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- | Journal: Pharmacological activation of aldehyde dehydrogenase 2 inhibits ferroptosis via SLC7A11/GPX4 axis to reduce kidney stone formation. (Pubmed Central) - Dec 11, 2024
However, the renoprotective effects of Alda-1 were inhibited by SLC7A11 siRNA. In conclusion, our study explores the applications of Alda-1 and highlights the potential of targeting ALDH2 as a promising therapeutical strategy for urolithiasis.
- | Journal: Targeting ALDH2 to Augment Platinum-Based Chemosensitivity through Ferroptosis in Lung Adenocarcinoma. (Pubmed Central) - Nov 16, 2024
At last, the effect of ALDH2 on ferroptosis and chemosensitivity is confirmed in patient-derived organoids and xenograft models. Collectively, this study demonstrates that ALDH2 deficiency confers sensitivity to platinum through ferroptosis in LUAD, and targeting ALDH2 is a promising new strategy to enhance the sensitivity of platinum-based chemotherapy for the treatment of LUAD patients.
- ADH5/ALDH2 Dehydrogenases and DNA Polymerase Theta Protect Hematopoietic Cells from Formaldehyde Challenge: Therapeutic Implications (Halls G-H (San Diego Convention Center)) - Nov 6, 2024 - Abstract #ASH2024ASH_5248;
In addition, simultaneous targeting of Pol? and ADH5 or ALDH2 exerted therapeutic effect against HR-deficient leukemias.
- | Journal: ALDH2 deficiency augments atherosclerosis through the USP14-cGAS-dependent polarization of proinflammatory macrophages. (Pubmed Central) - Aug 24, 2024
Consistently, USP14 knockdown in bone marrow cells alleviated proinflammatory responses in macrophages and protected against atherosclerosis. Our findings provide new mechanistic insights of ALDH2 deficiency-associated proinflammation and atherosclerosis and new therapeutic and preventive paradigms for treatment of atherosclerosis-associated CVD.
- | SP600125 / BMS
Journal, IO biomarker: Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage. (Pubmed Central) - Jul 29, 2024
Our findings provide new mechanistic insights of ALDH2 deficiency-associated proinflammation and atherosclerosis and new therapeutic and preventive paradigms for treatment of atherosclerosis-associated CVD. The repression of ALDH2 led to ACE accumulation, inducing cell apoptosis and DNA damage by the JNK/p38 MAPK signaling pathway activation in CRC.
- | Journal: Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) Protects against Binge Alcohol-Mediated Gut and Brain Injury. (Pubmed Central) - Jun 19, 2024
Additionally, alcohol exposure reduced Neuro2A cell viability with elevated oxidative stress-related PTMs and apoptosis, all of which were exacerbated by Aldh2 inhibition. Our results show for the first time that ALDH2 plays a protective role in binge alcohol-induced brain injury partly through the gut-brain axis, suggesting that ALDH2 is a potential target for attenuating alcohol-induced tissue injury.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Mitochondrial ALDH2 improves (Pubmed Central) - Jun 1, 2024
Mitochondrial ALDH2 activation could inhibit the progression of doxorubicin induced pancreatic ?-cell dysfunction by inhibiting the acid sphingomyelinase induction of ceramide, by regulating the activation of CK2 signaling. Our research lays the foundation of ALDH2 activation as a therapeutic target for the precise treatment of chemotherapy drug induced ?-cell dysfunction.
- | Biomarker, Journal: ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma. (Pubmed Central) - Feb 25, 2024
Overexpression of ALDH2 inhibited cell viability, proliferation, migration, and invasion of A375/SK-MEL-2 cells. ALDH2 is a new gene biomarker of melanoma, which exerts an inhibitory effect on melanoma.
- FP-045 / Foresee Pharma
A Multinational Phase 2, Randomized, Double-blinded, Placebo-controlled, Multiple-dose Study to Evaluate the Safety and Efficacy of FP-045, An Aldehyde Dehydrogenase 2 Activator in Patients With Pulmonary Hypertension Associated With Interstitial Lung Disease (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_957;
The change from baseline to week-12 in the SF-36v2-Health Survey, the Walking Impairment Questionnaire-(WIQ), and patient-reported-outcome measures-(PROM) as CAMPHOR-(or PAH-SYMPACT). Conclusion The WINDWARD Phase-2 Study aims to investigate the potential of FP-045 therapy as a first-in-class small molecule with a novel mechanism of action for patients with PH-ILD.
- | Journal: ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism. (Pubmed Central) - Jan 24, 2024
Moreover, chenodeoxycholic acid (CDCA) rescued ALDH2 downregulation induced TG accumulation in hepatocytes. Our study reveals that ALDH2 attenuates hepatocyte steatosis by regulating the alternative BA synthesis pathway, and ALDH2 may serve as a potential target for the treatment of MASLD.
- | disulfiram / Generic mfg.
Journal: Alcohol metabolism in alcohol use disorder: a potential therapeutic target. (Pubmed Central) - Jan 15, 2024
We detail the use of disulfiram, RNAi strategies, and kudzu/isoflavones to inhibit ALDH2 and increase acetaldehyde, ideally leading to decreases in drinking behavior...However, modulating ethanol metabolism has inherent risks, and we point out some of the key areas in which more data are needed to mitigate these potential adverse effects. Finally, we present our opinions on the future of treating AUD by the modulation of ethanol metabolism.
- | Preclinical, Journal: Determination of pharmacological inhibition of ALDH2 by ethanol clearance in mice. (Pubmed Central) - Jan 6, 2024
Inhibition of ethanol clearance is a useful in vivo method of inferring pharmacologic inhibition of hepatic ALDH2. This assay may be useful in the development of novel ALDH1A specific inhibitors for a variety of therapeutic indications.
- | Journal, IO biomarker: ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING pathway. (Pubmed Central) - Dec 25, 2023
We demonstrated that ALDH2 alleviated LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING signaling pathway, thereby protecting against LPS-induced cardiac injury. This study identifies a novel therapeutic approach for treating sepsis-induced cardiomyopathy (SIC).
- | disulfiram / Generic mfg.
Journal, IO biomarker: Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis. (Pubmed Central) - Dec 17, 2023
Our data delineate that ALDH2-mediated aldehyde metabolism drives tumor immune evasion by activating the NOD/NF-?B/VISTA axis. Targeting ALDH2 provides an effective combinatorial therapeutic strategy for immunotherapy.
- | Journal: Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches. (Pubmed Central) - Nov 27, 2023
Thus, we propose that quercetin-3-glucoronide, derived from the various forms of quercetin in red wines inhibits ALDH2, resulting in elevated acetaldehyde levels, and the subsequent appearance of headaches in susceptible subjects. Human-subject testing is needed to test this hypothesis.
- | sarizotan (EMD128130) / Newron, Rhopressa (netarsudil) / Alcon
Journal: Repurposing Drugs for Inhibition against ALDH2 via a 2D/3D Ligand-Based Similarity Search and Molecular Simulation. (Pubmed Central) - Nov 18, 2023
The electrostatic attraction with positively charged compounds, however, yielded very strong binding results with ALDH2. These findings reveal a deficiency in the modeling of electrostatic interactions (in particular, between charged moieties) in the virtual screening via the 2D/3D similarity search and molecular docking with the Vina scoring system.
- | Preclinical, Journal: Acetaldehyde dehydrogenase 2 ameliorates lung endothelial barrier and balances mitochondrial dynamics in mice with acute lung injury (Pubmed Central) - Sep 19, 2023
These findings reveal a deficiency in the modeling of electrostatic interactions (in particular, between charged moieties) in the virtual screening via the 2D/3D similarity search and molecular docking with the Vina scoring system. ALDH2 can ameliorate LPSinduced lung endothelial barrier damage in ALI mice by maintaining the balance of mitochondrial dynamics and inhibiting oxidative stress, and the mechanism may be related to the Nrf2/HO-1 pathway.
- | Journal: SLC3A2, as an indirect target gene of ALDH2, exacerbates alcohol-associated liver cancer via the sphingolipid biosynthesis pathway. (Pubmed Central) - Aug 18, 2023
The main finding of this study is that ALDH2 inhibited BSG expression through the TGF-?1 pathway, which indirectly inhibited SLC3A2 expression; subsequently, the sphingolipid metabolism pathway was also inhibited in HCC cells. Therefore, SLC3A2 is a novel target for HCC treatment.
- | Preclinical, Journal: Activation of aldehyde dehydrogenase-2 improves ischemic random skin flap survival in rats. (Pubmed Central) - Jul 17, 2023
ALDH2 activation can effectively enhance random skin flap viability via inhibiting PINK1/Parkin-dependent mitophagy. Moreover, enhancement of ALDH2 activity also exerts anti-inflammatory and angiogenic properties.
- | Preclinical, Journal: ALDH2 Inhibition by Lead and Ethanol Elicits Redox Imbalance and Mitochondrial Dysfunction in SH-SY5Y Human Neuroblastoma Cell Line: Reversion by Alda-1. (Pubmed Central) - Jul 17, 2023
Moreover, enhancement of ALDH2 activity also exerts anti-inflammatory and angiogenic properties. Notably, NAD (1mM for 24h) restored ALDH2 activity in all groups, while an ALDH2 enhancer (Alda-1, 20
- | Journal: ALDH2 promotes cancer stemness and metastasis in colorectal cancer through activating ?-catenin signaling. (Pubmed Central) - Jun 23, 2023
Together, our results demonstrate the prognostic value of ALDH2 in CRC as it regulates both CRC stemness and migration. Our findings also propose that the plant-derived isoflavone daidzein could be a potential chemotherapeutic drug targeting ALDH2 in CRC.
- | Journal: p53 protects against alcoholic fatty liver disease via ALDH2 inhibition. (Pubmed Central) - Apr 18, 2023
By contrast, overexpression of SCD1 in liver promotes ethanol-induced fatty liver development in wild-type mice, while it has a mild effect on p53 or ALDH2 mice. Overall, our findings reveal a previously unrecognized function of p53 in alcohol-induced fatty liver and uncover pyruvate as a natural regulator of ALDH2.
- The skin is equipped to metabolize alcohol and acetaldehyde () - Mar 4, 2023 - Abstract #ISID2023ISID_1421;
In conclusion, we demonstrate that the skin is equipped to metabolize EtOH and AcAH. However, compared to liver cells and keratinocytes, melanocytes have slower kinetics to metabolize EtOH, which may render melanocytes more vulnerable to EtOH/AcAH.
- | Journal: ALDH2 attenuates ischemia and reperfusion injury through regulation of mitochondrial fusion and fission by PI3K/AKT/mTOR pathway in diabetic cardiomyopathy. (Pubmed Central) - Jan 2, 2023
Moreover, ALDH2 suppressed the mitoPTP opening through reducing 4-HNE. Therefore, our results demonstrated that ALDH2 alleviated the ischemia and reperfusion injury in diabetic cardiomyopathy through inhibition of mitoPTP opening and activation of PI3K/AKT/mTOR pathway.
- | Preclinical, Journal: ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis. (Pubmed Central) - Dec 19, 2022
Furthermore, CRISPR/Cas9-mediated knockout of ALDH2 in T84 cells increased alcohol-mediated cell damage and paracellular permeability. All these findings demonstrate the critical role of ALDH2 in alcohol-induced epithelial barrier dysfunction and suggest that ALDH2 deficiency or gene mutation in humans is a risk factor for alcohol-mediated gut and liver injury, and that ALDH2 could be an important therapeutic target against alcohol-associated tissue or organ damage.
- cytarabine / Generic mfg.
The Role and Mechanism of ALDH2 in Regulating Oxidative Phosphorylation and Promoting Chemotherapy Resistance of Leukemia Stem Cells () - Nov 29, 2022 - Abstract #ASH2022ASH_7159;
Silencing of the key targets of RNF41 attenuates the chemotherapy resistance of ALDH2 to LSCs.Conclusion : ALDH2 inhibition increases the sensitivity of leukaemia stem cells to cytarabine therapy by glucose metabolism reprogramming and redox balance. Aldh2-mediated reduction of oxidative phosphorylation, loss of quiescence and differentiation of LSCs induced by oxidative stress, play an important role in cytarabine sensitization , suggesting an alternative strategy for the treatment of AML patients.
- | Journal: Trimethylamine oxide induces pyroptosis of vascular endothelial cells through ALDH2/ROS/NLRP3/GSDMD pathway. (Pubmed Central) - Nov 23, 2022
Aldh2-mediated reduction of oxidative phosphorylation, loss of quiescence and differentiation of LSCs induced by oxidative stress, play an important role in cytarabine sensitization , suggesting an alternative strategy for the treatment of AML patients. TMAO induces pyroptosis of vascular endothelial cells through the ALDH2/ROS/NLRP3/GSDMD signaling pathway, which may be a potential therapeutic target for improving the treatment of atherosclerosis.
- | Journal: ALDH2 Hampers Immune Escape in Liver Hepatocellular Carcinoma through ROS/Nrf2-mediated Autophagy. (Pubmed Central) - Nov 15, 2022
Moreover, ALDH2 considerably suppressed the growth of xenografts, increased autophagy and promoted the accumulation of T cells in tumors. In contrast, Nrf2 drastically reversed the repressive effect of ALDH2 on tumor growth.ALDH2 impaired the ROS/Nrf2 axis to promote autophagy, thereby repressing immune escape in LIHC.
- | disulfiram / Generic mfg.
Journal: Calycosin protects against oxidative stress-induced cardiomyocyte apoptosis by activating aldehyde dehydrogenase 2. (Pubmed Central) - Sep 7, 2022
In mice with MI, Calycosin therapy substantially reduced myocardial apoptosis, oxidative stress, and activated ALDH2. Collectively, our findings clearly suggest that Calycosin reduces oxidative stress and oxidative stress-induced apoptosis via the regulation of ALDH2 signaling, which supports potential therapeutic use in MI.
- | disulfiram / Generic mfg.
Journal: Aldehyde dehydrogenase 2 augments adiponectin signaling in coronary angiogenesis in HFpEF associated with diabetes. (Pubmed Central) - Jul 12, 2022
Treatment with disulfiram, an ALDH2 inhibitor, exacerbated 4HNE-mediated decreases in APN-induced increased coronary angiogenesis and APN-signaling cascades, whereas pretreatment with alda1, an ALDH2 activator, rescued the effect of 4HNE...Alda1 treatment improved APN-mediated angiogenesis in AF and db/db mice. In summary, 4HNE-induces APN resistance and a subsequent decrease in coronary angiogenesis in diabetic mouse heart which was rescued by ALDH2.
- | disulfiram / Generic mfg.
Journal: Exposure to the Dioxin-like Pollutant PCB 126 Afflicts Coronary Endothelial Cells via Increasing 4-Hydroxy-2 Nonenal: A Role for Aldehyde Dehydrogenase 2. (Pubmed Central) - Jun 24, 2022
However, pretreatment with 2.5 µM disulfiram (DSF), an ALDH2 inhibitor, or 10 µM Alda 1, an ALDH2 activator, before the PCB 126 challenge exacerbated and rescued the PCB 126-mediated decrease in coronary angiogenesis by modulating the 4HNE adduct levels respectively. Finally, we conclude that ALDH2 can be a therapeutic target to alleviate environmental pollutant-induced CMDs.
- disulfiram / Generic mfg.
Aldehyde Dehydrogenase 2 Augments Adiponectin Signaling In Coronary Angiogenesis In Hfpef Associated With Diabetes (Salon B, Lower Level) - Jun 18, 2022 - Abstract #BCVS2022BCVS_366;
Treatment with disulfiram (DSF), an ALDH2 inhibitor, exacerbated 4HNE-mediated decreases in APN-induced increased coronary angiogenesis and APN-signaling cascades, whereas pretreatment with alda1, an ALDH2 activator, rescued the effect of 4HNE...Alda-1 treatment improved APN-mediated angiogenesis significantly in db/db and AF mice. In conclusion, 4HNE-induces APN resistance and subsequently decreases coronary angiogenesis in diabetic HFpEF which was rescued by ALDH2 activation.
- | Journal, IO biomarker: Long Noncoding RNA SNHG16 Regulates the Growth of Human Lung Cancer Cells by Modulating the Expression of Aldehyde Dehydrogenase 2 (ALDH2). (Pubmed Central) - Jun 4, 2022
Finally, SNHG16 silencing was also found to inhibit in vivo tumor growth. Collectively, the study unveils the molecular role of SNHG16 in regulating the development of lung cancer by interacting with ALDH2.
- | paclitaxel / Generic mfg.
Journal: An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer. (Pubmed Central) - May 5, 2022
Collectively, the study unveils the molecular role of SNHG16 in regulating the development of lung cancer by interacting with ALDH2. Our findings suggest that ALDH2 status can help predict patient response to PTX therapy and ALDH2 inhibition may be a promising strategy to overcome PTX resistance in the clinic.
- | oxaliplatin / Generic mfg.
Journal: Aldehyde Dehydrogenase 2 Family Member (ALDH2) Is a Therapeutic Index for Oxaliplatin Response on Colorectal Cancer Therapy with Dysfunction p53. (Pubmed Central) - Apr 9, 2022
Finally, we found that combined treatment with ALDH2 inhibitor and oxaliplatin will reduce the sensitivity to oxaliplatin in p53 mutant HT29 cells. In conclusion, we demonstrate that ALDH2 may be a biomarker for oxaliplatin resistance status in CRC patients and bring new insight into treatment strategy for p53 mutant CRC patients.
- || Review, Journal: Comorbid alcohol use and post-traumatic stress disorders: Pharmacotherapy with aldehyde dehydrogenase 2 inhibitors versus current agents. (Pubmed Central) - Mar 11, 2022
Next, we summarize the shared pathological factors between AUD and PTSD. We conclude by providing a rationale for selectively inhibiting aldehyde dehydrogenase-2 as a potential target to treat comorbid AUD in persons with PTSD.
- | disulfiram / Generic mfg.
Journal: Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition. (Pubmed Central) - Nov 29, 2021
Pharmacological inhibition of ALDH2 with disulfiram recapitulated the alterations induced by exposure to low doses of pesticides...Similar biological abnormalities were found in primary BM-MSCs derived from MDS patients. (4) these results suggest that ALDH2 could participate in the pathophysiology of MDS in elderly people long exposed to low doses of pesticides.
- ANS-6637 / Amygdala Neurosci
Phase 2 Study of ANS-6637, a Specific Inhibitor of ALDH2, in Treatment Seeking Individuals With Alcohol Use Disorder: A Combined Human Laboratory and Outpatient Clinical Trial ([VIRTUAL]) - Nov 28, 2021 - Abstract #ACNP2021ACNP_967;
In addition, while the effects on alcohol craving measured in response to an alcohol cue-exposure paradigm after 1-week of dosing were small, data from the participants treated for 5 weeks provide preliminary evidence suggesting that selective ALDH2 inhibition may reduce drinking, alcohol consequences and craving. However, these results must be interpreted with caution as the effect sizes could be unreliable due to the small sample size.
- ANS-6637 / Amygdala Neurosci
Phase 2 Study of ANS-6637, a Specific Inhibitor of ALDH2, in Treatment Seeking Individuals With Alcohol Use Disorder: A Combined Human Laboratory and Outpatient Clinical Trial (Exhibit Hall C) - Nov 28, 2021 - Abstract #ACNP2021ACNP_262;
In addition, while the effects on alcohol craving measured in response to an alcohol cue-exposure paradigm after 1-week of dosing were small, data from the participants treated for 5 weeks provide preliminary evidence suggesting that selective ALDH2 inhibition may reduce drinking, alcohol consequences and craving. However, these results must be interpreted with caution as the effect sizes could be unreliable due to the small sample size.
- || disulfiram / Generic mfg.
PK/PD data, Journal: Integration of a physiologically-based pharmacokinetic model with a whole-body, organ-resolved genome-scale model for characterization of ethanol and acetaldehyde metabolism. (Pubmed Central) - Nov 24, 2021
Additionally, the model demonstrated that acetaldehyde exposure increased with higher dosages of disulfiram and decreased ALDH2 efficiency, and that moderate consumption rates of ethanol could lead to unexpected accumulations in acetaldehyde. This modelling framework combines the comprehensive steady-state analyses from genome-scale models with the dynamics of traditional PK models to create a highly personalized form of PBPK modelling that can push the boundaries of precision medicine.
- | Journal: Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts. (Pubmed Central) - Nov 4, 2021
Mag could enhance the activity of recombinant human ALDH2 proteins with a half-maximal effective concentration of 5.79 × 10 M. In addition, ALDH2 activation via Alda-1 inhibited cardiac fibroblast proliferation and collagen synthesis, while ALDH2 inhibition via daidzin partially blocked the suppressive effects of Mag. In summary, Mag may act as a natural ALDH2 agonist and inhibit cardiac fibroblast proliferation and collagen synthesis.
- || ANS-6637 / Amygdala Neurosci
Clinical, Journal: Interaction of Ethanol and Oral ANS-6637, a Selective ALDH2 Inhibitor in Males: A Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Cohort Study. (Pubmed Central) - Oct 9, 2021
A single oral dose of ANS-6637 with up to 5 standards drinks over 2.5 hrs was generally well tolerated in healthy males. The most common pharmacological response was flushing and an increase in HR, which are known effects of acetaldehyde accumulation and consistent with inhibition of ADLH2 with oral ANS-6637 in combination with alcohol. The results of this alcohol interaction study support further testing of ANS-6637 in individuals with substance use disorders who may consume alcohol.
- | disulfiram / Generic mfg.
Journal: Development of new disulfiram analogues as ALDH1a1-selective inhibitors. (Pubmed Central) - Sep 23, 2021
In this work, we successfully synthesized derivative 2b, in which two ethyl groups were replaced by two para fluorobenzyl groups. The 2b derivative showed a comparable activity to disulfiram against ALDH1a1; however, it was completely devoid of inhibitory activity against ALDH2.
- | Preclinical, Journal, IO biomarker: Impact of mitochondrial aldehyde dehydrogenase 2 on cognitive impairment in the AD model mouse. (Pubmed Central) - Aug 7, 2021
Taken together, ALDH2 overexpression significantly improves the cognitive function of the AD mice. Furthermore, our results suggested that ALDH2 protects against Aβ hippocampal neuronal toxicity possibly through alleviating toxic aldehydes and ROS, as well as increasing ATP production to preserve mitochondrial integrity and reduce neuronal apoptosis.
- | disulfiram / Generic mfg.
Journal: A role for aldehyde dehydrogenase (ALDH) 2 in angiotensin II-mediated decrease in angiogenesis of coronary endothelial cells. (Pubmed Central) - Jul 31, 2021
In summary, ALDH2 can be an important target in reducing 4HNE-induced proteotoxicity and improving angiogenesis in MCECs. Finally, we conclude ALDH2 activation can be a therapeutic strategy to improve coronary angiogenesis to ameliorate cardiometabolic diseases.
- [VIRTUAL] Aldehyde Dehydrogenase-2 Inhibition Heightens Neuropathic Pain () - Jun 29, 2021 - Abstract #IASP2021IASP_654;
ALDH2 activation with Alda-1 prevents CCI-induced increase in the aldehydic load without interfering wiith the H2O2 levels. Therefore, ALDH2 is a key enzyme that regulates neuropathic pain development.
- | methamphetamine / Generic mfg.
Journal: Brain Microdialysis Coupled to LC-MS/MS Revealed That CVT-10216, a Selective Inhibitor of Aldehyde Dehydrogenase 2, Alters the Neurochemical and Behavioral Effects of Methamphetamine. (Pubmed Central) - Jun 22, 2021
Moreover, the increase in 3-methoxytyramine levels following coadministration of CVT-10216 and MA could play a potential role in antagonizing the hyperlocomotion induced by MA. All of these findings suggest that the inhibition of ALDH2 protects against MA-induced hyperlocomotion and has therapeutic potential in MA addiction.
- | ANS-6637 / Amygdala Neurosci
Enrollment change, Trial withdrawal: Development of a Selective ALDH2 Inhibitor to Treat AUD (clinicaltrials.gov) - May 25, 2021
P2, N=0, Withdrawn, Sponsor: University of California, Los Angeles
All of these findings suggest that the inhibition of ALDH2 protects against MA-induced hyperlocomotion and has therapeutic potential in MA addiction. N=75 --> 0 | Not yet recruiting --> Withdrawn
- | Journal: Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy. (Pubmed Central) - May 25, 2021
Conversely, ALDH2 inhibition promoted the expression of LC3B by increasing 4-hydroxy-trans-2-nonenal accumulation. Consequently, ALDH2 may protect the heart from lipopolysaccharide-induced injury by suppressing PINK1/Parkin-dependent mitophagy.
- | Journal: Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype. (Pubmed Central) - May 15, 2021
ALDH2 deficiency is associated with a lower risk of AAD in patients and mice, possibly via suppressing VSMC phenotypical switch in a miR-31-5p-myocardin-dependent manner. These findings favour a role for ALDH2 and miR-31-5p as novel targets for AAD therapy.