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Preclinical, Journal: miR-762 activation confers acquired resistance to gefitinib in non-small cell lung cancer. (Pubmed Central) - Apr 12, 2020 Taken together, the present study revealed that subsets of RhoA-GEFs differentially promote axon branching of mammalian cortical neurons. Our findings provide a rationale for future efforts testing miR-762 inhibition and ABR restoration co-treatment in patients with recurrent EGFR mutant NSCLC to therapeutically combat the heterogeneity of EGFR-TKIs resistance mechanisms.
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