- |||||||||| Effect of hydrogen sulfide on the vascular dysfunction induced by severe traumatic brain injury in rats (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_11682;
1 mg/kg; i. p. , every 24 h for seven days) reversed TBI-induced vascular dysfunction by restoring carbachol-dependent vasorelaxation and norepinephrine-induced vasoconstriction with no effect on the body weight or sensorimotor impairments. These results suggest the use of NaHS as a possible treatment to reverse post-TBI vascular dysfunction.
- |||||||||| Journal: Hydrogen sulfide donor activates AKT-eNOS signaling and promotes lymphatic vessel formation. (Pubmed Central) - Oct 30, 2023
The results of in vivo Matrigel plug assay revealed increased lymphatic vessel density in Matrigel plugs containing NaHS compared with control plugs, however, no significant differences in angiogenesis and immune cell infiltration were observed. Collectively, these findings suggest that H2S donor NaHS promotes lymphatic vessel formation both in vitro and in vivo and may be utilized to promote reparative lymphangiogenesis to alleviate lymphatic dysfunction-related disorders.
- |||||||||| Biomarker, Journal, Tumor microenvironment: Hydrogen sulfide signaling in the tumor microenvironment: implications in cancer progression and therapy. (Pubmed Central) - Aug 19, 2023
Given the complexity and heterogeneity of tumor composition, mechanistic studies on context-dependent pharmacological effects of H2S donors for cancer therapy are necessary. These studies must determine the critical signaling pathways and the cellular components involved to allow advances in the rational use of H2S donors as antineoplastic agents.
- |||||||||| sodium polysulthionate (SG1002) / Sulfagenix
Hydrogen Sulfide Attenuates Duchenne Cardiomyopathy via Suppression of Sterile Inflammation (Zone 1, Science and Technology Hall, Level 2) - Aug 12, 2023 - Abstract #AHA2023AHA_5438;
These studies must determine the critical signaling pathways and the cellular components involved to allow advances in the rational use of H2S donors as antineoplastic agents. Our results demonstrate that early treatment with SG1002 preserves cardiac function in a mouse model of DMD and suggest a potential therapeutic role of NLRP3 inflammasome suppression as a protective strategy in DMD.
- |||||||||| Journal: Diet as a source of hydrogen sulfide and its effects on health and disease (Pubmed Central) - Jul 31, 2023
Currently, the role of S2H is well known as brain and cardiac protector, and its research as a therapeutic adjuvant in metabolic diseases such as obesity and type-2 diabetes is becoming increasingly important. The objective of this review is to examine how the contribution of donors and precursors of hydrogen sulfide by the diet impacts health and disease.
- |||||||||| GYY4137 / National University of Singapore
Intestinal production of H2S and its regulation of GLP-2 (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_144;
These findings suggest that GLP-2 may play a role in the interplay between H2S and gastric health. These results could provide support for the potential use of H2S drugs in the treatment of GI diseases.
- |||||||||| GYY4137 / National University of Singapore
Targeting Glutathione and Ferroptosis With Hydrogen Sulfide Alleviates Effects of Oxygen on Developing ASM (Marriott Marquis Washington, Marquis Ballroom, Salons 9-10 (Level M2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3112;
Our data suggest O2 detrimentally impacts already immature antioxidant systems and increases ferroptosis in developing ASM and that exogenous H2S alleviates detrimental effects of hyperoxia on glutathione, ferroptosis, and developing airway structure/function. These studies are supported by an American Heart Association Postdoctoral Fellowship 20POST35210002 (Bartman), NIH R01 HL 056470 (Prakash), and HL 138402 (Pabelick).
- |||||||||| Journal: Mitochondrial H2S donor AP39 induces stomatal closure by modulating guard cell mitochondrial activity. (Pubmed Central) - Mar 21, 2023
By using fluorescent probes and genetically-encoded biosensors we reported that AP39 hyperpolarized the mitochondrial inner potential (?m) and increased cytosolic ATP, cytosolic hydrogen peroxide levels, and oxidation of the glutathione pool in guard cells. These findings showed that mitochondrial-targeted H2S donors induce stomatal closure, modulate guard cell mitochondrial ETC activity, the cytosolic energetic and oxidative status, pointing to an interplay between mitochondrial H2S, mitochondrial activity, and stomatal closure.
- |||||||||| H2S donors as radiosensitizers for glioblastoma multiforme (GBM) (Section 19; Poster Board #27) - Mar 14, 2023 - Abstract #AACR2023AACR_5059;
We hypothesize that this attempted BER via simultaneous strand cleavage by AP endonuclease (Ape1) or glycosylase (Ogg1) may lead to build up of repair intermediates, threatening genomic stability and inducing DSB. Pursuing specific DNA repair biochemical assays is required to further understand this effect of DATS on DNA damage and repair inhibition.
- |||||||||| Journal, IO biomarker: Hydrogen sulfide alleviates lipopolysaccharide -induced myocardial injury through TLR4-NLRP3 pathway. (Pubmed Central) - Mar 11, 2023
Furthermore, NaHS did not further improve cardiac function and inflammation in TLR4-/- mice or mice in which NLRP3 activation was inhibited by MCC950, after LPS injection. In conclusion, these findings imply that decreased endogenous H2S promotes the progression of SIMD, whereas exogenous H2S alleviates SIMD by inhibiting inflammation via the TLR4-NLRP3 pathway suppression.
- |||||||||| Review, Journal: Recent development of hydrogen sulfide-releasing biomaterials as novel therapies: a narrative review. (Pubmed Central) - Feb 27, 2023
In this review, we highlight recent research works concerning the development and application of HS-releasing biomaterials with a special emphasis to different release triggering conditions in in vivo studies. We believe that the further exploration of the molecular mechanisms underlying HS donors and their function when incorporated with various biomaterials will potentially help us understand the pathophysiological mechanisms of different diseases and assist the development of HS-based therapies.
- |||||||||| Enhancing enzyme-triggered H2S-induced cytotoxicity in glioma via a supramolecular peptide-iron material (Discovery A (Hyatt Regency Indianapolis)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_3828;
Furthermore, the peptide-iron complex was examined in a C6 glioma cell line, exhibiting an improved cell-killing effect by inducing toxic hydroxyl radical (OH) via a Fenton reaction. We hope this peptide-metal material will provide a novel gas-amplified, enzyme-responsive therapeutic platform for synergistic cancer treatment in the future.
- |||||||||| Journal: Hydrogen Sulfide (H2S): As A Potent Modulator And Therapeutic Prodrug In Cancer. (Pubmed Central) - Jan 28, 2023
Finally, we describe the most recent preclinical applications focused on assessing the anti-cancer impact of most common H2S-releasing compounds. While the evidence in favour of H2S as an alternative cancer therapy in the field of translational medicine is yet to be clearly provided, application of H2S is emerging as potent anticancer therapies in preclinical trails.
- |||||||||| Review, Journal: Research Progress of HS Donors Conjugate Drugs Based on ADTOH. (Pubmed Central) - Jan 9, 2023
ADTOH and parent drug hybrids have become one of the important strategies for the development of HS donor conjugate drugs. This review summarizes molecular hybrids between ADTOH and clinical drugs to provide new ideas for the study of HS donor drug design.
- |||||||||| Review, Journal: Hydrogen sulfide as a therapeutic option for the treatment of Duchenne muscular dystrophy and other muscle-related diseases. (Pubmed Central) - Nov 29, 2022
Taking into account a wide range of physiological functions of HS and recent literature data on its possible protective role in DMD, we focused on the description of the 'old' and 'new' functions of HS, especially in muscle pathophysiology. Although the number of studies showing its essential regulatory action in dystrophic muscles is still limited, we propose that HS-based therapy has the potential to attenuate the progression of DMD and other muscle-related disorders.
- |||||||||| betaxolol hydrochloride / Generic mfg.
Journal: Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and HS Donors. (Pubmed Central) - Nov 27, 2022
Brinzolamide, betaxolol and brimonidine were linked to different HS donors...Experimental data showed that compounds 1c, 1d and 3d were the hybrids with the best properties, characterized by a significant and long-lasting production of the gasotransmitter both in the aqueous solution (in the presence of L-cysteine) and in the intracellular environment. Because, to date, the donation of HS by antiglaucoma HS donor hybrids using non-immortalized corneal cells has never been reported, these results pave the way to further investigation of the potential efficacy of the newly synthesized compounds.
- |||||||||| Journal: Intramolecular Thiol- and Selenol-Assisted Delivery of Hydrogen Sulfide. (Pubmed Central) - Nov 3, 2022
Herein, we report that H2S release from this valuable class of donors can be markedly enhanced through intramolecular nucleophilic assistance. Specifically, we demonstrate that both disulfide- and diselenide-linked thioamides are responsive to biologically relevant concentrations of glutathione and release two molar equivalents of H2S via an intramolecular cyclization that significantly augments their rate and efficiency of sulfide delivery in both buffer and live human cells.
- |||||||||| Review, Journal: Hydrogen Sulfide and Its Donors: Keys to Unlock the Chains of Nonalcoholic Fatty Liver Disease. (Pubmed Central) - Oct 28, 2022
Therefore, exogenous delivery of HS is conducive to probe the physiological and pathological roles of this gas in cellular and animal studies. In this review, the production and metabolic pathways of HS in vivo, the types of donors currently used for HS release, and study evidence of HS improvement effects on nonalcoholic fatty liver disease are systematically introduced.
- |||||||||| Effect of hydrogen sulfide on vascular dysfunction induced by type 2 Diabetes Mellitus in rat thoracic aorta (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_8869;
On the other hand, the treatment with DL-PAG did not affect the relaxant responses to Ang-1-7 or contractile responses to Ang II compared to the vehicle. These results suggest that chronic treatment with NaHS improved vascular dysfunction produced by streptozotocin-induced type 2 Diabetes Mellitus and may have a potential therapeutic application.
- |||||||||| Hydrogen sulfide improves vascular dysfunction induced by chronic stress restraint in rats (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_5961;
On the other hand, NaHS improved the vasorelaxation induced by CCh and SNP in the mesenteric artery. These findings suggest that NaHS reverted the chronic stress restraint-induced vascular dysfunction and may be used as a therapeutic option for the treatment of the cardiovascular alterations induced by chronic stress.
- |||||||||| Journal: Exogenous hydrogen sulfide mediates Na+ and K+ fluxes of salt gland in salt-secreting mangrove plant Avicennia marina. (Pubmed Central) - Sep 14, 2022
qRT-PCR analysis revealed that NaHS significantly increased the genes transcript levels of tonoplast Na+/H+ antiporter (NHX1), plasma membrane Na+/H+ antiporter (SOS1), plasma membrane H+-ATPase (AHA1), and tonoplast H+-ATPase subunit c (VHA-c1), while suppressed above-mentioned gene expressions by the application of HT and PAG. Overall, H2S promotes Na+ secretion from the salt glands of A. marina by up-regulating the plasma membrane and tonoplast Na+/H+ antiporter and H+-ATPase.
- |||||||||| Review, Journal: Progress and perspective on hydrogen sulfide donors and their biomedical applications. (Pubmed Central) - Aug 11, 2022
Finally, several critical challenges encountered in the development of multifunctional H S donors are discussed, and the direction of their future development as well as their biomedical applications is proposed. We expect that this review will reach extensive audiences across multiple disciplines and promote the innovation of H S biomedicine.
- |||||||||| GYY4137 / National University of Singapore
Journal: Hydrogen Sulfide Donor GYY4137 Rescues NRF2 Activation in Respiratory Syncytial Virus Infection. (Pubmed Central) - Jul 29, 2022
We found that treatment with the HS donor GYY4137 significantly increased NRF2 levels and AOEs gene expression by decreasing KEAP1 levels, and by modulating pathways involved in RSV-induced NRF2 degradation, such as NRF2 ubiquitination, and promyelocytic leukemia (PML) protein levels. These results suggest that the administration of exogenous HS can positively impact the altered redox balance associated with RSV infection, which represents an important determinant of RSV-induced lung disease.
- |||||||||| Clinical, Journal: Efficacy of Covexir® (Ferula foetida oleo-gum) treatment in symptomatic improvement of patients with mild to moderate COVID-19: A randomized, double-blind, placebo-controlled trial. (Pubmed Central) - Jul 28, 2022
Furthermore, on days 3 and 7, statistically significant differences were observed in myalgia, anorexia, anosmia, and sense of taste severity between two groups. Our findings revealed that Covexir® was very safe in the treatment of COVID-19 patients with mild to moderate symptoms and it can be recommended to improve clinical presentations of patients with COVID-19 such as cough, shortness of breath, myalgia, anorexia, anosmia, and sense of taste.
- |||||||||| GYY4137 / National University of Singapore
INHIBITORY EFFECT OF PHARMACOLOGICALLY-DERIVED OR ENDOGENOUSLY PRODUCED HYDROGEN SULFIDE (H2S) ON THE DEVELOPMENT OF BARRETT’S METAPLASIA THROUGH IL-1Β/COX-2/PGE2 PATHWAY LOOP (Poster Stage 4) - Jul 20, 2022 - Abstract #UEGW2022UEGW_1554;
Aims & Here, we explored the therapeutic potential of slow (GYY4137) and rapid (NaHS) H2S donors and the effect of CTH/CBS knock-out (-/-) by CRISPR/Cas9 technique in esophageal metaplasia development using anin vitromodel based on the human-derived esophageal (EPC2) cell line, as well as a surgicalin vivoBE model.Human EPC2 cells were pre-treated with an acidified bile mixture (BM), to mimic a BE- molecular profile and were treated with 100μM NaHS, GYY4137 and CTH/CBS inhibitors (PAG and AOAA, respectively)... We conclude that endogenous H2S or H2S-prodrugs may inhibit BE development and its further progression due to downregulation of overexpressed proinflammatory cytokine IL-1βand COX-2 together with a decrease in PGE2. [Funding: National Science Centre, Poland (UMO-2016/23/D/NZ4/01913)]
- |||||||||| Journal: Gaseotransmitters Modulate Inspiratory Drive from the Hypoglossal Nucleus. (Pubmed Central) - May 14, 2022
Furthermore, L-PAG mitigated transmission failures and increased the magnitude of inspiratory drive currents in XIIn neurons in HO-2 mice. These findings demonstrate that HO-2 and CSE regulate inspiratory drive from XIIn and suggest potential role for gaseotransmitters in regulating upper airway tone.
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