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- | Preclinical, Journal: Immune system-mediated atherosclerosis caused by deficiency of long noncoding RNA MALAT1 in ApoE-/- mice. (Pubmed Central) - Mar 9, 2020
The data suggest a molecular circuit involving the MALAT1-mascRNA system, interactions between MALAT1 and NEAT1, and key immune effector molecules, cumulatively impacting upon the development of atherosclerosis. It appears reasonable to look for therapeutic targets in this circuit and to screen for anomalies in the NEAT1-MALAT1 region in humans, too, as possible novel disease risk factors.
- | Clinical, Journal: HTLV-1-infected asymptomatic carriers compared to HAM/TSP patients over-express the apoptosis- and cytotoxicity-related molecules. (Pubmed Central) - Mar 8, 2020
ACs compared to HAM/TSP patients over-expressed the apoptosis- and cytotoxicity-related molecules. It could be concluded that successful control of the HTLV-1 infection and suppression of HAM/TSP development stem from the strong apoptosis and cytotoxic activity in the peripheral blood of ACs.
- | Preclinical, Journal: Different Effects of Interleukin 21 and Interleukin 15 on In Vitro Expanded CD8+ T Cells Stimulated by Alloantigen. (Pubmed Central) - Mar 8, 2020
IL-21 prevents the loss of CD28 molecules caused by IL-15 but cannot promote its re-expression in CD28 T cells. CD8 T cells expanded by IL-21 combined with IL-15 is characterized by cytotoxic phenotype.
- [VIRTUAL] A UNIQUE PD1+CD38+ CD8+ T CELL POPULATION CHARACTERIZES CHECKPOINT INHIBITOR-ASSOCIATED INFLAMMATORY ARTHRITIS (Nuki) - Mar 5, 2020 - Abstract #EULAR2020EULAR_954;
These cells may contribute to the amplified immune response seen in CI-A patients. Further functional and transcriptional analysis of these cells will help to elucidate their function may reveal key mechanisms driving CI-associated immune related adverse events.
- | Nexavar (sorafenib) / Bayer, Amgen
Journal: Sorafenib attenuated the function of natural killer cells infiltrated in HCC through inhibiting ERK1/2. (Pubmed Central) - Mar 4, 2020
This phenotype made us study the terminal function of NK cells, revealing that Sorafenib could decrease the production of effector molecules and cytokines, such as perforin, granzyme B, TNF-α, IFN-γ, etc. Besides, p-ERK1/2 in NK cells was inhibited after treatment with Sorafenib, and a similar tendency of NK cells could be achieved using ERK1/2 inhibitor. Collectively, our data suggested that Sorafenib functioned as a critical inhibitor that controlled the number and function of NK cells through inhibiting ERK1/2.
- [VIRTUAL] ERAP1-MEDIATED IMMUNOGENICITY AND IMMUNE-PHENOTYPES IN HLA-B51+ BEHÇET’S DISEASE POINT TO PATHOGENIC CD8 T CELL EFFECTOR RESPONSES (Rau) - Mar 4, 2020 - Abstract #EULAR2020EULAR_276;
This is mediated by an HLA-class I peptidome with propensity for longer peptides above 9mer and suggests loss or de-novo presentation of peptide-HLA-B51 complexes to cognate CD8 TCR. The reciprocal changes in antigen- experienced vs naive CD8 T cell subsets in affected subjects point to biologic significance of HLA-B51/Hap10 in BD.
- sepantronium bromide (YM155) / Astellas
[VIRTUAL] TRANSCRIPTIONAL ACTIVITY OF SURVIVIN CONTRIBUTES TO MATURATION AND FUNCTION OF THE INTERFERON-GAMMA PRODUCING T CELLS IN RHEUMATOID ARTHRITIS (Wollheim) - Mar 4, 2020 - Abstract #EULAR2020EULAR_208;
To study if BIRC5 is a part of IFN signalling, CD4 cells were cultured with survivin inhibitor YM155 and activated with IFNg... his study showed that survivin binds to DNA and regulates the core gene expression contributing to maturation and function of the IFNg producing Th1 cells.
- fluconazole / Generic mfg., sertraline / Generic mfg.
[VIRTUAL] CSF CYTOKINES AND CHEMOKINES ASSOCIATED WITH MORTALITY IN CRYPTOCOCCAL MENINGITIS ([VIRTUAL]) - Mar 2, 2020 - Abstract #CROI2020CROI_1316;
We prospectively enrolled Ugandans presenting with first episode cryptococcal meningitis from March 2015 to May 2017, as part of a larger study focused on drug treatment with amphotericin + fluconazole +/- sertraline to improve neurological outcomes...These findings demonstrate a crucial role for cytotoxic cell populations and naive T-cell stimulation in human cryptococcal outcomes. Further research efforts should include characterizing the role and activating stimuli of cytotoxic cells in the clearance of Cryptococcus as well as T-cell function in activation of the adaptive immune response in humans with cryptococcosis.
- [VIRTUAL] HIV-SPECIFIC CD8+ T CELLS EXHIBIT POOR CYTOLYTIC POTENTIAL IN THE HUMAN AIRWAY ([VIRTUAL]) - Mar 2, 2020 - Abstract #CROI2020CROI_442;
We demonstrate that airway-derived HIV-specific CD8+T cells poorly express cytolytic molecules (Granzyme B and Perforin) and possess markers consistent with high immune regulation (PD1 and Eomes). The poor cytolytic potential and highly regulated phenotype of airway HIV-specific CD8+T cells could promote the persistence of HIV-infected cells in the airway in individuals on long term ART.
- [VIRTUAL] IMPACT OF IMMUNE CHECKPOINT INHIBITORS IN VACCINE-INDUCED ANTI-HIV RESPONSES ([VIRTUAL]) - Mar 2, 2020 - Abstract #CROI2020CROI_440;
P1
Thus, we propose the combined use of ICI and therapeutic vaccines to boost vaccine-induced anti-HIV CD8+ responses in vivo. In addition, the use of combined ICI as an anti-HIV immunotherapeutic strategy in Chro warrants further investigation.
- [VIRTUAL] CXCR5+ NK CELLS IN THE LYMPH NODE ARE ASSOCIATED WITH CONTROL OF SHIV INFECTION ([VIRTUAL]) - Mar 2, 2020 - Abstract #CROI2020CROI_419;
Importantly, the frequency of CXCR5+ NK cells correlated inversely with plasma SHIV viral RNA levels and exhibited a significant negative association with germinal center Tfh cells Chronic SHIV infection is characterized by accumulation of NK cells within LN follicles and suggest that CXCR5+ NK cells could play an important role in controlling SHIV infection. Cure strategies should focus on inducing these cells for sustained HIV remission
- [VIRTUAL] IDENTIFYING CENTRAL COMPONENTS OF THE HIV-1+ PREGNANCY IMMUNE NETWORK ([VIRTUAL]) - Mar 2, 2020 - Abstract #CROI2020CROI_418;
However, the PP group had more high Strength scoring T-cell parameters, predominantly CD38 expressing T cells, suggesting these activated T cells are more influential in the HIV-1 positive pregnancy network. Our work highlights shared immune components that may be key regulators of pregnancy tolerance and has identified parameters uniquely impacted by HIV-1 that may negatively influence the pregnancy immune network.
- | Journal: PD‑L1/PD‑1 axis serves an important role in natural killer cell‑induced cytotoxicity in osteosarcoma. (Pubmed Central) - Mar 2, 2020
The present study proposed that the PD‑L1/PD‑1 axis serves an important role in NK cell‑induced cytotoxicity in osteosarcoma via granzyme B secretion. Our findings may contribute to the development of precise treatments for osteosarcoma based on the expression profile of PD‑L1 in patients with this disease.
- | Journal: Wiskott-Aldrich syndrome protein may be critical for CD8 T cell function following MCMV infection. (Pubmed Central) - Feb 29, 2020
Moreover, the number of apoptotic CD8 T cells increased in Was KO mice compared with the number in wild-type mice. Therefore, our results demonstrate that WASP may be involved in regulating cytotoxic function and apoptosis in CD8 T cells following MCMV infection, which is supported by the distribution and memory compartment of MCMV-specific T cells in MCMV infected WAS mice.
- | Preclinical, Journal, IO Biomarker: Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection. (Pubmed Central) - Feb 27, 2020
Further, nano2/4 therapy was effective in controlling the tissue infiltration of pro-fibrotic macrophages and established a balanced environment controlling the expression of collagens, metalloproteinases, and other markers of cardiomyopathy and improving the expression of Myh7 (encodes β myosin heavy chain) and Gsk3b (encodes glycogen synthase kinase 3) required for maintaining cardiac contractility in Chagas heart. We conclude that nano2/4 enhances the systemic T cell immunity that improves the host's ability to control chronic parasite persistence and Chagas cardiomyopathy.
- Inflammatory and genetic signatures for recurrent oropharynx cancer (The Westin Kierland Resort and Spa) - Feb 27, 2020 - Abstract #MHNCS2020MHNCS_228;
We conclude that nano2/4 enhances the systemic T cell immunity that improves the host's ability to control chronic parasite persistence and Chagas cardiomyopathy. While overall inflammation may be increased in HPV+ patients with recurrent disease, based on the current study, the tumor associated inflammation may be contributing to an enhanced immunosuppressive environment.
- Profiling the Spatial Composition of the Hypoxic Tumor-Immune Microenvironment through Multiplex Immunohistochemistry in a Prospective cohort of HPV Associated Oropharynx Cancer (The Westin Kierland Resort and Spa) - Feb 27, 2020 - Abstract #MHNCS2020MHNCS_104;
Absence of hypoxia in the TME of HPV associated oropharynx carcinoma is associated with a decreased density of immunosuppressive T-regulatory cells, M2 macrophages, and an increased density of infiltrated exhausted T-cells. Insight into tumor-immune cell relationships, may increase understanding for treatment resistance in hypoxic TMEs is being investigated in a larger prospective study.
- [VIRTUAL] Phase I trial of autologous cMET-directed CAR-t cells administered intravenously in patients with melanoma & breast carcinoma. (Poster Board 384) - Feb 27, 2020 - Abstract #ASCO2020ASCO_853;
P1
Future directions include examination of this target using a lentiviral construct in combination with lymphodepleting chemotherapy. Research Funding: U.S. National Institutes of Health, Other Foundation
- [VIRTUAL] Immune microenvironment profiling of breast cancer brain metastases using multiplex immunofluorescence. (Poster Board 17) - Feb 27, 2020 - Abstract #ASCO2020ASCO_180;
Preliminary results suggest that a more tolerogenic immune microenvironment is associated with worse OS and might represent a target for optimization of immunotherapy for these patients. Updated results for all 60 patients will be presented.
- | Tasigna (nilotinib) / Novartis, Inhibikase
Journal, PD(L)-1 Biomarker, IO Biomarker: Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers. (Pubmed Central) - Feb 26, 2020
A distinct poor outcome immunomodulatory microenvironment, hitherto poorly characterized, exhibited stromal restriction of CD8+ T cells, stromal expression of PD-L1 and enrichment for signatures of cholesterol biosynthesis. Metasignatures defining these TIME subtypes stratified TNBC, predicting outcome and identifying potential therapeutic targets for TNBC.
- | Journal: Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period. (Pubmed Central) - Feb 26, 2020
Postoperative lipid accumulation promotes the formation of metastases by impairing NK cell function in both preclinical surgical models and human surgical colorectal cancer patient samples. Understanding and targeting the mechanisms underlying lipid accumulation in innate immune NK cells can improve prognosis in cancer surgical patients.
- | Journal: Role of Regulatory B Cells in the Progression of Cervical Cancer. (Pubmed Central) - Feb 25, 2020
Breg cells are elevated in cervical cancer and associated with disease progression and metastasis. Moreover, they can inhibit the cytotoxicity of CD8 T cells.
- | Journal: Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant T cells. (Pubmed Central) - Feb 24, 2020
Lastly, SpeA induced granzyme B production in GC-T cells from RT tonsils with the capacity to kill B cells and the potential to hobble the germinal center response. These observations suggest that RT is a multifactorial disease and that contributors to RT susceptibility include HLA class II differences, aberrant SpeA-activated GC-T cells, and lower SpeA antibody titers.
- | Biomarker, Journal, Tumor microenvironment, PD(L)-1 Biomarker, IO Biomarker: Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment. (Pubmed Central) - Feb 23, 2020
Mechanistically, we demonstrated that simultaneous targeting of Tim-3, PD-1, and Lag-3 cooperatively increased the levels of granzyme B and tumor-specific cytolytic activities of CD8 TIL. Our data indicate that multiple checkpoint molecules are coordinately upregulated to inhibit the function of hyperactivated T cells in the TME and requirement for the simultaneous blockade of PD-1, Tim-3 and Lag3 for cancer treatment.
- MCAM Expression On Regulatory T Cells In Multiple Sclerosis (Exhibit Hall A, Convention Center - Board no. P260) - Feb 21, 2020 - Abstract #ACTRIMSForum2020ACTRIMS_FORUM_381;
These MCAM + Treg seem to maintain anti-inflammatory properties important for dampening inflammation and resolution of symptoms. By exploring the migration mechanisms of Treg, we would not only be advancing knowledge on the pathophysiology of MS, but would also be painting a target on a potential therapeutic novelty.
- Cellular Adhesion Molecules Are Differentially Regulated On Ms Patient’S Treg During Disease Modifying Therapy And Disease Progression (Exhibit Hall A, Convention Center - Board no. P237) - Feb 21, 2020 - Abstract #ACTRIMSForum2020ACTRIMS_FORUM_280;
Although Treg function seems decreased, a compensatory mechanism of upregulating CAMs to aid migration into the CNS might be at play, even more so since these CAMs are more upregulated in the CSF compared to peripheral blood. Anti-inflammatory cytokine production by these Treg might be enhanced.
- | Journal: GSDMD is required for effector CD8 T cell responses to lung cancer cells. (Pubmed Central) - Feb 20, 2020
Colocalization of GSDMD with granzyme B was observed in the proximity of immune synapses, and GSDMD deficiency reduced the cytolytic capacity of CD8 T cells. Overall, our study highlights a function, to our knowledge previously unknown, for GSDMD in CTLs and demonstrated that GSDMD is required for an optimal CTL response to cancer cells.
- | Biomarker, Review, Journal, Tumor microenvironment: Basophils in Tumor Microenvironment and Surroundings. (Pubmed Central) - Feb 19, 2020
The elucidation of the roles of basophils in tumor immunity will demand studies on increasing complexity beyond those assessing basophil density and their microlocalization in TME. There are several fundamental questions to be addressed in experimental models and clinical studies before we understand whether basophils are an ally, adversary, or even innocent bystanders in cancers.
- || Clinical, Journal: Interleukin-7 promotes CD8 T cell activity in patients with enterovirus 71 associated encephalitis. (Pubmed Central) - Feb 15, 2020
The present data indicated that IL-7 induced cytolytic and non-cytolytic functions of CD8 T cells in EV71 associated encephalitis. IL-7 might be considered as one of the immunomodulatory therapeutic candidates for EV71 infection.
- | Journal: M860, a Monoclonal Antibody against Human Lactoferrin, Enhances Tumoricidal Activity of Low Dosage Lactoferrin via Granzyme B Induction. (Pubmed Central) - Feb 15, 2020
LF-IC is able to colligate membrane-bound CD14 (a TLR4 co-receptor) and FcγRIIa (a low affinity activating Fcγ receptor) on the surface of human monocytes, thereby triggering the Syk-PI3K-AKT-mTOR pathway leading to GzB production. Our work identifies a novel pathway for LF-mediated tumoricidal activity and may extend the clinical application of LF in tumor therapy.
- | Zyclara (imiquimod) / Mochida, Mylan, Bausch Health, Vesimune (imiquimod) / UroGen
Preclinical, Journal: A TLR7 agonist strengthens T and NK cell function during BRAF-targeted therapy in a preclinical melanoma model. (Pubmed Central) - Feb 15, 2020
Indeed, resistance to BRAFi therapy was delayed and accompanied by high numbers of activated T and NK cells in tumors. Thus, combining BRAFi with an immune stimulating agent such as a TLR ligand could be a promising alternative approach for the treatment of melanoma.
- || Biomarker, Clinical, Retrospective data, Journal: Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer. (Pubmed Central) - Feb 15, 2020
The expression of GALNT10 and its product, Tn antigen, in HGSC specimens was associated with the increased infiltration of M2 macrophages and neutrophils, and the decreased infiltration of CD3+ T cells, NK cells, and B cells. Taken collectively, high GALNT10 expression confers with immunosuppressive microenvironment to promote tumor progression and predicts poor clinical outcomes in HGSC patients.
- | Journal, PD(L)-1 Biomarker, IO Biomarker: Exosomal PD-L1 Retains Immunosuppressive Activity and is Associated with Gastric Cancer Prognosis. (Pubmed Central) - Feb 14, 2020
Taken collectively, high GALNT10 expression confers with immunosuppressive microenvironment to promote tumor progression and predicts poor clinical outcomes in HGSC patients. Overall, exosomal PD-L1 predicts the worse survival and reflects the immune status in GC patients, resulting from a stronger T-cell dysfunction due to its stable and MHC-I expression.
- | Journal: Anti-Cancer Effects of Panax ginseng Berry Polysaccharides via Activation of Immune-Related Cells. (Pubmed Central) - Feb 13, 2020
Deficient of NK cells in animal model demonstrated that the anti-cancer effect of GBPP was through NK cell activation. Results of this study suggest that ginseng berry polysaccharides, owing to their modulation of the immune response, can be a potential curative applicant for the prevention and treatment of tumors.
- | Journal, PARP Biomarker: Immune Responses Raised in an Experimental Colon Carcinoma Model Following Oral Administration of Lactobacillus casei. (Pubmed Central) - Feb 10, 2020
Oral administration of Lactobacillus casei induced potent Th1 immune responses and cytotoxic T cell infiltration in the tumor tissue of tumorbearing mice, resulting in tumor growth inhibition. Thus, the microorganism may hold promise as a novel dietary immunoadjuvant in raising protective anticancer immune responses.
- | Journal, PD(L)-1 Biomarker, IO Biomarker: Histidine-rich glycoprotein augments natural killer cell function by modulating PD-1 expression via CLEC-1B. (Pubmed Central) - Feb 9, 2020
Because both PD-1 and CLEC-1B are associated with prognosis during malignancy, HRG incorporates these molecules to exert the antitumor immunity role. These facts indicate the potential of HRG to be a new target for cancer immunotherapy.
- | Journal: Anti-HIV potency of T-cell responses elicited by dendritic cell therapeutic vaccination. (Pubmed Central) - Feb 8, 2020
Epitope mapping confirmed that vaccination elicited responses against predicted T-cell epitopes, but also allowed to identify a set of 8 new HIV-1 HLA-DR-restricted CD4+ T-cell epitopes. These results may help to better design future DC therapeutic vaccines and underscore the role of vaccine-elicited CD4+ T-cell responses to achieve control of HIV replication.
- | Journal: Cx43-Gap Junctions Accumulate at the Cytotoxic Immunological Synapse Enabling Cytotoxic T Lymphocyte Melanoma Cell Killing. (Pubmed Central) - Feb 7, 2020
Using an HLA-A2-restricted/MART-1-specific CD8 T-cell clone, we confirmed these observations in human cells. Our results suggest that Cx43-channels are relevant components of cytotoxic immunological synapses and potentiate CTL-mediated tumor cell killing.
- | Preclinical, Journal: Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T cell responses and immune regulation. (Pubmed Central) - Feb 7, 2020
Remarkably, spleens of ECM-protected Batf3 mice had elevated levels of regulatory immune cells and interleukin 10. Thus, protection from ECM in PbA-infected Batf3 mice was associated with the absence of strong CD8 T cell activity and induction of immunoregulatory mediators and cells.
- | Journal, IO Biomarker: Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4 T Cells. (Pubmed Central) - Feb 7, 2020
While T-bet ablation restricted interferon-γ (IFN-γ) production, loss of Blimp-1 prevented GzmB expression in response to IL-2, suggesting two independent programs required for polyfunctionality of tumor-reactive CD4 T cells. Our findings underscore the role of Treg cells, IL-2, and Blimp-1 in controlling the differentiation of cytotoxic CD4 T cells and offer a pathway to enhancement of anti-tumor activity through their manipulation.
- | Biomarker, Journal, PD(L)-1 Biomarker, IO Biomarker: Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1 Stem-like CD8 T Cells during Chronic Infection. (Pubmed Central) - Jan 31, 2020
Stem-like Tcf-1 CD8 T cells initially differentiated into a transitory population of CD101Tim3 cells that later converted into CD101 Tim3 cells. Recently generated CD101Tim3 cells proliferated in vivo, contributed to viral control, and were marked by an effector-like transcriptional signature including expression of the chemokine receptor CX3CR1, pro-inflammatory cytokines, and granzyme B. PD-1 pathway blockade increased the numbers of CD101Tim3 CD8 T cells, suggesting that these newly generated transitional cells play a critical role in PD-1-based immunotherapy.
- | Journal: Effects of Candida albicans infection on defense effector secretion by human oral mucosal epithelial cells. (Pubmed Central) - Jan 30, 2020
Recently generated CD101Tim3 cells proliferated in vivo, contributed to viral control, and were marked by an effector-like transcriptional signature including expression of the chemokine receptor CX3CR1, pro-inflammatory cytokines, and granzyme B. PD-1 pathway blockade increased the numbers of CD101Tim3 CD8 T cells, suggesting that these newly generated transitional cells play a critical role in PD-1-based immunotherapy. These results suggest that C. albicans may exert a regulatory role in the defense response of oral mucosal epithelial cells by altering secretory levels of defense effector molecules.
- | Journal: Engraftment of mesothelin chimeric antigen receptor using a hybrid Sleeping Beauty/minicircle vector into NK-92MI cells for treatment of pancreatic cancer. (Pubmed Central) - Jan 28, 2020
These results suggest that C. albicans may exert a regulatory role in the defense response of oral mucosal epithelial cells by altering secretory levels of defense effector molecules. We provide proof of concept that allogeneic mesothelin-chimeric antigen receptor NK-92MI cells with hybrid Sleeping Beauty and minicircle technologies provide increased engraftment and cytotoxicity in vitro with potential safety benefits when translated to the clinical arena.
- || sirolimus / Generic mfg.
Clinical, Journal: Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation. (Pubmed Central) - Jan 26, 2020
Interestingly, numbers of IFN-γ CD4 T cells and serum IFN-γ levels increased with the addition of sirolimus treatment likely promoting ongoing anti-PD-1 efficacy. Thus, our results indicate that sirolimus has the potential to uncouple anti-PD-1 therapy toxicity and efficacy.
- Use of phenotypic and spatial data acquired from multiplex immunohistochemistry to model endogenous immune reactivity in the colon cancer tumor microenvironment. (Auditorium) - Jan 24, 2020 - Abstract #LCC2020LCC_234;
Modeling further revealed that when high levels of PD-L1+ APCs were present in the TME, CTL-TC intercellular distances were increased (mean = 55µm vs 22µm; p=0.0135) and mixing was decreased (g-function 25.1 vs 20.3; p=0.0421). Evaluation of immune interactions within the TME of metastatic colon cancer using mfIHC in combination with mathematical modeling can characterize cellular mixing of TCs and CTLs providing a novel strategy to better predict outcomes while identifying potential candidates for immune based therapies.
- | Journal: Anti-viral effects of superpositively charged mutant of green fluorescent protein. (Pubmed Central) - Jan 24, 2020
Evaluation of immune interactions within the TME of metastatic colon cancer using mfIHC in combination with mathematical modeling can characterize cellular mixing of TCs and CTLs providing a novel strategy to better predict outcomes while identifying potential candidates for immune based therapies. Generally, +36 GFP targets viral replication in vitro as well as helps to suppress the growth of HPV-related tumors in vivo.
- Short Course 26: Immunohistochemistry in Oncopathology: Indispensable Complement to a Morphology-Driven Pattern-Based Approach (LACC 402 AB) - Jan 24, 2020 - Abstract #USCAP2020USCAP_3018;
The USCAP is approved by the American Board of Pathology (ABPath) to offer Self-Assessment credits (SAMs) for the purpose of meeting the ABPath requirements for Continuing Certification (CC). Physicians can earn a maximum of 3 SAM credit hours.
- Multiparametric In Situ Imaging of NPM1-Mutated Acute Myeloid Leukemia Reveals Prognostically-Relevant Features of the Marrow Microenvironment (LACC West Exhibit Hall A, Poster Board Number: 244) - Jan 24, 2020 - Abstract #USCAP2020USCAP_2122;
In situ analyses further reveal that additional NPM1 wild-type cells within the microenvironment may support leukemia cell survival and be of prognostic significance. Additional multiparametric in situ analyses will be necessary to better define these populations.
- Clinicopathologic Analysis of CD8+ Primary Cutaneous Anaplastic Large Cell Lymphoma (LACC West Exhibit Hall A, Poster Board Number: 39) - Jan 24, 2020 - Abstract #USCAP2020USCAP_2012;
In this retrospective analysis, we found that CD8-positive PCALCL predominantly affects middle-aged men and displays indolent behavior like the usual CD4+ PCALCL. Interestingly, 42% of patients in our cohort were female and 29% were younger than 30 years.
- Abraxane (albumin-bound paclitaxel) / Otsuka, BMS, Tecentriq (atezolizumab) / Roche
Characterizing PD-L1 Expressing Immune Cells in Triple Negative Breast Cancer by Multiplex Immunofluorescence (LACC West Exhibit Hall A, Poster Board Number: 7) - Jan 24, 2020 - Abstract #USCAP2020USCAP_1602;
Phenotyping tumor immune cells in the study is highly informative to understand the immune microenvironment in TNBC. Characterizing PD-L1 expressing immune cells in TNBC might be helpful to predict the immunotherapy of PD-L1/PD-1 blockade.