 |
0 Companies | 0 Products |
|
|
0 Products | |
0 Diseases | |
0 Trials |  |
0 News |  |
| 12345678910111213...2627» |
- || Review, Journal: The biological function of Serpinb9 and Serpinb9-based therapy. (Pubmed Central) - Jul 5, 2024
Therefore, the objective of this review is to consolidate current knowledge regarding the biological role of Sb9. It aims to offer insights into its discovery, structure, functions, distribution, its association with various diseases, and the potential of nanoparticle-based therapies targeting Sb9.
- doxycycline / Generic mfg.
Exploring the Immunoregulatory Potential of Serpinb9 in Transplant Tolerance (118-ABC, Level 1) - May 6, 2024 - Abstract #ATC2024ATC_136;
It aims to offer insights into its discovery, structure, functions, distribution, its association with various diseases, and the potential of nanoparticle-based therapies targeting Sb9. For deeper insights, we established PI-9 conditional knockout mice by crossbreeding inducible PI-9 RNA interference (PI-9rtTA) transgenic mice with macrophage-specific LyzM-Cre mice, resulting in macrophage-specific PI-9 knockouts upon doxycycline administration (PI-9rtTA
- Role of Cytoskeleton and Adhesion in a Rare Subset of HIV-Infected Cells That Resist CTL () - Mar 16, 2024 - Abstract #CROI2024CROI_1198;
In cancer, lower stiffness and reduced integrin expression are mechanisms of escape. Small molecule and engineered CAR-T therapeutic approaches to target less adherent cells are under development for cancer and should be tested for their abilities to enhance elimination of HIV reservoirs.
- | Journal, IO biomarker: Overexpression of SerpinB9 in non-seminomatous germ cell tumors. (Pubmed Central) - Nov 22, 2023
These findings suggest that SerpinB9 contributes to the immune escape of testicular germ cell tumors. Targeting therapy for SerpinB9 might therefore be useful in immunotherapy for testicular germ cell tumors resistant to immune checkpoint inhibitors.
- Proteomic profiling identifies granzyme B inhibitor Serpin B9 as mediator of resistance to CAR T-cell and bispecific antibody treatment in nodal B-cell lymphoma (Room B) - May 4, 2023 - Abstract #ICML2023ICML_168;
- | Journal: Granzyme B as a therapeutic target: An update in 2022. (Pubmed Central) - Dec 22, 2022
Consequently, specific granzyme B inhibitors have been developed as new therapeutic approaches. Beyond applications in wound healing, other autoimmune and/or chronic inflammatory conditions related to exacerbated granzyme B activity may also benefit from the development of these inhibitors.
- T cell killing is facilitated by multiple cytotoxic pathways (Hall C) - Oct 6, 2022 - Abstract #SITC2022SITC_739;
We hypothesize that Granzyme A facilitates CAR T killing in the absence of Granzyme B, implying redundancy in granzyme expression. This study provides a comprehensive understanding of the main mechanisms associated with CAR T cell-mediated killing.
- | Journal: The role of CD8 Granzyme B T cells in the pathogenesis of Takayasu's arteritis. (Pubmed Central) - Jan 6, 2022
• We found the percentages of CD8GranzymeB T cells, CD8Perforin T cells, and CD8IFN-γ T cells in CD3CD8T cells were higher in TAK patients. • The proportion of CD8T cells in lymphocytes and the ratio of CD8GranzymeB T cells/CD8 T cells were significantly lower in TAK patients after treatment.
- | Journal, IO biomarker: Granzyme B and perforin produced by SEC2 mutant-activated human CD4 T cells and CD8 T cells induce apoptosis of K562 leukemic cells by the mitochondrial apoptotic pathway. (Pubmed Central) - Dec 17, 2021
Conversely, the granzyme B inhibitor or perforin inhibitor significantly weakened antitumor effect of ST-4, accompanied by a decrease of cleaved proapoptotic BAX and cytochrome c, and an increase of antiapoptotic BCL2. Taken together, these data suggest that granzyme B and perforin produced by ST-4-activated CD4 T cells and CD8 T cells play a pivotal role in inducing K562 cell apoptosis by the mitochondrial apoptotic pathway, and support ST-4 as a potential candidate for cancer immunotherapy.
- | Journal: Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells. (Pubmed Central) - Dec 5, 2021
Moreover, cytosolic granzyme B inhibitor Serpinb9a prevented caspase-3 processing and mast cell death in a granzyme B-dependent manner. Together, our findings demonstrate that cytosolic serpins provide an inhibitory shield preventing granule protease-induced mast cell apoptosis, and that the granzyme B-Serpinb9a-caspase-3 axis is critical in mast cell survival and could be targeted in the context of allergic diseases.
- | Journal, IO biomarker: DCLK1-isoform2 alternative splice variant promotes pancreatic tumor immunosuppressive M2-macrophage polarization. (Pubmed Central) - Jun 3, 2021
We conclude that DCLK1-isoform2 is a novel initiator of alternate macrophage activation that contributes to the immunosuppression observed in the PDAC TME. These data suggest that tumor DCLK1-isoform2 may be an attractive target for PDAC therapy, either alone or in conjunction with immunotherapeutic strategies.
- | Journal: Cluster Analysis According to Immunohistochemistry is a Robust Tool for Non-Small Cell Lung Cancer and Reveals a Distinct, Immune Signature-defined Subgroup. (Pubmed Central) - Jun 2, 2021
Importantly, for one "immune signature" cluster, the signature of the TIL (especially the amount of CD8+ TIL) was more crucial than the histologic or any other phenotypical aspect. This may be an important finding toward explaining why only a fraction of eligible patients respond to immunomodulating anticancer therapies.
- | Journal, IO biomarker: T cell cytotoxicity toward hematologic malignancy via B7-H3 targeting. (Pubmed Central) - Jun 2, 2021
Moreover, B7-H3Bi-Ab-armed T cells secreted more IFN-γ, TNF-α, IL-2, and Granzyme B and expressed higher levels of activating marker CD69 compared to unarmed T cells. In conclusion, B7-H3Bi-Ab enhances the ability of T cells to kill hematologic tumor cells, and B7-H3 may serve as a novel target for immunotherapy against hematologic malignancy.
- | Journal: Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8 T Cells and Macrophages. (Pubmed Central) - Jun 2, 2021
Furthermore, the effective dose of Akk-EVs was well-tolerated in normal cells. Our study revealed the promising prospects of Akk-EVs as an efficient and biocompatible immunotherapeutic agent for PCa treatment.
- | mupirocin / Generic mfg.
FDA event, Journal: Screening of FDA approved drugs for finding potential inhibitors against Granzyme B as a potent drug-repurposing target. (Pubmed Central) - Jun 1, 2021
Current drug repurposing study is a step ahead in finding potential lead compounds by screening database of FDA approved molecules. We have identified novel inhibitors (Tannic acid, Mupirocin, Phytonadiol sodium diphosphate, Cefpiramide, Xenazoic acid) that have potential to decrease the activity of Granzyme B.
- [VIRTUAL] Tim-3-Galectin-9-VISTA pathways major contributors to suppression of cytotoxic activities of T cells in acute myeloid leukaemia () - May 30, 2021 - Abstract #EACR2021EACR_3203;
Conclusion Tim-3-galectin-9-VISTA pathways play crucial role in suppression of cytotoxic activities of T cells in AML and several other types of human cancers. These pathways and the biochemical networks which regulate their activities need to be studied further as potential targets for fundamentally novel approaches in immunotherapy of cancer.
- [VIRTUAL] Tim-3-Galectin-9-VISTA pathways major contributors to suppression of cytotoxic activities of T cells in acute myeloid leukaemia () - May 30, 2021 - Abstract #EACR2021EACR_3202;
Conclusion Tim-3-galectin-9-VISTA pathways play crucial role in suppression of cytotoxic activities of T cells in AML and several other types of human cancers. These pathways and the biochemical networks which regulate their activities need to be studied further as potential targets for fundamentally novel approaches in immunotherapy of cancer.
- [VIRTUAL] Tim-3-Galectin-9-VISTA pathways major contributors to suppression of cytotoxic activities of T cells in acute myeloid leukaemia () - May 30, 2021 - Abstract #EACR2021EACR_3201;
Conclusion Tim-3-galectin-9-VISTA pathways play crucial role in suppression of cytotoxic activities of T cells in AML and several other types of human cancers. These pathways and the biochemical networks which regulate their activities need to be studied further as potential targets for fundamentally novel approaches in immunotherapy of cancer.
- [VIRTUAL] Tim-3-Galectin-9-VISTA pathways major contributors to suppression of cytotoxic activities of T cells in acute myeloid leukaemia () - May 30, 2021 - Abstract #EACR2021EACR_3200;
Conclusion Tim-3-galectin-9-VISTA pathways play crucial role in suppression of cytotoxic activities of T cells in AML and several other types of human cancers. These pathways and the biochemical networks which regulate their activities need to be studied further as potential targets for fundamentally novel approaches in immunotherapy of cancer.
- [VIRTUAL] Prostate cancer-associated Natural Killer cells support tumour angiogenesis via endothelial cell activation and M2-like/TAM macrophage polarization. () - May 30, 2021 - Abstract #EACR2021EACR_2783;
Finally, CMs from PCa circulating NKs recruit THP-1 and peripheral blood CD14+ monocyte and polarize THP-1 and peripheral blood CD14+ monocyte-derived macrophage towards M2-like/TAM macrophages. Conclusion Our data indicate that circulating NK cells from PCa patients can contribute to PCa progression by supporting angiogenesis and macrophage M2-like polarization.
- [VIRTUAL] Prostate cancer-associated Natural Killer cells support tumour angiogenesis via endothelial cell activation and M2-like/TAM macrophage polarization. () - May 30, 2021 - Abstract #EACR2021EACR_2782;
Finally, CMs from PCa circulating NKs recruit THP-1 and peripheral blood CD14+ monocyte and polarize THP-1 and peripheral blood CD14+ monocyte-derived macrophage towards M2-like/TAM macrophages. Conclusion Our data indicate that circulating NK cells from PCa patients can contribute to PCa progression by supporting angiogenesis and macrophage M2-like polarization.
- [VIRTUAL] Prostate cancer-associated Natural Killer cells support tumour angiogenesis via endothelial cell activation and M2-like/TAM macrophage polarization. () - May 30, 2021 - Abstract #EACR2021EACR_2781;
Finally, CMs from PCa circulating NKs recruit THP-1 and peripheral blood CD14+ monocyte and polarize THP-1 and peripheral blood CD14+ monocyte-derived macrophage towards M2-like/TAM macrophages. Conclusion Our data indicate that circulating NK cells from PCa patients can contribute to PCa progression by supporting angiogenesis and macrophage M2-like polarization.
- [VIRTUAL] Prostate cancer-associated Natural Killer cells support tumour angiogenesis via endothelial cell activation and M2-like/TAM macrophage polarization. () - May 30, 2021 - Abstract #EACR2021EACR_2780;
Finally, CMs from PCa circulating NKs recruit THP-1 and peripheral blood CD14+ monocyte and polarize THP-1 and peripheral blood CD14+ monocyte-derived macrophage towards M2-like/TAM macrophages. Conclusion Our data indicate that circulating NK cells from PCa patients can contribute to PCa progression by supporting angiogenesis and macrophage M2-like polarization.
- [VIRTUAL] Transforming growth factor-β2 antisense oligodeoxynucleotide in potentiating T-cell mediated antitumor immunity for immunotherapeutic strategy of triple-negative breast cancers () - May 30, 2021 - Abstract #EACR2021EACR_2203;
Decreased intra-tumoral Tregs facilitated the activation of cytotoxic T cells, associated with increased granzyme B expression. Conclusion Our results indicate the potential of TASO for potentiating T-cell mediated antitumor immunity, and we propose that TGF-β2 may be a promising target in the immunotherapeutic strategy of TNBC.
- [VIRTUAL] Transforming growth factor-β2 antisense oligodeoxynucleotide in potentiating T-cell mediated antitumor immunity for immunotherapeutic strategy of triple-negative breast cancers () - May 30, 2021 - Abstract #EACR2021EACR_2202;
Decreased intra-tumoral Tregs facilitated the activation of cytotoxic T cells, associated with increased granzyme B expression. Conclusion Our results indicate the potential of TASO for potentiating T-cell mediated antitumor immunity, and we propose that TGF-β2 may be a promising target in the immunotherapeutic strategy of TNBC.
- [VIRTUAL] Transforming growth factor-β2 antisense oligodeoxynucleotide in potentiating T-cell mediated antitumor immunity for immunotherapeutic strategy of triple-negative breast cancers () - May 30, 2021 - Abstract #EACR2021EACR_2201;
Decreased intra-tumoral Tregs facilitated the activation of cytotoxic T cells, associated with increased granzyme B expression. Conclusion Our results indicate the potential of TASO for potentiating T-cell mediated antitumor immunity, and we propose that TGF-β2 may be a promising target in the immunotherapeutic strategy of TNBC.
- [VIRTUAL] Transforming growth factor-β2 antisense oligodeoxynucleotide in potentiating T-cell mediated antitumor immunity for immunotherapeutic strategy of triple-negative breast cancers () - May 30, 2021 - Abstract #EACR2021EACR_2200;
Decreased intra-tumoral Tregs facilitated the activation of cytotoxic T cells, associated with increased granzyme B expression. Conclusion Our results indicate the potential of TASO for potentiating T-cell mediated antitumor immunity, and we propose that TGF-β2 may be a promising target in the immunotherapeutic strategy of TNBC.
- | Preclinical, Journal: Valproic acid triggers radiation-induced abscopal effect by modulating the unirradiated tumor immune microenvironment in a rat model of breast cancer. (Pubmed Central) - May 30, 2021
Furthermore, IR + VPA treatment led to macrophages infiltration into the unirradiated tumor sites and polarization to M1 phenotype, resulted in increased levels of pro-inflammatory cytokines such as IL-1β and IL-12, and decreased levels of anti-inflammatory cytokines such as IL-10 and TGF-β. Our data supports the proposition that VPA may be a potential therapeutic candidate to trigger radiation-induced abscopal effect by modulating the unirradiated tumor immune microenvironment.
- | Preclinical, Journal, IO biomarker: Protective immune response against P32 oncogenic peptide-pulsed PBMCs in mouse models of breast cancer. (Pubmed Central) - May 29, 2021
Consequently, significantly lower tumor sizes and prolonged survival time were detected in F4d and F4e subgroups compared to control after challenging mice with 4T1 cells. Accordingly, these results demonstrated that PBMCs pulsed F4 peptide-based vaccine could induce a protective immune response while it is a simple and less expensive vaccine.
- | Biomarker, Journal, Tumor microenvironment, PD(L)-1 Biomarker, IO biomarker: Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma. (Pubmed Central) - May 28, 2021
P2
Together, our results demonstrate that the immunological profile of DLBCL TME is heterogeneous and clinically meaningful. This highlights the potential impact of T-cell immune checkpoint in regulating survival and resistance to immunochemotherapy.
- | Journal, IO biomarker: Generation of multiepitope cancer vaccines based on large combinatorial libraries of survivin-derived mutant epitopes. (Pubmed Central) - May 28, 2021
In addition, we observed the presence of IFN-γ-, Granzyme B- and Perforin-producing lymphocytes along with modifications in the amount of CD11b+Ly6Cint/lowLy6G+ granulocytic myeloid-derived suppressor cells (G-MDSCs) and CD4+CD25+FoxP3+ regulatory T cells in the lungs and tumors of mice. In summary, we showed that the VELs represent a potent new class of cancer immunotherapy and propose the application of the VEL vaccine concept as a true alternative to currently available vaccine platforms.
- | Journal: Circulating CD4 T cells elicited by endemic coronaviruses display vast disparities in abundance and functional potential linked to both antigen specificity and age. (Pubmed Central) - May 28, 2021
The functional potential of these cross-reactive CD4 T cells was highly variable, with nucleocapsid-specific CD4 T cells, but not spike-reactive cells showing exceptionally high levels of granzyme production upon stimulation. These results are considered in light of recruitment of hCoV-reactive cells into responses of humans to SARS-CoV infections or vaccinations.
- | Journal: Interferon regulatory factor 4 deficiency in CD8 T cells abrogates terminal effector differentiation and promotes transplant acceptance. (Pubmed Central) - May 27, 2021
Hence, IRF4 deficiency in CD8 T cells abrogates their terminal effector differentiation and promotes transplant acceptance. These findings suggest that targeting IRF4 expression represents an attractive and promising therapeutic approach for inducing transplant acceptance.
- || Clinical, Journal: A combination of the percentages of IFN-γCD4T cells and granzyme BCD19B cells is associated with acute hepatic rejection: a case control study. (Pubmed Central) - May 22, 2021
These findings suggest that targeting IRF4 expression represents an attractive and promising therapeutic approach for inducing transplant acceptance. A combination of the percentages of IFN-γCD4T cells and granzyme BCD19B cells can distinguish rejection from non-rejection, which can be used as a potential prognostic marker for acute rejection in liver transplant recipients.
- | Journal: Glycodelin regulates the numbers and function of peripheral natural killer cells. (Pubmed Central) - May 21, 2021
Thus, during pregnancy, glycodelin modulates the function and the number of cytotoxic NK cells that pose a deleterious effect on the fetus, a semi-allograft. This study provides insights into the mechanism of the regulatory effect of glycodelin on NK cells and could possibly be exploited for the management of miscarriages.
- | Journal, IO biomarker: Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages. (Pubmed Central) - May 21, 2021
The therapeutic effect of targeting PKA is pronounced when combined with αCTLA-4 antibody, increasing cluster of differentiation 8 (CD8)GranzymeB T cells by about 60-fold. Our findings demonstrate critical roles of TAM PKA-C in tumor progression and suggest that targeting PKA-C efficiently augments cancer treatment responses.
- || cyclosporine / Generic mfg.
Review, Journal: Diagnosis and treatment of subcutaneous panniculitis-like T-cell lymphoma: A systematic literature review. (Pubmed Central) - May 21, 2021
Diagnosis is highly dependent on the immunohistochemical stains added to histopathologic and radiologic findings. Therapy is dependent on the pace of the disease, with encouraging results obtained with single-agent cyclosporine.
- | Lusduna (insulin glargine biosimilar) / Samsung
Journal: Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy. (Pubmed Central) - May 20, 2021
The therapeutic utility of Sb9 inhibition was demonstrated by the control of tumor growth, resulting in increased survival times in mice. Our studies describe a molecular target that permits a combination of tumor ablation, interference within the TME, and immunotherapy in one potential modality.
- || Opdivo (nivolumab) / Ono Pharma, BMS
Biomarker, Clinical, Review, Journal, Checkpoint inhibition, PD(L)-1 Biomarker, IO biomarker: Case Report: Simultaneous Hyperprogression and Fulminant Myocarditis in a Patient With Advanced Melanoma Following Treatment With Immune Checkpoint Inhibitor Therapy. (Pubmed Central) - May 20, 2021
We discuss the possibility that heightened pro-inflammatory T cell activity (rather than tumor-directed cytolytic activity) was induced by anti-PD-1 and anti-CTLA-4, which could have provoked both rapid tumor resistance mechanisms and myocarditis. This case highlights the fact that the mere presence of tumor infiltrating lymphocytes (TILs) does not necessarily correlate to ICI response and that additional functional markers are necessary to differentiate between inflammatory and cytolytic CD8 TILs.
- [VIRTUAL] Rapid activation and expansion of peripheral gammadelta (γδ) T cells in SARS-CoV-2-infected nonhuman primates following aerosol exposure () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_2177;
Collectively, these data suggest γδ T cells may be early responders to deep lung SARS-CoV-2 infection and the kinetics and quality of immune response are dependent upon route of exposure despite resulting in similar peak viral loads from infection. Further understanding of γδ T cell functions within the pulmonary compartment during SARS-CoV-2-driven acute inflammation may reveal tractable therapeutic approaches to further mitigate ARDS-like responses in COVID-19 patients.
- [VIRTUAL] Screening immunotherapy cancer drugs in a scalable, physiologically relevant 3D in vitro tumor microenvironment model () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1987;
Our results show combination treatment with cytokines and anti-PD-1 antibody led to higher secretion of IL-6/TNFa/IFNγ/GM-CSF, reduced tumor size, increased infiltration of the model by CD8+ T cells, stronger expression of Granzyme B resulting in enhanced tumor apoptosis and killing. This confirms our novel 3D in vitro TME model is a promising tool for studying cell-cell interactions and allows for HCS of novel candidates for anti-cancer drugs.
- [VIRTUAL] Skin-derived alternatively spliced IL-15 isoform-producing cells impair the generation of anti-viral effector CD8+ T cells in HSV-1 zosteriform mouse model () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1904;
The reverse relationship between the cell number of Langerhans cells and the increased expression of IL-15ΔE7 mRNA in dLN of P191 mice suggested that the influx of skin-derived IL-15ΔE7 expressing cells plays an important role in influencing the quantity and quality of anti-HSV-1 CD8+ T cells generated in P191 mice. More experiments will be carried out to understand how the alternatively cytokine splicing mechanism regulates a long term and effective CD8+ T cell immunity against virus infection.
- [VIRTUAL] Defects in the CD8+ T cell response to arthritogenic alphaviruses () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1902;
Finally, intravital imaging revealed that while both RRV and LCMV infection recruit CD8+ T cells and retain them in an antigen specific manner near infected cells, CD8+ T cells appear to have less contact with RRV than LCMV-infected cells. Identification of a specific defect in the CD8+ T cell response to arthritogenic alphaviruses would increase our understanding of viral immune evasion and provide a target for therapy of these debilitating infections.
- [VIRTUAL] Systematic examination of antigen-specific recall T cell responses to SARS-CoV-2 versus influenza virus reveals distinct inflammatory profile () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1892;
Overall, T cell responses to SARS-CoV-2 are robust; however, CD4+ Th1 responses predominate over CD8+ T cell responses, have a more inflammatory profile, and have a weaker pTfh response than the response to influenza virus within the same donors, potentially contributing to COVID-19 disease. Work is in progress to assess long-term T cell immunity 6 months to 1 year after SARS-CoV-2 infection.
- [VIRTUAL] The lymphoid microenvironment controls duration of T cell - DC interactions to promote accelerated effector cell generation () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1873;
Environmentally triggered CD8+ T cell detachment from DCs positively correlated with their entry into proliferation and granzyme B production while limiting PD-1 expression. In sum, our data assign a novel function to CCR7 ligands secreted by lymphoid stroma to limit the duration of CD8+ T cell - DC interactions for accelerated effector T cell generation.
- [VIRTUAL] Clearance of established oropharyngeal and genital HPV tumors by mucosal vaccination via induction of multiple cytotoxic effector populations () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1497;
Furthermore, the intranasal vaccine containing the combination of adjuvants induced significant frequencies of a unique subpopulation of NK cells expressing CD11c, granzyme B and IFNg, termed NKDC. Our results suggest that mucosal HPV E6/E7 peptide vaccine formulation containing QS-21+CpG-ODN adjuvants may provide an effective therapeutic strategy for the treatment of patients with HPV+ oropharyngeal and cervical cancers.
- [VIRTUAL] CD8 follicular T cells provide helper and cytolytic function in the B cell follicule during antibody-mediated autoimmunity () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1458;
However CD8 T cells promote plasma cell differentiation and antibody class switch, but do not alter germinal center B cell numbers. CD8 Tfc position coupled with cytokine production in the germinal center and follicle, and induction of activation-induced cytidine deaminase by B cells suggest a dominant helper-like role with cytolytic potential.
- [VIRTUAL] Analysis of soluble immune checkpoint proteins using quantitative multiplex microbead-based immunoassays () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1440;
Heatmaps demonstrate the detection of checkpoint proteins in the conditioned media collected from human tumor cell lines and stimulated PBMCs. In summary, our results demonstrate that these two multiplex immunoassays we developed are useful research tools for the simultaneous quantitation of circulating immune checkpoint proteins, as well as for its potential application in biomarker discovery and translational research.
- [VIRTUAL] A single-tube, 44-marker CyTOF assay to assess antigen-specific immunity in whole blood human samples with data analysis solution () - May 19, 2021 - Abstract #IMMUNOLOGY2021IMMUNOLOGY_1430;
Collectively, we demonstrate the flexibility of the Maxpar Direct Immune Profiling Assay to incorporate additional surface and intracellular markers to study antigen-specific immunity in the context of whole blood immune profiling. For RUO.