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  • ||||||||||  Journal:  The effect of acute exercise on attentional control and theta power (Pubmed Central) -  Sep 26, 2023   
    Our results add to the limited but growing body of research that suggests acute exercise produces a general increase in theta power, which in turn may play a role in enhancing cognitive performance. These results, combined with previous research, could have widespread implications in multiple settings such as in the investigation of a biomarker of physical fitness, neurorehabilitation, and in education.
  • ||||||||||  Journal:  Toxidrome of an Easily Obtainable Nootropic: A Case Report of Phenibut Intoxication and Withdrawal Delirium. (Pubmed Central) -  Sep 12, 2023   
    This study will undoubtedly aid researchers in looking for new PD treatment options. High-dose phenibut intoxication and withdrawal can appear as dramatic and dangerous as high-dose sedative withdrawal, however given its specified receptor affinity and binding profile we found that a pharmacotherapeutic approach targeting GABA-B, GABA-A, and gabapentenoid receptors were effective in stabilizing this patient, eventually leading to the patient's full and sustained recovery.
  • ||||||||||  Review, Journal:  Plant-derived nootropics and human cognition: A systematic review. (Pubmed Central) -  Sep 7, 2023   
    Caffeine enhances attention and executive functions. Together, the results from the compiled studies highlight the nootropic effects and the inconsistencies regarding PDNs that require further research.
  • ||||||||||  methylphenidate tablet / Generic mfg., reboxetine / Generic mfg.
    Journal:  Acetylcholine and noradrenaline enhance foraging optimality in humans. (Pubmed Central) -  Sep 1, 2023   
    Concurring with amplified goal-directedness and excluding heuristic explanations, nicotine independently also improved trial initiation and time perception. Our findings elucidate the neurochemical basis of behavioral flexibility and decision optimality and open unique perspectives on psychiatric disorders affecting these functions.
  • ||||||||||  memantine / Generic mfg.
    Review, Journal:  Therapeutic dilemmas: cognitive enhancers and risk of falling in older adults-a clinical review. (Pubmed Central) -  Aug 25, 2023   
    However, further clinical research is necessary to evaluate changes in bacteria taxa along with age- and sex-based differences. The use of cognitive enhancers should be regularly reviewed and decisions to deprescribe made on a case-by-case basis, considering both the risks and benefits of stopping these medications.
  • ||||||||||  Review, Journal:  Illiteracy, Neuropsychological Assessment, and Cognitive Rehabilitation: A Narrative Review. (Pubmed Central) -  Aug 19, 2023   
    For the assessment of illiterate individuals, it is imperative that neuropsychological tests with high ecological validity (i.e., tests related to activities of daily living) be administered so as not to underestimate their cognitive functioning. At the same time, cognitive enhancement/stimulation programs seem to be effective in this population group; however, this area needs further investigation.
  • ||||||||||  Preclinical, Journal:  Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice. (Pubmed Central) -  Aug 16, 2023   
    The effects of klotho on cognition were still present in mice lacking PF4, suggesting this platelet factor is sufficient to enhance cognition but not necessary for the effects of klotho-and that other unidentified factors probably contribute. Augmenting platelet factors, possible messengers of klotho, may enhance cognition in the young brain and decrease cognitive deficits in the aging brain.
  • ||||||||||  Journal:  Effects of nature on restorative and cognitive benefits in indoor environment. (Pubmed Central) -  Aug 14, 2023   
    Compared to the baseline, the sites with nature resulted in restorative (higher perceived restoration scores) and cognitive (higher working memory performance and lower delta-to-theta ratio (DTR), delta-to-alpha ratio (DAR), theta-to-beta ratio (TBR), and alpha-to-beta ratio (ABR) responses) benefits. These findings further our understanding of the effects of exposure to nature on restorative and cognitive benefits in an indoor environment, and help to build guidance for future research on the effects of nature indoors and designing restorative- and cognitive-enhancing indoor spaces.
  • ||||||||||  galantamine hydrobromide / Generic mfg.
    Journal:  Phytochemical Profiling, Antioxidant and Cognitive-Enhancing Effect of Helichrysum italicum ssp. italicum (Roth) G. Don (Asteraceae). (Pubmed Central) -  Aug 12, 2023   
    italicum extract (200 mg/kg/po) administered in combination with galantamine (3 mg/kg/po) for 12 days significantly improved the memory and learning process compared with galantamine alone in the passive avoidance test...Pyrones and acylphloroglucinols together with acylquinic acids could account for memory improvement. The presented research advanced our knowledge of H. italicum, highlighting the species as a rich source of secondary metabolites with cognitive-enhancing potential.
  • ||||||||||  Review, Journal:  Nootropic supplements for esports. (Pubmed Central) -  Aug 11, 2023   
    The published literature has focused on the effects of caffeine, which may exert both positive and negative effects on esports players. Additional, high-quality research is needed.
  • ||||||||||  Journal:  Inconsistencies in mapping current distribution in transcranial direct current stimulation. (Pubmed Central) -  Aug 9, 2023   
    An in-vivo current mapping technique proposed in this study demonstrated that much of the injected current in tDCS was not accounted for in human brain and deviated to the edge of the brain. These findings would have ramifications in the use of tDCS as a neuromodulator and may help explain some of the inconsistencies reported in other studies.
  • ||||||||||  Journal:  Control-theoretic integration of stimulation and electrophysiology for cognitive enhancement. (Pubmed Central) -  Aug 9, 2023   
    The proposed paradigm involves a tight coupling of tES and neuroimaging in which M/EEG is used to parameterize generative brain models as well as control tES delivery in a hybrid closed-loop fashion. We also present a novel quantitative framework for cognitive enhancement driven by a new computational objective: shaping how the brain reacts to potential "inputs" (e.g., task contexts) rather than enforcing a fixed pattern of brain activity.
  • ||||||||||  Retrospective data, Journal, Video:  A game-factors approach to cognitive benefits from video-game training: A meta-analysis. (Pubmed Central) -  Aug 6, 2023   
    Examination of specific gameplay features however showed selective and differential transfer to these outcome measures, whereas the genre labels of "action", "strategy", "casual", and "non-casual" were not similarly predictive of outcomes. We therefore recommend that future video-game interventions targeting cognitive enhancements should consider gameplay feature classification approach over existing genre classification, which may provide more fruitful training-related benefits to cognition.
  • ||||||||||  Review, Journal:  On pharmacological neuroenhancement as part of the new neurorights' pioneering legislation in Chile: a perspective. (Pubmed Central) -  Aug 3, 2023   
    If pharmacological neuroenhancers are going to be considered neurotechnologies, then new law proposals should seek harmonization with the already existing legislation regulating pharmacological health and consumer rights (both globally, taking into account international drug laws, and locally, according to each country's internal regulations) and of course, with the whole system of fundamental rights. Finally, we briefly discuss the ethical problem of equitable access to this new type of neurotechnologies (as part of the neurorights) and leave the debate open for new insights from the scientific community on the possible consequences of including (or not) pharmacological neuroenhancers as neurotechnologies for cognitive enhancement in the framework of the ethical and legal debate.
  • ||||||||||  Trivastal (piribedil) / Servier, pirepemat (IRL752) / IRLAB Therap
    Review, Journal:  A Systematic Review of Pharmacological Interventions for Apathy in Aging Neurocognitive Disorders. (Pubmed Central) -  Jul 29, 2023   
    Pharmacological interventions for apathy in aging neurocognitive disorders are complex and under-investigated. The continuation of systematic research efforts and the provision of individualized treatment for patients suffering from these disorders is vital.
  • ||||||||||  Journal:  The impact of COVID-19 pandemic on elderly with neurocognitive disorders. (Pubmed Central) -  Jul 15, 2023   
    Specialized training for caregivers' and nursing staff focusing on the inclusion of self-hygiene measures in patients' daily routine. Patients' familiarization with online tools both for cognitive enhancement programs and for diagnostic/ monitoring purposes.
  • ||||||||||  Journal:  VR for Cognition and Memory. (Pubmed Central) -  Jul 13, 2023   
    This chapter will provide a review of research into human cognition through the lens of VR-based paradigms for studying memory. Emphasis is placed on why VR increases the ecological validity of memory research and the implications of such enhancements.
  • ||||||||||  Preclinical, Journal:  Poor inhibitory control predicts sex-specific vulnerability to nicotine rewarding properties in mice. (Pubmed Central) -  Jul 13, 2023   
    Emphasis is placed on why VR increases the ecological validity of memory research and the implications of such enhancements. Thus, our study suggests that poor inhibitory control and its modulation by nicotine may be a behavioural biomarker for sensitivity to nicotine reward and consequent vulnerability to nicotine addiction in males but not females.
  • ||||||||||  Review, Journal:  Whole body vibration therapy and cognitive functions: a systematic review. (Pubmed Central) -  Jul 10, 2023   
    Therefore, a systematic review of the literature was performed, consulting the ProQuest, MEDLINE and Scopus bibliographic databases, to summarize the available scientific evidence on the effects of whole-body vibration on cognitive functions in adults. Results of the review suggest that whole-body vibration therapy enhances a wide spectrum of cognitive functions in adults although there isn't enough evidence available yet to be able to design a standardized protocol to achieve optimum cognitive enhancement.
  • ||||||||||  APOE4 Genotype Relates with Body Mass and Percent Fat Mass in Cognitively Normal Older Adults (In-Person) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_8892;    
    These findings suggest that APOE4 status may influence body weight and body composition, which may represent a way APOE4 increases the risk of symptomatic AD. Future studies are needed to explore the mechanisms underpinning the relationship of APOE4 with decreased body mass and differential body compositions and to determine if these results are consistent in different life stages.
  • ||||||||||  Alzheimer's disease clinical management is determined by presence and severity of apathy (In-Person) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_8687;    
    Future studies are needed to explore the mechanisms underpinning the relationship of APOE4 with decreased body mass and differential body compositions and to determine if these results are consistent in different life stages. We observed different patterns of apathy in outpatients with MCI and patients with dementia; significant negative effect on early neurological assessment of those patients, and therefore deleterious effect on their opportunities for a correct approach in the early stages of the disease.
  • ||||||||||  galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
    Analysis of persistence rate of cognitive enhancers in Alzheimer (Virtual) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_7737;    
    Also, donepezil and memantine were associated with longer persistence than rivastigmine and galantamine and choline alfocerate. In particular, in case of Nootropics, a high rate of initial prescription is given to patients with dementia, but rate of continuous prescription is not high.
  • ||||||||||  Computerized Games versus Crosswords Training in Mild Cognitive Impairment: The COG-IT trial (Hall 12) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_6912;    
    Common directionality was observed in the primary outcome of ADAS-Cog (cognition) and the secondary outcomes of FAQ (function) score and changes in MRI hippocampal volume and cortical thickness (neurodegeneration). If these effects are replicated and expanded in future trials with the inclusion of a control group that does not receive cognitive training, crossword puzzles training could become a home-based, scalable, cognitive enhancement tool for individuals with MCI.
  • ||||||||||  galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
    Symptomatic Alzheimer's Disease Therapy Utilization in 3 National Cohorts (In-Person) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_6792;    
    Time on first therapy was relatively short (<1 year) and the majority of patients did not utilize a second therapy. These results underscore the unmet need for additional therapies to alleviate the significant burden of AD.
  • ||||||||||  galantamine hydrobromide / Generic mfg., memantine / Generic mfg., rivastigmine / Generic mfg.
    Analysis of persistence rate of cognitive enhancers in Alzheimer (Virtual) -  Jul 6, 2023 - Abstract #AAIC2023AAIC_5671;    
    Also, donepezil and memantine were associated with longer persistence than rivastigmine and galantamine and choline alfocerate. In particular, in case of Nootropics, a high rate of initial prescription is given to patients with dementia, but rate of continuous prescription is not high.