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- NAD(P)H QUINONE OXIDOREDUCTASE 1 (NQO1) PREVENTS GASTROINTESTINAL EPITHELIUM AGAINST REDOX IMBALANCE AS A MOLECULAR TARGET OF ENDOGENOUS HYDROGEN SULFIDE (H2S)-SIGNALING AND NOVEL OXIDATION-SENSITIVE H2S-PRODRUGS (Poster Stage 6) - Jul 18, 2024 - Abstract #UEGW2024UEGW_2117;
NQO1 and its persulfidation could be also considered as an early biomarker of BE development. NQO1 activity in gastric mucosa depends on the H2S-bioavailability.
- || Review, Journal: Pills of Multi-Target H2S Donating Molecules for Complex Diseases. (Pubmed Central) - Jul 13, 2024
By incorporating an H2S donor moiety into a native drug, researchers have been able to simultaneously target multiple therapeutic pathways, resulting in improved treatment outcomes. This review gives the reader some pills of successful multi-target H2S-donating molecules as worthwhile tools to combat the multifactorial nature of complex disorders, such as inflammatory-based diseases and cancer, as well as cardiovascular, metabolic, and neurodegenerative disorders.
- | hydroxocobalamin (vit B12) / Generic mfg.
Journal: Hydrogen Sulfide Promotes Platelet Autophagy via PDGFR-?/PI3K/Akt Signaling in Cirrhotic Thrombocytopenia. (Pubmed Central) - Jul 12, 2024
inhibitor)...Diminished platelet autophagy potentially contributes to thrombocytopenia in cirrhotic patients. H2S modulates platelet autophagy and functions possibly via the PDGFR-?/PI3K/Akt/mTOR signaling pathway.
- | Journal: Biofilm microenvironment-activated multimodal therapy nanoplatform for effective anti-bacterial treatment and wound healing. (Pubmed Central) - Jul 11, 2024
Furthermore, both H2S and Cu2+ could modulate M2 macrophages polarization and regulate immune microenvironment dynamics. These strategies collectively provide a novel approach for developing antibacterial nanomedical platforms.
- | sodium polysulthionate (SG1002) / Sulfagenix
Journal: Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction. (Pubmed Central) - Jul 10, 2024
Follow-up SG1002 monotherapy studies inferred an improved phenotype with combination therapy beyond either monotherapy. These data demonstrate the differing effects of SGLT2i and H2S therapy while also revealing the superior efficacy of the combination therapy in cardiometabolic HFpEF.
- | Journal: Transdermal Hydrogen Sulfide Delivery Enabled by Open-Metal-Site Metal-Organic Frameworks. (Pubmed Central) - Jul 5, 2024
Not only is this significantly longer than sodium sulfide but this represents the first example of controlled transdermal delivery of pure H2S gas. Overall, H2S-loaded Mg2(dobdc) is an easily accessible, solid-state source of H2S, enabling safe storage and transdermal delivery of this therapeutically relevant gas.
- | Journal: The hydrogen sulfide donor 4-carboxyphenyl-isothiocyanate decreases blood pressure and promotes cardioprotective effect through reduction of oxidative stress and nuclear factor kappa B/matrix metalloproteinase (MMP)-2 axis in hypertension. (Pubmed Central) - Jul 1, 2024
Overall, H2S-loaded Mg2(dobdc) is an easily accessible, solid-state source of H2S, enabling safe storage and transdermal delivery of this therapeutically relevant gas. H2S is a mediator that promotes cardioprotective effects and decreases blood pressure, and 4-CPI seems to be a good candidate to reverse the maladaptive remodeling and cardiac dysfunction in renovascular hypertension.
- | GYY4137 / National University of Singapore
Preclinical, Journal: H2S Donor GYY4137 Mitigates sFlt-1-Induced Hypertension and Vascular Dysfunction in Pregnant Rats. (Pubmed Central) - Jun 28, 2024
Replenishing H2S with the donor GYY4137 mitigates hypertension and improves vascular function and fetal growth outcomes. This suggests modulation of H2S could offer a novel therapeutic strategy for managing gestational hypertension and adverse fetal effects.
- | Journal: Hydrogen sulfide mitigates ox?LDL?induced NLRP3/caspase?1/GSDMD dependent macrophage pyroptosis by S?sulfhydrating caspase?1. (Pubmed Central) - Jun 14, 2024
Conversely, NaHS increased S?sulfhydration of pro?caspase?1, reducing caspase?1 activity and caspase?1?dependent macrophage pyroptosis. The present study demonstrated the molecular mechanism by which H2S ameliorates macrophage pyroptosis by suppressing the pyroptosis signaling pathway and S?sulfhydration of pro?caspase?1, thereby suppressing the generation of active caspase-1 and activity of caspase-1.
- || Review, Journal: Exploring the impact of hydrogen sulfide on hematologic malignancies: A review. (Pubmed Central) - Jun 11, 2024
Furthermore, we systematically examine their impact on pivotal aspects, encompassing hematologic malignancies' cellular proliferation, invasion, and migration capacities. Therefore, this review may contribute novel insights to our understanding of the prospective therapeutic significance of H2S and its donors within the realm of hematologic malignancies.
- | Journal: Application of Quality by Design in the Development of Hydrogen Sulfide Donor Loaded Polymeric Microparticles. (Pubmed Central) - Jun 8, 2024
Finally, the target product performance was validated by comparing predicted and experimental outcomes. The QbD approach helped in achieving overall desired microparticle characteristics with fewer trials and provided a mathematical relationship between the CPPs and the CQAs useful for further manipulation and optimization of release profile up to at least 30
- | GYY4137 / National University of Singapore
Preclinical, Journal: Supplementation of sperm cryopreservation media with H2S donors enhances sperm quality, reduces oxidative stress, and improves in vitro fertilization outcomes. (Pubmed Central) - May 30, 2024
Finally, we found that supplementation of the extender with NaHS and GYY4137 enhanced IVF outcomes in terms of blastocyst rate and quality of blastocysts. Our results suggest that both donors can be applied for cryopreservation as antioxidants to improve sperm quality and IVF outcomes of frozen-thawed goat sperm.
- || Retrospective data, Review, Journal: The role of exogenous hydrogen sulfide in mitigating cadmium toxicity in plants: A comprehensive meta-analysis. (Pubmed Central) - May 15, 2024
Notably, NaHS concentrations exceeding 200 ?M may adversely affect plants. Overall, our study underscores the role of exogenous H2S in mitigating Cd toxicity and elucidates its mechanism, providing insights for utilizing H2S to combat Cd pollution in agriculture.
- | Journal: Recent Developments On Activatable Turn-On Fluorogenic Donors of Hydrogen Sulfide (H2S). (Pubmed Central) - May 15, 2024
Interestingly, the fluorogenic H2S donors offer additional advantages with the non-invasive real-time monitoring of the H2S release utilizing the simultaneous turn-on fluorogenic processes. The review summarizes the recent developments in turn-on fluorogenic donors of H2S and the potential biological applications that have developed over the years.
- | nitroprusside / Generic mfg.
Journal: Synergistic regulation of hydrogen sulfide and nitric oxide on biochemical components, exopolysaccharides, and nitrogen metabolism in nickel stressed rice field cyanobacteria. (Pubmed Central) - May 9, 2024
The review summarizes the recent developments in turn-on fluorogenic donors of H2S and the potential biological applications that have developed over the years. Nonetheless, the adverse impact of Ni can be mitigated through the exogenous supplementation of NaHS [sodium hydrosulfide (8
- | dizocilpine (MK801) / Merck (MSD)
Journal: Decreased levels of hydrogen sulfide in the hypothalamic paraventricular nucleus contribute to sympathetic hyperactivity induced by cerebral infarction. (Pubmed Central) - May 6, 2024
The inhibition of NMDAR by MK-801 microinjected in PVN of rats with MCAO also could lower blood pressure and renal sympathetic discharge...Decreased levels of H2S in PVN were involved in regulating sympathetic efferent activity after cerebral infarction. Our results might provide a new strategy and target for the prevention and treatment of PSH.
- UW Supplementation with AP39 Improves Liver Viability Following Static Cold Storage (Poster Hall, Exhibit Hall A, Level 2) - May 6, 2024 - Abstract #ATC2024ATC_482;
Furthermore, AP39 was associated with better bile production and markers of bile quality, suggesting that cholangiocytes may also be better protected, as well as endothelial cells and hepatocytes. Histologic examination and molecular analysis are underway to confirm and elucidate the mechanisms underlying these observations.
- | Journal: H2S is involved in drought-mediated stomatal closure through PLD?1 in Arabidopsis. (Pubmed Central) - May 4, 2024
qRT-PCR analysis of stomatal movement-related genes showed that the expression of CAX1, ABCG5, SCAB1, and SLAC1 genes in pld?1 and lcd were down-regulated, while ACA1 and OST1 gene expression was significantly up-regulated. Thus, PLD?1 and LCD are required for stomatal closure to improve drought stress tolerance.
- | Journal: Neuromodulator hydrogen sulfide attenuates sickness behavior induced by lipopolysaccharide. (Pubmed Central) - Apr 8, 2024
These findings were reinforced by a lack of effect on plasma interleukin levels but significant reduction in GFAP expression. Our findings support the central role of H2S in modulating neuroinflammation and sickness behavior, highlighting the therapeutic potential of targeting H2S signaling in neuroinflammatory conditions.
- | Miostat (carbachol) / Novartis
Journal: NaHS reverts chronic stress-induced cardiovascular alterations by reducing oxidative stress. (Pubmed Central) - Apr 8, 2024
In addition, NaHS treatment increased relative adrenal gland weight and the GSH2/GSSG ratio. Taken together, our results demonstrate that NaHS alleviates CRS-induced hypertension by reducing oxidative stress and restoring vascular function in the thoracic aorta.
- | doxorubicin hydrochloride / Generic mfg.
Journal: AP39, a novel mitochondria-targeted hydrogen sulfide donor ameliorates doxorubicin-induced cardiotoxicity by regulating the AMPK/UCP2 pathway. (Pubmed Central) - Apr 7, 2024
Furthermore, the protective effect of AP39 was significantly attenuated by the inhibition of AMPK and UCP2. The results suggest that AP39 ameliorates DOX-induced cardiotoxicity by regulating the expression of AMPK/UCP2.
- | Preclinical, Journal: An Expanded Palette of Fluorescent COS/H2S-Releasing Donors for H2S Delivery, Detection, and In Vivo Application. (Pubmed Central) - Apr 5, 2024
All donors are biocompatible and release H2S in live cell environments. In addition, we demonstrate that the NIR donor allows for imaging H2S release in live rats via subcutaneous injection of the donor loaded into an alginate gel, which to the best of our knowledge is the first in vivo tracking of H2S release from a fluorogenic donor in non-transparent organisms.
- | Journal: Synthesis of sinomenine derivatives with potential anti-leukemia activity. (Pubmed Central) - Apr 4, 2024
In-depth studies demonstrated that a11 arrested cell cycle at G1 phase, induced apoptosis via both morphological changes in nucleus and membrane potential collapse in mitochondria. These results indicated a11 exerted an antiproliferative effect through apoptosis induction via mitochondrial pathway.
- | GYY4137 / National University of Singapore
Journal: Contractions Induced in Human Pulmonary Arteries by a H2S Donor, GYY 4137, Are Inhibited by Low-Frequency (20 kHz) Ultrasound. (Pubmed Central) - Apr 1, 2024
These results indicated a11 exerted an antiproliferative effect through apoptosis induction via mitochondrial pathway. The transient GYY4137 contractions were reversed by low-frequency ultrasound, a blocker of KV7 channels, XE-991 (10
- | GYY4137 / National University of Singapore, Miostat (carbachol) / Novartis
Journal: Gasotransmitters do not prevent changes in transepithelial ion transport induced by hypoxia followed by reoxygenation. (Pubmed Central) - Apr 1, 2024
The transient GYY4137 contractions were reversed by low-frequency ultrasound, a blocker of KV7 channels, XE-991 (10 The present results demonstrate that none of the exogenous gasotransmitter releasing drugs significantly ameliorated the changes in epithelial ion transport during the hypoxia/reoxygenation cycle ex
- | Journal: Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation. (Pubmed Central) - Mar 30, 2024
In conclusion, our study demonstrates a pivotal role of reduced cGMP levels in impaired vasorelaxation in a murine model of MetS involving an impairment of both H2S and NO signaling. Exogenous H2S supplementation through Erucin represents a promising alternative in MetS therapy, targeting smooth muscle cells and supporting the importance of lifestyle and nutrition in managing MetS.
- | Journal: Infection Microenvironment-Responsive Coating on Titanium Surfaces for On-Demand Release of Therapeutic Gas and Antibiotic. (Pubmed Central) - Mar 27, 2024
In vitro antibacterial experiments validated significant antibacterial activity of the coating against both Gram-negative (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus). Crucially, this coating effectively suppressed implant-associated infection with 98.7% antibacterial efficiency in a rat femoral bone defect model, mitigated inflammation at the defect site and promoted osseointegration of the Ti orthopedic implant.
- | Journal: 2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels. (Pubmed Central) - Mar 24, 2024
Cell-based studies reveal that TTS can effectively increase intracellular sulfane sulfur levels and compensate for certain aspects of sulfide:quinone oxidoreductase (SQR) deficiency. These properties make TTS a conceptually new strategy for the design of donors of reactive sulfane sulfur species.
- | Preclinical, Journal: Effects of H2S-donor ascorbic acid derivative and ischemia/reperfusion-induced injury in isolated rat hearts. (Pubmed Central) - Mar 11, 2024
All the examined autophagy-related proteins showed increased expression levels in the BM-164 treated group in comparison to the drug-free control and/or ascorbic acid treated groups, while the changes in the expression of apoptotic markers were not obvious. In conclusion, the designed water soluble H2S releasing ascorbic acid derivative, BM-164, showed better cardiac protection against ischemia/reperfusion-induced injury compared to the untreated and ascorbic acid treated hearts, respectively.
- | Journal: H2S donor S-propargyl-cysteine for skin wound healing improvement via smart transdermal delivery. (Pubmed Central) - Mar 4, 2024
These results surface that SPRC hydrogel can promote wound healing and play a positive role in reducing scar formation. Our results imply that SPRC can facilitate wound healing and play a positive role in reducing scar formation.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation. (Pubmed Central) - Feb 26, 2024
In addition, the protective effect of NaHS on DOX-induced ferroptosis was closely related to the S-sulfhydrated Keap1, which in turn promoted nuclear translocation of Nrf2 and the transcription of SLC7A11 and GPx4. In conclusion, our findings suggest that H2S may exert protective effect on DoIC by inhibiting DOX-induced ferroptosis via Keap1/Nrf2-dependent SLC7A11/GSH/GPx4 antioxidant pathway.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Glycosidase-activated H2S donorsto enhance chemotherapy efficacy. (Pubmed Central) - Feb 26, 2024
A synergistic effect was observed between Man1 and Doxorubicin in HepG2 and Hela cells. All these results indicated glycosidase-activated H2S donorshave promising potential for cancer therapy.
- | Journal: Impact of Reactive Sulfur Species on Entamoeba histolytica: Modulating Viability, Motility, and Biofilm Degradation Capacity. (Pubmed Central) - Feb 24, 2024
Thus, our study reveals how RSS perturbs critical cellular functions in E. histolytica, potentially influencing its pathogenicity and interactions within the gut microbiota. Understanding these molecular mechanisms offers novel insights into amebiasis pathogenesis and unveils potential therapeutic avenues targeting RSS-mediated modifications in parasitic infections.
- GYY4137 / National University of Singapore
Hydrogen Sulfide (H2S) Alleviates Effects of Hyperoxia on Mitochondrial Structure and Function in Human Developing Airway Smooth Muscle (San Diego Convention Center, Room 30A-B (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5364;
fASM were treated for 24-72 hours with either long-acting H2S donor GYY4137, long-acting mitochondrial-specific H2S donor AP39, or vehicle control (DMSO)... Our data suggest O2 detrimentally impacts mitochondrial dynamics and homeostasis in developing ASM and that exogenous H2S targeting the mitochondria alleviates effects of hyperoxia on mitochondrial morphology, oxidative stress response, mitochondrial calcium uptake, and cellular respiration.
- || GYY4137 / National University of Singapore
Review, Journal: Hydrogen sulfide donors across time: From origins to cutting-edge applications. (Pubmed Central) - Feb 20, 2024
This article discusses both inorganic and organic types of H2S donors, including NaHS and Na2S, GYY4137, AP39, and AP123, as well as briefly outlines research and applications of H2S donors in nanotechnology, advanced materials, composite materials, nanostructures, and optical properties...In terms of applications, the review summarizes the extensive use of H2S donors in biomedical research, encompassing cardiovascular, neurological, anti-inflammatory, and anti-cancer characteristics, as well as their potential applications in the treatment of metabolic diseases. Finally, challenges and limitations faced by H2S donor research are discussed, and potential future research directions are proposed.
- || Review, Journal: Therapeutic potential of hydrogen sulfide in osteoarthritis development. (Pubmed Central) - Feb 19, 2024
Recent developments have produced a variety of H2S donors, including sustained-release H2S donors, natural H2S donors, and synthetic H2S donors. Understanding the role of H2S in OA can lead to the discovery of new therapeutic targets, while innovative H2S donors offer promising new treatments for patients with OA.
- || GYY4137 / National University of Singapore, Jingzhuda (entinostat) / EOC Pharma, EddingPharm
Review, Journal: Investigating the impact of protein S-sulfhydration modification on vascular diseases: A comprehensive review. (Pubmed Central) - Feb 19, 2024
The review also emphasizes the antithrombotic effects of HS in regulating platelet aggregation and thrombosis. The aim of this review is to enhance our understanding of the function and mechanism of protein S-sulfhydration modification in vascular diseases, and to provide new insights into the clinical application of this modification.
- | Journal: H2S alleviates renal ischemia and reperfusion injury by suppressing ERS-induced autophagy. (Pubmed Central) - Feb 12, 2024
The aim of this review is to enhance our understanding of the function and mechanism of protein S-sulfhydration modification in vascular diseases, and to provide new insights into the clinical application of this modification. Our results suggest that the CSE/H2S system is an important therapeutic target for protecting against renal IRI, and it may protect renal tubule epithelial cells from IRI by suppressing ERS-induced autophagy.
- | Preclinical, Journal: Choline induced cardiac dysfunction by inhibiting the production of endogenous hydrogen sulfide in spontaneously hypertensive rats. (Pubmed Central) - Jan 16, 2024
Three months of NaHS significantly increased plasma H2S levels, ameliorated cardiac dysfunction and inhibited cardiac fibrosis and apoptosis in SHR fed with choline. In conclusion, choline aggravated cardiac dysfunction in HHD through inhibiting the production of endogenous H2S, which was reversed by supplementation of exogenous H2S donor.
- | Journal: Endothelium-Mimicking Bilayer Vascular Grafts with Dual-Releasing of NO/HS for Anti-Inflammation and Anticalcification. (Pubmed Central) - Dec 29, 2023
Bilayer grafts could effectively prevent vascular calcification, reduce inflammation, and alleviate endothelial dysfunction. The in vivo study in a rat abdominal aorta replacement model for 1 month showed that the graft had a good patency rate and had potential for vascular remodeling in situ.
- GYY4137 / National University of Singapore
THE FUNCTION OF THE CYSTATHIONINE-GAMMA-LYASE/HYDROGEN SULFIDE AXIS IN THE PATHOGENESIS OF ULCERATIVE COLITIS (Bellagio Ballroom - Bellagio Las Vegas) - Dec 24, 2023 - Abstract #CCCongress2024CCCongress_309;
These studies demonstrate that CSE regulates mucosal TNF-alpha signaling, pro- and anti-inflammatory responses as well as colonic epithelial repair. Adding the H2S donor GYY4137 reduces inflammation, suggesting the restoration of normal TNF-alpha signaling function.
- | Journal: Erucin Exerts Cardioprotective Effects on Ischemia/Reperfusion Injury through the Modulation of mitoKATP Channels. (Pubmed Central) - Dec 23, 2023
Specific investigations on isolated cardiac mitochondria were carried out to evaluate the involvement of mitoK channels. The results obtained showed ERU cardioprotective effects against ischemia/reperfusion (I/R) damage through the involvement of mitoK channels and the consequent depolarizing effect, which in turn reduced calcium entry and preserved mitochondrial integrity.
- | GYY4137 / National University of Singapore
Journal: The Protective Action of Hsp70 and Hydrogen Sulfide Donors in THP-1 Macrophages in the Lipopolysaccharide-Induced Inflammatory Response by Modulating Endocytosis (Pubmed Central) - Dec 8, 2023
The role of endocytosis in the mechanisms of protection of cells by H2S and Hsp70 donors from the action of LPS was studied. It has been found that GYY4137 pretreatment of LPS-exposed cells reduces the LPS-induced induction of various pro-inflammatory genes and affects the expression of genes of various intracellular signaling pathways.
- || Review, Journal: Emerging relationship between hydrogen sulfide and ferroptosis: A literature review. (Pubmed Central) - Dec 7, 2023
Several recent studies have revealed a close relationship between ferroproteins and their precursors, H2S, and the enzymes that produce them. This review summarizes the current information pertaining to the relationship between ferroptosis and H2S, with a particular focus on the underlying mechanisms and biological applications of this knowledge.
- | metformin / Generic mfg.
Preclinical, Journal: Anti-Proliferative Properties of the Novel Hybrid Drug Met-ITC, Composed of the Native Drug Metformin with the Addition of an Isothiocyanate HS Donor Moiety, in Different Cancer Cell Lines. (Pubmed Central) - Nov 29, 2023
Finally, its ability to affect the cell cycle and to induce both early and late apoptosis has been demonstrated on the most sensitive cell line (MCF-7). These results confirmed that Met-ITC is a new hybrid molecule endowed with potential anti-cancer properties derived both from Met and HS.
- | Journal: The Effects of Novel Triazolopyrimidine Derivatives on H2S Production in Lung and Vascular Tonus in Aorta. (Pubmed Central) - Nov 27, 2023
We found that Cpd2, a newly synthesized RVT analog, is an H2S-inducing molecule and vasorelaxant similar to RVT. Since H2S has antioxidant and anti-inflammatory effects, Cpd2 has a potential for the treatment of respiratory diseases where oxidative stress and decreased H2S levels are present.
- | Journal: Pyranthiones/Pyrones: "Click and Release" Donors for Subcellular Hydrogen Sulfide Delivery and Labeling. (Pubmed Central) - Nov 21, 2023
Moreover, we synthesized substituted pyranthiones with H2S release kinetics that can address the range of physiologically relevant H2S dynamics in cells and achieved quantitative H2S release efficiency in vitro. Finally, we explored the potential of pyranthiones as H2S/COS donors for mitochondrial-targeted H2S delivery in living cells.
- | Journal: The potential role of hydrogen sulfide in regulating macrophage phenotypic changes via PINK1/parkin-mediated mitophagy in sepsis-related cardiorenal syndrome. (Pubmed Central) - Nov 17, 2023
These results demonstrated that the immunoregulatory effects of H2S donors were through the PINK1/Parkin-mediated mitophagy pathway. Overall, our study provided a new therapeutic direction in LPS-induced cardiorenal injury.
- | Journal: Persulfidation of plant and bacteroid proteins is involved in legume nodule development and senescence. (Pubmed Central) - Nov 12, 2023
Our results using recombinant proteins and nodulated plants support a crosstalk among H2S, ROS and RNS, a protective function of persulfidation on redox-sensitive enzymes, and a beneficial effect of H2S on symbiotic nitrogen fixation. We conclude that the general decrease of persulfidation levels observed in plant proteins of aging nodules is one of the mechanisms that disrupt redox homeostasis leading to senescence.
- Dermal delivery of AP39, a hydrogen sulphide donor, reduces inflammation associated with impaired wound healing in hyperglycaemic environments and increases wound closure rates () - Nov 6, 2023 - Abstract #ISDS2023ISDS_267;
We conclude that the general decrease of persulfidation levels observed in plant proteins of aging nodules is one of the mechanisms that disrupt redox homeostasis leading to senescence. Our observations show aqueous gels prepared with the H2S donor molecule AP39 reduces inflammation and improves angiogenesis and has the potential to facilitate diabetic wound healing.