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- | SP600125 / BMS
Preclinical, Journal: Dectin-1 participates in the immune-inflammatory response to mouse Aspergillus fumigatus keratitis by modulating macrophage polarization. (Pubmed Central) - Oct 31, 2024
Pre-treatment of RAW264.7 cells with MAPK cell signaling pathway inhibitors SB203580 (p38 inhibitor, 10
- | fluconazole oral / Generic mfg., nystatin oral / Generic mfg.
Preclinical, Journal: Dectin-1 induces TRPV1 sensitization and contributes to visceral hypersensitivity of irritable bowel syndrome in male mice. (Pubmed Central) - Jul 2, 2024
This work provides direct evidence for the functional regulation of TRPV1 channel by Dectin-1 activity, proposing a new mechanism underlying TRPV1 sensitization. Control of intestinal fungi might be beneficial for the treatment of refractory abdominal pain in patients with IBS or IBD in remission.
- DECTIN-1 INDUCES TRPV1 SENSITIZATION AND CONTRIBUTES TO VISCERAL HYPERSENSITIVITY OF IRRITABLE BOWEL SYNDROME IN MICE (140AB - Walter E. Washington Convention Center) - Mar 14, 2024 - Abstract #DDW2024DDW_6048;
Control of intestinal fungi might be beneficial for the treatment of refractory abdominal pain in patients with IBS or IBD in remission. Dectin-1 receptors contribute to the development of visceral hypersensitivity in IBS or IBD in remission and activation of Dectin-1 induces TRPV1 sensitization.
- | Journal: Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma. (Pubmed Central) - Mar 13, 2024
Dectin-1 receptors contribute to the development of visceral hypersensitivity in IBS or IBD in remission and activation of Dectin-1 induces TRPV1 sensitization. Dectin-1 activation in asthma induced caspase-11/4 mediated macrophage pyroptosis, which subsequently stimulated the secretion of chemokines, leading to the exacerbation of airway neutrophil inflammation.
- | Journal: Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity. (Pubmed Central) - Feb 28, 2024
In comparison, two prototypical particulate ?-glucans, one isolated from I. obliquus and one from Saccharomyces cerevisiae (zymosan), are agonists for Dectin-1 but not TLR2 or TLR4, and are unable to trigger anti-cancer functions of macrophages. We conclude that the water-soluble polysaccharides AcF1 and AcF3 from I. obliquus have a strong potential for cancer immunotherapy by triggering multiple PRRs and by inducing potent anti-cancer activity of macrophages.
- | Journal: Self-recognition through Dectin-1 exacerbates liver inflammation. (Pubmed Central) - Feb 22, 2024
These results highlight a role of self-recognition through Dectin-1 that triggers hepatic innate immune responses and contributes to the exacerbation of inflammation in pathogenic settings. Thus, the blockade of this axis may provide a therapeutic option for liver inflammatory diseases.
- | Journal: Dectin-1 signaling coordinates innate and adaptive immunity for potent host defense against viral infection. (Pubmed Central) - Jun 23, 2023
Our study provides a promising approach to overcoming the limitations of conventional FMD vaccines. Based on the proposed vaccine's safety and efficacy, it represents a breakthrough among next-generation FMD
- | Journal: Immunogenetics associated with severe coccidioidomycosis. (Pubmed Central) - Sep 29, 2022
Patients with DCM have impaired β-glucan sensing or response affecting TNF-α and H2O2 production. Impaired Coccidioides recognition and decreased cellular response are associated with disseminated coccidioidomycosis.
- | Journal, PD(L)-1 Biomarker, IO biomarker: Dectin-1 signaling in neutrophils up-regulates PD-L1 and triggers ROS-mediated suppression of CD4 T cells. (Pubmed Central) - Sep 11, 2022
This response may serve to limit excess CD4 T cell-driven inflammation in infection or autoimmunity while preserving host-defense functions of neutrophils. Summary sentence: Mechanisms by which Dectin-1 signaling in neutrophils promotes a cellular phenotype with T cell-suppressive properties.
- Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of Aging and HIV-infection (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1942;
- | Journal: Human Plasmacytoid Dendritic Cells Express C-Type Lectin Receptors and Attach and Respond to Aspergillus fumigatus. (Pubmed Central) - Jul 28, 2022
The indirect activation of pDCs by curdlan was much stronger than direct stimulation and was mediated through cytokine production by other PBMCs. Overall, our data indicate pDCs express various C-type lectin receptors, recognize and respond to Aspergillus hyphal Ag, and serve as immune enhancers or modulators in the overarching fungal immune response.
- Analysis of Dectin-1 expression and its impact on recurrence in nasal polyp (Room E1, Channel 3) - Apr 30, 2022 - Abstract #EAACI2022EAACI_427;
The patients who had a relapse of CRSwNP showed significantly lower expression of Dectin-1 mRNA in NP than those without recurrence. Conclusion Taken altogether, the expression of Dectin-1 can be utilized as a predictive factor for the recurrence of NP, and the role of Dectin-1 agonist as a therapeutic agent can be considered.
- | Preclinical, Journal: Adjuvant Curdlan Contributes to Immunization against Cryptococcus gattii Infection in a Mouse Strain-Specific Manner. (Pubmed Central) - Apr 24, 2022
The adjuvant curdlan favors the control of C. gattii infection depending on the immune response profile of the mouse strain. This study will have implications for developing new immunotherapeutic approaches to treat C. gattii infection.
- | Journal: Ganoderma Lucidum Polysaccharides Ameliorated Depression-Like Behaviors in the Chronic Social Defeat Stress Depression Model via Modulation of Dectin-1 and the Innate Immune System. (Pubmed Central) - Feb 8, 2022
To determine whether the antidepressant effect was mediated by Dectin-1, we found that GLP treatment enhanced Dectin-1 expression in the hippocampus in CSDS mice, and the Dectin-1-specific inhibitor laminarin almost completely blocked the antidepressant effect of GLP. This study identified GLP, an agonist of Dectin-1, as a novel and rapid antidepressant with clinical potential and multiple beneficial mechanisms, particularly in regulating the neuroimmune system and, subsequently, AMPA receptor function.
- | TVGV-HB / Thevax Genetics Vaccine
Journal, IO biomarker: Repolarization of glioblastoma macrophage cells using non-agonistic Dectin-1 ligand encapsulating TLR-9 agonist: plausible role in regenerative medicine against brain tumor. (Pubmed Central) - Nov 21, 2021
The nanoparticles entrapping CpG ODN 1826 were prepared by using a fungal polymer Schizophyllan (SPG)...However, post treatment results revealed significantly high expression of intracellular ROS and IFN-γ as well as IL-1β. These alterations indicated towards the repolarization of macrophages from M2 to M1phase.
- | Preclinical, Journal: The Adjuvants Polyphosphazene (PCEP) and a Combination of Curdlan Plus Leptin Promote a Th17-Type Immune Response to an Intramuscular Vaccine in Mice. (Pubmed Central) - Jun 3, 2021
Together, these data suggest that the cytokine environments induced by these immunostimulants did not predict induction of an antigen-specific Th17-type adaptive immune response. This is the first report of these adjuvants inducing a Th17-type adaptive immune response.
- | Preclinical, Journal: Dectin-1 Stimulation of Hematopoietic Stem and Progenitor Cells Occurs In Vivo and Promotes Differentiation Toward Trained Macrophages via an Indirect Cell-Autonomous Mechanism. (Pubmed Central) - Mar 25, 2021
This points to new mechanisms by which pathogen detection by HSPCs may modulate hematopoiesis in real time to generate myeloid cells better prepared to deal with the infection. Manipulation of this process may help to boost the innate immune response during candidiasis.
- [VIRTUAL] Interaction of eosinophils and dermal fibroblasts/keratinocytes in fungal-infection-related atopic dermatitis () - May 19, 2020 - Abstract #EAACI2020EAACI_752;
The results demonstrated the interaction between the skin and eosinophils upon fungal colonization. Further experiments are ongoing to evaluate the underlying pathological mechanism of fungal infection in AD.
- | Journal: Macrophage activation by edible mushrooms is due to the collaborative interaction of toll-like receptor agonists and dectin-1b activating beta glucans derived from colonizing microorganisms. (Pubmed Central) - Apr 2, 2020
In addition, co-stimulation of macrophages with the TLR agonists and insoluble beta glucan was found to result in a synergistic enhancement of in vitro cytokine production. Taken together, these findings indicate that the in vitro macrophage activating potential of edible mushrooms is due to the collaborative interaction of water-soluble TLR agonists (derived from colonizing bacteria) and water-insoluble beta glucans (derived from colonizing yeast).
- Keytruda (pembrolizumab) / Merck (MSD), Imprime PGG (PGG beta-glucan) / Biothera Pharma
Response and clinical benefit assessment of the combination of the Dectin-1 agonist Imprime PGG and anti-PD-1 Pembrolizumab in chemotherapy-resistant metastatic triple negative breast cancer (TNBC) (Hemisfair Ballroom - 3rd Level) - Sep 25, 2019 - Abstract #SABCS2019SABCS_1842;
P2
Biopsy analyses consistently showed activation of both myeloid and T cells with extensive infiltration into tumor tissue. Examination of response patterns and clinical benefit revealed extended OS even in pts not classified as responders by RECIST.