFGAP1 mutated isoforms have lost their inhibitory function with a consequence of hyperactivation of RAC1 thus leading to autophagy inhibition. Autophagy disruption seems to be an interesting element of pathophysiology in sarcoidosis, previously evoked in WES studies and through the efficacy of autophagy modulating drug during sarcoidosis.
- sirolimus / Generic mfg.
[VIRTUAL] Cigarette-decreased NAD/SIRT1 aggravates pulmonary fibrosis by promoting senescence of alveolar type 2 cells through autophagy inhibition and mitochondrial oxidative stress induction (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_223;
After senescent markers were increased, they were treated with bleomycin (BLM) and smoke for 4 weeks...Then, effects of autophagy inducer rapamycin, SIRT1 activator SRT1720, NAD+ precursor NMN, PARP1 inhibitor olaparib and mitochondrial ROS (mtROS) scavenger, mitoquinone (MQ) were examined...Conclusion Cigarette-decreased NAD+/SIRT1 resulting from PARP1 activation induce AT2 senescence by inhibiting autophagy, which further activate PARP1 via mtROS-induced DNA damage by impairing mitophagy. Therefore, there is a positive loop in cigarette-induced senescence, which may play a key role in lung fibrosis.
- [VIRTUAL] Autophagy Regulates the Therapeutic Potential of Adipocyte Stem Cells in LPS-Induced Pulmonary Microvascular Barrier Damage (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_7516;
Autophagy is a positive mediating factor in the paracrine process of ADSC, the regulation of autophagy might be a potential strategy for modulating the treatment efficacy of ADSCs in lung injury. These results are helpful for illuminating the role and mechanism of ADSC paracrine effects and developing effective therapies in acute lung injury.
- sirolimus / Generic mfg.
[VIRTUAL] Autophagy Mediates the High Mobility Group Box 1 (HMGB1)-Compromised Macrophage Phagocytosis in Hyperoxia (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5938;
Inhibition of hyperoxia-induced autophagy with chloroquine significantly improved macrophage phagocytosis. Taken together, these data suggest that autophagy mediates HMGB1-compromised phagocytosis in hyperoxic macrophages.
- hydroxychloroquine / Generic mfg.
[VIRTUAL] Endothelial Autophagy and the Lung Tumor Microenvironment (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5774;
This stimulation does not appeared to be related to acidic or poor nutrient conditions suggesting an active mediator process. Intact autophagy is necessary for endothelial cells to invade the extracellular matrix as well as for the expression of active endothelial MMP14.
- sirolimus / Generic mfg., norethindrone / Generic mfg.
[VIRTUAL] Treatment as Old as Time for Pulmonary Lymphangioleiomyomatosis (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_5390;
In the MILES trial, sirolimus showed improvement in FVC, FEV1, quality of life, and functional performance when compared to the placebo group 3 . Sirolimus is an agent for the treatment of LAM, indicated for FEV1 of less than 70% of predicted, patients on traditional therapies are recommended to be transitioned to newer FDA approved drugs for LAM.
- tamoxifen / Generic mfg.
[VIRTUAL] The Influence of Autophagy Inhibition on Sepsis-Induced Skeletal Muscle Wasting, Metabolic Derangements and Mortality (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_3747;
We conclude that autophagy plays a protective role by preserving muscle mitochondrial quality and function and that autophagy inhibition in skeletal muscles worsens sepsis-induced loss of body weight and muscle atrophy possibly due to exaggerated responses to catabolic stimuli triggered by sepsis. Our results also indicate that autophagy in septic skeletal muscles play a protective role against sepsis-induced metabolic derangements and mortality.
- sirolimus / Generic mfg.
[VIRTUAL] Cigarette-Decreased NAD + /SIRT1 of Alveolar Type 2 Cells Aggravates Pulmonary Fibrosis by Promoting Cellular Senescence Through Autophagy Inhibition and Mitochondrial Oxidative Stress Induction (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_2065;
RESULTS Mice with 3 weeks history of smoking exhibited senescent AT2 and more severe fibrotic changes after bleomycin administration...Their effects were reversed by SIRT1 inhibitor Ex527...Autophagy suppression further promoted DNA damage by inducing mitochondrial reactive oxidative stress due to impaired mitophagy. Consequently, there is a positive loop in cigarette-induced senescence of AT2, which may play a key role in lung fibrogenesis.
- [VIRTUAL] Macrophage Migration Inhibitory Factor Promotes Asthmatic Airway Remodeling by Inducing Autophagy of Airway Smooth Muscle Cell (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1230;
Overall, this study demonstrates that MIF can promote airway remodeling in experimental asthma model by modulating ASMC autophagy and MIF may be produced by activated macrophage. Moreover, the specific mechanism is possibly that MIF binds to its receptor CD74.
- [VIRTUAL] NLRP3 Deficiency Alleviates Chronic Intermittent Hypoxia-Induced Neuroinflammation and Oxidative Stress Via Parkin-Mediated Mitophagy (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1014;
In summary, these results revealed NLRP3 deficiency acted as a protective promotor through enhancing Parkin-depended mitophagy in CIH-induced neuroinflammation. Thus, NLRP3 gene knockout or pharmacological blockage could be as a potential therapeutic strategy for OSA-associated neurocognitive impairment.
- sirolimus / Generic mfg.
[VIRTUAL] Relationship Between Autophagy-Lysosomes Pathway and Ventilator-Induced Diaphragmatic Dysfunction (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_930;
Methods : To determine the role of autophagy-lysosomes (AL) pathway on the MV-induced diaphragmatic injury and atrophy, thirty-two rats were assigned to control, MV (for 18 hours), MV+chloroquine and MV+rapamycin groups,respectively. This study demonstrated that activation of autophagy in the rat diaphragm contributed to the muscle atrophy and injury during MV.
- bortezomib / Generic mfg.
[VIRTUAL] DOWN REGULATION OF AUTOPHAGY ENHANCES BORTEZOMIB-INDUCED APOPTOSIS OF MYELOMA CELL BY UP REGULATION OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4366;
Our experiment showed crosstalk between autophagy and mitochondrial ROS and its redox enzymes during BTZ-induced MM cell apoptosis. Inhibition of autophagy with 3-MA potentiates BTZ-induced apoptosis of MM cells via up regulation of mitochondrial ROS.
- bortezomib / Generic mfg.
[VIRTUAL] DOWN REGULATION OF AUTOPHAGY ENHANCES BORTEZOMIB-INDUCED APOPTOSIS OF MYELOMA CELL BY UP REGULATION OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4365;
Our experiment showed crosstalk between autophagy and mitochondrial ROS and its redox enzymes during BTZ-induced MM cell apoptosis. Inhibition of autophagy with 3-MA potentiates BTZ-induced apoptosis of MM cells via up regulation of mitochondrial ROS.
- bortezomib / Generic mfg.
[VIRTUAL] DOWN REGULATION OF AUTOPHAGY ENHANCES BORTEZOMIB-INDUCED APOPTOSIS OF MYELOMA CELL BY UP REGULATION OF MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4364;
Our experiment showed crosstalk between autophagy and mitochondrial ROS and its redox enzymes during BTZ-induced MM cell apoptosis. Inhibition of autophagy with 3-MA potentiates BTZ-induced apoptosis of MM cells via up regulation of mitochondrial ROS.
- sirolimus / Generic mfg.
[VIRTUAL] AUTOPHAGY IN ENDOTHELIAL CELLS REGULATES THEIR HAEMATOPOIESIS-SUPPORTING ABILITY (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3133;
Defective autophagy in BM ECs may be involved in the pathogenesis of PGF post-allotransplant. Although further validation is required, our data suggest that improving autophagy in BM ECs may be a potential therapeutic approach in PGF patients after allo-HSCT.
- sirolimus / Generic mfg.
[VIRTUAL] AUTOPHAGY IN ENDOTHELIAL CELLS REGULATES THEIR HAEMATOPOIESIS-SUPPORTING ABILITY (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3132;
Defective autophagy in BM ECs may be involved in the pathogenesis of PGF post-allotransplant. Although further validation is required, our data suggest that improving autophagy in BM ECs may be a potential therapeutic approach in PGF patients after allo-HSCT.