Astrocyte mod 
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  • ||||||||||  Preclinical, Journal:  Mechanobiological Modulation of In Vitro Astrocyte Reactivity Using Variable Gel Stiffness. (Pubmed Central) -  Jun 13, 2024   
    The stiffest 1 kPa substrates led to astrocytes with basal morphologies, similar to a physiological state. These results advance our understanding of astrocyte mechanotransduction processes and provide evidence of how substrates with engineered stiffness can mimic the injury microenvironment.
  • ||||||||||  Journal:  Lithium-loaded GelMA-Phosphate glass fibre constructs: Implications for astrocyte response. (Pubmed Central) -  May 1, 2024   
    The results suggest that the combination of bioactive phosphate-based glass fibers and lithium loading into GelMA structures may impact GFAP expression and early IL-6 expression. Furthermore, GelMA-PGFs (Fe) constructs have shown improved performance in modulating glial scarring over GFAP regulation.
  • ||||||||||  Journal:  The Impact of Treadmill Training on Tissue Integrity, Axon Growth, and Astrocyte Modulation. (Pubmed Central) -  Apr 17, 2024   
    Despite these advancements, the study notes a limited impact of treadmill training on motoneuron adaptation and highlights minimal changes in the astrocyte and neuron-glial antigen 2 (NG2) response. This suggests that, while treadmill training is instrumental in functional improvements post-SCI, its influence on certain neural cell types and glial populations is constrained.
  • ||||||||||  RGFP966 / BioMarin
    Journal:  A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity. (Pubmed Central) -  Apr 10, 2024   
    Administration of RGFP966, a small molecule HDAC3 inhibitor, blocks reactive astrocyte formation and promotes neuroprotection in vivo in mice. Collectively, these results establish a platform for discovering modulators of reactive astrocyte states, inform the mechanisms that control astrocyte reactivity and demonstrate the therapeutic benefits of modulating astrocyte reactivity for neurodegenerative diseases.
  • ||||||||||  Preclinical, Journal:  Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy. (Pubmed Central) -  Apr 1, 2024   
    We further demonstrated that AEG-1 upregulation by AAV1 delivery in the DG-induced anticonvulsant activities such as the delay of seizure onset and inhibition of spontaneous recurrent seizures (SRS) through GCD suppression in the mouse model of TLE, while the inhibition of AEG-1 expression increased susceptibility to seizures. The present observations suggest that AEG-1 is a potent regulator of GCD formation and seizure development associated with TLE, and the significant induction of AEG-1 in the DG may have therapeutic potential against epilepsy.
  • ||||||||||  Journal:  Nuclear SphK2/S1P signaling is a key regulator of ApoE production and A? uptake in astrocytes. (Pubmed Central) -  Apr 1, 2024   
    Together with our previous findings that SphK2 activity is upregulated in AD brain and promotes A? production in neurons, these results indicate that SphK2/S1P signaling is a promising multifunctional therapeutic target for AD that can modulate astrocyte function by stabilizing the effects of RXR and LXR agonists, and simultaneously regulate neuronal pathogenesis.
  • ||||||||||  Journal:  Acute Genetic Damage Induced by Ethanol and Corticosterone Seems to Modulate Hippocampal Astrocyte Signaling. (Pubmed Central) -  Mar 5, 2024   
    Obtained results revealed that astrocytes exposed to acute EtOH and/or CTS preserved their typical morphology but presented severe DNA damage, triggered canonical DDR pathways, and early changes in the cell signaling mediated by EVs and NTs. Further deepening of this initial morphological and quantitative analysis is necessary to identify the mechanistic links between genetic damage, DDR, cell-cell communication, and their possible impact on hippocampal neural cells.
  • ||||||||||  Review, Journal:  Nanomaterials as therapeutic agents to modulate astrocyte-mediated inflammation in spinal cord injury. (Pubmed Central) -  Dec 11, 2023   
    In this review, we aim to condense the present knowledge regarding the astrocyte-mediated inflammation following TSCI. We then review the various categories of nanomaterials utilized in the management of astrocyte-mediated inflammation in TSCI and conclude by summarizing their functions and advantages to offer novel insights for the advancement of effective clinical strategies targeting TSCI.
  • ||||||||||  Circadian clock controls ER calcium response in primary mouse astrocyte culture (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_8592;    
    Intracellular Ca2+ serves as a key mediator of astrocyte functions including gliotransmission, intercellular communications, and vascular function. Therefore, our results suggest that circadian clock modulate astrocyte functions in a timely manner by gating ER calcium response according to different times of the day.
  • ||||||||||  Cerebellar astrocytes encode and regulate reward-associated behavior (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_8583;    
    Activation of both Gq and Gi pathways resulted in decreased Ca2+ transients, leading to observable changes in reward behaviors, including fewer activated trials during the 30-minute period and shorter licking time. Overall, our study provides compelling evidence that cerebellar astrocytes actively encode and regulate reward behaviors, shedding light on their important role in the reward circuitry.
  • ||||||||||  Inactivation of Astrocytes in Dentate Gyrus Results in Anxiolytic-like and Cognitive Phenotypes (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_7151;    
    CalEx-expressing mice also displayed enhanced performance in reversal learning phase of the Morris water maze and a latent inhibition deficit. We propose that astrocytes in dentate gyrus may modulate anxiety-like behavior in mice, and that normal astrocytic function is essential for some aspects of memory tasks facilitated by the dentate gyrus and possibly play a critical role in memory tasks that involve memory interference.
  • ||||||||||  Striatal astrocytic mechanisms underlying the development of compulsive heroin seeking habits (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_7138;    
    In separate groups of rats, we tested the influence of chronic inhibition (using a virally transduced calcium extruder) or activation (using hM3Dq) of NAcC astrocytes on the functional engagement of the aDLS dopamine-dependent habits following a prolonged history of heroin seeking. This bidirectional modulation of NAcC astrocytes differentially impacted the sensitivity of heroin seeking to bilateral delivery of a dopamine receptor agonist into the aDLS, providing causal evidence for the role of NAcC astrocytes in the development of aDLS-dependent heroin seeking habits.
  • ||||||||||  Gliapharm compounds to rescue hypometabolism in alzheimer (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_5849;    
    Importantly, oral administration of GP-101 increases long-term memory in young and aged mice, as shown in Inhibitory Avoidance and Morris Water Maze memory tasks. Our data indicate that promoting brain energy metabolism by targeting astrocyte-mediated pathways has a positive impact on brain functions and has therapeutic potential for restoring and normalizing brain hypometabolic conditions in neurological diseases such as Alzheimer's disease.
  • ||||||||||  Sonic hedgehog signaling is stimulated in an activity-dependent manner (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_4588;    
    Taken together, our current work revealed a novel activity-dependent role for Shh signaling between neurons and astrocytes and suggests that Shh regulates gene expression programs underlying astrocyte modulation of synapses. Ongoing work aims to determine whether Shh signaling regulates activity-dependent neuronal plasticity.
  • ||||||||||  Identifying driver transcription factors of human astrocyte development (WCC Halls A-C) -  Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_3199;    
    Radial glia overexpressing FOXG1 or LHX2 both exhibit a significant upregulation of astrocytic genes and downregulation of neuronal genes, supporting an additional role for these TFs in shifting cell fate commitment towards astrogenesis. Ultimately, understanding the key drivers of the gliogenic switch will provide insight into how perturbations to the timing and production of astrocytes contribute to the pathogenesis of neurodevelopmental disorders.
  • ||||||||||  Review, Journal:  Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor-Receptor Interactions. (Pubmed Central) -  Oct 28, 2023   
    The purpose of this review article is to provide an overview of currently identified receptor complexes containing dopamine receptors and of their modulatory action on dopamine-mediated signaling between neurons and between neurons and astrocytes. Pharmacological possibilities offered by targeting receptor complexes in terms of addressing neuropsychiatric disorders associated with altered dopamine signaling will also be briefly discussed.
  • ||||||||||  Journal:  Curcumin modulates astrocyte function under basal and inflammatory conditions. (Pubmed Central) -  Sep 18, 2023   
    Both curcumin and piperine had important anti-inflammatory actions in astrocytes. We herein provide new insights into the actions of curcumin in the CNS that may aid in the search for new molecular targets and possible treatments for neurological diseases.
  • ||||||||||  Preclinical, Journal:  Astrocytic Responses to Binge Alcohol Intake in the Mouse Hindbrain. (Pubmed Central) -  Sep 7, 2023   
    Thus, binge levels of ethanol intake selectively affect astrocyte populations in the brainstem and cerebellum. Sex hormones can affect the ethanol-induced neurotoxicity via modulation of astrocyte reactivity.
  • ||||||||||  Miostat (carbachol) / Novartis
    Journal:  Synaptogenesis by Cholinergic Stimulation of Astrocytes. (Pubmed Central) -  Sep 1, 2023   
    Sex hormones can affect the ethanol-induced neurotoxicity via modulation of astrocyte reactivity. Pre-treatment of astrocytes with the acetylcholine receptor agonist carbachol increased the expression of synaptic proteins, the number of pre- and postsynaptic puncta, and the number of functional synapses in hippocampal neurons after 24
  • ||||||||||  Review, Journal:  Chemogenetic manipulation of astrocyte activity at the synapse- a gateway to manage brain disease. (Pubmed Central) -  Aug 3, 2023   
    This is likely a reflection of regional and disease/disease progression-associated astrocyte heterogeneity. Therefore, a thorough investigation of the effects of such astrocyte manipulation(s) must be conducted considering the specific cellular and molecular environment characteristic of each disease and disease stage before this has therapeutic applicability.
  • ||||||||||  Sex modulates the role of astrocyte reactivity in preclinical Alzheimer (In-Person) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_1944;    
    on tau phosphorylation in the presence of Ast+ in men than in women may have implications for interpretation of biomarkers in clinical trials testing as anti-A? therapies already showed different effects between men and women.
  • ||||||||||  Journal:  Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis. (Pubmed Central) -  Jun 16, 2023   
    In TSC, TPPU reduces the cytokine storm and attenuates the microglia activated P2X7/Cathepsin S/Fractalkine pathway and reduces the astrocyte activation and glutamate levels. Collectively, our findings revealed that sEH inhibition mitigates hypersensitive nociception through the regulation of microglia activation and astrocyte modulation, demonstrating the potential use of sEH inhibitors as immunoresolvents in the treatment of autoimmune disorders.
  • ||||||||||  Review, Journal:  Astrocytes: Dissecting Their Diverse Roles in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. (Pubmed Central) -  Jun 14, 2023   
    We then address how astrocyte pathology is recapitulated in animal and cellular models of ALS/FTD and how we used these models both to understand the molecular mechanisms driving glial dysfunction and as platforms for pre-clinical testing of therapeutics. Finally, we present the current clinical trials for ALS/FTD, restricting our discussion to treatments that modulate astrocyte functions, directly or indirectly.