 |
Companies | Products |
|
|
Products | |
Diseases | |
Trials |  |
News |  |
| «12...100101102103104105106107108109110...135136» |
- | Journal: Inhibition of the Wnt/β-catenin signaling pathway reduces autophagy levels in complement treated podocytes. (Pubmed Central) - Jun 1, 2021
This may explain the observation that blocking the Wnt/β-catenin signaling pathway attenuated C5b-9 podocyte damage, while inhibiting autophagy. The results of the present study also suggest that regulation of these two pathways may serve as a novel method for the treatment of idiopathic membranous nephropathy.
- | Journal: The Role and Mechanism of ATM-Mediated Autophagy in the Transition From Hyper-Radiosensitivity to Induced Radioresistance in Lung Cancer Under Low-Dose Radiation. (Pubmed Central) - Jun 1, 2021
ATM may influence autophagy through p-JNK and AMBRA1 to participate in the regulation of the HRS/IRR phenomenon. Autophagy interacts with the cellular carbon metabolite DL-Norvaline to participate in regulating the low-dose radiosensitivity of cells.
- CUDC-305 / Debiopharm, Curis
[VIRTUAL] METPlatform identifies brain metastasis vulnerabilities and predicts patient response to therapy () - May 30, 2021 - Abstract #EACR2021EACR_3290;
DEBIO-0932, a blood-brain barrier permeable HSP90 inhibitor, shows high potency against mouse and human brain metastases from different primary origin and oncogenomic profile at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery...Conclusion Our work validates METPlatform as a potent resource for metastasis research integrating drug-screening and unbiased omic approaches that is fully compatible with human samples and questions the rationale of excluding patients with brain metastasis from clinical trials. We envision that METPlatform will be established as a clinically relevant strategy to personalize the management of metastatic disease in the brain and elsewhere.
- CUDC-305 / Debiopharm, Curis
[VIRTUAL] METPlatform identifies brain metastasis vulnerabilities and predicts patient response to therapy () - May 30, 2021 - Abstract #EACR2021EACR_3289;
DEBIO-0932, a blood-brain barrier permeable HSP90 inhibitor, shows high potency against mouse and human brain metastases from different primary origin and oncogenomic profile at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery...Conclusion Our work validates METPlatform as a potent resource for metastasis research integrating drug-screening and unbiased omic approaches that is fully compatible with human samples and questions the rationale of excluding patients with brain metastasis from clinical trials. We envision that METPlatform will be established as a clinically relevant strategy to personalize the management of metastatic disease in the brain and elsewhere.
- CUDC-305 / Debiopharm, Curis
[VIRTUAL] METPlatform identifies brain metastasis vulnerabilities and predicts patient response to therapy () - May 30, 2021 - Abstract #EACR2021EACR_3288;
DEBIO-0932, a blood-brain barrier permeable HSP90 inhibitor, shows high potency against mouse and human brain metastases from different primary origin and oncogenomic profile at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery...Conclusion Our work validates METPlatform as a potent resource for metastasis research integrating drug-screening and unbiased omic approaches that is fully compatible with human samples and questions the rationale of excluding patients with brain metastasis from clinical trials. We envision that METPlatform will be established as a clinically relevant strategy to personalize the management of metastatic disease in the brain and elsewhere.
- CUDC-305 / Debiopharm, Curis
[VIRTUAL] METPlatform identifies brain metastasis vulnerabilities and predicts patient response to therapy () - May 30, 2021 - Abstract #EACR2021EACR_3287;
DEBIO-0932, a blood-brain barrier permeable HSP90 inhibitor, shows high potency against mouse and human brain metastases from different primary origin and oncogenomic profile at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery...Conclusion Our work validates METPlatform as a potent resource for metastasis research integrating drug-screening and unbiased omic approaches that is fully compatible with human samples and questions the rationale of excluding patients with brain metastasis from clinical trials. We envision that METPlatform will be established as a clinically relevant strategy to personalize the management of metastatic disease in the brain and elsewhere.
- hydroxychloroquine / Generic mfg.
[VIRTUAL] Connections between leukemic cells and mesenchymal stem cells through extracellular vesicles promoted chemo-resistance in leukemia, proposing the potential role of autophagy () - May 30, 2021 - Abstract #EACR2021EACR_2883;
Explicitly found after adding it with the previous compound (IDA+tMSC-EVs) contributed to a significant increase in the cytotoxic effects of IDA in U937 and KG-1 cells and reduction in cells’ viability and metabolic activity. Conclusion We provide direct evidence that AML-EVs are able to modulate MSCs to the way of supporting leukemic progression, outlining the potent role of MSCs and autophagy machinery in the AML development at the level of BMM context.
- hydroxychloroquine / Generic mfg.
[VIRTUAL] Connections between leukemic cells and mesenchymal stem cells through extracellular vesicles promoted chemo-resistance in leukemia, proposing the potential role of autophagy () - May 30, 2021 - Abstract #EACR2021EACR_2882;
Explicitly found after adding it with the previous compound (IDA+tMSC-EVs) contributed to a significant increase in the cytotoxic effects of IDA in U937 and KG-1 cells and reduction in cells’ viability and metabolic activity. Conclusion We provide direct evidence that AML-EVs are able to modulate MSCs to the way of supporting leukemic progression, outlining the potent role of MSCs and autophagy machinery in the AML development at the level of BMM context.
- hydroxychloroquine / Generic mfg.
[VIRTUAL] Connections between leukemic cells and mesenchymal stem cells through extracellular vesicles promoted chemo-resistance in leukemia, proposing the potential role of autophagy () - May 30, 2021 - Abstract #EACR2021EACR_2881;
Explicitly found after adding it with the previous compound (IDA+tMSC-EVs) contributed to a significant increase in the cytotoxic effects of IDA in U937 and KG-1 cells and reduction in cells’ viability and metabolic activity. Conclusion We provide direct evidence that AML-EVs are able to modulate MSCs to the way of supporting leukemic progression, outlining the potent role of MSCs and autophagy machinery in the AML development at the level of BMM context.
- hydroxychloroquine / Generic mfg.
[VIRTUAL] Connections between leukemic cells and mesenchymal stem cells through extracellular vesicles promoted chemo-resistance in leukemia, proposing the potential role of autophagy () - May 30, 2021 - Abstract #EACR2021EACR_2880;
Explicitly found after adding it with the previous compound (IDA+tMSC-EVs) contributed to a significant increase in the cytotoxic effects of IDA in U937 and KG-1 cells and reduction in cells’ viability and metabolic activity. Conclusion We provide direct evidence that AML-EVs are able to modulate MSCs to the way of supporting leukemic progression, outlining the potent role of MSCs and autophagy machinery in the AML development at the level of BMM context.
- cisplatin / Generic mfg., pemetrexed / Generic mfg.
[VIRTUAL] Combination therapy with pemetrexed disodium heptahydrate and cisplatin impedes the growth of A549 KRAS-dependent lung cancer cells () - May 30, 2021 - Abstract #EACR2021EACR_1507;
Moreover, combined therapy inhibited the RAS/RAF/MEK/ERK signaling pathway, while AMPK was inactivated under combined treatment, leading to the inhibition of autophagy activity. Conclusion Our results revealed novel mechanisms of action of combined therapy with cisplatin and pemetrexed, indicating a potential anticancer effect in A549 cells.
- cisplatin / Generic mfg., pemetrexed / Generic mfg.
[VIRTUAL] Combination therapy with pemetrexed disodium heptahydrate and cisplatin impedes the growth of A549 KRAS-dependent lung cancer cells () - May 30, 2021 - Abstract #EACR2021EACR_1506;
Moreover, combined therapy inhibited the RAS/RAF/MEK/ERK signaling pathway, while AMPK was inactivated under combined treatment, leading to the inhibition of autophagy activity. Conclusion Our results revealed novel mechanisms of action of combined therapy with cisplatin and pemetrexed, indicating a potential anticancer effect in A549 cells.
- cisplatin / Generic mfg., pemetrexed / Generic mfg.
[VIRTUAL] Combination therapy with pemetrexed disodium heptahydrate and cisplatin impedes the growth of A549 KRAS-dependent lung cancer cells () - May 30, 2021 - Abstract #EACR2021EACR_1505;
Moreover, combined therapy inhibited the RAS/RAF/MEK/ERK signaling pathway, while AMPK was inactivated under combined treatment, leading to the inhibition of autophagy activity. Conclusion Our results revealed novel mechanisms of action of combined therapy with cisplatin and pemetrexed, indicating a potential anticancer effect in A549 cells.
- cisplatin / Generic mfg., pemetrexed / Generic mfg.
[VIRTUAL] Combination therapy with pemetrexed disodium heptahydrate and cisplatin impedes the growth of A549 KRAS-dependent lung cancer cells () - May 30, 2021 - Abstract #EACR2021EACR_1504;
Moreover, combined therapy inhibited the RAS/RAF/MEK/ERK signaling pathway, while AMPK was inactivated under combined treatment, leading to the inhibition of autophagy activity. Conclusion Our results revealed novel mechanisms of action of combined therapy with cisplatin and pemetrexed, indicating a potential anticancer effect in A549 cells.
- | Journal, PD(L)-1 Biomarker, IO biomarker: ULK1 Inhibition Restores Antigen Presentation in LKB1-Mutant Lung Cancer. (Pubmed Central) - May 30, 2021
Conclusion Our results revealed novel mechanisms of action of combined therapy with cisplatin and pemetrexed, indicating a potential anticancer effect in A549 cells. Inhibiting the autophagy regulator ULK1 enhanced response to anti-PD-1 in LKB1-mutant lung tumors.
- [VIRTUAL] Islet Autophagic Flux Is Impaired Prior to the Onset of Type 1 Diabetes (Virtual Exhibits and Poster Hall) - May 29, 2021 - Abstract #ADA2021ADA_1980;
Impairments in the autophagy pathway may worsen beta cell ER, oxidative and inflammatory stress, ultimately leading to cell death and hastening the progression to diabetes. These data suggest that therapies targeting restoration of autophagy should be evaluated as interventions to delay or prevent T1D.
- | ramelteon / Generic mfg., sirolimus / Generic mfg.
Preclinical, Journal: Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury. (Pubmed Central) - May 29, 2021
Intracerebroventricular injection of rapamycin, an autophagy activator, compromised the neuroprotection of ramelteon, suggesting ramelteon might attenuate ischemic injury by counteracting autophagic cell death. These data demonstrate for the first time the potential benefits of ramelteon in the treatment of both acute and chronic ischemic brain injury and provide the rationale for the application of ramelteon in stroke therapy.
- | SP600125 / BMS
Journal: Phanginin R Induces Cytoprotective Autophagy via JNK/c-Jun Signaling Pathway in Non-Small Cell Lung Cancer A549 Cells. (Pubmed Central) - May 29, 2021
These data demonstrate for the first time the potential benefits of ramelteon in the treatment of both acute and chronic ischemic brain injury and provide the rationale for the application of ramelteon in stroke therapy. PR induced cytoprotective autophagy in NSCLC A549 cells via the JNK/c-Jun signaling pathway, and autophagy inhibition could further improve the anti-cancer potential of PR.
- | Preclinical, Journal: In vitro treatment of 3 T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway. (Pubmed Central) - May 29, 2021
The protective effect of CaMKIV in adipocytes is affected at least partly through mTOR/CREB signaling. Our finding may offer novel opportunities for treating obesity and type 2 diabetes.
- | Journal: Astragalus membranaceus Injection Suppresses Production of Interleukin-6 by Activating Autophagy through the AMPK-mTOR Pathway in Lipopolysaccharide-Stimulated Macrophages. (Pubmed Central) - May 29, 2021
These findings showed that AM injection might enhance autophagy by activating AMPK and might further play a repressive effect on the LPS-stimulated expression of IL-6. This study explored the relationship between autophagy, signaling pathways, and the production of inflammatory factors in a model of endotoxin infection and treatment with AM injection.
- | Journal: Geniposide Enhances Macrophage Autophagy through Downregulation of TREM2 in Atherosclerosis. (Pubmed Central) - May 29, 2021
Taken together, augmenting the autophagy levels in plaque macrophages by inhibiting the TREM2/mTOR axis can potentially impede atherosclerotic progression. The promising therapeutic effects of GP seen in this study should be validated in future trials, and the underlying mechanisms have to be elucidated in greater detail.
- | Journal, Immunogenic cell death: Autophagy Impairment through Lysosome Dysfunction by Brucine Induces Immunogenic Cell Death (ICD). (Pubmed Central) - May 29, 2021
Thus, these results imply the importance of Brucine in cancer immunotherapy. Therefore, Brucine may be used as an ICD inducer and improve its application in cancer treatment with minimized toxicity.
- | doxycycline / Generic mfg.
Journal: Blocking lncRNA H19/miR-194-5p/SIRT1 axis in cardiac myocyte is responsible for doxycycline inhibiting autophagy. (Pubmed Central) - May 29, 2021
Therefore, Brucine may be used as an ICD inducer and improve its application in cancer treatment with minimized toxicity. No abstract available
- | doxycycline / Generic mfg.
Journal: Reply to letter by Ye et al., blocking lncRNA H19/miR-194-5p/SIRT1 axis in cardiac myocyte is responsible for doxycycline inhibiting autophagy. (Pubmed Central) - May 29, 2021
No abstract available No abstract available
- | Journal: Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps. (Pubmed Central) - May 29, 2021
Mechanistically, we showed that the ability of liraglutide to enhance autophagy is mediated by the activation of transcription factor EB (TFEB) and its subsequent entry into the nucleus to activate autophagy genes, a phenomenon that may result from AMPK-MCOLN1-calcineurin signalling pathway activation. Taken together, our results show that liraglutide is an effective drug that can significantly improve the survival rate of random flaps by enhancing autophagy, inhibiting oxidative stress in tissues, reducing pyroptosis, and promoting angiogenesis, which may be due to the activation of TFEB via the AMPK-MCOLN1-calcineurin signalling pathway.
- | sirolimus / Generic mfg.
Preclinical, Journal: Ergosterol peroxide suppresses porcine deltacoronavirus (PDCoV)-induced autophagy to inhibit virus replication via p38 signaling pathway. (Pubmed Central) - May 29, 2021
Pharmacologically induced autophagy with rapamycin increased the expression of PDCoV N, while pharmacologically inhibited autophagy with wortmannin decreased the expression of PDCoV N, suggesting that PDCoV-induced autophagy facilitates virus replication...Finally, we employed a piglet model of PDCoV infection to demonstrate that EP prevented PDCoV infection by suppressing PDCoV-induced autophagy via p38 signaling pathway in vivo. Collectively, these findings accelerate the understanding of the pathogenesis of PDCoV infection and provide new insights for the development of EP as an effective therapeutic strategy for PDCoV.
- | Journal, Epigenetic controller: Epidermal Growth Factor Protects Against High Glucose-Induced Podocyte Injury Possibly via Modulation of Autophagy and PI3K/AKT/mTOR Signaling Pathway Through DNA Methylation. (Pubmed Central) - May 29, 2021
In summary, our results demonstrated that EGF exerted protective effects on HG-induced podocytes injury via enhancing cell proliferation and inhibiting cell apoptosis. Further mechanistic studies implied that EGF-mediated protective effects in HG-stimulated podocytes may be associated with modulation of autophagy and PI3K/AKT/mTOR signaling pathway.
- | chloroquine phosphate / Generic mfg.
Journal: Inhibition of autophagy in theca cells induces CYP17A1 and PAI-1 expression via ROS/p38 and JNK signalling during the development of polycystic ovary syndrome. (Pubmed Central) - May 28, 2021
Autophagy inhibition by palmitic acid and chloroquine in bovine theca cells increased p62 and ubiquitin and induced the expression of cytochrome P450 17A1 (CYP17A1) and plasminogen activator inhibitor-1 (PAI-1) mRNA...Inhibition of p38 and JNK significantly reduced CYP17A1 and PAI-1 mRNA expression. We showed that inhibition of autophagy in theca cells may have contributed to the pathogenesis of PCOS, based on CYP17A1 and PAI-1 mRNA expression via the ROS/p38 and JNK signalling pathways.
- | Journal: Gamma irradiation promotes chemo-sensitization potential of gallic acid through attenuation of autophagic flux to trigger apoptosis in NRF2 inactivation signalling pathway. (Pubmed Central) - May 28, 2021
The modulation of apoptosis and autophagy in tumor inhibition was determined. In conclusion, the study proposed, change in electrochemical properties by gamma radiation enhances the anticancer efficacy of gallic acid through ROS mediated apoptosis fuelled by inhibition of lipophagy in an NRF2 dependent signaling pathway.
- | Journal: miRNA-21-3p targeting of FGF2 suppresses autophagy of bovine ovarian granulosa cells through AKT/mTOR pathway. (Pubmed Central) - May 28, 2021
These data indicate that regulation of miR-21-3p on BGCs autophagy through AKT/mTOR pathway. In summary, this study suggests that miR-21-3p targets FGF2 to inhibit BGCs autophagy by repressing AKT/mTOR signaling.
- | Journal: miR-30e-3p Promotes Cardiomyocyte Autophagy and Inhibits Apoptosis via Regulating Egr-1 during Ischemia/Hypoxia. (Pubmed Central) - May 28, 2021
In addition, inhibition of miR-30e-3p reduced autophagy and increased apoptosis and cell injury. miR-30e-3p may be involved in promoting cardiomyocyte autophagy and inhibiting apoptosis by indirectly regulating Egr-1 expression in an IH environment.
- | Journal, BRCA Biomarker: Autophagy inhibition perturbs ERBB2 trafficking and abolishes tumorigenesis in ERBB2-driven breast cancer. (Pubmed Central) - May 28, 2021
Mechanistically, autophagy inhibition perturbs ERBB2 intracellular trafficking and triggers its release via small extracellular vesicles. Our results demonstrate a new mechanism for autophagy to promote tumorigenesis in ERBB2-driven BrCA and could supplement current strategies for anti-ERBB2 therapy.
- | hydroxychloroquine / Generic mfg.
Journal: Macropinocytosis: the big drinker behind cancer cell self-consumption. (Pubmed Central) - May 28, 2021
Concurrent autophagy and MP blockade effectively cuts off the cancer cell's nutrient and supplies, leading to rapid tumor regression. These findings suggest MP to be an important target in cancer treatment and that shutting off the energy spigot is a promising therapeutic strategy.
- | Journal: Bidirectional interconversion between PtdIns4P and PtdIns(4,5)P is required for autophagic lysosome reformation and protection from skeletal muscle disease. (Pubmed Central) - May 28, 2021
Therefore on autolysosomes, both PtdIns(4,5)P generation and its removal by INPP5K is required for completion of ALR. Furthermore, skeletal muscle shows a dependence on the membrane recycling ALR pathway to maintain lysosome homeostasis and ensure the protective role of autophagy against disease.
- | chloroquine phosphate / Generic mfg.
Journal, IO biomarker: ROS-Triggered Autophagy Is Involved in PFOS-Induced Apoptosis of Human Embryo Liver L-02 Cells. (Pubmed Central) - May 28, 2021
The autophagy inhibitor 3-methyladenine and chloroquine decreased apoptosis and cleaved-caspase-3 protein level and increased the Bcl-2/Bax ratio. In summary, our results suggest that ROS-triggered autophagy is involved in PFOS-induced apoptosis in L-02 cells.
- | dexamethasone / Generic mfg.
Journal: Endoplasmic reticulum stress, unfolded protein response and autophagy contribute to resistance to glucocorticoid treatment in human acute lymphoblastic leukaemia cells. (Pubmed Central) - May 27, 2021
The synthetic glucocorticoid (GC) dexamethasone (Dex) is commonly used to treat ALL, the main drawback of which is the development of resistance to this treatment...The leukaemia cell lines CEM‑C7‑14, CEM‑C1‑15 and MOLT4 treated with chloroquine (CLQ), thapsigargin (TG) and rotenone (ROT) were used to explore the roles of autophagy, endoplasmic reticulum (ER) stress/unfolded protein response (UPR) and reactive oxygen species (ROS) generation in the response to GC treatment...Taken together, the results of the present study demonstrated that autophagy may be a pro‑survival mechanism in GC‑resistant leukaemia, and by modulating intracellular and surface GRP94 protein levels, Dex is involved in the regulation of ER stress/UPR‑dependent cell death and immune surveillance. These observations may be of clinical importance if confirmed in patients.
- | Journal: Syndecan 4 contributes to osteoclast differentiation induced by RANKL through enhancing autophagy. (Pubmed Central) - May 27, 2021
This study reveals that SDC4 may contribute to osteoclast differentiation during periodontitis through activating autophagy. It sheds light on the important role of SDC4 in periodontitis.
- | Preclinical, Journal: Hyperbaric Oxygen Improves Cerebral Ischemia/Reperfusion Injury in Rats Probably via Inhibition of Autophagy Triggered by the Downregulation of Hypoxia-Inducing Factor-1 Alpha. (Pubmed Central) - May 27, 2021
As shown by western blot analysis, HBO significantly reduced autophagy by regulating autophagy-related proteins (mTOR, p-mTOR, Atg13, LC3B II and LC3B II) in the hippocampus 72 hours after I/R, which was accompanied by inhibiting the expression of hypoxia inducible factor-1α (HIF-1α) in hippocampus. The results suggest that HBO may improve cerebral I/R injury, possibly via inhibiting HIF-1α, the upstream molecule of autophagy, and therefore, subsequently inhibiting autophagy in the rat model of ischemic stroke.
- | pentoxifylline / Generic mfg.
Journal: Pentoxifylline Can Reduce the Inflammation Caused by LPS after Inhibiting Autophagy in RAW264.7 Macrophage Cells. (Pubmed Central) - May 27, 2021
Furthermore, in RAW264.7 macrophage cells, our data indicated that AMPK signaling perhaps functioned importantly in repressed autophagy. In addition, in RAW264.7 macrophages, our data suggested that AMPK signaling might play an important role in inhibiting autophagy during the process of PTX ameliorating LPS-mediated inflammation.
- | chloroquine phosphate / Generic mfg.
Journal: Silence of circBANP increases radiosensitivity of colorectal cancer cells and inhibits growth of subcutaneous xenografts by up-regulating miR-338-3p expression (Pubmed Central) - May 27, 2021
CircBANP can regulate the radiosensitivity of colorectal cancer cells by regulating the expression of miR-338-3p, and affect the growth of transplanted tumor in nude mice. CircBANP may be a potential target for enhancing radiosensitivity of colorectal cancer cells.
- | chloroquine phosphate / Generic mfg.
Journal: Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury. (Pubmed Central) - May 26, 2021
Concomitantly, LAPTM4B mice showed higher accumulation of the autophagy markers LC3-II (microtubule-associated protein 1A/1B-light chain 3), but not P62, in the I/R heart, whereas they did not alter chloroquine-induced further increases of LC3-II and P62 in both sham and I/R hearts...The mTORC1 inhibition or TFEB-overexpression rescued the LAPTM4B-/--induced impairment in autophagic flux and I/R injury, whereas TFEB-knockdown abolished the LAPTM4B-overexpression-mediated recovery of autophagic flux and cardioprotection. The downregulation of LAPTM4B contributes to myocardial I/R-induced impairment of autophagic flux via modulation of the mTORC1/TFEB pathway.
- | Journal: Nicotinamide adenine dinucleotide treatment alleviates the symptoms of experimental autoimmune encephalomyelitis by activating autophagy and inhibiting the NLRP3 inflammasome. (Pubmed Central) - May 26, 2021
Our results indicate that NAD + suppresses the NLRP3 inflammasome at least in part through the activation of autophagy to relieve the symptoms of EAE. Therefore, regulation of autophagy by NAD + treatment may be an effective therapeutic strategy for MS.
- | Journal: Electroacupuncture Inhibits Autophagy of Neuron Cells in Postherpetic Neuralgia by Increasing the Expression of miR-223-3p. (Pubmed Central) - May 26, 2021
qRT-PCR revealed that miR-223-3p expression in the model group decreased but was increased by EA. EA inhibits neuron cell autophagy in PHN by increasing miR-223-3p expression.
- | Journal, Epigenetic controller: Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma via AMPK-FOXO1-ULK1 signaling axis-mediated autophagy. (Pubmed Central) - May 25, 2021
We demonstrated that HDIs triggers FOXO1-dependent autophagy, which ultimately promotes EMT, limiting the clinical outcome of HDI-based therapies. Our study suggests that the combination of an HDI and a FOXO1 inhibitor is an effective therapeutic strategy for the treatment of HCC.
- || Clinical, Journal: MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells. (Pubmed Central) - May 25, 2021
Administration of receptor kinase inhibitor or autophagy-inducing compounds rescues the functional defects of Maea-deficient HSCs. Our results suggest that MAEA provides E3 ubiquitin ligase activity, guarding HSC function by restricting cytokine receptor signalling via autophagy.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Hsa_circ_0092276 promotes doxorubicin resistance in breast cancer cells by regulating autophagy via miR-348/ATG7 axis. (Pubmed Central) - May 25, 2021
In conclusion, our data demonstrate that hsa_circ_0092276 promotes autophagy and DOX resistance in breast cancer by regulating miR-348/ATG7 axis. Thus, this article highlights a novel competing endogenous RNA circuitry involved in DOX resistance in breast cancer.
- | Journal: Potential cytotoxicity of silver nanoparticles: Stimulation of autophagy and mitochondrial dysfunction in cardiac cells. (Pubmed Central) - May 25, 2021
More importantly, the addition of N-acetyl-L-cysteine (NAC) inhibited autophagy and significantly reduced the cytotoxicity of AgNPs in H9c2 cells. The study highlights the prospective toxicity of AgNPs on cardiac cells, collectively signifying a potential health risk.
- | dimethyl fumarate / Generic mfg.
Journal: Anti-Inflammatory Effects of Dimethyl Fumarate in Microglia via an Autophagy Dependent Pathway. (Pubmed Central) - May 25, 2021
The anti-inflammatory effect of DMF in microglia was significantly reduced by pretreatment with autophagy inhibitors. These data suggest that DMF leads to the induction of autophagy in microglia and that its anti-inflammatory effects are partially mediated through an autophagy-dependent pathway.
- | Journal: 3-Chloro-1, 2-Propanediol inhibits autophagic flux by impairment of lysosomal function in HepG2 cells. (Pubmed Central) - May 22, 2021
These results suggested that 3-MCPD could induce the autophagic flux blockage in HepG2 cells. The possible mechanism was due to the destruction of lysosomal function.
- | Journal: The Effect of FOXC2-AS1 on White Adipocyte Browning and the Possible Regulatory Mechanism. (Pubmed Central) - May 22, 2021
The autophagy inhibitor 3-methyladenine restored the reduced UCP1 protein level and thermogenic capacity caused by inhibiting FOXC2-AS1. Overall, the present study characterized the potential role of FOXC2-AS1 and further identified a lncRNA-mediated mechanism for inducing browning of human white adipocytes and maintaining thermogenesis, further providing a potential strategy for treating obesity and related disorder.