ADGRE1 antag News - LARVOL Sigma

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|||||||||| small interfering RNA anti-fibrotic / Nitto Denko, SBI Biotech
DUAL SILENCING OF YAP1/WWTR1 AS A NOVEL THERAPEUTICAL APPROACH FOR LIVER FIBROSIS () - Oct 15, 2024 - Abstract #AASLD2024AASLD_2334;
Dual silencing of YAP1/WWTR1 suppressed YAP/TAZ pathway synergistically in vitro, and ameliorated steatosis and fibrosis in the liver of CDAHFD fed mice with advanced fibrosis. These findings suggest that dual silencing of YAP/TAZ would be a novel therapeutical approach for advanced fibrosis in MASH.

|||||||||| SNRNASEQ AND GEOMX () - Oct 15, 2024 - Abstract #AASLD2024AASLD_911;
Loss of Clu, Chka, and Naaladl2 expression in cholangiocytes is a marker of biliary fibroinflammation and may worsen PSC. H19-mediated upreguation of Lama4, Kcnip4, and Csmd1 may exacerbate disease progression.

|||||||||| Extra Domain A-Spliced Fibronectin Variant Contributes to Peritoneal Inflammation and Fibrosis in a Murine Model of Peritoneal Fibrosis (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3923;
H19-mediated upreguation of Lama4, Kcnip4, and Csmd1 may exacerbate disease progression. Our data suggest that increased peritoneal EDA-FN expression in PDF-treated mice contributes to peritoneal inflammation and fibrosis in PD.

|||||||||| clodronate disodium / Generic mfg.
Journal: Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1. (Pubmed Central) - Aug 28, 2024
This was further supported by adoptive transfer of atg5-/- macrophages, but not WT macrophages, to cause more severe AKI in clodronate liposomes-induced macrophage depletion mice...Furthermore, we found that ubiquitinated TARM1 was internalized from plasma membrane into endosomes, and then recruited by the ubiquitin-binding autophagy receptors TAX1BP1 and SQSTM1 into the autophagy-lysosome pathway for degradation. In conclusion, macrophage autophagy protects against AKI by inhibiting renal inflammation through the MARCHF1- and MARCHF8-mediated degradation of TARM1.

|||||||||| New trial: A Study on the New Mechanisms of Pathological and the New Strategies of Immune Prevention and Treatment of Chronic Liver Infection (EUDRACT) - Jul 15, 2024
P=N/A, N=11, Not yet recruiting, Sponsor: The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People

|||||||||| Preclinical, Journal: Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model. (Pubmed Central) - Jul 10, 2024
Moreover, PGRN and GRN protein levels were higher in the kidneys of UUO-WT mice than in mice that did not undergo UUO. Elevated GRN levels associated with excess PGRN levels may be involved in the occurrence of renal inflammation and fibrosis in UUO mice.

|||||||||| Preclinical, Journal: Dietary sugar kelp (Saccharina latissima) consumption did not attenuate atherosclerosis in low-density lipoprotein receptor knockout mice. (Pubmed Central) - Jun 17, 2024
Moreover, lipopolysaccharide-stimulated splenocytes isolated from HF/HC-SK-fed mice showed no significant changes in the mRNA levels of pro-inflammatory genes compared with those from the HF/HC mice. In summary, the consumption of dietary sugar kelp did not elicit anti-atherogenic and hepatoprotective effects in Ldlr KO mice.

|||||||||| Journal: 6-Formylindolo[3,2-b]carbazole, a potent ligand for the aryl hydrocarbon receptor, attenuates concanavalin-induced hepatitis by limiting T-cell activation and infiltration of proinflammatory CD11b+ Kupffer cells. (Pubmed Central) - May 29, 2024
While there was overall more accessible chromatin of the Adgre1 (F4/80) promoter in the FICZ-treated group, we observed less open chromatin in the Itgam (CD11b) promoter in Kupffer cells, supporting the ability of FICZ to reduce the infiltration of proinflammatory cytokine producing CD11b+ Kupffer cells. Taken together, these data demonstrate that aryl hydrocarbon receptor activation by FICZ suppresses liver injury through the limitation of CD3+ T-cell activation and CD11b+ Kupffer cell infiltration.

|||||||||| Preclinical, Journal: Vitamin D3 exacerbates steatosis while calcipotriol inhibits inflammation in non-alcoholic fatty liver disease in Sod1 knockout mice: a comparative study of two forms of vitamin D. (Pubmed Central) - Apr 23, 2024
In summary, our study found that VD3 accentuated hepatic steatosis, while calcipotriol diminished inflammation levels in SKO mice, and the difference might stem from their distinct cellular selectivity in activating VDR. This study provides a reference for the application of VD in the treatment of lean NAFLD.

|||||||||| Investigating the role of specialized intestinal macrophages in preserving gut-vascular barrier integrity during experimental cirrhosis (Space 1+2) - Apr 2, 2024 - Abstract #EASLILC2024EASL_ILC_1313;
This study provides a reference for the application of VD in the treatment of lean NAFLD. Our data provide novel insights into the role of specialized intestinal lamina propria macrophages in GVB barrier failure and bacterial translocation in an experimental model of cirrhosis.

|||||||||| Parsabiv (etelcalcetide) / Amgen
Calcimimetics reduce the progression of high-phosphate diet-induced tubular damage (Focussed Oral Room 1) - Mar 23, 2024 - Abstract #ERAEDTA2024ERA_EDTA_1315;
In a preclinical study, cinacalcet was shown to stabilize podocyte function in proteinuric mice...After four months, one HPD group was additionally treated with 1 mg/kg body weight/day etelcalcetide (KP-2326)... Treatment with KP-2326 was able to reduce the progression of HPD-induced tubule damage, at least in part due to the reduction in PTH and FGF23 levels.

|||||||||| tamoxifen / Generic mfg.
THE EFFECTS OF HYPOXIA-INDUCIBLE FACTOR-2 INACTIVATION IN MURINE KIDNEY DISEASE MODELS (MON-086; Exhibition Hall and Main Foyer) - Mar 8, 2024 - Abstract #ISNWCN2024ISN_WCN_819;
Tg(UBC-CreERT2); Epas1F/F mice were used to achieve global inactivation of HIF-2 through tamoxifen induction... HIF-2 inactivation does not have remarkable impacts on kidney injury in preclinical models.

|||||||||| Single-cell Transcriptomic Analysis of Bronchoalveolar Lavage Cells Following Murine Exposure to Ozone and Lipopolysaccharide (San Diego Convention Center, Room 6E (Upper Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5026;
Oxidative phosphorylation in macrophages has been linked to macrophage anti-inflammatory/ proresolution activity. We speculate that resident AMs in our model of ALI are defective in oxidative phosphorylation and upregulate this pathway in an attempt to resolve inflammation.

|||||||||| Single-Cell Expression Analysis of Lung Lining Cells Following World Trade Center Dust Exposure and Chronic Intermittent Hypoxia (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4309;
We can observe variations in the regulation of critical pathways within these clusters that may relate to the mechanism of injury. Further analyses will be required to confirm the activation and deactivation of these pathways.

|||||||||| Journal: ATG5-regulated CCL2/MCP-1 production in myeloid cells selectively modulates anti-malarial CD4+ Th1 responses. (Pubmed Central) - Feb 18, 2024
Conclusively, our study highlights the previously unrecognized role of ATG5 in modulating myeloid cells apoptosis and sequentially affecting CCL2 production, which selectively promotes CD4+ Th1 cell responses. Our findings provide new insights into the development of immune interventions and effective anti-malarial vaccines.

|||||||||| Journal: Characterization of the circRNA Landscape in Interleukin-4 Induced Anti-Inflammatory Microglia. (Pubmed Central) - Dec 23, 2023
We found that circAdgre1 promoted IL-4-induced anti-inflammatory responses and further conferred neuroprotective effects upon lipopolysaccharide (LPS) stimuli. Taken together, our results show that circRNAs might be possible therapeutic targets for microglia-mediated neuroinflammation and neurodegenerative diseases.

|||||||||| Voluntary wheel running in old mice reduces age-related inflammation in the colon (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_8259;
The main finding of our study is that both the hippocampus and colon exhibit an increase in inflammatory markers during aging, and that voluntary wheel running in old age exclusively attenuates intestinal inflammation. Based on the existence of the gut-brain axis, our results extend therapeutic approaches preserving cognitive functions in the elderly to the colon.

|||||||||| Leveraging Transcriptomic Data to Study Erythromyeloblastic Island (EMBI) Macrophages: Using Spic-GFP As a Marker for Embi Macrophages (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_5277;
To verify these transcriptomic results on the protein level, we performed IFC with CD169, Mertk, and other EMBI macrophage markers providing further insights to the heterogeneity of their expression on the central macrophages within intact EMBIs. We anticipate that the Spic -GFP + reporter mouse will be a useful tool in EMBI studies, providing a specific and sensitive marker to trace and isolate the majority of EMBI macrophages.

|||||||||| Synovial Macrophage Subsets Defined by ScRNAseq Demonstrate Sexually Dimorphic Gene Expression in RA and a Mouse Inflammatory Arthritis Model (Exhibit Hall A-B; in person) - Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_1599;
We also validate the ZIA mouse model by mapping to human RA and demostrate that it is sexually dimorphic. We are currently exploring mechanistics studies to determine the roles of sex dependent factors, like steroid hormone signaling and X-inactivation, and their specific interactions with the IFN signaling axis.

|||||||||| Edurant (rilpivirine) / J&J
Journal, Immunomodulating: Anti-inflammatory and immunomodulating effects of rilpivirine: Relevance for the therapeutics of chronic liver disease. (Pubmed Central) - Sep 23, 2023
RPV was also proven anti-inflammatory in PBMC from patients with CLD treated ex vivo. In conclusion, beyond its well-described role in antiretroviral therapy, RPV manifests anti-inflammatory and immunoregulatory effects, a finding that could be of great relevance for the search of novel targets or repositioning strategies for CLD.

|||||||||| Endothelium-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Abdominal Aortic Aneurysm (Zone 1, Science and Technology Hall, Level 2) - Aug 12, 2023 - Abstract #AHA2023AHA_5007;
Endothelial CNP plays an important role in attenuating AAA formation by preserving aortic structure and function. Therapeutic strategies aimed at mimicking CNP bioactivity may prevent the clinical progression of AAA.

|||||||||| Immune Modulation to Treat Ischemic Heart Failure (Moderated Digital Posters 5, Science and Technology Hall, Level 2) - Aug 12, 2023 - Abstract #AHA2023AHA_2589;
IF demonstrated a novel immune response in the treated group absent in the controls. This response is isolated to the epicardial infarct-patch interface.

|||||||||| Journal: Conventional, High Frequency and Differential Targeted Multiplexed Spinal Cord Stimulation in experimental Painful Diabetic Peripheral Neuropathy: pain behavior and role of the central inflammatory balance. (Pubmed Central) - Jul 25, 2023
In summary, Con-SCS showed a shift of the inflammatory balance towards a pro-inflammatory state whilst HF- and DTM-SCS shifted the balance towards an anti-inflammatory state. These findings suggest that the underlying mechanism of Con-SCS induced pain relief in PDPN differs from that induced by HF- and DTM-SCS.

|||||||||| Journal: mthl1, a potential Drosophila homologue of mammalian adhesion GPCRs, is involved in antitumor reactions to injected oncogenic cells in flies. (Pubmed Central) - Jul 21, 2023
Of great potential interest is our observation that the expression of the mouse gene coding for the adhesion G-protein-coupled receptor E1 (Adgre1, also known as F4/80), a potential mammalian homologue of mthl1, is significantly induced by B16-F10 melanoma cell inoculation 3 d postinjection in both the bone marrow and spleen (nests of immature and mature myeloid-derived immune cells), respectively. This observation is compatible with a role of this GPCR in the early response to injected tumor cells in mice.

|||||||||| Anti-inflammatory and antioxidant effects of SGLT-2 inhibitors in epicardial adipose tissue of subjects with severe heart failure (London Hall) - Jul 2, 2023 - Abstract #EASD2023EASD_873;
This observation is compatible with a role of this GPCR in the early response to injected tumor cells in mice. SGLT-2i treatment is associated with reduced inflammation and oxidative stress in epicardial adipose tissue, which could at least partially explain their cardioprotective effects.

|||||||||| Preclinical, Journal: Post-Effects of Time-Restricted Feeding against Adipose Tissue Inflammation and Insulin Resistance in Obese Mice. (Pubmed Central) - Jun 14, 2023
The post-TRF animals displayed liver mass similar to those in the TRF group, but the TRF effects on the mRNA of inflammation markers in the liver vanished completely. Together, these results indicate that, although the lasting effects of TRF may differ by tissues and genes, the impact of TRF on adipose tissue inflammation and immune cell infiltration could last a couple of weeks, which may, in part, contribute to the maintenance of insulin sensitivity even after the cessation of TRF.

|||||||||| Neutrophil-derived Factor XIII-A transglutaminase contributes to adipose tissue fibrosis and inflammation in mouse-obesity model (Room:518) - Jun 6, 2023 - Abstract #ISTH2023ISTH_2417;
FXIII-A showed crosslinking activity and externalization in NETosis. Exogenous fibrin(ogen) colocalized to NETs and this was inhibited by TG inhibitor, NC9.

|||||||||| Preclinical, Journal: Pharmacologic inhibition of HNF4? prevents parenteral nutrition associated cholestasis in mice. (Pubmed Central) - May 17, 2023
These data identify HNF4? antagonism as a potential therapeutic target for prevention and treatment of PNAC.

|||||||||| Preclinical, Journal: Central growth hormone action regulates neuroglial and proinflammatory markers in the hypothalamus of male mice. (Pubmed Central) - Apr 28, 2023
Conversely, brain-specific GHR knockout mice showed reduced expression of Gfap, Adgre1, and Vim (vimentin), indicating that brain GHR signaling is necessary to mediate GH-induced changes in the expression of several neuroglial markers. In conclusion, the hypothalamic mRNA levels of several neuroglial markers associated with inflammation are directly modulated by GHR signaling in male mice.

|||||||||| SGLT2 Inhibitors Exert Anti-inflammatory and Antioxidant Effects in Epicardial Adipose Tissue of Severe Heart Failure Subjects (Room 28; [Board No. 37]) - Apr 10, 2023 - Abstract #ADA2023ADA_149;
Finally, enhanced enrichment of ether lipids with oleic acid noted on metabolomic analysis suggests reduced disposition to ferroptosis (iron-dependent lipid peroxidation-regulated cell death) further contributing to decreased oxidative stress in EAT of SGLT-2i subjects. In conclusion, SGLT-2i treatment is associated with reduced inflammation and oxidative stress in EAT, which could at least partially explain their cardioprotective effects.

|||||||||| C1QA MUSCULARIS MACROPHAGE POPULATION REGULATES GASTROINTESTINAL MOTILITY THROUGH CLOSE ASSOCIATION WITH ENTERIC NEURONS (S106 - McCormick Place) - Mar 23, 2023 - Abstract #DDW2023DDW_4222;
We identified a novel population of MMs expressing C1qa in the GI tract that affects GI transit potentially by regulating synapse formation. Ongoing studies focus on dissecting the effect of macrophage-released C1qa on synapse formation and pruning and C1qa MMs

|||||||||| Journal: FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation. (Pubmed Central) - Mar 13, 2023
Our data demonstrate a distinct set of FOXP3+ macrophages with enhanced scavenging capability, which could be a target in immunomodulatory therapy against AIS.Abbreviations: ADGRE1/F4/80: adhesion G protein-coupled receptor E1; AIF1/Iba1: allograft inflammatory factor 1; AIS: acute ischemic stroke; ARG1: arginase 1; ATP: adenosine triphosphate; BECN1/Beclin1: Beclin 1, autophagy related; BMDM: bone marrow-derived macrophages; CKO: conditional knockout; CSF1/M-CSF: colony stimulating factor 1 (macrophage); CSF2/GM-CSF: colony stimulating factor 2; CSF3/G-CSF: colony stimulating factor 3; CUT & RUN: cleavage under targets and release using nuclease; CyD: cytochalasin D; DAMP: danger/damage-associated molecular pattern; DIL: dioctadecyl-3,3,3,3-tetramethylin docarbocyanine; ELISA: enzyme linked immunosorbent assay; GO: Gene Ontology; FCGR3/CD16: Fc receptor, IgG, low affinity III; HMGB1: high mobility group box 1; IFNG/IFN?: interferon gamma; IP: immunoprecipitation; KEGG: Kyoto Encyclopedia of Genes and Genomes; ITGAM/CD11b: integrin subunit alpha M; ITGAX/CD11c: integrin subunit alpha X; LAP: LC3-associated phagocytosis; LC-MS: liquid chromatography-mass spectrometry; LPS: lipopolysaccharide; MRC1/CD206: mannose receptor, C type 1; O4: oligodendrocyte marker O4; PBMC: peripheral blood mononuclear cells; RBC: red blood cells; PTPRC/CD45: protein tyrosine phosphatase, receptor type, C; RBFOX3/NeuN: RNA binding protein, fox 1 homolog (C. elegans) 3; RUBCN/Rubicon: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein; scRNAseq: single cell RNA sequencing; SQSTM1/p62 (sequestosome 1); TGFB/TGF?: transforming growth factor, beta; tMCAO: transient middle cerebral artery occlusion; TNF/TNF?: tumor necrosis factor; Treg: regulatory T cell.

|||||||||| Preclinical, Journal: Barley Grass Juice Attenuates Hydrodynamic Transfection-Induced HCC Initiation in Mice. (Pubmed Central) - Feb 27, 2023
Our results indicate that barley grass could be beneficial for HCC alleviation, partly by regulating immune cell infiltration. The ingredients of barley grass affect immune cell infiltration in HCC, and the detailed mechanism requires further study.

|||||||||| Preclinical, Journal: Administration of nicotinamide mononucleotide improves oocyte quality of obese mice. (Pubmed Central) - Nov 5, 2022
The ingredients of barley grass affect immune cell infiltration in HCC, and the detailed mechanism requires further study. NMN could improve the oocyte quality of HFD-induced obese mice.

|||||||||| epacadostat (INCB024360) / Incyte, Turalio (pexidartinib) / Daiichi Sankyo
CAR-T Cell Therapy of Solid Tumors Invokes an Expanded Set of Myeloid Cells in an Orthotopic Tumor Model for Rhabdomyosarcoma (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_6446;
The origin of myeloid cells within an i.m. tumor lesion can arise from mis-differentiated bone marrow-derived cells that infiltrate the lesion, from monocytes responding to tissue-generated signals, from tissue resident macrophages already present, or from innate myeloid cells present in muscle tissue that were generated embryonically from liver or even earlier from the AGM (aorta gonad mesonephros), and which have their own intrinsic tissue regulatory biology. The strongest transcript expressed was for an uncharacterized protein, GM52800, indicating there is much to discover in the biology of tumor-associated myeloid cells, especially in the context of CAR-T therapy.

|||||||||| Journal: Integrating network pharmacology and experimental verification to decipher the immunomodulatory effect of Bu-Zhong-Yi-Qi-Tang against poly (I:C)-induced pulmonary inflammation. (Pubmed Central) - Oct 29, 2022
Through integrating results from network pharmacology, experiments, and the published literature, isoliquiritigenin, Z-ligustilide, atractylenolide I, atractylenolide III, formononetin, ferulic acid, hesperidin, and cimigenoside were presumed as the bioactive components of BZYQT against pulmonary inflammation. Overall, our findings demonstrated that BZYQT possesses a pronounced immunomodulatory effect on poly (I:C)-induced pulmonary inflammation, which provides a pharmacological basis for BZYQT in the treatment of respiratory disorders.

|||||||||| Preclinical, Journal, BRCA Biomarker: miR155 deficiency reduces breast tumor burden in the MMTV-PyMT mouse model. (Pubmed Central) - Oct 27, 2022
Overall, miR155 deficiency reduced BrCA and improved the tumor microenvironment through the reduction of genes associated with pro-tumorigenic processes. However, given the inconsistencies in the literature, additional studies are needed before any attempts are made to harness miR155 as a potential oncogenic or tumor suppressive miRNA.

|||||||||| HNF4α ANTAGONIST PREVENTS PARENTERAL NUTRITION ASSOCIATED CHOLESTASIS IN MICE BY INHIBITING NFkB SIGNALING (Room 145) - Oct 23, 2022 - Abstract #AASLD2022AASLD_379;
This study suggests that inhibition of HNF4α has a protective effect in PNAC through both a switch to M2 macrophages and inhibition of NFkB signaling in hepatocytes. HNF4α may be a therapeutic target in PNAC.

|||||||||| PF-8380 / Pfizer
Journal: A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence. (Pubmed Central) - Oct 4, 2022
In therapeutic studies, supplementation with LPA or the autophagy inducer rapamycin significantly promotes dMφ autophagy and cell residence, and improves embryo resorption in Enpp2 and spontaneous abortion mouse models, which should be dependent on the activation of DDIT4-autophagy-CLDN7-adhesion molecules axis. This observation reveals that inactivation of ENPP2-LPA metabolism and insufficient autophagy of dMφ result in resident obstacle of dMφ and further increase the risk of spontaneous abortion, and provides potential therapeutic strategies to prevent spontaneous abortion.Abbreviations: ACTB: actin beta; ADGRE1/F4/80: adhesion G protein-coupled receptor E1; Atg5: autophagy related 5; ATG13: autophagy related 13; BECN1: beclin 1; CDH1/E-cadherin: cadherin 1; CDH5/VE-cadherin: cadherin 5; CFSE: carboxyfluorescein succinimidyl ester; CLDN7: claudin 7; CSF1/M-CSF: colony stimulating factor 1; CSF2/GM-CSF: colony stimulating factor 2; Ctrl: control; CXCL10/IP-10: chemokine (C-X-C) ligand 10; DDIT4: DNA damage inducible transcript 4; dMφ: decidual macrophage; DSC: decidual stromal cells; ENPP2/ATX: ectonucleotide pyrophosphatase/phosphodiesterase 2; Enpp2: Enpp2 heterozygous knockout mouse; ENPP2i/PF-8380: ENPP2 inhibitor; EPCAM: epithelial cell adhesion molecule; ESC: endometrial stromal cells; FGF2/b-FGF: fibroblast growth factor 2; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GPCPD1: glycerophosphocholine phosphodiesterase 1; HE: heterozygote; HIF1A: hypoxia inducible factor 1 subunit alpha; HNF4A: hepatocyte nuclear factor 4 alpha; HO: homozygote; ICAM2: intercellular adhesion molecule 2; IL: interleukin; ITGAV/CD51: integrin subunit alpha V; ITGAM/CD11b: integrin subunit alpha M; ITGAX/CD11b: integrin subunit alpha X; ITGB3/CD61: integrin subunit beta 3; KLRB1/NK1.1: killer cell lectin like receptor B1; KRT7/cytokeratin 7: keratin 7; LPA: lysophosphatidic acid; LPAR: lysophosphatidic acid receptor; lpar1: lpar1 homozygous knockout mouse; LPAR1i/AM966: LPAR1 inhibitor; LY6C: lymphocyte antigen 6 complex, locus C1; LYPLA1: lysophospholipase 1; LYPLA2: lysophospholipase 2; Lyz2: lysozyme 2; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MARVELD2: MARVEL domain containing 2; 3-MA: 3-methyladenine; MBOAT2: membrane bound O-acyltransferase domain containing 2; MGLL: monoglyceride lipase; MRC1/CD206: mannose receptor C-type 1; MTOR: mechanistic target of rapamycin kinase; NP: normal pregnancy; PDGF: platelet derived growth factor; PLA1A: phospholipase A1 member A; PLA2G4A: phospholipase A2 group IVA; PLPP1: phospholipid phosphatase 1; pMo: peripheral blood monocytes; p-MTOR: phosphorylated MTOR; PPAR: peroxisome proliferator activated receptor; PPARG/PPARγ: peroxisome proliferator activated receptor gamma; PPARGi/GW9662: PPARG inhibitor; PTPRC/CD45: protein tyrosine phosphatase receptor type, C; Rapa: rapamycin; RHEB: Ras homolog, mTORC1 binding; SA: spontaneous abortion; SELE: selectin E; SELL: selectin L; siCLDN7: CLDN7-silenced; STAT: signal transducer and activator of transcription; SQSTM1: sequestosome 1; TJP1: tight junction protein 1; VCAM1: vascular cell adhesion molecule 1; WT: wild type.

|||||||||| Pain in Osteoarthritis - Identification of GPR34 and GPR150 as Novel Targets in the Dorsal Root Ganglia (Room 108) - Sep 17, 2022 - Abstract #ACRConvergence2022ACR_CONVERGENCE_3663;
We have shown that the number of DRG macrophages is increased in an experimental model of OA (PMX), and that Gpr34 is specifically expressed by DRG macrophages. Since these are druggable targets, our findings open new avenues for exploring the effect of targeting either non-neuronal cells (macrophages expressing GPR34) or neuronal cells (GRP150) in models of OA pain.

|||||||||| Q&A (Moderated Digital Posters 1) - Aug 11, 2022 - Abstract #AHA2022AHA_3745;
Since these are druggable targets, our findings open new avenues for exploring the effect of targeting either non-neuronal cells (macrophages expressing GPR34) or neuronal cells (GRP150) in models of OA pain. There is no abstract associated with this presentation.

|||||||||| probenecid / Generic mfg.
Journal: Microcystin-LR incorporated into colonic cells through probenecid-sensitive transporters leads to upregulated MCP-1 expression induced by JNK activation. (Pubmed Central) - Jul 27, 2022
The findings of transporter inhibitors indicated that microcystin-LR is incorporated into cells via ATP Binding Cassette (ABC) or solute carrier (SLC) transporters other than the organic anion transporting polypeptides (OATPs)1B1, 1B3, 2B1, and 1A2, which this leads to increased MCP-1 expression in the colon through activating JNK. Thus, increased MCP-1 expression induced by microcystin-LR might be a trigger for initiating tumorigenesis with inflammation in the colon because increased MCP-1 expression induces inflammation associated with macrophage infiltration into the colon, and chronic inflammation is associated with the initiation of tumorigenesis.

|||||||||| Journal, IO biomarker: A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets in Uterine Corpus Endometrial cancer. (Pubmed Central) - Jun 22, 2022
Thus, increased MCP-1 expression induced by microcystin-LR might be a trigger for initiating tumorigenesis with inflammation in the colon because increased MCP-1 expression induces inflammation associated with macrophage infiltration into the colon, and chronic inflammation is associated with the initiation of tumorigenesis. The adhesion GPCRs, especially ADGRF1, might be used as immunotherapeutic targets and prognostic markers of UCEC.

|||||||||| 5-fluorouracil / Generic mfg.
5-Fluorouracil Alters Skeletal Muscle Mitochondrial Content And Inflammation In Mice (Exhibit Hall F) - Jun 2, 2022 - Abstract #ACSM2022ACSM_1485;
Collectively, these results demonstrate 1 cycle of 5FU notably impacts mitochondrial content and inflammation concomitant with decreases in body weight and cage activity. While changes in skeletal muscle function were not found, the observed changes in mitochondria and the inflammatory micro-environment may precede the functional decrements in skeletal muscle.

|||||||||| Journal, Gene Signature: Inflammation-Related Gene Signature for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma. (Pubmed Central) - May 21, 2022
The immune cell infiltration analysis suggested that 5 hub genes (ADGRE1, OLR1, TIMP1, GPR132 and CCR7) were negatively correlated with tumor purity and positively correlated with the infiltration of immune cells. Our study established a novel signature consisting of 7 hub genes for the prognostic prediction in patients with HNSCC.

|||||||||| Journal: Altered Adipose Tissue Inflammatory Markers in Mothers With Gestational Diabetes. (Pubmed Central) - May 14, 2022
Our study established a novel signature consisting of 7 hub genes for the prognostic prediction in patients with HNSCC. Data support that mothers with GDM differentially express AT adipokines and genes associated with inflammation, insulin resistance and altered lipid metabolism than mothers with NGT.

|||||||||| DEPLETION OF HEPATIC STELLATE CELLS REDUCES HEPATIC STEATOSIS (ePoster - DDW Virtual) - Apr 25, 2022 - Abstract #DDW2022DDW_1502;
Compared with that of hepatocyte monoculture, intracellular TG level was significantly higher in the presence of HSCs. Conclusion s: As observed in the in vitro experiment, HSCs enhanced steatosis of hepatocytes, and depletion of HSCs in mice treated with GTX prevented hepatic steatosis and fibrogenesis, suggesting that HSCs are promising targets in the treatment of NASH.

|||||||||| MODELING MACROPHAGE-ENTERIC NEURON INTERCELLULAR COMMUNICATION AT SINGLE CELL LEVEL (Poster Hall - San Diego Convention Center) - Apr 25, 2022 - Abstract #DDW2022DDW_1232;
Conclusion s: Nichenet represents a new tool for decoding MMs-ENs communication at single-cell level in an unbiased fashion. Multiple interactions were identified, and further studies are needed to functionally dissect the interactions described by this model.Supported by DK127992, ANMS Young Investigator grant and AGA grant#36, P30DK084567, DK115255.

|||||||||| Preclinical, Journal: NUCB2/Nesfatin-1 Reduces Obesogenic Diet Induced Inflammation in Mice Subcutaneous White Adipose Tissue. (Pubmed Central) - Apr 19, 2022
An obesogenic diet can induce significant inflammation in the ScWAT of NUCB2 KO mice, involving the HMGB1, NRF2 and NF-kB pathways, while nesfatin-1 reduces the pro-inflammatory response in LPS-stimulated 3T3-L1 cells. These findings provide a novel insight into the metabolic regulation of inflammation in WAT.

|||||||||| Preclinical, Journal: Voluntary Wheel Running in Old C57BL/6 Mice Reduces Age-Related Inflammation in the Colon but Not in the Brain. (Pubmed Central) - Apr 9, 2022
The main finding of our study is that both the hippocampus and colon exhibit an increase in inflammatory markers during aging, and that voluntary wheel running in old age exclusively attenuates intestinal inflammation. Based on the existence of the gut-brain axis, our results extend therapeutic approaches preserving cognitive functions in the elderly to the colon.



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