- |||||||||| Genetics of serum electrolytes: a genome-wide association approach in two European cohorts (Focussed Oral Room 3) - Mar 23, 2024 - Abstract #ERAEDTA2024ERA_EDTA_2013;
Genes already reported to be associated with kidney abnormalities offer hints of their actual involvement in electrolyte imbalances and related disease. Moreover, associations pointing at cardiac diseases strengthen the involvement of these genes in renal electrolyte abnormalities, being one of the secondary causes of cardiomyopathies.
- |||||||||| Journal: Identification of the transcriptome signatures and immune-inflammatory responses in postmenopausal osteoporosis. (Pubmed Central) - Jan 8, 2024
Finally, we developed a combined risk prediction model based on lasso-logistic regression to predict postmenopausal osteoporosis, which combined eleven genes (PTGS2, CXCL16, NECAP1, RPS23, SSR3, CD74, IL4R, BTBD2, PIGS, LILRA2, MAP3K11) and three pieces of clinical information (age, procollagen I N-terminal propeptide, ? isomer of C-terminal telopeptide of type I) and provided the best prediction ability (AUC
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Journal, IO biomarker: Identification of bicalutamide resistance-related genes and prognosis prediction in patients with prostate cancer. (Pubmed Central) - May 9, 2023
In this study, bicalutamide resistance genes and hub genes were identified in PCa, a risk model for predicting the prognosis of patients with PCa was constructed, and the tumor mutation heterogeneity and immune infiltration in high- and low-risk groups were analyzed. These findings offer new insights into ADT resistance targets and prognostic prediction in patients with PCa.
- |||||||||| Journal: NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors. (Pubmed Central) - Dec 10, 2022
NEDDylation of Cullin 3 activates this pathway, and inhibition of protein NEDDylation or depletion of Cullin 3 sensitizes cancer cells to TOP1 inhibitors. Collectively, our data uncover a previously unidentified NEDD8-Cullin 3 pathway involved in the adaptive response to TOP1 inhibitors, which can be targeted to improve the efficacy of TOP1 drugs in cancer therapy.
- |||||||||| OBJECTIVE AND SUBJECTIVE MEASURES OF SLEEP INITIATION ARE DIFFERENTIALLY ASSOCIATED WITH DNA METHYLATION IN ADOLESCENTS (Room W206) - May 20, 2022 - Abstract #SLEEP2022SLEEP_119;
Objective and subjective sleep initiation in adolescents is associated with altered DNA methylation in genes previously identified in adult GWAS of sleep and circadian phenotypes. Our data provides evidence for a potential epigenetic link between habitual (subjective and ACT) SOL and in-lab SOT and DNAm in genes involved in circadian regulation (i.e., RASD1, RAI1), metabolism (i.e., FADS1, WNK1, SLC5A6), and neuropsychiatric disorders (i.e., PRR7, SDK1, FAM172A).
- |||||||||| dactinomycin / Generic mfg.
A NOVEL HUR TARGET—THE ABTB1 GENE—IS INVOLVED IN A POTENTIAL MECHANISM OF OBESITY-RELATED COLORECTAL CARCINOGENESIS (Poster Hall - San Diego Convention Center) - Apr 25, 2022 - Abstract #DDW2022DDW_4631;
The mRNA stability of the identified target was assessed by actinomycin D chase experiments...Conclusion : Dominant cytoplasmic HuR expression in CRC, which is related to visceral obesity and insulin exposure, and alteration of its binding fraction to its targets are active underlying mechanisms of obesity-related CRC development. Notably, ABTB1 was identified as a novel HuR target and a gene involved in colorectal carcinogenesis.
- |||||||||| Journal: Mechanism of Gegen Qinlian Decoction Regulating ABTB1 Expression in Colorectal Cancer Metastasis Based on PI3K/AKT/FOXO1 Pathway. (Pubmed Central) - Mar 23, 2022
It was found that the densities of p-PI3K, p-AKT, and p-FOXO1 in the experimental group of mice were 26.55 g/cm, 70.2 g/cm, and 24.36 g/cm, respectively, which were significantly increased compared with the control group, P < 0.05; the density of ABTB1 was 35.4 g/cm, which was significantly increased compared with the control group, P < 0.05; the proliferation and migration ability of CRC cells in the experimental group were significantly decreased, P < 0.05. GQD can promote the expression of ABTB1 by activating the PI3K/AKT/FOXO1 signaling pathway, in order to inhibit the proliferation and growth ability of CRC cells.
- |||||||||| Journal: Preliminary Study on the Sequencing of Whole Genomic Methylation and Transcriptome-Related Genes in Thyroid Carcinoma. (Pubmed Central) - Mar 11, 2022
The targeted bisulfite sequencing assay revealed that CHST2, DPP4, DUSP6, ITGA2, SLC1A5, TIAM1, TNIK, and ABTB2 methylation levels were dramatically lowered in thyroid cancer patients when compared to the controls, but GALNTL6, HTR7, SPOCD1, and GRM5 methylation levels were significantly raised. Our study revealed that the whole-genome DNA methylation patterns and gene expression profiles in thyroid cancer shed new light on the tumorigenesis of thyroid cancer.
- |||||||||| Journal: Putative regulatory functions of SNPs associated with bronchial asthma, arterial hypertension and their comorbid phenotype. (Pubmed Central) - Jan 29, 2022
The risk of developing a comorbid phenotype of AD and AH is associated with the A allele of rs7038716 and the T allele of rs7025144 of the TLR4/AL160272.2 genes, the A allele of rs1010461 of the ANG gene and the C allele of rs2022318 of the ABTB2/CAT genes. Variants rs7038716 and rs7025144 can change the expression levels of the TLR4 gene in blood cells, while rs1010461 and rs2022318 influence the expression levels of the ANG and RNASE4 genes as well as the CAT and ABTB2 genes in blood cells, lungs/vessels/heart.
- |||||||||| Clinical, Journal: Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence. (Pubmed Central) - Jun 16, 2021
Epidemiological analyses on the identified genes showed associations between polymorphisms in SIRT1 and ABTB1 and cognitive performance as well as interactions between SIRT1 genotype and physical activity and between GRB10 genotype and adherence to a Mediterranean diet. Our study contributes to the understanding of neural stem cell molecular mechanisms underlying human cognitive aging and hints at lifestyle modifiable factors.
- |||||||||| Journal, IO biomarker: Weighted Gene Co-Expression Network Analysis Identifies Key Modules and Hub Genes Associated with Mycobacterial Infection of Human Macrophages. (Pubmed Central) - Jan 28, 2021
Moreover, by network analysis applied to the 74 genes with the best correlation with mycobacteria infection, we identified the top 10 hub-connecting genes: NAMPT, IRAK2, SOCS3, PTGS2, CCL20, IL1B, ZC3H12A, ABTB2, GFPT2, and ELOVL7. Interestingly, apart from the well-known Toll-like receptor and inflammation-associated genes, other genes may serve as novel TB diagnosis markers and potential therapeutic targets.
- |||||||||| Journal: MicroRNA-125b-5p Regulates Hepatocyte Proliferation During the Termination Phase of Liver Regeneration. (Pubmed Central) - Dec 12, 2020
Further, we found that ankyrin repeat and BTB/POZ domain containing protein 1 (Abtb1) is a direct target of miR-125b-5p in primary mouse and human hepatocytes and contributes to the pro-proliferative activity of miR-125b-5p by forkhead box G1 (FOXG1) and the cyclin-dependent kinase inhibitor 1A (p21) pathway. miR-125b-5p has an important role in regulating hepatocyte proliferation in the termination phase of liver regeneration and may serve as a potential therapeutic target in various liver diseases that often exhibit deregulated hepatocyte proliferation.
- |||||||||| Journal: Effects of long-term feeding of rapeseed meal on skeletal muscle transcriptome, production efficiency and meat quality traits in Norwegian Landrace growing-finishing pigs. (Pubmed Central) - Mar 20, 2020
In parallel, higher levels of NR4A3, PDK4 and FGF21, and a drop in adropin, ELOVL6 and CIDEC/FSP27 indicated increased lipolysis and fatty acid oxidation, reflective of lower dressing percentage. Finally, pigs exposed to RSM showed greater expression level of genes responsive to oxidative stress, indicated by upregulation of GPX1, GPX2, and TXNIP.
- |||||||||| Preclinical, Journal: Genome-wide association studies for the number of animals born alive and dead in duroc pigs. (Pubmed Central) - Mar 8, 2020
After stepwise conditional analyses around the putative regions, eight independent signals were ultimately identified for NBA, NS, and NM, and there were seven promising candidate genes related to these traits, including ARID1A, RXRG, NFATC4, ABTB2, GRAMD1B, NDRG1, and APC. Our findings contribute to the understanding of the significant genetic causes of piglets born alive and dead, and could have a positive effect on pig production efficiency and economic profits.
- |||||||||| Journal: Differential Expression of Genes for Ubiquitin Ligases in Medulloblastoma Subtypes. (Pubmed Central) - Dec 20, 2019
This was illustrated by analysis of gene expression of ubiquitin ligases of the Pfister dataset and confirmed in the dataset of Cavalli. We conclude that genes for ubiquitin ligases can be used as genetic markers for MB subtypes and that the proteins coded for by these genes should be investigated as subtype specific therapeutic targets for MB.
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