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- | Preclinical, Journal: H2S treatment reverts cardiac hypertrophy and increases SERCA2a activity but does not fully restore cardiac Ca2+ handling in hypertensive rats. (Pubmed Central) - Apr 5, 2025
In conclusion, NaHS treatment does not appear to normalize all Ca2+ handling properties during hypertensive LVH. On the contrary, NaHS may exert an arrhythmogenic effect, likely due to enhanced SERCA2a activity under conditions of unresolved RyR2 Ca2+ hypersensitivity.
- | Journal: Superoxide anion-responsive persulfide and all-trans retinoic acid co-donating peptide assemblies attenuate myocardial ischemia-reperfusion injury. (Pubmed Central) - Apr 5, 2025
In vivo assessment of the co-assembly also displays an excellent therapeutic effect of MIRI on rats. In terms of good biocompatibility and outstanding efficacy, we believe that S/A-P will have a bright future for the treatment of cardiovascular diseases or other related diseases.
- | Journal: Aminopeptidase N-Activated Self-immolative Hydrogen Sulfide Donor for Inflammatory Response-Specific Wound Healing. (Pubmed Central) - Apr 3, 2025
By introducing a caged coumarin fluorophore to the molecular architecture, self-reporting fluorescence could be generated accompanied with APN-mediated COS/H2S release, which achieved the visualization of H2S delivery in vitro and in vivo. This work not only offers a useful tool for studying the bioactivity of H2S on inflammation, but also provides new insights for developing novel therapies to cope with inflammation-associated diseases.
- | Preclinical, Journal: Diallyl Trisulfide Attenuates Ischemia-Reperfusion-Induced ER Stress and Kidney Dysfunction in Aged Female Mice. (Pubmed Central) - Mar 30, 2025
DATS treatment upregulated PI3K, AKT, p-mTOR, and pMAPK signaling to stimulate angiogenesis, which improved vascular density, blood flow, and renal function. Together, our results suggest that DATS rescues the aged female kidney IRI by modulating ER stress and upregulation of angiogenesis.
- | Journal: Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Brain Cells. (Pubmed Central) - Mar 24, 2025
Our novel liposomal formulation encapsulating AP39 improves stability, promotes sustained release, and enhances BBB permeability while preserving antioxidant effects. These findings indicate that liposomal AP39 is a suitable therapeutic approach to further investigate in the treatment of neurodegenerative diseases.
- || Review, Journal: Therapeutic importance of hydrogen sulfide in cognitive impairment diseases. (Pubmed Central) - Mar 23, 2025
This review aims to detail the roles of H2S in various models of cognitive impairment and in human subjects, highlighting its potential mechanisms and providing experimental support for its use as a novel therapeutic approach in treating cognitive disorders. Overall, H2S plays a significant role in the treatment of cognitive impairment diseases, but further large-scale studies are still required to support the results of current research.
- | Preclinical, Journal: Multidimensional analysis of selected bioelements in rat's brain subjected to stroke procedure and treatment with H2S donor AP-39. (Pubmed Central) - Mar 23, 2025
Stroke and AP-39 treatment significantly altered bioelement concentrations. The bioelements most susceptible to changes under MCAO procedures were zinc, iron and magnesium.
- | Journal: A superoxide anion responsive and self-reporting fluorescent H2S donor for the treatment of diabetic wound. (Pubmed Central) - Mar 14, 2025
The bioelements most susceptible to changes under MCAO procedures were zinc, iron and magnesium. This H2S donor exhibits several advantages: (1) rapid response to superoxide anions (O2
- | Preclinical, Journal: Hydrogen sulfide repairs testicular damage induced by heat stress in rats. (Pubmed Central) - Mar 5, 2025
and interleukin-6, and resulted in a significant decrease in malondialdehyde levels and in increased activity of catalase and ratio of reduced/oxidized glutathione compared to the heat stress group. This study suggests that H2S donor NaHS can effectively restore testicular damage caused by heat stress in rats by inhibiting inflammation and oxidative stress.
- | Journal: Tunable Light-Activated Platform for Controlled Hydrogen Sulfide Release with Tracking. (Pubmed Central) - Mar 5, 2025
This study suggests that H2S donor NaHS can effectively restore testicular damage caused by heat stress in rats by inhibiting inflammation and oxidative stress. Furthermore, this H2S-releasing platform is suitable for
- | Journal: In Situ Slow-Release Hydrogen Sulfide Therapeutics for Advanced Disease Treatments. (Pubmed Central) - Mar 4, 2025
Remarkably, these findings closely resemble endogenous H2S levels in treating epilepsy and tumors. This innovative slow-release, in-situ H2S the rapeutic approach via hydrolysis rejuvenates the development of H2S-basedtherapeutics.
- | acetylcysteine solution / Generic mfg.
Journal: Multifunctional injectable hydrogel with self-supplied H2S release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K/Akt pathway. (Pubmed Central) - Mar 3, 2025
This study presents a multifunctional injectable hydrogel, OC@?-PL-SATO, composed of oxidized hyaluronic acid and N-acetylcysteine (NAC) as an initiator, carboxymethyl chitosan and S-aroylthiooxime modified ?-Poly-(l-lysine) (?-PL-SATO)...Importantly, the sustained generation of H2S gas significantly promotes angiogenesis and collagen deposition, ultimately accelerating the wound repair. In conclusion, this study provides a multifunctional injectable hydrogel with rapid gelatinization and continuous H2S release for accelerating the infected wound healing.
- | Journal: Endothelial endogenous CSE/H2S inhibits endothelial pyroptosis by activating sirtuin1 to attenuate LPS-induced acute lung injury. (Pubmed Central) - Mar 3, 2025
Mechanistically, H2S-mediated regulation of sirtuin-1 (SIRT1) expression and activation (via sulfhydration) contributed to the modulatory process. Collectively, we uncovered that endothelial endogenous CSE/H2S alleviates endothelial pyroptosis by activating SIRT1, thereby preventing LPS-induced acute lung injury.
- || Review, Journal: Research Progress in the Field of Hydrogen Sulfide Donors in the Last Five Years. (Pubmed Central) - Mar 3, 2025
Therefore, it is necessary to study H2S as a delivery vehicle at the cellular and in?vivo levels. This review provides an overview of advancements made over the past five years regarding H2S donors and their applications in biology, encompassing indirectly released donors of carbonyl sulfide (COS), directly released small molecule donors, Nanocomposite scaffolds, and hydrogels.
- || Review, Journal: Synthetic organic polysulfanes as H2S donors and anticancer agents. (Pubmed Central) - Feb 28, 2025
Therefore, this review aims to fill the gap by exploring the synthesis and H2S donating capacities of various synthetic organopolysulfanes and their pharmacological benefits for cancer treatment. The insights provided here will help correlate synthetic organopolysulfanes as H2S donors with their therapeutic potentials, offering a clearer perspective on their roles in drug development.
- | Journal: Synergistic Effects of NO/H2S Gases on Antibacterial, Anti-inflammatory, and Analgesic Properties in Oral Ulcers Using a Gas-Releasing Nanoplatform. (Pubmed Central) - Feb 27, 2025
Furthermore, H2S and NO synergistically promote the transformation of M1 to M2 macrophages, attenuating inflammation. Importantly, the combined action of H2S and NO alleviates pain by downregulating TRPV1 and TRPV4, supporting the restoration of normal dietary behavior and improving quality of life.
- || Review, Journal: CSE/H2S Signaling Pathways in Enhancing Muscle Function and Insulin Sensitivity During Exercise. (Pubmed Central) - Feb 26, 2025
Furthermore, the challenges and future directions in CSE/H2S research are addressed, emphasizing the need for further mechanistic studies and clinical applications. This review underscores the therapeutic potential of targeting the CSE/H2S pathway to optimize the benefits of exercise and improve metabolic health.
- | Journal: Hydrogen Sulfide Promotes TAM-M1 Polarization through Activating IRE-1? Pathway via GRP78 S-Sulfhydrylation to against Breast Cancer. (Pubmed Central) - Feb 24, 2025
Collectively, GRP78 S-sulfhydrylation mediated by H2S at the Cys420 residue decreased the tumor burden and inhibited lung metastasis of BC through reprograming TAMs via activating the IRE-1? pathway, indicating that targeting GRP78 S-sulfhydration represents a promising intervention for TAM-M1 repolarization in BC.
- | Journal: Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation. (Pubmed Central) - Feb 21, 2025
pathway, indicating that targeting GRP78 S-sulfhydration represents a promising intervention for TAM-M1 repolarization in BC. Endogenous H2S persulfidated ETAR at Cys69 to inhibit the binding of ET-1 to ETAR, subsequently suppressed PASMC proliferation, and antagonized pulmonary vascular structural remodeling.
- | Journal: S-Allyl-Cysteine Ameliorates Cirrhotic Portal Hypertension by Enhancing Lymphangiogenesis via a VEGF-C-Independent Manner. (Pubmed Central) - Feb 19, 2025
SAC significantly alleviated BDL-induced liver cirrhosis and PHT. Meanwhile, elevated H2S induced by SAC facilitated lymphangiogenesis via a VEGF-C-independent manner, which contributed to the alleviation of PHT.
- | dizocilpine (MK801) / Merck (MSD)
Journal: Hydrogen Sulfide Alleviates Schizophrenia-Like Behavior Through Regulating Apoptosis by S-Sulfhydrylation Modification. (Pubmed Central) - Feb 18, 2025
Meanwhile, elevated H2S induced by SAC facilitated lymphangiogenesis via a VEGF-C-independent manner, which contributed to the alleviation of PHT. H2S content is significantly reduced in SZ, and supplementation of H2S can alleviate SZ-like behavior by inducing S-sulfhydration of apoptotic proteins.
- | Preclinical, Journal: Hydrogen Sulfide Attenuates Sepsis-Induced Cardiac Dysfunction in Infant Rats by Inhibiting the Expression of Cold-Inducible RNA-Binding Protein. (Pubmed Central) - Feb 17, 2025
In conclusion, this study demonstrated that H2S exerted cardioprotective effects by inhibiting the CIRP/ERS pathway in infant rats with sepsis. These findings might indicate a novel target in the treatment of sepsis in infants.
- | Journal: H2S Donor SPRC Ameliorates Ischemic Stroke by Upregulating CD24. (Pubmed Central) - Feb 15, 2025
CD24 could be a potential target of inhibiting neuroinflammation. SPRC reduces inflammation in ischemic stroke by regulating the CD24/I?-B?/NF-?B inflammatory signaling pathway and improves the migration ability of M2 microglia via CD24/Src/Fak/Pyk2 signaling pathway, which further alleviates the inflammatory response at the lesion.
- | Journal: Transient Receptor Potential Ankyrin 1 (TRPA1) Mediates Hydrogen Sulfide-induced Ca2+ Entry and Nitric Oxide Production in Human Cerebrovascular Endothelium. (Pubmed Central) - Feb 14, 2025
These findings demonstrate for the time that H2S stimulates TRPA1 to induce NO production in human brain microvascular endothelial cells. Additionally, they show that this signaling pathway can be recruited by an endothelial agonist to modulate NO-dependent events at the human neurovascular unit.
- | GYY4137 / National University of Singapore
Journal: An Enhanced Osseointegration of Titanium Implants by H2S Sustained-Release Coating via Promoting Osteogenesis and Inhibiting Osteoclastogenesis. (Pubmed Central) - Feb 12, 2025
The coating consists of bovine serum albumin nanoparticles encapsulating the H2S donor morpholin-4-ium(4-methoxyphenyl)-morpholin-4-ylsulfanylidenesulfido-?5-phosphane (GYY4137), which is prepared with the participation of dopamine self-polymerization...The coating restores the bone homeostasis imbalance surrounding the functionalized titanium implants in the femurs of osteoporotic rats, thereby accelerating new bone formation and enhancing the osseointegration capability of the implants. This work provides a practical strategy for the development of titanium implants suitable for osteoporosis patients.
- | acetylcysteine solution / Generic mfg.
Journal: Mitigation of depleted uranium-induced mitochondrial damage by ethylmalonic encephalopathy 1 protein via modulation of hydrogen sulfide and glutathione pathways. (Pubmed Central) - Feb 12, 2025
When the H2S donor sodium hydrosulfide and GSH precursor N-acetylcysteine were used to treat animals or cells, cellular ATP levels were increased, oxidative stress markers were reduced, and kidney damage was mitigated...These findings suggest that the ETHE1/H2S/GSH pathway plays a critical role in mediating DU-induced mitochondrial dysfunction in renal cells, highlighting potential therapeutic targets for mitigating the harmful effects of DU. Thus, this study expands our understanding of DU-induced renal damage pathways, providing avenues for further research and intervention strategies.
- | Preclinical, Journal: AP39, a novel mitochondria-targeted hydrogen sulfide donor, promotes cutaneous wound healing in an in vivo murine model of acute frostbite injury. (Pubmed Central) - Feb 6, 2025
Thus, this study expands our understanding of DU-induced renal damage pathways, providing avenues for further research and intervention strategies. While 200?nM AP39 improved granulation tissue maturation (p?<?0.001), angiogenesis (p?<?0.01) and cell proliferation (p?<?0.001) compared to vehicle control, 1?
- | metformin / Generic mfg.
Preclinical, Journal: Novel mechanistic insights of the potential role of gasotransmitters and autophagy in the protective effect of metformin against hepatic ischemia/reperfusion injury in rats. (Pubmed Central) - Feb 6, 2025
These findings reveal, for the first time, that increasing CO, H2S, and autophagy levels with subsequent decreasing NO level play a critical role in metformin's protective action against hepatic I/RI. The ability of L-NAME, CORM-A1, NaHS, and RAPA to boost metformin's protective effect in hepatic I/RI may positively be attributed to their ability to lower hepatic oxidative stress, nitrosative stress, inflammation, and apoptosis.
- | Journal: Design and synthesis of phenylthiophosphoryl dichloride derivatives and evaluation of their antitumour and anti-inflammatory activities. (Pubmed Central) - Feb 5, 2025
In addition, compound S11 exhibited a potent anti-inflammatory effect on macrophages, effectively reducing the levels of inflammatory mediators TNF-?, IL-10 and HO-1. Compound S11 can be used as a new chemical entity for the discovery of new anti-cancer drugs or anti-inflammatory drugs.
- | Journal: Hydrogen sulfide-generating semiconducting polymer nanoparticles for amplified radiodynamic-ferroptosis therapy of orthotopic glioblastoma. (Pubmed Central) - Feb 3, 2025
This kind of amplified radiodynamic-ferroptosis therapeutic strategy could remarkably inhibit glioma progression in an orthotopic GBM mouse model. Our study demonstrates the potential of PFeD@Ang for GBM treatment via targeted delivery and combinational therapeutic actions of RDT and ferroptosis therapy.
- doxorubicin hydrochloride / Generic mfg.
EVALUATION OF TISSUE LIPID PROFILES IN A MOUSE MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY COMPLICATED BY HYPERTENSION - Mallika Datta (Moderated Poster Theater 5) - Jan 27, 2025 - Abstract #ACC2025ACC_6072;
Inverse relationships between cardiac sphingomyelins and ceramides were observed in cardiac injury. Plasma ceramide and sphingolipid levels may predict adverse cardiac outcomes, as indicated by significant correlations between cardiac function and lipidomic data.
- | Journal: ASB1 engages with ELOB to facilitate SQOR ubiquitination and H2S homeostasis during spermiogenesis. (Pubmed Central) - Jan 15, 2025
This process is crucial for preserving H2S homeostasis and redox balance. Overall, our findings offer valuable insights into the role of ASB1 during spermiogenesis and propose H2S supplementation as a promising therapeutic approach for oxidative stress-related male infertility.
- | Journal: Hydrogen sulfide attenuates disturbed flow-induced vascular remodeling by inhibiting LDHB-mediated autophagic flux. (Pubmed Central) - Jan 15, 2025
These data identify a molecular mechanism by which H2S attenuates DF-induced vascular remodeling by inhibiting LDHB and disrupting the interaction between LDHB and ATP6V1A, thereby impeding the autophagy process. Our findings provide insight that H2S or targeting LDHB has therapeutic potential for preventing and treating vascular remodeling.
- || Review, Journal: Application of hydrogen sulfide donor conjugates in different diseases. (Pubmed Central) - Jan 13, 2025
In this article, H2S donor conjugates will be reviewed and classified according to different diseases, such as inflammation, cardiovascular and cerebrovascular diseases, diseases of central nervous system and cancer. This review aims to provide an idea for researchers for further study of H2S and H2S donor conjugates.
- || Review, Journal: Critical role of hydrogen sulfide in the management of neurodegenerative disease. (Pubmed Central) - Jan 13, 2025
Some studies have revealed that treatment with H2S donors has improved neuronal damage, restored memory and cognition in animal models. In this review, we have discussed the role of H2S donors as neuroprotective agents with examples of some of the natural and synthetic H2S donors, and also briefly enumerated the molecules used to detect H2S in neurodegenerative diseases.
- | Journal: Gas-Releasing Polymer Tubesomes: Boosting Gas Delivery of Nanovehicles via Membrane Stretching. (Pubmed Central) - Jan 12, 2025
More importantly, it is demonstrated that the tubesomes as polymer-type H2S donors have better anticancer performance than those spherical polymersomes. This would inspire new possibilities to boost gas therapeutic efficacy through shaping the morphology of gas nanovehicles.
- | Journal: UW supplementation with AP39 improves liver viability following static cold storage. (Pubmed Central) - Jan 12, 2025
Additionally, bile production and glucose, as well as energy charge were improved by the addition of AP39. These results indicate that AP39 supplementation improves liver viability during static cold storage.
- | Journal: A microenvironment-adaptive GelMA-ODex@RRHD hydrogel for responsive release of H2S in promoted chronic diabetic wound repair. (Pubmed Central) - Jan 12, 2025
This enhancement resulted in the skin quality being more similar to normal skin during the wound healing process. By aligning therapeutic delivery with the natural healing process, this approach offers a promising pathway toward more effective and personalized treatments for chronic diabetic wounds.
- | GYY4137 / National University of Singapore
Journal: GYY4137 protects against type 2 diabetes mellitus-associated myocardial autophagy by suppressing FOXO1 signal pathway. (Pubmed Central) - Jan 12, 2025
AS1842856 displayed a notable capacity to shield cardiomyocytes against diabetes-induced injury similar to that achieved by GYY4137. GYY4137 protected against cardiac dysfunction and fibrosis in T2DM mice, and the mechanism might involve suppression of FOXO1-induced autophagy.
- | Journal: Hydrogen sulfide improved learning and memory deficits by reversing the inhibition of methylmercuric chloride on BDNF/TrkB signaling pathway. (Pubmed Central) - Dec 29, 2024
GYY4137 protected against cardiac dysfunction and fibrosis in T2DM mice, and the mechanism might involve suppression of FOXO1-induced autophagy. Our findings demonstrated that H2S ameliorated learning memory deficits in mice by reversing the inhibitory effects of MMC on BDNF/TrkB signaling pathway.
- | Journal: Delivery of small interfering RNA by hydrogen sulfide-releasing nanomotor for the treatment of Parkinson's disease. (Pubmed Central) - Dec 21, 2024
PCM@siRNA that reached neuronal cells can not only be utilized to play the role of silencing the ?-syn gene to inhibit the formation of ?-syn aggregates by siRNA, but also to degrade the formed ?-syn aggregates by using the H2S produced by its chemotaxis process to achieve an effective treatment for PD. This therapeutic modality, which can simultaneously inhibit the formation of ?-syn aggregates and promote their degradation, has the therapeutic potential to reverse the pathological state of ?-syn, which is important for the treatment of PD.
- | Journal: Sulfhydrylation of chlorothalonil in pak choi from cultivation to sample analysis and exposure risk assessment. (Pubmed Central) - Dec 21, 2024
The consumption of 4-SH-CHT in several tissue-destroyed pak choi samples was higher than the threshold level. This study provides valuable information for further comprehensive safety evaluations of CHT in sulfur-rich vegetables and related foods.
- | Journal: A cysteine-activated fluorescent H2S donor for visualizing H2S release and alleviating cellular inflammation. (Pubmed Central) - Dec 19, 2024
Bcy-NCS selectively responds to Cys, releases H2S, and enables fluorescence-based monitoring. It also reduces LPS-induced inflammation in RAW 264.7 cells, indicating potential for inflammation treatment.
- | Preclinical, Journal, IO biomarker: Protective effect of hydrogen sulfide on intestinal ischemia/reperfusion injury in rats by regulating c-Jun N-terminal kinase/activator protein-1 signaling pathway (Pubmed Central) - Dec 19, 2024
It also reduces LPS-induced inflammation in RAW 264.7 cells, indicating potential for inflammation treatment. H2S exerts a protective effect on intestinal I/R injury in rats by down-regulate the expression of the JNK/AP-1 signaling pathway, as well as reducing oxidative stress levels.
- | Preclinical, Journal: Therapeutic Efficacy of a Synthetic Brain-Targeted H2S Donor Cross-Linked Nanomicelle in Autism Spectrum Disorder Rats through Aerobic Glycolysis. (Pubmed Central) - Dec 18, 2024
These findings suggest a connection between ASD deficits and the dysregulation of astrocytic aerobic glycolysis, underscoring the role of H2S. Identifying the Aldh3b1 gene within aerobic glycolysis pathways provides a promising target for ASD treatment.
- | ibuprofen / Generic mfg.
Journal: Sequential Release of Ibuprofen and the Gasotransmitter Hydrogen sulfide using Oxanorbornane-based Synthetic Lipids as Carriers. (Pubmed Central) - Dec 13, 2024
In this regard, this report presents a novel drug delivery system from oxanorbornane-based synthetic lipids that carries a H2S-releasing 1,2-dithiole-3-thione moiety as part of the head group. Nanoaggregates of the resulting conjugate are not only capable of efficiently entrapping a non-steroidal anti-inflammatory drug such as ibuprofen, but also release this drug and H2S in a controlled and sequential manner.
- | Journal: The emerging roles of hydrogen sulfide in ferroptosis. (Pubmed Central) - Dec 12, 2024
Nanoaggregates of the resulting conjugate are not only capable of efficiently entrapping a non-steroidal anti-inflammatory drug such as ibuprofen, but also release this drug and H2S in a controlled and sequential manner. Discovering more reliable and stable novel H2S donors and achieving their targeted delivery will enable further clinical trials for diseases associated with ferroptosis inhibition by H2S, determining their safety, efficacy, and tolerance.
- | Journal: A fluorogenic ROS-triggered hydrogen sulfide donor for alleviating cerebral ischemia-reperfusion injury. (Pubmed Central) - Dec 11, 2024
This compound has demonstrated protective effects against cerebral ischemia-reperfusion (I/R) injury and contributes to the reconstruction of brain structure and function in a rat stroke model (tMCAO/R). As a ROS-responsive, self-reporting, and fluorescent H2S donor, HSDF-NH2 holds considerable promise for the treatment of ischemic diseases beyond stroke.
- | Journal: LIFU-unlocked endogenous H2S generation for enhancing atherosclerosis-specific gas-enzymatic therapy. (Pubmed Central) - Dec 7, 2024
Moreover, the high level of reactive oxygen species in the inflammatory microenvironment of the plaque was mitigated. Overall, LyP-1Lip@HS provides a specific and controlled treatment to prevent oxidative stress, inflammation and lipid metabolism disorders, making it a candidate for AS treatment.
- || Preclinical, Review, Journal: Hydrogen sulfide protects the endometrium in a rat model of type 1 diabetes via modulation of PPAR?/mTOR and Nrf-2/NF-?b pathways. (Pubmed Central) - Dec 3, 2024
NaHS administration reversed the previous conditions while PAG administration got them worse. We concluded that H2S prevented endometrial overgrowth in a rat model of type 1 diabetes through modulation of PPAR?/mTOR and Nrf-2/NF-?B pathways.