- |||||||||| Journal: Neuroinformatics Applications of Data Science and Artificial Intelligence. (Pubmed Central) - Nov 20, 2024
This fusion mirrors the quest for nuclear fusion energy, both driven by the need to unlock profound sources of understanding. As STEM disciplines continue to drive core developments of foundational models of the brain, neuroinformatics promises to lead innovations in augmented intelligence, personalized healthcare, and effective decision-making systems.
- |||||||||| Journal: Ethical considerations for the use of brain-computer interfaces for cognitive enhancement. (Pubmed Central) - Nov 13, 2024
We discuss the ethical, legal, and scientific implications of eBCIs, including issues related to privacy, autonomy, inequality, and the broader societal impact of cognitive enhancement technologies. We conclude that the development of eBCIs raises challenges far beyond practical pros and cons, prompting fundamental questions regarding the nature of conscious selfhood and about who-and what-we are, and ought, to be.
- |||||||||| Journal: On the control of recurrent neural networks using constant inputs. (Pubmed Central) - Nov 6, 2024
Simulation results are presented to illustrate the theoretical findings and demonstrate the efficacy of the proposed control strategies. These results offer a novel control synthesis for an important class of neural network models that may, in turn, enable the design of brain stimulation protocols to modulate whole-brain activity in therapeutic and cognitive enhancement applications.
- |||||||||| Journal: Exercise and Acute Cognitive Enhancement. (Pubmed Central) - Nov 5, 2024
These observed benefits are likely due to the impacts acute exercise can have on physiological arousal, brain function, and brain neurotrophic factors. Advancements in our understanding of the potential of a single session of exercise to benefit cognitive performance are important for exercise prescription and to inform chronic exercise programs designed to benefit cognition.
- |||||||||| amphetamine/dextroamphetamine immediate release tablet / Generic mfg.
Journal: Chronic exposure to inhaled vaporized cannabis high in ?9-THC suppresses Adderall-induced brain activity. (Pubmed Central) - Nov 4, 2024 This exploratory study shows that short, daily exposures to inhaled cannabis, something equivalent to recreational use, affects the sensitivity to the psychostimulant Adderall. The reduced Adderall effect on brain activity, particularly circuitry associated with dopaminergic signaling raises concerns about escalation in psychostimulant use.
- |||||||||| Journal: Can neurotechnology revolutionize cognitive enhancement? (Pubmed Central) - Oct 29, 2024
The development and implementation of neurotechnology for cognitive enhancement could spearhead a new wave of innovation in the information age. However, we argue here that this will only happen with a more fundamental understanding of human brain function.
- |||||||||| Viibryd (vilazodone) / AbbVie
Preclinical, Journal: Vilazodone, (Pubmed Central) - Oct 28, 2024 This diminished impact on gene regulation was seen throughout the striatum, including the nucleus accumbens, where increased dynorphin expression has previously been associated with various aspects of addiction. Our findings suggest that vilazodone may serve as a better adjunct SSRI with reduced addiction-facilitating properties.
- |||||||||| Clinical, Journal: Lightening the mind with audiovisual stimulation as an accessible alternative to breath-focused meditation for mood and cognitive enhancement. (Pubmed Central) - Oct 27, 2024
The identification of modafinil analogs in this context is important so that consumers are not, knowingly or unknowingly, consuming these active pharmaceutical ingredients in products marketed as dietary supplements. Remarkably, the mood benefits from AVS closely aligned with those achieved through breath-focused meditation with additional evidence that a brief AVS exposure of approximately five minutes may be sufficient or even optimal for improving mood to a comparable or greater degree than meditation sessions of equal or longer durations (11-22
- |||||||||| Review, Journal: Advances in VNS efficiency and mechanisms of action on cognitive functions. (Pubmed Central) - Oct 24, 2024
Future research should focus on optimizing VNS protocols and elucidating specific cognitive domains that benefit most from VNS interventions. This ongoing exploration is essential for maximizing the therapeutic potential of VNS in clinical practice.
- |||||||||| Journal: Neural interfaces: Bridging the brain to the world beyond healthcare. (Pubmed Central) - Oct 23, 2024
This perspective outlines these challenges and discusses the progress in neural interfaces, contrasting non-invasive and invasive approaches, and explores the dynamics between stimulation and direct interfacing. Emphasis is placed on applications beyond healthcare, highlighting the need for implantable interfaces with high-resolution recording and stimulation capabilities.
- |||||||||| Journal: Effectiveness of Medhasagar Rasa (Pubmed Central) - Oct 18, 2024
Reflecting on our results on job-associated drug use by neurosurgeons, we propose the judicious use of pharmacological or nonpharmacological adjuncts, alongside the prioritization of neurosurgeons' well-being. Medhasagar Rasa effectively enhanced cognitive functions and alleviated anxiety and sleep disturbances in aging-related mild neurocognitive disorder, offering a promising therapeutic option.
- |||||||||| fluphenazine / Generic mfg., haloperidol / Generic mfg., clozapine / Generic mfg.
Clinical, Retrospective data, Review, Journal: Antipsychotic Drugs and Cognitive Function: A Systematic Review and Pairwise Network Meta-Analysis. (Pubmed Central) - Oct 16, 2024 The overall small superior outcomes compared to placebo may be explained by less disordered thought patterns associated with fewer positive symptoms rather than cognitive deficits in the proper sense. The findings also suggest that harmonizing measurement of cognitive function in randomized clinical trials would be beneficial.
- |||||||||| methylphenidate tablet / Generic mfg., methamphetamine / Generic mfg.
Journal: Quantitative analysis of drugs of abuse and cognitive enhancers in influent wastewater by means of two chromatographic methods. (Pubmed Central) - Oct 16, 2024 A method for the detection and quantification of DOA, cognitive enhancers, and their biomarkers in wastewater was successfully developed and validated. Moreover, six proof-of-concept samples were analyzed in which AMPH, BZE, COC, MDMA, MPH, and RA were identified and further quantified.
- |||||||||| Journal: Production of ?-Glycerylphosphorylcholine in Fermented Roots, Tubers, and Fruits. (Pubmed Central) - Oct 16, 2024
This dual-purpose potential presents new market opportunities for producers by leveraging both biofuel and nootropic compound production. Furthermore, the observed relationship between methanol and ?-GPC production warrants further investigation to elucidate the metabolic pathways involved.
- |||||||||| Journal: Enhancement of perceptual and cognitive functions in near-death experience: A perspective from embodiment theories. (Pubmed Central) - Oct 5, 2024
NDE events are perceived, recalled, and embodied by strong activation of sensorimotor systems in a state of perceptual and cognitive enhancement, although sensorimotor systems seem to be unresponsive to sensory stimuli during NDE. Finally, based on theories of embodied cognition, we conclude that the enhancement of cognitive functions that takes place in the state of NDE is the result of enhancement in perceptual functions.
- |||||||||| Review, Journal: Impact of psilocybin on cognitive function: A systematic review. (Pubmed Central) - Oct 2, 2024
The observed mixed findings underscore the complexity of psilocybin's cognitive influence. Further research is essential to provide a clearer understanding of psilocybin's impact on cognitive domains and to guide the development of safe and effective interventions.
- |||||||||| hyoscine butylbromide oral / Generic mfg.
Preclinical, Journal: Anti-Amnesic Effect of Agastache rugosa on Scopolamine-Induced Memory Impairment in Mice. (Pubmed Central) - Sep 29, 2024 The ARE improved hippocampal neurogenesis via doublecortin- (0.4-fold vs. 1.1-fold) and KI-67-positive (6.3 vs. 12.0) cells. Therefore, the ARE exerts protective effects against cognitive decline through cholinergic system modulation and antioxidant activity, supporting its potential use as a cognitive enhancer.
- |||||||||| Journal: Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement. (Pubmed Central) - Sep 24, 2024
P=N/A Cross-frequency stimulations modestly boosted processing speed with or without impairing task accuracy depending on the stimulation protocol. This research adds to the understanding of physiology-inspired brain stimulation for cognitive enhancement in older subjects.
- |||||||||| Journal: Ellagic acid improves the symptoms of early-onset Alzheimer's disease: Behavioral and physiological correlates. (Pubmed Central) - Sep 23, 2024
Moreover, the neuromodulatory effects of EA were attributed to the regulation of CREB levels, Dnm-1 expression, and synaptophysin levels, thereby enhancing LTP and synaptic plasticity. EA also induced beneficial cytological and behavioral changes, improving both long-term and short-term spatial memory as well as associative learning behavior in the animal model, which underscores its cognitive enhancement properties.
- |||||||||| Journal: Effects of educational attainment on comorbidity of pain and depression in Chinese older adults. (Pubmed Central) - Sep 20, 2024
Older adults with higher levels of education tend to live in urban areas and have better control over alcohol consumption, which may contribute to a lower incidence of PD. Therefore, interventions aimed at enhancing cognitive abilities, improving living environments, and promoting healthier lifestyles and habits among older adults could potentially reduce their burden of PD.
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